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Volumn 5, Issue 4, 2009, Pages 390-407

Novel strategies and tools for enhanced sensitivity in routine biomolecule analytics

Author keywords

Biomarker analysis; ELISA; Immuno PCR; Pharmacokinetics; Polyplex; Sensitivity

Indexed keywords

BIOLOGICAL MARKER; BIOMATERIAL; DRUG;

EID: 75149163554     PISSN: 15734129     EISSN: None     Source Type: Journal    
DOI: 10.2174/157341209789649104     Document Type: Review
Times cited : (9)

References (145)
  • 1
    • 0023461268 scopus 로고
    • Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction
    • Mullis, K.B.; Faloona, F. Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction. Methods Enzymol., 1987, 155, 335-350.
    • (1987) Methods Enzymol , vol.155 , pp. 335-350
    • Mullis, K.B.1    Faloona, F.2
  • 2
    • 0028117342 scopus 로고
    • Multiplex PCR: Advantages, development, and applications
    • Edwards, M.C.; Gibbs, R.A. Multiplex PCR: advantages, development, and applications. PCR Methods Appl., 1994, 3, S65-S75.
    • (1994) PCR Methods Appl , vol.3
    • Edwards, M.C.1    Gibbs, R.A.2
  • 6
    • 59849085069 scopus 로고    scopus 로고
    • qPCR assays - end user practices and latest vendor offerings
    • Comley, J. qPCR assays - end user practices and latest vendor offerings. Drug Discovery World, 2009, 10, 45-66.
    • (2009) Drug Discovery World , vol.10 , pp. 45-66
    • Comley, J.1
  • 7
    • 0026644604 scopus 로고
    • Immuno-PCR: Very sensitive antigen detection by means of specific antibody-DNA conjugates
    • Sano, T.; Smith, C.L.; Cantor, C.R. Immuno-PCR: very sensitive antigen detection by means of specific antibody-DNA conjugates. Science, 1992, 258, 120-122.
    • (1992) Science , vol.258 , pp. 120-122
    • Sano, T.1    Smith, C.L.2    Cantor, C.R.3
  • 8
    • 75149188831 scopus 로고    scopus 로고
    • The Rise of ImmunoPCR
    • Available at
    • Swanson, J. The Rise of ImmunoPCR. Genome Technol., 2007, 23-26, Available at: http://www.genomeweb.com/rise-immunopcr
    • (2007) Genome Technol , pp. 23-26
    • Swanson, J.1
  • 9
    • 44049102386 scopus 로고    scopus 로고
    • Sensitivity by combination: Immuno-PCR and related technologies
    • Adler, M.; Wacker, R.; Niemeyer, C.M. Sensitivity by combination: immuno-PCR and related technologies. Analyst, 2008, 133, 702-718.
    • (2008) Analyst , vol.133 , pp. 702-718
    • Adler, M.1    Wacker, R.2    Niemeyer, C.M.3
  • 10
    • 75149114122 scopus 로고    scopus 로고
    • Adler, M. In Frontiers in Nanoscience and Nanotechnology, A. Narlikar, ed.; OUP: Oxford, 2009; 2 - Properties and Potential of Protein-DNA Conjugates for Analytic Applications.
    • Adler, M. In Frontiers in Nanoscience and Nanotechnology, A. Narlikar, ed.; OUP: Oxford, 2009; Vol. 2 - Properties and Potential of Protein-DNA Conjugates for Analytic Applications.
  • 11
    • 15044351755 scopus 로고    scopus 로고
    • Immuno-PCR: High sensitivity detection of proteins by nucleic acid amplification
    • Niemeyer, C.M.; Adler, M.; Wacker, R. Immuno-PCR: high sensitivity detection of proteins by nucleic acid amplification. Trends Biotechnol., 2005, 23, 208-216.
    • (2005) Trends Biotechnol , vol.23 , pp. 208-216
    • Niemeyer, C.M.1    Adler, M.2    Wacker, R.3
  • 12
    • 0033105089 scopus 로고    scopus 로고
    • DNA-Directed Immobilization: Efficient, Reversible and Site-Selective Surface Binding of Proteins by Means of Covalent DNA-Streptavidin Conjugates
    • Niemeyer, C.M.; Boldt, L.; Ceyhan, B.; Blohm, D. DNA-Directed Immobilization: Efficient, Reversible and Site-Selective Surface Binding of Proteins by Means of Covalent DNA-Streptavidin Conjugates. Anal. Biochem., 1999, 268, 54-63.
    • (1999) Anal. Biochem , vol.268 , pp. 54-63
    • Niemeyer, C.M.1    Boldt, L.2    Ceyhan, B.3    Blohm, D.4
  • 13
    • 2942605493 scopus 로고    scopus 로고
    • DDI-microFIA - A readily configurable microarray-fluorescence immunoassay based on DNAdirected immobilization of proteins
    • Wacker, R.; Niemeyer, C.M. DDI-microFIA - A readily configurable microarray-fluorescence immunoassay based on DNAdirected immobilization of proteins. Chembiochem., 2004, 5, 453-459.
    • (2004) Chembiochem , vol.5 , pp. 453-459
    • Wacker, R.1    Niemeyer, C.M.2
  • 14
    • 0035019366 scopus 로고    scopus 로고
    • Nanostructured dnaprotein aggregates consisting of covalent oligonucleotidestreptavidin conjugates
    • Niemeyer, C.M.; Adler, M.; Gao, S.; Chi, L. Nanostructured dnaprotein aggregates consisting of covalent oligonucleotidestreptavidin conjugates. Bioconjug. Chem., 2001, 12, 364-371.
    • (2001) Bioconjug. Chem , vol.12 , pp. 364-371
    • Niemeyer, C.M.1    Adler, M.2    Gao, S.3    Chi, L.4
  • 15
    • 0029113465 scopus 로고
    • Analyte detection with DNA-labeled antibodies and polymerase chain reaction
    • Joerger, R.D.; Truby, T. M.; Hendrickson, E.R.; Young, R.M.; Ebersole, R.C. Analyte detection with DNA-labeled antibodies and polymerase chain reaction. Clin. Chem., 1995, 41, 1371-1377.
