Alleviating transcriptional inhibition of the norepinephrine Slc6a2 transporter gene in depolarized neurons

Journal of Neuroscience

Volumn 30, Issue 4, 2010, Pages 1494-1501

  Harikrishnan, K N ^a   Bayles, Richard ^a   Ciccotosto, Giuseppe D ^b   Maxwell, Scott ^a   Cappai, Roberto ^b   Pelka, Gregory J ^c   Tam, Patrick P L ^c   Christodoulou, John ^c,d   El Osta, Assam ^a  

^a BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

^d CHILDREN S HOSPITAL AT WESTMEAD   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRM PROTEIN; HISTONE; MESSENGER RNA; METHYL CPG BINDING PROTEIN 2; NORADRENALIN; PROTEIN SWI; RNA POLYMERASE II; TRANSCRIPTION FACTOR SNF; TRANSCRIPTION FACTOR SP1;

ANIMAL CELL; ARTICLE; CHROMATIN; CONTROLLED STUDY; DNA METHYLATION; FEMALE; GENE; GENE CONTROL; GENE EXPRESSION; GENE SEQUENCE; MALE; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; SLC6A2 GENE;

ANIMALS; CELLS, CULTURED; CEREBRAL CORTEX; CHROMATIN ASSEMBLY AND DISASSEMBLY; DNA METHYLATION; FEMALE; GENE EXPRESSION REGULATION; HISTONE ACETYLTRANSFERASES; MALE; MEMBRANE POTENTIALS; METHYL-CPG-BINDING PROTEIN 2; METHYLATION; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEURONS; NOREPINEPHRINE; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; REGULATORY ELEMENTS, TRANSCRIPTIONAL; REPRESSOR PROTEINS; RNA, MESSENGER; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION;

EID: 75349098919     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4675-09.2010     Document Type: Article

References (26)

