Detection of apoptotsis induced by gentamicin in rat hepatocytes

International Journal of Zoological Research

Volumn 5, Issue 4, 2009, Pages 161-170

  Alkahtani, Saad ^a   Alarifi, Saud A ^b   Al Doaiss, Amin Abdullah ^b  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Apopotosis; Gentamicin; PARP; Rat liver

Indexed keywords

RATTUS;

EID: 75449108721     PISSN: 18119778     EISSN: 18119786     Source Type: Journal    
DOI: 10.3923/ijzr.2009.161.170     Document Type: Article

References (23)

1. Brock, W., L. Milas, S. Bergh, R. Lo, C. Szabó and A. Mason, 2004. Radiosensitization of human and rodent cell lines by INO-101, a novel inhibitor of poly (ADP-ribose) polymerase. Cancer Lett., 205: 155-160.
2. Conde de la Rosa, L., M. Schoemaker, T. Vrenken, M. Buist-Homan, R. Havinga, P. Jansen and H. Moshage, 2006. Superoxide anions and hydrogen peroxide induce hepatocyte death by different mechanisms: Involvement of JNK and ERK MAP kinases. J. Hepatol., 44: 918-929.
3. Dehne, N., U. Rauen, H. Groot and J. Lautermann, 2002. Involvement of the mitochondrial permeability transition in gentamicin ototoxicity. Hear. Res., 169: 47-55.
4. El-Mouedden, M., G. Laurent, M. Mingeot-Leclercq and P. Tulkens, 2000. Gentamicin-induced apoptosis in renal cell lines and embryonic rat fibroblasts. Toxicol. Sci., 56: 229-239.
5. Ho, Y., H. Lee, C. Chang and J. Lin, 1999. Induction of bax protein and degradation of lamin A during p53-dependent apoptosis induced by chemotherapeutic agents in human cancer cell lines. Biochemical Pharmacol., 57: 143-154.
6. Hossain, K., A. Akhand, M. Kato, J. Due and K. Takeda et al., 2000. Arsenite induces apoptosis of murine T lymphocytes through membrane raft-linked signaling for activation of c-Jun amino-terminal kinase. J. Immunol., 165: 4290-4297.
7. Jung, J., C. Han, Y. Jeong, H. Kim and H. Lim et al., 2007. Epigallocatechin gallate inhibits nitric oxide-induced apoptosis in rat PC12 cells. Neurosci. Lett., 411: 222-227.
8. Jurkiewicz, M., D. Averill-Bates, M. Marion and F. Denizeau, 2004. Involvement of mitochondrial and death receptor pathways in tributyltin-induced apoptosis in rat hepatocytes. Biochimica Biophysica Acta (BBA)-Molecular Cell Res., 1693: 15-27.
9. Kalayarasan, S., P. Nagendraprabhu, N. Sriram, R. Manikandan, M. Arumugam and G. Sudhandiran, 2009. Diallyl sulfide enhances antioxidants and inhibits inflammation through the activation of Nrf2 against gentamicin-induced nephrotoxicity in Wistar rats. Eur. J. Pharmacol., 606: 162-171.
10. Kang, H.M., S.K. Lee, D.S. Shin, M.Y. Lee and D.C. Han et al., 2006. Dehydrotrametenolic acid selectively inhibits the growth of H-ras transformed rat2 cells and induces apoptosis through caspase-3 pathway. Life Sci., 78: 607-613.
11. Lee, D.H., M. Szczepanski and Y. Lee, 2008. Role of Bax in quercetin-induced apoptosis in human prostate cancer cells. Biochemical Pharmacol., 75: 2345-2355.
12. Mathas, S., A. Lietz, M. Janz, M. Hinz and F. Jundt et al., 2003. Inhibition of NF-kB essentially contributes to arsenic-induced apoptosis. Am. Soc. Hematol., 102: 1028-1034.
13. Mclaren, S.H., D. Gao, L. Chen, R. Lin and J.R. Eshleman et al., 2006. Oxidative stress and DNA damage-DNA repair system in vascular smooth muscle cells in artery and vein grafts. J. Cardiothroracic Renal Res., 1: 59-72.
14. Mikami, O., S. Yamamoto, N. Yamanaka and Y. Nakajima, 2004. Porcine hepatocyte apoptosis and reduction of albumin secretion induced by deoxynivalenol. Toxicology, 204: 241-249.
15. Moronvalle-Halley, V., B. Sacré-Salem, V. Sallez, G. Labbe and J.C. Gautier, 2005. Evaluation of cultured, precision-cut rat liver slices as a model to study drug-induced liver apoptosis. Toxicology, 207: 203-214.
16. Nguewa, P., M. Fuertes, C. Alonso and J. Perez, 2003. Pharmacological modulation of Poly(ADP-ribose) polymerase-mediated cell death: Exploitation in cancer chemotherapy. Mol. Pharmacol., 64: 1007-1014.
17. Ochi, T., K. Kita, T. Suzuki, A. Rumpler, W. Goessler and K. Francesconi, 2008. Cytotoxic, Genotoxic and cell-cycle disruptive effects of thio-dimethylarseinate in cultured human cells and the role of glutathione. Toxicol. Applied Pharmacol., 228: 59-67.
18. Qin, X., L. Hudson, W. Liu, G. Timmins and K. Liu, 2008. Low concentration of arsenite exacerbates UVR-induced DNA strand breaks by inhibiting PARP-1 activity. Toxicol. Applied Pharmacol., 232: 41-50.
19. Servais, H., P. Smissen, G. Thirion, G. Essen, F. Bambeke, P. Tulkens and M. Mingeot-Leclercq, 2005. Gentamicin-induced apoptosis in LLC-PK1 cells: Involvement of lysosomes and mitochondria. Toxicol. Applied Pharmacol., 206: 321-333.
20. Shi, H., L. Hudson and K. Liu, 2004. Oxidative stress and apoptosis in metal ion-induced carcinogenesis. Free Radic. Biol. Med., 37: 582-593.
21. Wijk, S. and G. Hageman, 2005. Poly(ADP-ribose)polymerase-1 mediated caspase-independent cell death after ischemia/reperfusion. Free Radic. Biol. Med., 39: 81-90.
22. Yasin, K.F., M. Sabir, M.I.K. Sherwani, M. Zafar, S. Yasmin and M.I. Alam, 2003. Amelioration of Gentamicin Nephrotoxicity by vitamin B6 (a general and histochemical profile). Pak. J. Med. Res., 42: 69-73.
23. Yu, Q.T., M. Saruta and K.A. Papadakis, 2008. Visilizumab induces apoptosis of mucosal T lymphocytes in ulcerative colitis through activation of caspase 3 and 8 dependent pathways. Clin. Immunol., 127: 322-329.