Differential roles of the glycogen-binding domains of β subunits in regulation of the Snf1 kinase complex

Eukaryotic Cell

Volumn 9, Issue 1, 2010, Pages 173-183

  Mangat, Simmanjeet ^a   Chandrashekarappa, Dakshayini ^a   McCartney, Rhonda R ^a   Elbing, Karin ^a,b   Schmidt, Martin C ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CASEIN KINASE II; GLUCOSE; GLYCOGEN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; ISOENZYME; MULTIPROTEIN COMPLEX; PROTEIN SERINE THREONINE KINASE; PROTEIN SUBUNIT; SACCHAROMYCES CEREVISIAE PROTEIN; SIP1 PROTEIN, S CEREVISIAE; SNF1 RELATED PROTEIN KINASES; SNF1-RELATED PROTEIN KINASES;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY; SACCHAROMYCES CEREVISIAE; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CASEIN KINASE II; GENE EXPRESSION REGULATION, FUNGAL; GLUCOSE; GLYCOGEN; ISOENZYMES; MOLECULAR SEQUENCE DATA; MULTIPROTEIN COMPLEXES; PROTEIN SUBUNITS; PROTEIN-SERINE-THREONINE KINASES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION;

SACCHAROMYCES CEREVISIAE;

EID: 75649125966     PISSN: 15359778     EISSN: None     Source Type: Journal    
DOI: 10.1128/EC.00267-09     Document Type: Article

References (34)

1. Charbon, G., et al. 2004. Key role of Ser562/661 in Snf1-dependent regulation of Cat8p in Saccharomyces cerevisiae and Kluyveromyces lactis. Mol. Cell. Biol. 24:4083-4091.
2. Dyck, J. R., et al. 1996. Regulation of 5 -AMP-activated protein kinase activity by the noncatalytic beta and gamma subunits. J. Biol. Chem. 271: 17798-17803.
3. Elbing, K., et al. 2006. Purification and characterization of the three Snf1activating kinases of Saccharomyces cerevisiae. Biochem. J. 393:797-805.
4. Ghaemmaghami, S., et al. 2003. Global analysis of protein expression in yeast. Nature 425:737-741.
5. Goldstein, A., and J. O. Lampen. 1975. β-D-Fructofuranoside fructohydrolase from yeast. Methods Enzymol. 42C:504-511.
6. Hardie, D. G. 2007. AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. Nat. Rev. Mol. Cell Biol. 8:774-785.
7. Hedbacker, K., and M. Carlson. 2008. SNF1/AMPK pathways in yeast. Front. Biosci. 13:2408-2420.
8. Hedbacker, K., et al. 2004. Pak1 protein kinase regulates activation and nuclear localization of Snf1-Gal83 protein kinase. Mol. Cell. Biol. 24:8255-8263.
9. Hong, S. P., and M. Carlson. 2007. Regulation of snf1 protein kinase in response to environmental stress. J. Biol. Chem. 282:16838-16845.
10. Kushnirov, V. V. 2000. Rapid and reliable protein extraction from yeast. Yeast 16:857-860.
11. Machovic, M., and S. Janecek. 2006. The evolution of putative starch-binding domains. FEBS Lett. 580:6349-6356.
12. McBride, A., et al. 2009. The glycogen-binding domain on the AMPK beta subunit allows the kinase to act as a glycogen sensor. Cell Metab. 9:23-34.
13. McCartney, R. R., and M. C. Schmidt. 2001. Regulation of Snf1 kinase. Activation requires phosphorylation of threonine 210 by an upstream kinase as well as a distinct step mediated by the Snf4 subunit. J. Biol. Chem. 276:36460-36466.
14. Meggio, F., et al. 1994. Substrate specificity of protein kinase CK2. Cell. Mol. Biol. Res. 40:401-409.
15. Momcilovic, M., et al. 2008. Roles of the glycogen-binding domain and Snf4 in glucose inhibition of SNF1 protein kinase. J. Biol. Chem. 283:19521-19529.
16. Nath, N., et al. 2002. Purification and characterization of Snf1 kinase complexes containing a defined beta subunit composition. J. Biol. Chem. 277: 50403-50408.
17. Neumann, D., et al. 2003. Mammalian AMP-activated protein kinase: functional, heterotrimeric complexes by co-expression of subunits in Escherichia coli. Protein Expr. Purif. 30:230-237.
18. Nolan, T., et al. 2006. Quantification of mRNA using real-time RT-PCR. Nat. Protoc. 1:1559-1582.
19. Polekhina, G., et al. 2003. AMPK beta subunit targets metabolic stress sensing to glycogen. Curr. Biol. 13:867-871.
20. Polekhina, G., et al. 2005. Structural basis for glycogen recognition by AMP-activated protein kinase. Structure 13:1453-1462.
21. Proft, M., et al. 1995. CAT5, a new gene necessary for derepression of gluconeogenic enzymes in Saccharomyces cerevisiae. EMBO J. 14:6116-6126.
22. Rubenstein, E. M., et al. 2008. Access denied: Snf1 activation loop phosphorylation is controlled by availability of the phosphorylated threonine 210 to the PP1 phosphatase. J. Biol. Chem. 283:222-230.
23. Sanders, M. J., et al. 2007. Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade. Biochem. J. 403:139-148.
24. Schmidt, M. C., and R. R. McCartney. 2000. Beta-subunits of Snf1 kinase are required for kinase function and substrate definition. EMBO J. 19:4936-4943.
25. Schmittgen, T. D., and K. J. Livak. 2008. Analyzing real-time PCR data by the comparative C(T) method. Nat. Protoc. 3:1101-1108.
26. Scott, J. W., et al. 2004. CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations. J. Clin. Invest. 113:274-284.
27. Sikorski, R. S., and P. Hieter. 1989. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122:19-27.
28. Smith, F. C., et al. 1999. The SNF1 kinase complex from Saccharomyces cerevisiae phosphorylates the transcriptional repressor protein Mig1p in vitro at four sites within or near regulatory domain 1. FEBS Lett. 453:219-223.
29. Southern, J. A., et al. 1991. Identification of an epitope on the P and V proteins of simian virus 5 that distinguishes between two isolates with different biological characteristics. J. Gen. Virol. 72:1551-1557.
30. Tomas-Cobos, L., and P. Sanz. 2002. Active Snf1 protein kinase inhibits expression of the Saccharomyces cerevisiae HXT1 glucose transporter gene. Biochem. J. 368:657-663.
31. Treitel, M. A., et al. 1998. Snf1 protein kinase regulates phosphorylation of the Mig1 repressor in Saccharomyces cerevisiae. Mol. Cell. Biol. 18:6273-6280.
32. Vincent, O., et al. 2001. Subcellular localization of the Snf1 kinase is regulated by specific beta subunits and a novel glucose signaling mechanism. Genes Dev. 15:1104-1114.
33. Xiao, B., et al. 2007. Structural basis for AMP binding to mammalian AMP-activated protein kinase. Nature 449:496-500.
34. Zhang, B. B., et al. 2009. AMPK: an emerging drug target for diabetes and the metabolic syndrome. Cell Metab. 9:407-416.