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Volumn 39, Issue 2-3, 2001, Pages 349-362

Effects of the diarrhetic shellfish toxin, okadaic acid, on cytoskeletal elements, viability and functionality of rat liver and intestinal cells

Author keywords

Actin; Anoikis; Apoptosis; Bile canaliculus; Caspase inhibitor; Colonocyte; Cytoskeleton; Hepatocyte; Intermediate filament; K 252a; Keratin; Microtubule; Naringin; Vanadate

Indexed keywords

AURANTIIN; CASPASE INHIBITOR; DIARRHETIC SHELFISH TOXIN; DNA FRAGMENT; FLAVONOID; K 252A; KERATIN; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR; PROTEIN KINASE INHIBITOR; TOXIN; TUBULIN; UNCLASSIFIED DRUG; VANADIC ACID; ZVAD.FMK;

EID: 0034598636     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-0101(00)00137-9     Document Type: Article
Times cited : (57)

References (38)
  • 2
    • 0033902938 scopus 로고    scopus 로고
    • Prevention of toxin-induced cytoskeletal disruption and apoptotic liver cell death by the grapefruit flavonoid, naringin
    • in press
    • Blankson, H., Grotterød, E.M., Seglen, P.O., 2000. Prevention of toxin-induced cytoskeletal disruption and apoptotic liver cell death by the grapefruit flavonoid, naringin. Cell Death and Differentiation, in press.
    • (2000) Cell Death and Differentiation
    • Blankson, H.1    Grotterød, E.M.2    Seglen, P.O.3
  • 3
    • 0029077946 scopus 로고
    • Disruption of the cytokeratin cytoskeleton and inhibition of hepatocytic autophagy by okadaic acid
    • Blankson H., Holen I., Seglen P.O. Disruption of the cytokeratin cytoskeleton and inhibition of hepatocytic autophagy by okadaic acid. Exp. Cell Res. 218:1995;522-530.
    • (1995) Exp. Cell Res. , vol.218 , pp. 522-530
    • Blankson, H.1    Holen, I.2    Seglen, P.O.3
  • 4
    • 0025823502 scopus 로고
    • The protein phosphatase inhibitor okadaic acid induces morphological changes typical of apoptosis in mammalian cells
    • Bøe R., Gjertsen B.T., Vintermyr O.K., Houge G., Lanotte M., Døskeland S.O. The protein phosphatase inhibitor okadaic acid induces morphological changes typical of apoptosis in mammalian cells. Exp. Cell Res. 195:1991;237-246.
    • (1991) Exp. Cell Res. , vol.195 , pp. 237-246
    • Bøe, R.1    Gjertsen, B.T.2    Vintermyr, O.K.3    Houge, G.4    Lanotte, M.5    Døskeland, S.O.6
  • 6
    • 0029994358 scopus 로고    scopus 로고
    • Integrin-mediated activation of mitogen activated protein (MAP) or extracellular signal-related kinase kinase (MEK) and kinase is independent of Ras
    • Chen Q.M., Lin T.H., Der C.J., Juliano R.L. Integrin-mediated activation of mitogen activated protein (MAP) or extracellular signal-related kinase kinase (MEK) and kinase is independent of Ras. J. Biol. Chem. 271:1996;18122-18127.
    • (1996) J. Biol. Chem. , vol.271 , pp. 18122-18127
    • Chen, Q.M.1    Lin, T.H.2    Der, C.J.3    Juliano, R.L.4
  • 7
    • 0028360655 scopus 로고
    • Mitotic arrest with anti-microtubule agents or okadaic acid is associated with increased glycoprotein terminal GlcNAc's
    • Chou C.-F., Omary M.B. Mitotic arrest with anti-microtubule agents or okadaic acid is associated with increased glycoprotein terminal GlcNAc's. J. Cell Sci. 107:1994;1833-1843.