    • (1995) Clin. Chem , vol.41 , pp. 1371-1377
    • Joerger, R.D.1    Truby, T.M.2    Hendrickson, E.R.3    Young, R.M.4    Ebersole, R.C.5
  • 16
    • 0028912546 scopus 로고
    • High Sensitivity Multianalyte Immunoassay Using Covalent DNA-Labeled Antibodies and Polymerase Chain Reaktion
    • Hendrickson, E.R.; Hatfield Truby, T.M.; Joerger, R.D.; Majarian, W.R.; Ebersole, R.C. High Sensitivity Multianalyte Immunoassay Using Covalent DNA-Labeled Antibodies and Polymerase Chain Reaktion. Nucleic Acids Res., 1995, 23, 522-529.
    • (1995) Nucleic Acids Res , vol.23 , pp. 522-529
    • Hendrickson, E.R.1    Hatfield Truby, T.M.2    Joerger, R.D.3    Majarian, W.R.4    Ebersole, R.C.5
  • 17
    • 0035826719 scopus 로고    scopus 로고
    • Protein quantification from complex protein mixtures using a proteomics methodology with single-cell resolution
    • Zhang, H.T.; Kacharmina, J.E.; Miyashiro, K.; Greene, M.I.; Eberwine, J. Protein quantification from complex protein mixtures using a proteomics methodology with single-cell resolution. Proc. Natl. Acad. Sci. USA, 2001, 98, 5497-5502.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 5497-5502
    • Zhang, H.T.1    Kacharmina, J.E.2    Miyashiro, K.3    Greene, M.I.4    Eberwine, J.5
  • 18
    • 0031865848 scopus 로고    scopus 로고
    • Expression immunoassay based on antibodies labeled with a deoxyribonucleic acid fragment encoding the alpha-peptide of beta- galactosidase
    • White, S.R.; Chiu, N.H.; Christopoulos, T.K. Expression immunoassay based on antibodies labeled with a deoxyribonucleic acid fragment encoding the alpha-peptide of beta- galactosidase. Analyst, 1998, 123, 1309-1314.
    • (1998) Analyst , vol.123 , pp. 1309-1314
    • White, S.R.1    Chiu, N.H.2    Christopoulos, T.K.3
  • 19
    • 0032758397 scopus 로고    scopus 로고
    • Two-site expression immunoassay using a firefly luciferase-coding DNA label
    • Chiu, N. H.; Christopoulos, T. K. Two-site expression immunoassay using a firefly luciferase-coding DNA label. Clin. Chem., 1999, 45, 1954-1959.
    • (1999) Clin. Chem , vol.45 , pp. 1954-1959
    • Chiu, N.H.1    Christopoulos, T.K.2
  • 20
    • 0029449916 scopus 로고
    • Expression immunoassay. Antigen quantitation using antibodies labeled with enzyme-coding DNA fragments
    • Christopoulos, T.K.; Chiu, N.H. Expression immunoassay. Antigen quantitation using antibodies labeled with enzyme-coding DNA fragments. Anal. Chem., 1995, 67, 4290-4294.
    • (1995) Anal. Chem , vol.67 , pp. 4290-4294
    • Christopoulos, T.K.1    Chiu, N.H.2
  • 24
    • 75149169270 scopus 로고    scopus 로고
    • ELSEVIER Spektrum Akademischer Verlag: Munich
    • Raem, A.M.; Rauch, P. Immunoassays, ELSEVIER Spektrum Akademischer Verlag: Munich 2007.
    • (2007) Immunoassays
    • Raem, A.M.1    Rauch, P.2
  • 25
    • 21344432109 scopus 로고    scopus 로고
    • Immuno-PCR as a clinical laboratory tool
    • Adler, M. Immuno-PCR as a clinical laboratory tool. Adv. Clin. Chem., 2005, 39, 239-292.
    • (2005) Adv. Clin. Chem , vol.39 , pp. 239-292
    • Adler, M.1
  • 27
    • 34547135703 scopus 로고    scopus 로고
    • Ultrasensitive assays for proteins
    • Zhang, H.; Zhao, Q.; Li, X. F.; Le, X.C. Ultrasensitive assays for proteins. Analyst, 2007, 132, 724-737.
    • (2007) Analyst , vol.132 , pp. 724-737
    • Zhang, H.1    Zhao, Q.2    Li, X.F.3    Le, X.C.4
  • 28
    • 0027751662 scopus 로고
    • Universal immuno-PCR for ultra-sensitive target protein detection
    • Zhou, H.; Fisher, R.J.; Papas, T.S. Universal immuno-PCR for ultra-sensitive target protein detection. Nucleic Acids Res., 1993, 21, 6038-6039.
    • (1993) Nucleic Acids Res , vol.21 , pp. 6038-6039
    • Zhou, H.1    Fisher, R.J.2    Papas, T.S.3
  • 29
    • 0023475248 scopus 로고
    • Theoretical analysis of the sensitivity of the solid phase antibody assay(ELISA)
    • Griswold, W.R. Theoretical analysis of the sensitivity of the solid phase antibody assay(ELISA). Mol. Immunol., 1987, 24, 1291-1294.
    • (1987) Mol. Immunol , vol.24 , pp. 1291-1294
    • Griswold, W.R.1
  • 30
    • 21344443260 scopus 로고    scopus 로고
    • Detection of Rotavirus from stool samples using a standardized immuno-PCR ("Imperacer") method with end-point and real-time detection
    • Adler, M.; Schulz, S.; Fischer, R.; Niemeyer, C.M. Detection of Rotavirus from stool samples using a standardized immuno-PCR ("Imperacer") method with end-point and real-time detection. Biochem. Biophys. Res. Commun., 2005, 333, 1289-1294.
    • (2005) Biochem. Biophys. Res. Commun , vol.333 , pp. 1289-1294
    • Adler, M.1    Schulz, S.2    Fischer, R.3    Niemeyer, C.M.4
  • 31
    • 63449091811 scopus 로고    scopus 로고
    • Immunomagnetic quantitative immuno-PCR for detection of less than one HIV-1 virion
    • Barletta, J.; Bartolome, A.; Constantine, N. T. Immunomagnetic quantitative immuno-PCR for detection of less than one HIV-1 virion. J. Virol. Methods, 2009, 157, 122-132.
