The methyl ester of okadaic acid is more potent than okadaic acid in disrupting the actin cytoskeleton and metabolism of primary cultured hepatocytes

British Journal of Pharmacology

Volumn 159, Issue 2, 2010, Pages 337-344

  Espiña, Begoña ^a   Louzao, McArmen ^a   Cagide, Eva ^a   Alfonso, Amparo ^a   Vieytes, Mercedes R ^a   Yasumoto, Takeshi ^b   Botana, Luis M ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^b JAPAN FOOD RESEARCH LABORATORIES   (Japan)

Author keywords

Actin cytoskeleton; Glucose uptake kinetics; Metabolic rate; Methyl okadaate; Microcystin; Okadaic acid; Phycotoxins; Protein phosphatase and rat hepatocytes

Indexed keywords

ACTIN; ARGININE; GLUCOSE; LEUCINE; METHYL OKADAATE; MICROCYSTIN; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR; SERINE THREONINE PROTEIN PHOSPHATASE; SERINE THREONINE PROTEIN PHOSPHATASE 1; SERINE THREONINE PROTEIN PHOSPHATASE 2A; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL IMMORTALIZATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSKELETON; DRUG MECHANISM; DRUG POTENCY; ENZYME ASSAY; ENZYME INHIBITION; GLUCOSE TRANSPORT; LIVER CELL; LIVER METABOLISM; METABOLIC RATE; NONHUMAN; PRIORITY JOURNAL; RAT;

ACTINS; ANIMALS; CELLS, CULTURED; CYTOSKELETON; ETHERS, CYCLIC; GLUCOSE; HEPATOCYTES; HUMANS; MICROCYSTINS; OKADAIC ACID; PROTEIN PHOSPHATASE 2; RATS;

EID: 75649137218     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00512.x     Document Type: Article

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