    • (1994) J. Cell Sci. , vol.107 , pp. 1833-1843
    • Chou, C.-F.1    Omary, M.B.2
  • 8
    • 0025181418 scopus 로고
    • Okadaic acid: A new probe for the study of cellular regulation
    • Cohen P., Holmes C.F.B., Tsukitani Y. Okadaic acid: A new probe for the study of cellular regulation. Trends Biochem. Sci. 15:1990;98-102.
    • (1990) Trends Biochem. Sci. , vol.15 , pp. 98-102
    • Cohen, P.1    Holmes, C.F.B.2    Tsukitani, Y.3
  • 9
    • 0024208869 scopus 로고
    • Toxic mussels and okadaic acid induce rapid hypersecretion in the rat small intestine
    • Edebo L., Lange S., Li X.P., Allenmark S. Toxic mussels and okadaic acid induce rapid hypersecretion in the rat small intestine. APMIS. 96:1988;1029-1035.
    • (1988) APMIS , vol.96 , pp. 1029-1035
    • Edebo, L.1    Lange, S.2    Li, X.P.3    Allenmark, S.4
  • 11
    • 84970582448 scopus 로고
    • Liver pathology in mice in poisoning by the blue-green alga Microcystis aeruginosa
    • Falconer I.R., Jackson A.R.B., Langley J., Runnegar M.T. Liver pathology in mice in poisoning by the blue-green alga Microcystis aeruginosa. Aust. J. Biol. Sci. 34:1981;179-187.
    • (1981) Aust. J. Biol. Sci. , vol.34 , pp. 179-187
    • Falconer, I.R.1    Jackson, A.R.B.2    Langley, J.3    Runnegar, M.T.4
  • 12
    • 0026544023 scopus 로고
    • Cytoskeletal changes in hepatocytes induced by Microcystis toxins and their relation to hyperphosphorylation of cell proteins
    • Falconer I.R., Yeung D.S.K. Cytoskeletal changes in hepatocytes induced by Microcystis toxins and their relation to hyperphosphorylation of cell proteins. Chem. Biol. Interact. 81:1992;181-196.
    • (1992) Chem. Biol. Interact. , vol.81 , pp. 181-196
    • Falconer, I.R.1    Yeung, D.S.K.2
  • 13
    • 0028057613 scopus 로고
    • Disruption of epithelial cell-matrix interactions induces apoptosis
    • Frisch S.M., Francis H. Disruption of epithelial cell-matrix interactions induces apoptosis. J. Cell Biol. 124:1994;619-626.
    • (1994) J. Cell Biol. , vol.124 , pp. 619-626
    • Frisch, S.M.1    Francis, H.2
  • 14
    • 0027272945 scopus 로고
    • Tumor promotion by inhibitors of protein phosphatases 1 and 2A: The okadaic acid class of compounds
    • Fujiki H., Suganuma M. Tumor promotion by inhibitors of protein phosphatases 1 and 2A: the okadaic acid class of compounds. Adv. Cancer Res. 61:1993;143-194.
    • (1993) Adv. Cancer Res. , vol.61 , pp. 143-194
    • Fujiki, H.1    Suganuma, M.2
  • 15
    • 0026648674 scopus 로고
    • Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
    • Gavrieli Y., Sherman Y., Ben-Sasson S.A. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell. Biol. 119:1992;493-501.
    • (1992) J. Cell. Biol. , vol.119 , pp. 493-501
    • Gavrieli, Y.1    Sherman, Y.2    Ben-Sasson, S.A.3
  • 16
    • 0028957045 scopus 로고
    • Protection, by naringin and some other flavonoids, of hepatocytic autophagy and endocytosis against inhibition by okadaic acid
    • Gordon P.B., Holen I., Seglen P.O. Protection, by naringin and some other flavonoids, of hepatocytic autophagy and endocytosis against inhibition by okadaic acid. J. Biol. Chem. 270:1995;5830-5838.