    • (2009) J. Virol. Methods , vol.157 , pp. 122-132
    • Barletta, J.1    Bartolome, A.2    Constantine, N.T.3
  • 32
    • 0033913780 scopus 로고    scopus 로고
    • Painting Qa-2 onto Ped slow preimplantation embryos increases the rate of cleavage
    • McElhinny, A.S.; Exley, G.E.; Warner, C.M. Painting Qa-2 onto Ped slow preimplantation embryos increases the rate of cleavage. Am. J. Reprod. Immunol., 2000, 44, 52-58.
    • (2000) Am. J. Reprod. Immunol , vol.44 , pp. 52-58
    • McElhinny, A.S.1    Exley, G.E.2    Warner, C.M.3
  • 33
    • 0031697367 scopus 로고    scopus 로고
    • The expression pattern of the Qa-2 antigen in mouse preimplantation embryos and its correlation with the Ped gene phenotype
    • McElhinny, A.S.; Kadow, N.; Warner, C.M. The expression pattern of the Qa-2 antigen in mouse preimplantation embryos and its correlation with the Ped gene phenotype. Mol. Hum. Reprod., 1998, 4, 966-971.
    • (1998) Mol. Hum. Reprod , vol.4 , pp. 966-971
    • McElhinny, A.S.1    Kadow, N.2    Warner, C.M.3
  • 37
    • 75149168361 scopus 로고    scopus 로고
    • Adler, M.; N.N. Controlled Expression and Monitoring of HIV p66 / pol Protein in Cell Culture Samples. Manuscript in preparation, 2009.
    • Adler, M.; N.N. Controlled Expression and Monitoring of HIV p66 / pol Protein in Cell Culture Samples. Manuscript in preparation, 2009.
  • 38
    • 75149134282 scopus 로고    scopus 로고
    • Detection of myostatin propeptide and follistatin in serum and tissue using highly sensitive Immuno PCR - effects of training and skeletal muscle mass
    • in press
    • Diel, P.; Schiffer, T.; Geisler, S.; Hertrampf, T.; Schulz, S.; Wintgens, K.F.; Adler, M. Detection of myostatin propeptide and follistatin in serum and tissue using highly sensitive Immuno PCR - effects of training and skeletal muscle mass. J. Appl. Physiol., 2009, in press.
    • (2009) J. Appl. Physiol
    • Diel, P.1    Schiffer, T.2    Geisler, S.3    Hertrampf, T.4    Schulz, S.5    Wintgens, K.F.6    Adler, M.7
  • 39
    • 0043095428 scopus 로고    scopus 로고
    • A real-time immuno-PCR assay for routine ultrasensitive quantification of proteins
    • Adler, M.; Wacker, R.; Niemeyer, C.M. A real-time immuno-PCR assay for routine ultrasensitive quantification of proteins. Biochem. Biophys. Res. Commun., 2003, 308, 240-250.
    • (2003) Biochem. Biophys. Res. Commun , vol.308 , pp. 240-250
    • Adler, M.1    Wacker, R.2    Niemeyer, C.M.3
  • 48
    • 0035801520 scopus 로고    scopus 로고
    • Hapten-Functionalized DNA-Streptavidin Nanocircles as Supramolecular Reagents in a Novel Competitive Immuno-PCR
    • Niemeyer, C.M.; Wacker, R.; Adler, M. Hapten-Functionalized DNA-Streptavidin Nanocircles as Supramolecular Reagents in a Novel Competitive Immuno-PCR. Angew Chem. Int. Ed., 2001, 40, 3169-3172.
    • (2001) Angew Chem. Int. Ed , vol.40 , pp. 3169-3172
    • Niemeyer, C.M.1    Wacker, R.2    Adler, M.3
  • 49
    • 15044365439 scopus 로고    scopus 로고
    • Detection of femtogram amounts of biogenic amines using self-assembled DNA-protein nanostructures
    • Adler, M.; Wacker, R.; Booltink, E.; Manz, B.; Niemeyer, C.M. Detection of femtogram amounts of biogenic amines using self-assembled DNA-protein nanostructures. Nat. Methods, 2005, 2, 147-149.
    • (2005) Nat. Methods , vol.2 , pp. 147-149
    • Adler, M.1    Wacker, R.2    Booltink, E.3    Manz, B.4    Niemeyer, C.M.5
  • 50
    • 49049119668 scopus 로고    scopus 로고
    • Determination of phenanthrene by antibody-coated competitive real-time immuno-PCR assay
    • Zhou, C.; Wang, Q.E.; Zhuang, H.S. Determination of phenanthrene by antibody-coated competitive real-time immuno-PCR assay. Anal. Bioanal. Chem., 2008, 391, 2857-2863.
    • (2008) Anal. Bioanal. Chem , vol.391 , pp. 2857-2863
    • Zhou, C.1    Wang, Q.E.2    Zhuang, H.S.3
  • 51
    • 33646399777 scopus 로고    scopus 로고
    • New FACTT technique is conservatively over 1000-times more sensitive than ELISA. Cancer Biol. Ther., 2006, 5, 346-348.
    • New FACTT technique is conservatively over 1000-times more sensitive than ELISA. Cancer Biol. Ther., 2006, 5, 346-348.
  • 52
    • 0031781017 scopus 로고    scopus 로고
    • Cellular immuno-PCR. Detection of a carbohydrate tumor marker
    • Zhang, Z.; Irie, R.F.; Chi, D.D.; Hoon, D.S. Cellular immuno-PCR. Detection of a carbohydrate tumor marker. Am. J. Pathol., 1998, 152, 1427-1432.
    • (1998) Am. J. Pathol , vol.152 , pp. 1427-1432
    • Zhang, Z.1    Irie, R.F.2    Chi, D.D.3    Hoon, D.S.4
  • 53
    • 33344465376 scopus 로고    scopus 로고
    • High-Sensitivity Detection of Prostate Specific Antigen
    • Adler, M.; Schulz, S.; Wacker, R. High-Sensitivity Detection of Prostate Specific Antigen. Am. Biotechnol. Lab., 2006, 24, 17.
    • (2006) Am. Biotechnol. Lab , vol.24 , pp. 17
    • Adler, M.1    Schulz, S.2    Wacker, R.3
  • 54
    • 24344433967 scopus 로고    scopus 로고
    • Development and evaluation of three realtime immuno-PCR assemblages for quantification of PSA
    • Lind, K.; Kubista, M. Development and evaluation of three realtime immuno-PCR assemblages for quantification of PSA. J. Immunol. Methods, 2005, 304, 107-116.
