Key role of Ser562/661 in Snf1-dependent regulation of Cat8p in Saccharomyces cerevisiae and Kluyveromyces lactis

Molecular and Cellular Biology

Volumn 24, Issue 10, 2004, Pages 4083-4091

  Charbon, Godefroid ^a   Breunig, Karin D ^b   Wattiez, Ruddy ^c   Vandenhaute, Jean ^a   Noël Georis, Isabelle ^a,c  

^a UNIVERSITY OF NAMUR   (Belgium)

^b UNIVERSITY OF MONS   (Belgium)

^c MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; CARBON; FUNGAL PROTEIN; FUNGAL PROTEIN CAT 8P; FUNGAL PROTEIN SNF 1; GLUTAMIC ACID; MUTANT PROTEIN; PHOSPHOTRANSFERASE; SERINE; UNCLASSIFIED DRUG; ZINC; CAT8 PROTEIN, S CEREVISIAE; FUNGAL DNA; SACCHAROMYCES CEREVISIAE PROTEIN; TRANSACTIVATOR PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; CLUSTER ANALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; GENE MUTATION; HYPOTHESIS; KLUYVEROMYCES; MOLECULAR MIMICRY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; TWO HYBRID SYSTEM; BIOLOGICAL MODEL; CHEMISTRY; FUNGAL GENE; GENETICS; METABOLISM; NUCLEOTIDE SEQUENCE; PHOSPHORYLATION; PROTEIN TERTIARY STRUCTURE; RESTRICTION MAPPING; SITE DIRECTED MUTAGENESIS; SPECIES DIFFERENCE; TRANSACTIVATION;

KLUYVEROMYCES LACTIS; SACCHAROMYCES CEREVISIAE;

BASE SEQUENCE; CARBON; DNA, FUNGAL; FUNGAL PROTEINS; GENES, FUNGAL; KLUYVEROMYCES; MODELS, BIOLOGICAL; MUTAGENESIS, SITE-DIRECTED; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; RESTRICTION MAPPING; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SERINE; SPECIES SPECIFICITY; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 2942568007     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.24.10.4083-4091.2004     Document Type: Article

References (40)