    • (1995) J. Biol. Chem. , vol.270 , pp. 5830-5838
    • Gordon, P.B.1    Holen, I.2    Seglen, P.O.3
  • 17
    • 0022402504 scopus 로고
    • Severe hepatotoxicity caused by the tropical cyanobacterium (blue-green alga) Cylindrospermopsis raciborskii (Woloszynska) Seenaya and Subba Raju isolated from a domestic water supply reservoir
    • Hawkins P.R., Runnegar M.T.C., Jackson A.R.B., Falconer I.R. Severe hepatotoxicity caused by the tropical cyanobacterium (blue-green alga) Cylindrospermopsis raciborskii (Woloszynska) Seenaya and Subba Raju isolated from a domestic water supply reservoir. Appl. Environ. Microbiol. 50:1985;1292-1295.
    • (1985) Appl. Environ. Microbiol. , vol.50 , pp. 1292-1295
    • Hawkins, P.R.1    Runnegar, M.T.C.2    Jackson, A.R.B.3    Falconer, I.R.4
  • 18
    • 0024592297 scopus 로고
    • Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism
    • Haystead T.A.J., Sim A.T.R., Carling D., Honnor R.C., Tsukitani Y., Cohen P., Hardie D.G. Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism. Nature. 337:1989;78-81.
    • (1989) Nature , vol.337 , pp. 78-81
    • Haystead, T.A.J.1    Sim, A.T.R.2    Carling, D.3    Honnor, R.C.4    Tsukitani, Y.5    Cohen, P.6    Hardie, D.G.7
  • 19
    • 0030698810 scopus 로고    scopus 로고
    • The apoptosis-necrosis paradox. Apoptogenic proteases activated after mitochondrial permeability transition determine the mode of cell death
    • Hirsch T., Marchetti P., Susin S.A., Dallaporta B., Zamzami N., Marzo I., Geuskens M., Kroemer G. The apoptosis-necrosis paradox. Apoptogenic proteases activated after mitochondrial permeability transition determine the mode of cell death. Oncogene. 15:1997;1573-1581.
    • (1997) Oncogene , vol.15 , pp. 1573-1581
    • Hirsch, T.1    Marchetti, P.2    Susin, S.A.3    Dallaporta, B.4    Zamzami, N.5    Marzo, I.6    Geuskens, M.7    Kroemer, G.8
  • 20
    • 0026645413 scopus 로고
    • Protein kinase-dependent effects of okadaic acid on hepatocytic autophagy and cytoskeletal integrity
    • Holen I., Gordon P.B., Seglen P.O. Protein kinase-dependent effects of okadaic acid on hepatocytic autophagy and cytoskeletal integrity. Biochem. J. 284:1992;633-636.
    • (1992) Biochem. J. , vol.284 , pp. 633-636
    • Holen, I.1    Gordon, P.B.2    Seglen, P.O.3
  • 21
    • 0027296748 scopus 로고
    • Inhibition of hepatocytic autophagy by okadaic acid and other protein phosphatase inhibitors
    • Holen I., Gordon P.B., Seglen P.O. Inhibition of hepatocytic autophagy by okadaic acid and other protein phosphatase inhibitors. Eur. J. Biochem. 215:1993;113-122.
    • (1993) Eur. J. Biochem. , vol.215 , pp. 113-122
    • Holen, I.1    Gordon, P.B.2    Seglen, P.O.3
  • 22
    • 0025986006 scopus 로고
    • Regional orientation of actin filaments in the pericanalicular cytoplasm of rat hepatocytes
    • Ishii M., Washioka H., Tonosaki A., Toyota T. Regional orientation of actin filaments in the pericanalicular cytoplasm of rat hepatocytes. Gastroenterology. 101:1991;1663-1672.