    • (2005) J. Immunol. Methods , vol.304 , pp. 107-116
    • Lind, K.1    Kubista, M.2
  • 55
    • 33645125969 scopus 로고    scopus 로고
    • Detection of norovirus capsid proteins in faecal and food samples by a real time immuno-PCR method
    • Tian, P.; Mandrell, R. Detection of norovirus capsid proteins in faecal and food samples by a real time immuno-PCR method. J. Appl. Microbiol., 2006, 100, 564-574.
    • (2006) J. Appl. Microbiol , vol.100 , pp. 564-574
    • Tian, P.1    Mandrell, R.2
  • 57
    • 0028951148 scopus 로고
    • Development of a two-site immuno-PCR assay for hepatitis B surface antigen
    • Maia, M.; Takahashi, H.; Adler, K.; Garlick, R.K.; Wands, J.R. Development of a two-site immuno-PCR assay for hepatitis B surface antigen. J. Virol. Methods, 1995, 52, 273-286.
    • (1995) J. Virol. Methods , vol.52 , pp. 273-286
    • Maia, M.1    Takahashi, H.2    Adler, K.3    Garlick, R.K.4    Wands, J.R.5
  • 58
    • 0031106820 scopus 로고    scopus 로고
    • Fluorometric Polymerase Chain Reaction (PCR) Enzyme-Linked Immunosorbent Assay for Quantification of Immuno-PCR Products in Microplates
    • Niemeyer, C.M.; Adler, M.; Blohm, D. Fluorometric Polymerase Chain Reaction (PCR) Enzyme-Linked Immunosorbent Assay for Quantification of Immuno-PCR Products in Microplates. Anal. Biochem., 1997, 246, 140-145.
    • (1997) Anal. Biochem , vol.246 , pp. 140-145
    • Niemeyer, C.M.1    Adler, M.2    Blohm, D.3
  • 59
    • 33644922940 scopus 로고    scopus 로고
    • Applications of real-time immuno-polymerase chain reaction (rt-IPCR) for the rapid diagnoses of viral antigens and pathologic proteins
    • Barletta, J. Applications of real-time immuno-polymerase chain reaction (rt-IPCR) for the rapid diagnoses of viral antigens and pathologic proteins. Mol. Aspects Med., 2006, 27, 224-253.
    • (2006) Mol. Aspects Med , vol.27 , pp. 224-253
    • Barletta, J.1
  • 60
    • 3042807048 scopus 로고    scopus 로고
    • Lowering the detection limits of HIV-1 viral load using real-time immuno-PCR for HIV-1 p24 antigen
    • Barletta, J.M.; Edelman, D.C.; Constantine, N.T. Lowering the detection limits of HIV-1 viral load using real-time immuno-PCR for HIV-1 p24 antigen. Am. J. Clin. Pathol., 2004, 122, 20-27.
    • (2004) Am. J. Clin. Pathol , vol.122 , pp. 20-27
    • Barletta, J.M.1    Edelman, D.C.2    Constantine, N.T.3
  • 61
    • 0036499110 scopus 로고    scopus 로고
    • Development of a quantitative immuno-PCR assay and its use to detect mumpsspecific IgG in serum
    • McKie, A.; Samuel, D.; Cohen, B.; Saunders, N.A. Development of a quantitative immuno-PCR assay and its use to detect mumpsspecific IgG in serum. J. Immunol. Methods, 2002, 261, 167-175.
    • (2002) J. Immunol. Methods , vol.261 , pp. 167-175
    • McKie, A.1    Samuel, D.2    Cohen, B.3    Saunders, N.A.4
  • 63
    • 34247849222 scopus 로고    scopus 로고
    • A quantitative real-time immuno-PCR approach for detection of staphylococcal enterotoxins
    • Fischer, A.; von Eiff, C.; Kuczius, T.; Omoe, K.; Peters, G.; Becker, K. A quantitative real-time immuno-PCR approach for detection of staphylococcal enterotoxins. J. Mol. Med., 2007, 85, 461-469.
    • (2007) J. Mol. Med , vol.85 , pp. 461-469
    • Fischer, A.1    von Eiff, C.2    Kuczius, T.3    Omoe, K.4    Peters, G.5    Becker, K.6
  • 64
    • 30844467501 scopus 로고    scopus 로고
    • An immuno-PCR method for detecting Bacillus thuringiensis Cry1Ac toxin
    • Allen, R.C.; Rogelj, S.; Cordova, S.E.; Kieft, T.L. An immuno-PCR method for detecting Bacillus thuringiensis Cry1Ac toxin. J. Immunol. Methods, 2006, 308, 109-115.
    • (2006) J. Immunol. Methods , vol.308 , pp. 109-115
    • Allen, R.C.1    Rogelj, S.2    Cordova, S.E.3    Kieft, T.L.4
  • 65
    • 0035042413 scopus 로고    scopus 로고
    • Detection of Clostridium botulinum neurotoxin type A using immuno-PCR
    • Wu, H.C.; Huang, Y.L.; Lai, S.C.; Huang, Y.Y.; Shaio, M.F. Detection of Clostridium botulinum neurotoxin type A using immuno-PCR. Lett. Appl. Microbiol., 2001, 32, 321-325.
    • (2001) Lett. Appl. Microbiol , vol.32 , pp. 321-325
    • Wu, H.C.1    Huang, Y.L.2    Lai, S.C.3    Huang, Y.Y.4    Shaio, M.F.5
  • 66
    • 1242314782 scopus 로고    scopus 로고
    • A highly sensitive immuno-polymerase chain reaction assay for Clostridium botulinum neurotoxin type A
    • Chao, H.Y.; Wang, Y.C.; Tang, S.S.; Liu, H.W. A highly sensitive immuno-polymerase chain reaction assay for Clostridium botulinum neurotoxin type A. Toxicon, 2004, 43, 27-34.
