Dehydrotrametenolic acid selectively inhibits the growth of H-ras transformed rat2 cells and induces apoptosis through caspase-3 pathway

Life Sciences

Volumn 78, Issue 6, 2006, Pages 607-613

  Kang, Hyun Mi ^a   Lee, Su Kyung ^a   Shin, Dae Seop ^a,b   Lee, Mi Young ^a   Han, Dong Cho ^a   Baek, Nam In ^c   Son, Kwang Hee ^a   Kwon, Byoung Mog ^a,b  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b University of Science and Technology (UST)   (South Korea)

^c Kyung Hee University   (South Korea)

Author keywords

Apoptosis; Caspase 3; Cell cycle arrest; Dehydrotrametenolic acid; H ras; Poria cocos Wolf

Indexed keywords

CASPASE 3; DEHYDROTRAMETENOLIC ACID; DNA FRAGMENT; LAMININ; MITOGEN ACTIVATED PROTEIN KINASE; NATURAL PRODUCT; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PORIA COCOS EXTRACT; PROTEIN KINASE B; TRITERPENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL GROWTH; CELL PROLIFERATION; CELL STRAIN; CELL TRANSFORMATION; CHROMOSOME; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG ISOLATION; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; ENZYME ACTIVATION; FLUORESCENCE ACTIVATED CELL SORTING; FUNGAL SCLEROTIUM; GENE EXPRESSION; GROWTH INHIBITION; MITOSIS INHIBITION; NONHUMAN; ONCOGENE H RAS; POLYPORACEAE; PORIA COCOS; PROTEIN DEGRADATION; RAT; SIGNAL TRANSDUCTION; STEREOCHEMISTRY;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CASPASES; CELL CYCLE; CELL LINE, TRANSFORMED; CELL LINE, TUMOR; CELL PROLIFERATION; GENES, RAS; HUMANS; LAMIN TYPE A; POLY(ADP-RIBOSE) POLYMERASES; RATS; TRITERPENES;

ANIMALIA; POLYPORACEAE; PORIA COCOS;

EID: 28944450745     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2005.05.066     Document Type: Article

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