1. Ausubel, F. M., R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl (ed.). 1994. Current protocols in molecular biology. John Wiley & Sons, Inc., New York, N.Y.
2. Breunig, K. D., M. Bolotin-Fukuhara, M. M. Bianchi, D. Bourgarel, C. Falcone, I. Ferrero, L. Frontali, P. Goffrini, J. J. Krijger, C. Mazzoni, C. Milkowski, H. Y. Steensma, M. Wesolowski-Louvel, and A. M. Zeeman. 2000. Regulation of primary carbon metabolism in Kluyveromyces lactis. Enzyme Microb. Technol. 26:771-780.
3. Breunig, K. D., and P. Kuger. 1987. Functional homology between the yeast regulatory proteins GAL4 and LAC9: LAC9-mediated transcriptional activation in Kluyveromyces lactis involves protein binding to a regulatory sequence homologous to the GAL4 protein-binding site. Mol. Cell. Biol. 7:4400-4406.
4. Carlson, M., B. C. Osmond, and D. Botstein. 1981. Mutants of yeast defective in sucrose utilization. Genetics 98:25-40.
5. Caspary, F., A. Hartig, and H.-J. Schüller. 1997. Constitutive and carbon source-responsive promoter elements are involved in the regulated expression of the Saccharomyces cerevisiae malate synthase gene MLS1. Mol. Gen. Genet. 255:619-627.
6. Ciriacy, M. 1977. Isolation and characterization of yeast mutants defective in intermediary carbon metabolism and in carbon catabolite derepression. Mol. Gen. Genet. 154:213-220.
7. Dale, S., W. A. Wilson, A. M. Edelman, and D. G. Hardie. 1995. Similar substrate recognition motifs for mammalian AMP-activated protein kinase, higher plant HMG-CoA reductase kinase-A, yeast SNF1, and mammalian calmodulin-dependent protein kinase I. FEBS Lett. 361:191-195.
8. De Deken, R. H. 1966. The Crabtree effect: a regulatory system in yeast. J. Gen. Microbiol. 44:149-156.
9. Delaveau, T., A. Delahodde, E. Carvajal, J. Subik, and C. Jacq. 1994. PDR3, a new yeast regulatory gene, is homologous to PDR1 and controls the multidrug resistance phenomenon. Mol. Gen. Genet. 244:501-511.
10. de Mesquita, J. F., O. Zaragoza, and J. M. Gancedo. 1998. Functional analysis of upstream activating elements in the promoter of the FBP1 gene from Saccharomyces cerevisiae. Curr. Genet. 33:406-411.
11. DeRisi, J. L., V. R. Iyer, and P. O. Brown. 1997. Exploring the metabolic and genetic control of gene expression on a genomic scale. Science 278:680-686.
12. Georis, I., J.-P. Cassart, K. D. Breunig, and J. Vandenhaute. 1999. Glucose repression of the Kluyveromyces lactis invertase gene KlINV1 does not require Mig1p. Mol. Gen. Genet. 261:862-870.
13. Georis, I., J.-J. Krijger, K. D. Breunig, and J. Vandenhaute. 2000. Differences in regulation of yeast gluconeogenesis revealed by Cat8p-independent activation of PCK1 and FBP1 genes in Kluyveromyces lactis. Mol. Gen. Genet. 1-2:193-203.
14. Goffrini, P., A. Ficarelli, C. Donnini, T. Lodi, P. P. Puglisi, and I. Ferrero. 1996. FOG1 and FOG2 genes, required for the transcriptional activation of glucose-repressible genes of Kluyveromyces lactis, are homologous to GAL83 and SNF1 of Saccharomyces cerevisiae. Curr. Genet. 29:316-326.
15. 1 and S phase protein phosphatase that associates with Cdk2. Cell 75:791-803.
16. Haurie, V., M. Perrot, T. Mini, P. Jeno, F. Sagliocco, and H. Boucherie. 2001. The transcriptional activator Cat8p provides a major contribution to the reprogramming of carbon metabolism during the diauxic shift in Saccharomyces cerevisiae. J. Biol. Chem. 276:76-85.
17. Hedges, D., M. Proft, and K.-D. Entian. 1995. CAT8, a new zinc cluster-encoding gene necessary for derepression of gluconeogenic enzymes in the yeast Saccharomyces cerevisiae. Mol. Cell. Biol. 15:1915-1922.
18. Kratzer, S., A. Schöler, and H.-J. Schüller. 1995. Regulatory factors of carbon source-dependent transcription of gluconeogenic genes ICL1 and ACS1 in S. cerevisiae. Yeast 11:S214.
19. Kratzer, S., and H.-J. Schüller. 1995. Carbon source-dependent regulation of the acetyl-coenzyme A synthetase-encoding gene ACS1 from Saccharomyces cerevisiae. Gene 161:75-79.