    • (2004) Toxicon , vol.43 , pp. 27-34
    • Chao, H.Y.1    Wang, Y.C.2    Tang, S.S.3    Liu, H.W.4
  • 68
    • 0028936269 scopus 로고
    • Rapid induction of tumor necrosis factor alpha in the cerebrospinal fluid after intracerebroventricular injection of lipopolysaccharide revealed by a sensitive capture immuno-PCR assay
    • Sanna, P.P.; Weiss, F.; Samson, M.E.; Bloom, F.E.; Pich, E.M. Rapid induction of tumor necrosis factor alpha in the cerebrospinal fluid after intracerebroventricular injection of lipopolysaccharide revealed by a sensitive capture immuno-PCR assay. Proc. Natl. Acad. Sci. USA, 1995, 92, 272-275.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 272-275
    • Sanna, P.P.1    Weiss, F.2    Samson, M.E.3    Bloom, F.E.4    Pich, E.M.5
  • 72
    • 27544510640 scopus 로고    scopus 로고
    • Colorimetric bio-barcode amplification assay for cytokines
    • Nam, J.M.; Wise, A.R.; Groves, J.T. Colorimetric bio-barcode amplification assay for cytokines. Anal. Chem., 2005, 77, 6985-6988.
    • (2005) Anal. Chem , vol.77 , pp. 6985-6988
    • Nam, J.M.1    Wise, A.R.2    Groves, J.T.3
  • 73
    • 75149112226 scopus 로고    scopus 로고
    • Mullenix, M.; Dondero, R.; Hirock, D.; Egholm, M.; Kingsmore, S.; Perlee, L. In DNA Amplification - current technologies and applications, V.V.; Broude Demidov, N.E., ed.; Horizon Bioscience: Norfolk, 2004; Chapter 4.2., 313-331.
    • Mullenix, M.; Dondero, R.; Hirock, D.; Egholm, M.; Kingsmore, S.; Perlee, L. In DNA Amplification - current technologies and applications, V.V.; Broude Demidov, N.E., ed.; Horizon Bioscience: Norfolk, 2004; Chapter 4.2., 313-331.
  • 76
    • 44049090030 scopus 로고    scopus 로고
    • Immuno-PCR - highly sensitive protein detection: Results of the detection of native mistletoe lectin in human serum samples
    • Adler, M.; Eisenbraun, J. Immuno-PCR - highly sensitive protein detection: Results of the detection of native mistletoe lectin in human serum samples. Phytomedicine, 2007, 14, 50.
    • (2007) Phytomedicine , vol.14 , pp. 50
    • Adler, M.1    Eisenbraun, J.2
  • 80
    • 0036887575 scopus 로고    scopus 로고
    • McKie, A.; Samuel, D.; Cohen, B.; Saunders, N. A. A quantitative immuno-PCR assay for the detection of mumps-specific IgG. J. Immunol. Methods, 2002, 270, 135-141.
    • McKie, A.; Samuel, D.; Cohen, B.; Saunders, N. A. A quantitative immuno-PCR assay for the detection of mumps-specific IgG. J. Immunol. Methods, 2002, 270, 135-141.
  • 81
    • 20444470223 scopus 로고    scopus 로고
    • Detection of ultra-low levels of pathologic prion protein in scrapie infected hamster brain homogenates using real-time immuno-PCR
    • Barletta, J.M.; Edelman, D.C.; Highsmith, W.E.; Constantine, N.T. Detection of ultra-low levels of pathologic prion protein in scrapie infected hamster brain homogenates using real-time immuno-PCR. J. Virol. Methods, 2005, 127, 154-164.
    • (2005) J. Virol. Methods , vol.127 , pp. 154-164
    • Barletta, J.M.1    Edelman, D.C.2    Highsmith, W.E.3    Constantine, N.T.4
  • 82
    • 34548154323 scopus 로고    scopus 로고
    • Detecting antigens by quantitative immuno-PCR
    • Niemeyer, C.M.; Adler, M.; Wacker, R. Detecting antigens by quantitative immuno-PCR. Nat. Protoc., 2007, 2, 1918-1930.
    • (2007) Nat. Protoc , vol.2 , pp. 1918-1930
    • Niemeyer, C.M.1    Adler, M.2    Wacker, R.3
  • 83
    • 0025856887 scopus 로고
    • The biotin-(strept)avidin system: Principles and applications in biotechnology
    • Diamandis, E.P.; Christopoulos, T.K. The biotin-(strept)avidin system: principles and applications in biotechnology. Clin. Chem., 1991, 37, 625-636.
    • (1991) Clin. Chem , vol.37 , pp. 625-636
    • Diamandis, E.P.1    Christopoulos, T.K.2
  • 84
    • 0030822587 scopus 로고    scopus 로고
    • Detection of major histocompatibility complex class I antigens on the surface of a single murine blastocyst by immuno-PCR
    • McElhinny, A.S.; Warner, C.M. Detection of major histocompatibility complex class I antigens on the surface of a single murine blastocyst by immuno-PCR. Biotechniques, 1997, 23, 660-662.
    • (1997) Biotechniques , vol.23 , pp. 660-662
    • McElhinny, A.S.1    Warner, C.M.2
  • 85
    • 17444435985 scopus 로고    scopus 로고
    • The universality of immuno-PCR for ultrasensitive antigen detection
    • Case, M.; Major, G.N.; Bassendine, M.F.; Burt, A.D. The universality of immuno-PCR for ultrasensitive antigen detection. Biochem. Soc. Trans., 1997, 25, 374S.
    • (1997) Biochem. Soc. Trans , vol.25
    • Case, M.1    Major, G.N.2    Bassendine, M.F.3    Burt, A.D.4
  • 88
    • 23944457508 scopus 로고    scopus 로고
    • Synthesis of covalent DNA-protein conjugates by expressed protein ligation
    • Lovrinovic, M.; Spengler, M.; Deutsch, C.; Niemeyer, C. M. Synthesis of covalent DNA-protein conjugates by expressed protein ligation. Mol. BioSyst., 2005, 1, 64-69.
    • (2005) Mol. BioSyst , vol.1 , pp. 64-69
    • Lovrinovic, M.1    Spengler, M.2    Deutsch, C.3    Niemeyer, C.M.4
  • 89
    • 13444258243 scopus 로고    scopus 로고
    • Using protein-DNA chimeras to detect and count small numbers of molecules
    • Burbulis, I.; Yamaguchi, K.; Gordon, A.; Carlson, R.; Brent, R. Using protein-DNA chimeras to detect and count small numbers of molecules. Nat. Methods, 2005, 2, 31-37.