1. Adams VH, McBryant SJ, Wade PA, Woodcock CL, Hansen JC (2007) Intrinsic disorder and autonomous domain function in the multifunctional nuclear protein, MeCP2. J Biol Chem 282:15057-15064.
2. Bellingham SA, Ciccotosto GD, Needham BE, Fodero LR, White AR, Masters CL, Cappai R, Camakaris J (2004) Gene knockout of amyloid precursor protein and amyloid precursor-like protein-2 increases cellular copper levels in primary mouse cortical neurons and embryonic fibroblasts. J Neurochem 91:423- 428.
3. Chahrour M, Jung SY, Shaw C, Zhou X, Wong ST, Qin J, Zoghbi HY (2008) MeCP2, a key contributor to neurological disease, activates and represses transcription. Science 320:1224 -1229.
4. Chang Q, Khare G, Dani V, Nelson S, Jaenisch R (2006) The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression. Neuron 49:341-348.
5. Chen WG, Chang Q, Lin Y, Meissner A, West AE, Griffith EC, Jaenisch R, Greenberg ME (2003) Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. Science 302:885- 889.
6. Ciccotosto GD, Tew DJ, Drew SC, Smith DG, Johanssen T, Lal V, Lau TL, Perez K, Curtain CC, Wade JD, Separovic F, Masters CL, Smith JP, Barnham KJ, Cappai R (2009) Stereospecific interactions are necessary for Alzheimer disease amyloid-beta toxicity. Neurobiol Aging. Advance online publication. Retrieved January 14, 2010. doi:10.1016/j.neurobiolaging. 2009.02.018.
7. Cukier HN, Perez AM, Collins AL, Zhou Z, Zoghbi HY, Botas J (2008) Genetic modifiers of MeCP2 function in Drosophila. PLoS Genet 4:e1000179.
8. El-Osta A, Kantharidis P, Zalcberg JR, Wolffe AP (2002) Precipitous release of methyl-CpG binding protein 2 and histone deacetylase 1 from the methylated human multidrug resistance gene (MDR1) on activation. Mol Cell Biol 22:1844 -1857.
9. Galvão TC, Thomas JO (2005) Structure-specific binding of MeCP2 to four-way junction DNA through its methyl CpG-binding domain. Nucleic Acids Res 33:6603- 6609.
10. Georgel PT, Horowitz-Scherer RA, Adkins N, Woodcock CL, Wade PA, Hansen JC (2003) Chromatin compaction by human MeCP2. Assembly of novel secondary chromatin structures in the absence of DNA methylation. J Biol Chem 278:32181-32188.
11. Habecker BA, Willison BD, Shi X, Woodward WR (2006) Chronic depolarization stimulates norepinephrine transporter expression via catecholamines. J Neurochem 97:1044 -1051.
12. Harikrishnan KN, Chow MZ, Baker EK, Pal S, Bassal S, Brasacchio D, Wang L, Craig JM, Jones PL, Sif S, El-Osta A (2005) Brahma links the SWI/SNF chromatin-remodeling complex with MeCP2-dependent transcriptional silencing. Nat Genet 37:254 -264.
13. Harikrishnan KN, Pal S, Yarski M, Baker EK, Chow MZ, de Silva MG, Okabe J, Wang L, Jones PL, Sif S, El-Osta A (2006) Reply to "Testing for association between MeCP2 and the brahma-associated SWI/SNF chromatinremodeling complex". Nat Genet 38:964 -967.
14. Hite KC, Adams VH, Hansen JC (2009) Recent advances in MeCP2 structure and function. Biochem Cell Biol 87:219 -227.
15. Hu K, Nan X, Bird A, Wang W (2006) Testing for association between MeCP2 and the brahma-associated SWI/SNF chromatin-remodeling complex. Nat Genet 38:962-964, author reply 964-967.
16. Jacob G, Shannon JR, Costa F, Furlan R, Biaggioni I, Mosqueda-Garcia R, Robertson RM, Robertson D (1999) Abnormal norepinephrine clearance and adrenergic receptor sensitivity in idiopathic orthostatic intolerance. Circulation 99:1706 -1712.
17. Jones PL, Veenstra GJ, Wade PA, Vermaak D, Kass SU, Landsberger N, Strouboulis J, Wolffe AP (1998) Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription. Nat Genet 19:187-191.
18. Kim CH, Kim HS, Cubells JF, Kim KS (1999) A previously undescribed intron and extensive 5' upstream sequence, but not Phox2a-mediated transactivation, are necessary for high level cell type-specific expression of the human norepinephrine transporter gene. J Biol Chem 274:6507-6518.
19. Klein ME, Lioy DT, Ma L, Impey S, Mandel G, Goodman RH (2007) Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA. Nat Neurosci 10:1513-1514.
20. Martinowich K, Hattori D, Wu H, Fouse S, He F, Hu Y, Fan G, Sun YE (2003) DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation. Science 302:890-893.
21. Nan X, Ng HH, Johnson CA, Laherty CD, Turner BM, Eisenman RN, Bird A (1998) Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 393:386 -389.
22. Nikitina T, Shi X, Ghosh RP, Horowitz-Scherer RA, Hansen JC, Woodcock CL (2007) Multiple modes of interaction between the methylated DNA binding protein MeCP2 and chromatin. Mol Cell Biol 27:864-877.
23. Pelka GJ, Watson CM, Radziewic T, Hayward M, Lahooti H, Christodoulou J, Tam PP (2006) Mecp2 deficiency is associated with learning and cognitive deficits and altered gene activity in the hippocampal region of mice. Brain 129:887- 898.
24. Shannon JR, Flattem NL, Jordan J, Jacob G, Black BK, Biaggioni I, Blakely RD, Robertson D (2000) Orthostatic intolerance and tachycardia associated with norepinephrine-transporter deficiency. N Engl J Med 342:541-549.
25. Weitzel JM, Buhrmester H, Strätling WH (1997) Chicken MAR-binding protein ARBP is homologous to rat methyl-CpG-binding protein MeCP2. Mol Cell Biol 17:5656 -5666.
26. Yasui DH, Peddada S, Bieda MC, Vallero RO, Hogart A, Nagarajan RP, Thatcher KN, Farnham PJ, Lasalle JM (2007) Integrated epigenomic analyses of neuronal MeCP2 reveal a role for long-range interaction with active genes. Proc Natl Acad Sci U S A 104:19416 -19421.