New benzoxanthone derivatives as topoisomerase inhibitors and DNA cross-linkers

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 3, 2010, Pages 1010-1017

  Cho, Hee Ju ^a   Jung, Mi Ja ^b   Woo, Sangwook ^a   Kim, Jungsook ^c   Lee, Eung Seok ^d   Kwon, Youngjoo ^b   Na, Younghwa ^a  

^a Catholic University of Daegu   (South Korea)

^b Ewha Womans University   (South Korea)

^c Dongguk University   (South Korea)

^d Yeungnam University   (South Korea)

Author keywords

Anticancer activities; DNA cross linking; Oxiranylmethoxybenzoxanthones; Thiiranylmethoxybenzoxanthones; Topoisomerase inhibition

Indexed keywords

1 HYDROXY 3 (OXIRAN 2 YLMETHOXY) 12H BENZO[B]XANTHEN 12 ONE; 1 HYDROXY 3 (THIIRAN 2 YLMETHOXY) 12H BENZO[B]XANTHEN 12 ONE; 1,3 BIS(OXIRAN 2 YLMETHOXY) 12H BENZO[B]XANTHEN 12 ONE; 1,3 BIS(THIIRAN 2 YLMETHOXY) 12H BENZO[B]XANTHEN 12 ONE; 1,3 DIHYDROXY 12H BENZO[B]XANTHEN 12 ONE; 11 HYDROXY 9 (OXIRAN 2 YLMETHOXY) 12H BENZO[A]XANTHEN 12 ONE; 11 HYDROXY 9 (THIIRAN 2 YLMETHOXY) 12H BENZO[A]XANTHEN 12 ONE; 8 HYDROXY 10 (OXIRAN 2 YLMETHOXY) 7H BENZO[C]XANTHEN 7 ONE; 8 HYDROXY 10 (THIIRAN 2 YLMETHOXY) 7H BENZO[C]XANTHEN 7 ONE; 8,10 BIS(OXIRAN 2 YLMETHOXY) 7H BENZO[C]XANTHEN 7 ONE; 8,10 BIS(THIIRAN 2 YLMETHOXY) 7H BENZO[C]XANTHEN 7 ONE; 8,10 DIHYDROXY 7H BENZO[C]XANTHEN 7 ONE; 9,11 BIS(OXIRAN 2 YLMETHOXY) 12H BENZO[A]XANTHEN 12 ONE; 9,11 BIS(THIIRAN 2 YLMETHOXY) 12H BENZO[A]XANTHEN 12 ONE; 9,11 DIHYDROXY 12H BENZO[A]XANTHEN 12 ONE; CAMPTOTHECIN; DNA; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE INHIBITOR; DOUBLE STRANDED DNA; DOXORUBICIN; EPOXIDE; ETHYLENE OXIDE DERIVATIVE; ETOPOSIDE; UNCLASSIFIED DRUG; XANTHONE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CELL GROWTH; CONTROLLED STUDY; CYTOTOXICITY; DNA CROSS LINKING; DRUG EFFICACY; DRUG INHIBITION; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; GROWTH INHIBITION; HUMAN; HUMAN CELL; PROTEIN FUNCTION; RING OPENING;

ANTINEOPLASTIC AGENTS; BENZENE DERIVATIVES; CELL LINE, TUMOR; CELL PROLIFERATION; DNA; DNA TOPOISOMERASES; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MOLECULAR STRUCTURE; NEOPLASMS; XANTHONES;

EID: 75149164811     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.12.069     Document Type: Article

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