    • (2005) Nat. Methods , vol.2 , pp. 31-37
    • Burbulis, I.1    Yamaguchi, K.2    Gordon, A.3    Carlson, R.4    Brent, R.5
  • 90
    • 0031834105 scopus 로고    scopus 로고
    • Statistical science and quantitative understanding
    • Finney, D.J. Statistical science and quantitative understanding. J. Toxicol. Sci., 1998, 23, 93-104.
    • (1998) J. Toxicol. Sci , vol.23 , pp. 93-104
    • Finney, D.J.1
  • 91
    • 75149177133 scopus 로고    scopus 로고
    • FDA; CDER; CVM. Guidance for Industry: Bioanalytical Method Validation, 2001, pp. 1-22.
    • FDA; CDER; CVM. Guidance for Industry: Bioanalytical Method Validation, 2001, pp. 1-22.
  • 92
    • 41849126791 scopus 로고    scopus 로고
    • Validation of Analytical procedures: Text and Methodology
    • http://www.fda.gov/cder/Guidance/ichq1322a.pdf
    • ICH. Validation of Analytical procedures: Text and Methodology Harmonised Tripartite Guideline, 2005, Q2(R1), http://www.fda.gov/cder/Guidance/1320fnl.pdf / http://www.fda.gov/cder/Guidance/ ichq1322a.pdf.
    • (2005) Harmonised Tripartite Guideline , vol.Q2 , Issue.R1
  • 93
    • 1942524457 scopus 로고    scopus 로고
    • Combination of DNA-directed immobilization and immuno-PCR: Very sensitive antigen detection by means of self-assembled DNA-protein conjugates
    • Niemeyer, C.M.; Wacker, R.; Adler, M. Combination of DNA-directed immobilization and immuno-PCR: very sensitive antigen detection by means of self-assembled DNA-protein conjugates. Nucleic Acids Res., 2003, 31, e90.
    • (2003) Nucleic Acids Res , vol.31
    • Niemeyer, C.M.1    Wacker, R.2    Adler, M.3
  • 94
    • 0013452474 scopus 로고    scopus 로고
    • High Sensitivity Detection of Antigens using Immuno-PCR
    • Niemeyer, C.M.; Adler, M.; Blohm, D. High Sensitivity Detection of Antigens using Immuno-PCR NUNC Tech Note, 1999, 5, 1-2.
    • (1999) NUNC Tech Note , vol.5 , pp. 1-2
    • Niemeyer, C.M.1    Adler, M.2    Blohm, D.3
  • 95
    • 50849128778 scopus 로고    scopus 로고
    • Application of highly sensitive, modified glass substrate-based immuno-PCR on the early detection of nasopharyngeal carcinoma
    • Wang, T.W.; Lu, H.Y.; Lou, P.J.; Lin, F.H. Application of highly sensitive, modified glass substrate-based immuno-PCR on the early detection of nasopharyngeal carcinoma. Biomaterials, 2008, 29, 4447-4454.
    • (2008) Biomaterials , vol.29 , pp. 4447-4454
    • Wang, T.W.1    Lu, H.Y.2    Lou, P.J.3    Lin, F.H.4
  • 96
    • 0141868926 scopus 로고    scopus 로고
    • Nanoparticle-based bio-bar codes for the ultrasensitive detection of proteins
    • Nam, J.M.; Thaxton, C.S.; Mirkin, C.A. Nanoparticle-based bio-bar codes for the ultrasensitive detection of proteins. Science, 2003, 301, 1884-1886.
    • (2003) Science , vol.301 , pp. 1884-1886
    • Nam, J.M.1    Thaxton, C.S.2    Mirkin, C.A.3
  • 97
    • 75149128568 scopus 로고    scopus 로고
    • Adler, M.; Niemeyer, C.M. In DNA Amplification - Current Technologies and Applications, V.V. Demidov; Broude, N.E., eds.; Horizon Bioscience: Norfolk, 2004, 293-312.
    • Adler, M.; Niemeyer, C.M. In DNA Amplification - Current Technologies and Applications, V.V. Demidov; Broude, N.E., eds.; Horizon Bioscience: Norfolk, 2004, 293-312.
  • 98
    • 0034214018 scopus 로고    scopus 로고
    • Immunopolymerase chain reaction using real-time polymerase chain reaction for detection
    • Sims, P.W.; Vasser, M.; Wong, W.L.; Williams, P.M.; Meng, Y.G. Immunopolymerase chain reaction using real-time polymerase chain reaction for detection. Anal. Biochem., 2000, 281, 230-232.
    • (2000) Anal. Biochem , vol.281 , pp. 230-232
    • Sims, P.W.1    Vasser, M.2    Wong, W.L.3    Williams, P.M.4    Meng, Y.G.5
  • 99
    • 0041587377 scopus 로고    scopus 로고
    • Real-time Immuno-PCR on the iCycler iQ System
    • Lind, K.; Kubista, M. Real-time Immuno-PCR on the iCycler iQ System. BioRadiations, 2002, 109, 32-33.
    • (2002) BioRadiations , vol.109 , pp. 32-33
    • Lind, K.1    Kubista, M.2
  • 100
    • 34147221051 scopus 로고    scopus 로고
    • Real-time PCR assay for ultrasensitive quantification of DNA-binding proteins
    • Hou, P.; Chen, Z.; Ji, M.; He, N.; Lu, Z. Real-time PCR assay for ultrasensitive quantification of DNA-binding proteins. Clin. Chem., 2007, 53, 581-586.
    • (2007) Clin. Chem , vol.53 , pp. 581-586
    • Hou, P.1    Chen, Z.2    Ji, M.3    He, N.4    Lu, Z.5
  • 101
    • 75149158427 scopus 로고    scopus 로고
    • Hintergrund bei Immunoassays.
    • Rauch, P.; Polifke, T.; Wiesman, H.P. Hintergrund bei Immunoassays. Bioforum, 2005, 11, 22-24.
    • (2005) Bioforum , vol.11 , pp. 22-24
    • Rauch, P.1    Polifke, T.2    Wiesman, H.P.3
  • 102
    • 0032753840 scopus 로고    scopus 로고
    • Interference in immunoassay
    • Selby, C. Interference in immunoassay. Ann. Clin. Biochem., 1999, 36 ( Pt 6), 704-721.