20. Krijger, J.-J. 2002. Carbon source-responsive elements and gene regulation by CAT8 and SIP4 in the yeast Kluyveromyces lactis. PhD thesis. Martin-Luther-Universität, Halle-Wittenberg, Germany.
21. 6 zinc cluster transcriptional activator: a new role for SNF1 in the glucose response. Mol. Cell. Biol. 16:1921-1928.
22. Lodi, T., M. Saliola, C. Donnini, and P. Goffrini. 2001. Three target genes for the transcriptional activator Cat8p of Kluyveromyces lactis: acetyl coenzyme A synthetase genes KlACS1 and KlACS2 and lactate permease gene KlJEN1. J. Bacteriol. 183:5257-5261.
23. Mercado, J. J., and J. M. Gancedo. 1992. Regulatory regions in the yeast FBP1 and PCK1 genes. FEBS Lett. 311:110-114.
24. Miller, J. H. 1972. Experiments in molecular genetics. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
25. Poch, O. 1997. Conservation of a putative inhibitory domain in the GAL4 family members. Gene 184:229-235.
26. Proft, M., D. Grzesitza, and K.-D. Entian. 1995. Identification and characterization of regulatory elements in the phosphoenolpyruvate carboxykinase gene PCK1 of Saccharomyces cerevisiae. Mol. Gen. Genet. 246:367-373.
27. Rahner, A., M. Hiesinger, and H.-J. Schüller. 1999. Deregulation of gluconeogenic structural genes by variants of the transcriptional activator Cat8p in the yeast Saccharomyces cerevisiae. Mol. Microbiol. 34:146-156.
28. Rahner, A., A. Schöler, E. Martens, B. Goolwitzer, and H.-J. Schüller. 1996. Dual influence of the yeast Cat1p (Snf1p) protein kinase on carbon source-dependent transcriptional activation of gluconeogenic genes by the regulatory gene CAT8. Nucleic Acids Res. 24:2331-2337.
29. Randez-Gil, F., N. Bojunga, M. Proft, and K.-D. Entian. 1997. Glucose derepression of gluconeogenic enzymes in Saccharomyces cerevisiae correlates with phosphorylation of the gene activator Cat8p. Mol. Cell. Biol. 17:2502-2510.
30. 6 zinc cluster family of transcriptional regulators. Nucleic Acids Res. 24:4599-4607.
31. Schöler, A., and H.-J. Schüller. 1994. A carbon source-responsive promoter element necessary for activation of the isocitrate lyase gene ICL1 is common to genes of the gluconeogenic pathway in the yeast Saccharomyces cerevisiae. Mol. Cell. Biol. 14:3613-3622.
32. Treitel, M. A., S. Kuchin, and M. Carlson. 1998. Snf1 protein kinase regulates phosphorylation of the Mig1 repressor in Saccharomyces cerevisiae. Mol. Cell. Biol. 18:6273-6280.
33. Vidal, M., R. K. Brachmann, A. Fattaey, E. Harlow, and J. D. Boeke. 1996. Reverse two-hybrid and one-hybrid systems to detect dissociation of protein-protein and DNA-protein interactions. Proc. Natl. Acad. Sci. USA 93:10315-10320.
34. Vincent, O., and M. Carlson. 1998. Sip4, a snf1 kinase-dependent transcriptional activator, binds to the carbon source-responsive element of gluconeogenic genes. EMBO J. 17:7002-7008.
35. Vincent, O., and J. M. Gancedo. 1995. Analysis of positive elements sensitive to glucose in the promoter of the FBP1 gene from yeast. J. Biol. Chem. 270:12832-12838.
36. Vincent, O., S. Kuchin, S. Hong, R. Townley, V. Vjas, and M. Carlson. 2001. Interaction of the Srb10 kinase with Sip4, a transcriptional activator of gluconeogenic genes in Saccharomyces cerevisiae. Mol. Cell. Biol. 21:5790-5796.
37. Vincent, O., R. Townley, S. Kuchin, and M. Carlson. 2001. Subcellular localization of the Snf1 kinase is regulated by specific beta subunits and a novel glucose signaling mechanism. Genes Dev. 15:1104-1114.
38. Wésolowski-Louvel, M., K. D. Breunig, and H. Fukuhara. 1996. Kluyveromyces lactis, p. 139-201. In K. Wolf (ed.), Non-conventional yeasts in biotechnology. Springer-Verlag, Heidelberg, Germany.
39. Young, E. T., K. M. Dombek, C. Tachibana, and T. Ideker. 2003. Multiple pathways are co-regulated by the protein kinase Snf1 and the transcription factors Adr1 and Cat8. J. Biol. Chem., 278:26146-26158.
40. Zimmermann, F. K., I. Kaufmann, H. Rasenberger, and P. Haubetamann. 1977. Genetics of carbon catabolite repression in Saccharomyces cerevisiae: genes involved in the derepression process. Mol. Gen. Genet. 151:95-103.