Design, synthesis and biological evaluation of new 2,3-diarylquinoline derivatives as selective cyclooxygenase-2 inhibitors

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 3, 2010, Pages 1029-1033

  Ghodsi, Razieh ^a   Zarghi, Afshin ^a   Daraei, Bahram ^b   Hedayati, Mehdi ^a  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TARBIAT MODARES UNIVERSITY   (Iran)

Author keywords

2,3 Diarylquinolines; Cyclooxygenase 2 inhibition; SAR

Indexed keywords

2 ( 4 (METHYLSULFONYL)PHENYL) 3 PHENYLQUINOLINE; 2 ( 4 (METHYLSULFONYL)PHENYL) 3 PHENYLQUINOLINE 4 CARBOXYLIC ACID; 2,3 DIARYLQUINOLINE; 3,4 DIPHENYL 2 ( 4 (METHYLSULFONYL)PHENYL)QUINOLINE; 4 AMINO 2 ( 4 (METHYLSULFONYL)PHENYL) 3 PHENYLQUINOLINE; 4 METHYL 2 ( 4 (METHYLSULFONYL)PHENYL) 3 PHENYLQUINOLINE; ARGININE; BENZENE DERIVATIVE; CARBOXYLIC ACID; CARBOXYLIC ACID DERIVATIVE; CELECOXIB; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; PHENYLALANINE; QUINOLINE DERIVATIVE; SERINE; SUCCIMER; UNCLASSIFIED DRUG; VALINE;

ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG DESIGN; DRUG INHIBITION; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; IN VITRO STUDY; MOLECULAR MODEL; PHARMACOPHORE; RING OPENING; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANIMALS; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; MODELS, MOLECULAR; PROTEIN BINDING; QUINOLINES; SHEEP; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 75149177657     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.12.060     Document Type: Article

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