    • (1999) Ann. Clin. Biochem , vol.36 , Issue.PART 6 , pp. 704-721
    • Selby, C.1
  • 103
    • 75149156978 scopus 로고    scopus 로고
    • EDAR - New Bimoarkers for Alzheimer's Disease (European collaborative study) http://www.edarstudy.eu/, 2007, STREP 37670.
    • EDAR - New Bimoarkers for Alzheimer's Disease (European collaborative study) http://www.edarstudy.eu/, 2007, STREP 37670.
  • 104
    • 75149146689 scopus 로고    scopus 로고
    • The merging of nucleic acid detection and immunoassays
    • Available at
    • Jablonski, E.; Adams, T. The merging of nucleic acid detection and immunoassays. Medical Device, 2006, IVDT 2006, Available at: http://www.devicelink.com/ivdt/archive/06/11/009.html
    • (2006) Medical Device , vol.IVDT 2006
    • Jablonski, E.1    Adams, T.2
  • 105
    • 5444226637 scopus 로고    scopus 로고
    • Demonstration of an alternative approach to immuno-PCR
    • Banin, S.; Wilson, S.M.; Stanley, C.J. Demonstration of an alternative approach to immuno-PCR. Clin. Chem., 2004, 50, 1932-1934.
    • (2004) Clin. Chem , vol.50 , pp. 1932-1934
    • Banin, S.1    Wilson, S.M.2    Stanley, C.J.3
  • 107
    • 0027269832 scopus 로고
    • Mistletoe (viscum album) lectins as cytokine inducers and immunoadjuvant in tumor therapy. A review
    • Bocci, V. Mistletoe (viscum album) lectins as cytokine inducers and immunoadjuvant in tumor therapy. A review. J. Biol. Regul. Homeost. Agents., 1993, 7, 1-6.
    • (1993) J. Biol. Regul. Homeost. Agents , vol.7 , pp. 1-6
    • Bocci, V.1
  • 108
    • 0033568443 scopus 로고    scopus 로고
    • Cloning of the mistletoe lectin gene and characterization of the recombinant A-chain
    • Eck, J.; Langer, M.; Mockel, B.; Baur, A.; Rothe, M.; Zinke, H.; Lentzen, H. Cloning of the mistletoe lectin gene and characterization of the recombinant A-chain. Eur. J. Biochem., 1999, 264, 775-784.
    • (1999) Eur. J. Biochem , vol.264 , pp. 775-784
    • Eck, J.1    Langer, M.2    Mockel, B.3    Baur, A.4    Rothe, M.5    Zinke, H.6    Lentzen, H.7
  • 109
    • 0033569985 scopus 로고    scopus 로고
    • Characterization of recombinant and plant-derived mistletoe lectin and their B-chains
    • Eck, J.; Langer, M.; Mockel, B.; Witthohn, K.; Zinke, H.; Lentzen, H. Characterization of recombinant and plant-derived mistletoe lectin and their B-chains. Eur. J. Biochem., 1999, 265, 788-797.
    • (1999) Eur. J. Biochem , vol.265 , pp. 788-797
    • Eck, J.1    Langer, M.2    Mockel, B.3    Witthohn, K.4    Zinke, H.5    Lentzen, H.6
  • 110
    • 75149145001 scopus 로고    scopus 로고
    • Wacker, R.; Spengler, M.; Adler, M. High sensitivity CNS biomarker detection 11th ICAD - International Conference of Alzheimer's Disease, Chicago July 26-31, 2008, P 1-400 / Abstract T336.
    • Wacker, R.; Spengler, M.; Adler, M. High sensitivity CNS biomarker detection 11th ICAD - International Conference of Alzheimer's Disease, Chicago July 26-31, 2008, P 1-400 / Abstract T336.
  • 112
    • 0033523687 scopus 로고    scopus 로고
    • Niemeyer, C.M.; Blohm, D. DNA Microarrays. Angew. Chem. Int. Ed. Engl., 1999, 38, 2865-2869.
    • Niemeyer, C.M.; Blohm, D. DNA Microarrays. Angew. Chem. Int. Ed. Engl., 1999, 38, 2865-2869.
  • 113
    • 37149048936 scopus 로고    scopus 로고
    • Protein microchips in biomedicine and biomarker discovery
    • Spisak, S.; Tulassay, Z.; Molnar, B.; Guttman, A. Protein microchips in biomedicine and biomarker discovery. Electrophoresis, 2007, 28, 4261-4273.
    • (2007) Electrophoresis , vol.28 , pp. 4261-4273
    • Spisak, S.1    Tulassay, Z.2    Molnar, B.3    Guttman, A.4
  • 117
    • 33644909067 scopus 로고    scopus 로고
    • Cytokine detection by multiplex technology useful for assessing antigen specific cytokine profiles and kinetics in whole blood cultured up to seven days
    • Lagrelius, M.; Jones, P.; Franck, K.; Gaines, H. Cytokine detection by multiplex technology useful for assessing antigen specific cytokine profiles and kinetics in whole blood cultured up to seven days. Cytokine, 2006, 33, 156-165.
    • (2006) Cytokine , vol.33 , pp. 156-165
    • Lagrelius, M.1    Jones, P.2    Franck, K.3    Gaines, H.4
  • 118
    • 34347225102 scopus 로고    scopus 로고
    • Cytokine quantitation: Technologies and applications
    • Sachdeva, N.; Asthana, D. Cytokine quantitation: technologies and applications. Front. Biosci., 2007, 12, 4682-4695.
    • (2007) Front. Biosci , vol.12 , pp. 4682-4695
    • Sachdeva, N.1    Asthana, D.2
  • 123
    • 0031831323 scopus 로고    scopus 로고
    • Mutation detection and single-molecule counting using isothermal rolling-circle amplification
    • Lizardi, P.M.; Huang, X.; Zhu, Z.; Bray-Ward, P.; Thomas, D.C.; Ward, D.C. Mutation detection and single-molecule counting using isothermal rolling-circle amplification. Nat. Genet, 1998, 19, 225-232.