    • (1991) Gastroenterology , vol.101 , pp. 1663-1672
    • Ishii, M.1    Washioka, H.2    Tonosaki, A.3    Toyota, T.4
  • 23
    • 0028633424 scopus 로고
    • Injury and recovery process of intestine caused by okadaic acid and related compounds
    • Ito E., Terao K. Injury and recovery process of intestine caused by okadaic acid and related compounds. Nat. Toxins. 2:1994;371-377.
    • (1994) Nat. Toxins , vol.2 , pp. 371-377
    • Ito, E.1    Terao, K.2
  • 26
    • 0027096275 scopus 로고
    • Cantharidin-binding protein: Identification as protein phosphatase 2A
    • Li Y.M., Casida J.E. Cantharidin-binding protein: identification as protein phosphatase 2A. Proc. Natl. Acad. Sci. USA. 89:1992;11867-11870.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 11867-11870
    • Li, Y.M.1    Casida, J.E.2
  • 27
    • 0027451706 scopus 로고
    • The extracellular matrix as a cell survival factor
    • Meredith J.E., Fazeli B., Schwartz M.A. The extracellular matrix as a cell survival factor. Mol. Biol. Cell. 4:1993;953-961.
    • (1993) Mol. Biol. Cell , vol.4 , pp. 953-961
    • Meredith, J.E.1    Fazeli, B.2    Schwartz, M.A.3
  • 28
    • 0026100142 scopus 로고
    • Hepatotoxicity of microcystin-LR in fed and fasted rats
    • Miura G.A., Robinson N.A., Lawrence W.B., Pace J.G. Hepatotoxicity of microcystin-LR in fed and fasted rats. Toxicon. 29:1991;337-346.
    • (1991) Toxicon , vol.29 , pp. 337-346
    • Miura, G.A.1    Robinson, N.A.2    Lawrence, W.B.3    Pace, J.G.4
  • 29
    • 0020467073 scopus 로고
    • The catalog of human cytokeratins: Patterns of expression in normal epithelia, tumors and cultured cells
    • Moll R., Franke W.W., Schiller D.L., Geiger B., Krepler R. The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells. Cell. 31:1982;11-24.
    • (1982) Cell , vol.31 , pp. 11-24
    • Moll, R.1    Franke, W.W.2    Schiller, D.L.3    Geiger, B.4    Krepler, R.5
  • 30
    • 0027057360 scopus 로고
    • Hyperphosphorylation of cytokeratins 8 and 18 by microcystin-LR, a new liver tumor promoter, in primary cultured rat hepatocytes
    • Ohta T., Nishiwaki R., Yatsunami J., Komori A., Suganuma M., Fujiki H. Hyperphosphorylation of cytokeratins 8 and 18 by microcystin-LR, a new liver tumor promoter, in primary cultured rat hepatocytes. Carcinogenesis. 13:1992;2443-2447.
    • (1992) Carcinogenesis , vol.13 , pp. 2443-2447
    • Ohta, T.1    Nishiwaki, R.2    Yatsunami, J.3    Komori, A.4    Suganuma, M.5    Fujiki, H.6
  • 31
    • 0032530577 scopus 로고    scopus 로고
    • Regional selective neuronal degeneration after protein phosphatase inhibition in hippocampal slice cultures: Evidence for a MAP kinase-dependent mechanism
    • Rundén E., Seglen P.O., Haug F.-M., Ottersen O.P., Wieloch T., Shamloo M., Laake J.H. Regional selective neuronal degeneration after protein phosphatase inhibition in hippocampal slice cultures: Evidence for a MAP kinase-dependent mechanism. J. Neurosci. 18:1998;7296-7305.
    • (1998) J. Neurosci , vol.18 , pp. 7296-7305
    • Rundén, E.1    Seglen, P.O.2    Haug, F.-M.3    Ottersen, O.P.4    Wieloch, T.5    Shamloo, M.6    Laake, J.H.7
  • 32
    • 0019453393 scopus 로고
    • Deformation of isolated rat hepatocytes by a peptide hepatotoxin from the blue-green alga Microcystis aeruginosa
    • Runnegar M.T., Falconer I.R., Silver J. Deformation of isolated rat hepatocytes by a peptide hepatotoxin from the blue-green alga Microcystis aeruginosa. Naunyn-Schmiedeberg's Arch. Pharmacol. 317:1981;268-272.
