Structural characterization of intact antibodies by high-resolution LTQ Orbitrap mass spectrometry

Journal of Mass Spectrometry

Volumn 45, Issue 1, 2010, Pages 112-120

  Zhang, Jennifer ^a   Liu, Hongbin ^a   Katta, Viswanatham ^a  

^a GENENTECH INC   (United States)

Author keywords

HCD; Intact antibody; LTQ orbitrap mass spectrometry; Mass determination; Middle down

Indexed keywords

ENERGY COLLISIONS; FORCED OXIDATION; GLYCOFORMS; HEAVY CHAIN; HIGH RESOLUTION; INTACT ANTIBODY; LC/MS/MS; LIGHT CHAIN; MASS DETERMINATION; ORBITRAP; RECOMBINANT MONOCLONAL ANTIBODY; SINGLE CHAINS; SITE-SPECIFIC; SITE-SPECIFIC MODIFICATIONS; STRUCTURAL CHARACTERIZATION;

MASS SPECTROMETERS; MONOCLONAL ANTIBODIES;

MASS SPECTROMETRY;

ANTIBODY; IMMUNOGLOBULIN F(AB) FRAGMENT; LYSINE; METHIONINE;

ACCURACY; ARTICLE; ENERGY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; OXIDATION; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; CHO CELLS; CRICETINAE; CRICETULUS; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 75149170146     PISSN: 10765174     EISSN: 10969888     Source Type: Journal    
DOI: 10.1002/jms.1700     Document Type: Article

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