    • (1998) Nat. Genet , vol.19 , pp. 225-232
    • Lizardi, P.M.1    Huang, X.2    Zhu, Z.3    Bray-Ward, P.4    Thomas, D.C.5    Ward, D.C.6
  • 130
    • 75149148079 scopus 로고    scopus 로고
    • Highly sensitive detection of prions - new opportunities in the diagnosis of transmissible spongiform encephalopathies
    • Poster available online
    • König, C.; Engemann, C.; Krummrei, U.; Wacker, R.; Hoffmann, R. Highly sensitive detection of prions - new opportunities in the diagnosis of transmissible spongiform encephalopathies. Presentation during Prion2005 conference, 2005, Poster available online: http://priontype.com/files/Poster-Prion2005.Adobe5.0.pdf
    • (2005) Presentation during Prion2005 conference
    • König, C.1    Engemann, C.2    Krummrei, U.3    Wacker, R.4    Hoffmann, R.5
  • 132
    • 33745463535 scopus 로고    scopus 로고
    • Azzazy, H.M.; Mansour, M.M.; Kazmierczak, S.C. Nanodiagnostics: a new frontier for clinical laboratory medicine. Clin. Chem., 2006, 52, 1238-1246.
    • Azzazy, H.M.; Mansour, M.M.; Kazmierczak, S.C. Nanodiagnostics: a new frontier for clinical laboratory medicine. Clin. Chem., 2006, 52, 1238-1246.
  • 133
    • 75149138766 scopus 로고    scopus 로고
    • Wacker, R.; Chalbot, S.; Schulz, S.; Grundke-Iqbal, I.; Iqbal, K.A. Quantitative real-time immuno-pcr to measure tau phosphorylated at serine 199 in cerebrospinal fluid 11th ICAD - International Conference of Alzheimer's Disease, Chicago July 26-31, 2008, Lecture.
    • Wacker, R.; Chalbot, S.; Schulz, S.; Grundke-Iqbal, I.; Iqbal, K.A. Quantitative real-time immuno-pcr to measure tau phosphorylated at serine 199 in cerebrospinal fluid 11th ICAD - International Conference of Alzheimer's Disease, Chicago July 26-31, 2008, Lecture.
  • 135
    • 75149121902 scopus 로고    scopus 로고
    • A quantitative real-time Immuno-PCR to measure TAU phosphorylated at serine 199 in cerebospinal fluid 11th ICAD -
    • Chicago July 26-31, Poster
    • Wacker, R.; Chalbot, S.; Schulz, S.; Grundke-Igbal, I.; Iqbal, K. A quantitative real-time Immuno-PCR to measure TAU phosphorylated at serine 199 in cerebospinal fluid 11th ICAD - International Conference of Alzheimer's Disease, Chicago July 26-31, 2008, Poster.
    • (2008) International Conference of Alzheimer's Disease
    • Wacker, R.1    Chalbot, S.2    Schulz, S.3    Grundke-Igbal, I.4    Iqbal, K.5
  • 136
    • 33748682929 scopus 로고    scopus 로고
    • Kessler, M.; Goldsmith, D.; Schellekens, H. Immunogenicity of biopharmaceuticals. Nephrol. Dial. Transplant., 2006, 21(Suppl 5), v9-12.
    • Kessler, M.; Goldsmith, D.; Schellekens, H. Immunogenicity of biopharmaceuticals. Nephrol. Dial. Transplant., 2006, 21(Suppl 5), v9-12.
  • 137
    • 34250655364 scopus 로고    scopus 로고
    • The bio-barcode assay for the detection of protein and nucleic acid targets using DTT-induced ligand exchange
    • Hill, H.D.; Mirkin, C.A. The bio-barcode assay for the detection of protein and nucleic acid targets using DTT-induced ligand exchange. Nat. Protoc., 2006, 1, 324-336.
    • (2006) Nat. Protoc , vol.1 , pp. 324-336
    • Hill, H.D.1    Mirkin, C.A.2
  • 138
    • 32044455323 scopus 로고    scopus 로고
    • A fluorophore-based bio-barcode amplification assay for proteins
    • Oh, B.K.; Nam, J.M.; Lee, S.W.; Mirkin, C.A. A fluorophore-based bio-barcode amplification assay for proteins. Small, 2006, 2, 103-108.
    • (2006) Small , vol.2 , pp. 103-108
    • Oh, B.K.1    Nam, J.M.2    Lee, S.W.3    Mirkin, C.A.4
  • 140
    • 75149139859 scopus 로고    scopus 로고
    • Spengler, U.; Laue, T. Das TaqMan-Prinzip. BioTec, 1998, 56-57.
    • Spengler, U.; Laue, T. Das TaqMan-Prinzip. BioTec, 1998, 56-57.
  • 143
    • 36549078612 scopus 로고    scopus 로고
    • Development and clinical validation of a real-time PCR using a uni-molecular Scorpion-based probe for the detection of Mycoplasma pneumoniae in clinical isolates
    • Di Marco, E.; Cangemi, G.; Filippetti, M.; Melioli, G.; Biassoni, R. Development and clinical validation of a real-time PCR using a uni-molecular Scorpion-based probe for the detection of Mycoplasma pneumoniae in clinical isolates. New Microbiol, 2007, 30, 415-421.
    • (2007) New Microbiol , vol.30 , pp. 415-421
    • Di Marco, E.1    Cangemi, G.2    Filippetti, M.3    Melioli, G.4    Biassoni, R.5
  • 144
    • 23944512774 scopus 로고    scopus 로고
    • Rapid synthesis of DNA-cysteine conjugates for expressed protein ligation
    • Lovrinovic, M.; Niemeyer, C.M. Rapid synthesis of DNA-cysteine conjugates for expressed protein ligation. Biochem. Biophys. Res. Commun., 2005, 335, 943-948.
    • (2005) Biochem. Biophys. Res. Commun , vol.335 , pp. 943-948
    • Lovrinovic, M.1    Niemeyer, C.M.2
  • 145
    • 33846288351 scopus 로고    scopus 로고
    • Microtiter plate-based screening for the optimization of DNA-protein conjugate synthesis by means of expressed protein ligation
    • Lovrinovic, M.; Niemeyer, C.M. Microtiter plate-based screening for the optimization of DNA-protein conjugate synthesis by means of expressed protein ligation. ChembioChem., 2007, 8, 61-67.
    • (2007) ChembioChem , vol.8 , pp. 61-67
    • Lovrinovic, M.1    Niemeyer, C.M.2


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