    • (1981) Naunyn-Schmiedeberg's Arch. Pharmacol. , vol.317 , pp. 268-272
    • Runnegar, M.T.1    Falconer, I.R.2    Silver, J.3
  • 33
    • 0028335948 scopus 로고
    • Anchorage dependence, integrins, and apoptosis
    • Ruoslahti E., Reed J.C. Anchorage dependence, integrins, and apoptosis. Cell. 77:1994;477-478.
    • (1994) Cell , vol.77 , pp. 477-478
    • Ruoslahti, E.1    Reed, J.C.2
  • 34
    • 0017101039 scopus 로고
    • Preparation of isolated rat liver cells
    • Seglen P.O. Preparation of isolated rat liver cells. Meth. Cell Biol. 13:1976;29-83.
    • (1976) Meth. Cell Biol. , vol.13 , pp. 29-83
    • Seglen, P.O.1
  • 35
    • 0029940289 scopus 로고    scopus 로고
    • Rapid onset of apoptosis in vitro follows disruption of beta 1-integrin/matrix interactions in human colonic crypt cells
    • Strater J., Wedding U., Barth T.F., Koretz K., Elsing C., Moller P. Rapid onset of apoptosis in vitro follows disruption of beta 1-integrin/matrix interactions in human colonic crypt cells. Gastroenterology. 110:1996;1776-1784.
    • (1996) Gastroenterology , vol.110 , pp. 1776-1784
    • Strater, J.1    Wedding, U.2    Barth, T.F.3    Koretz, K.4    Elsing, C.5    Moller, P.6
  • 36
    • 0031024815 scopus 로고    scopus 로고
    • Protein phosphatases maintain the organization and structural interactions of hepatic keratin intermediate filaments
    • Toivola D.M., Goldman R.D., Garrod D.R., Eriksson J.E. Protein phosphatases maintain the organization and structural interactions of hepatic keratin intermediate filaments. J. Cell Sci. 110:1997;23-33.
    • (1997) J. Cell Sci. , vol.110 , pp. 23-33
    • Toivola, D.M.1    Goldman, R.D.2    Garrod, D.R.3    Eriksson, J.E.4
  • 37
    • 0030006616 scopus 로고    scopus 로고
    • Detection of microcystins, a blue-green algal hepatotoxin, in drinking water sampled in Haimen and Fusui, endemic areas of primary liver cancer in China, by highly sensitive immunoassay
    • Ueno Y., Nagata S., Tsutsumi T., Hasegawa A., Watanabe M.F., Park H.D., Chen G.C., Chen G., Yu S.Z. Detection of microcystins, a blue-green algal hepatotoxin, in drinking water sampled in Haimen and Fusui, endemic areas of primary liver cancer in China, by highly sensitive immunoassay. Carcinogenesis. 17:1996;1317-1321.
    • (1996) Carcinogenesis , vol.17 , pp. 1317-1321
    • Ueno, Y.1    Nagata, S.2    Tsutsumi, T.3    Hasegawa, A.4    Watanabe, M.F.5    Park, H.D.6    Chen, G.C.7    Chen, G.8    Yu, S.Z.9
  • 38
    • 0030044393 scopus 로고    scopus 로고
    • Protein-tyrosine phosphatase regulation of endothelial cell apoptosis and differentiation
    • Yang C., Chang J., Gorospe M., Passaniti A. Protein-tyrosine phosphatase regulation of endothelial cell apoptosis and differentiation. Cell Growth Differ. 7:1996;161-171.
    • (1996) Cell Growth Differ. , vol.7 , pp. 161-171
    • Yang, C.1    Chang, J.2    Gorospe, M.3    Passaniti, A.4


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