메뉴 건너뛰기




Volumn 264, Issue 3, 1999, Pages 775-784

Cloning of the mistletoe lectin gene and characterization of the recombinant A-chain

Author keywords

Active site cloning; Heterologous expression; Ribosome inactivating protein; Toxic lectin; Viscum album

Indexed keywords

RIBOSOME INACTIVATING PROTEIN; RIBOSOME RNA; RICIN; VISCUM ALBUM LECTIN;

EID: 0033568443     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.1999.00638.x     Document Type: Article
Times cited : (80)

References (53)
  • 1
    • 0027269832 scopus 로고
    • Mistletoe (Viscum album) lectins as cytokine inducers and immunoadjuvant in tumour therapy
    • 1. Bocci, V. (1993) Mistletoe (Viscum album) lectins as cytokine inducers and immunoadjuvant in tumour therapy. J. Biol. Regulators Homeo-static Agents 7, 1-6.
    • (1993) J. Biol. Regulators Homeo-static Agents , vol.7 , pp. 1-6
    • Bocci, V.1
  • 2
    • 0025313821 scopus 로고
    • Increased secretion of tumor necrosis factor α, interleukin 1, and interleukin 6 by human mononuclear cells exposed to β-galactoside-specific lectin from clinically applied mistletoe extract
    • 2. Hajto, T., Hostanska, K., Frei, K., Rordorf, C. & Gabius, H.-J. (1990) Increased secretion of tumor necrosis factor α, interleukin 1, and interleukin 6 by human mononuclear cells exposed to β-galactoside-specific lectin from clinically applied mistletoe extract. Cancer Res. 50, 3322-3326.
    • (1990) Cancer Res. , vol.50 , pp. 3322-3326
    • Hajto, T.1    Hostanska, K.2    Frei, K.3    Rordorf, C.4    Gabius, H.-J.5
  • 3
    • 0030999014 scopus 로고    scopus 로고
    • Clinical relevance of immunoactive mistletoe lectin-I
    • 3. Beuth, J. (1997) Clinical relevance of immunoactive mistletoe lectin-I. Anti-Cancer Drugs 8, S53-S55.
    • (1997) Anti-cancer Drugs , vol.8
    • Beuth, J.1
  • 4
    • 0029090289 scopus 로고
    • Quantitative determination of lectins in mistletoe preparations
    • 4. Jäggy, C., Musielski, H., Urech, K. & Schaller, G. (1995) Quantitative determination of lectins in mistletoe preparations. Drug Res. 45, 905-909.
    • (1995) Drug Res. , vol.45 , pp. 905-909
    • Jäggy, C.1    Musielski, H.2    Urech, K.3    Schaller, G.4
  • 5
    • 0022514587 scopus 로고
    • Effects of mistletoe (Viscum album L.) extracts on cultured tumor cells
    • 5. Ribéreau-Gayon, G., Jung, M.L., Baudino, S., Sallé, G. & Beck, J.P. (1986) Effects of mistletoe (Viscum album L.) extracts on cultured tumor cells. Experientia 42, 594-599.
    • (1986) Experientia , vol.42 , pp. 594-599
    • Ribéreau-Gayon, G.1    Jung, M.L.2    Baudino, S.3    Sallé, G.4    Beck, J.P.5
  • 6
    • 0022623826 scopus 로고
    • Differences in the in vitro effectiveness of preparations produced from mistletoes of various host trees
    • 6. Hülsen, H., Doser, C. & Mechelke, F. (1986) Differences in the in vitro effectiveness of preparations produced from mistletoes of various host trees. Drug Res. 36, 433-436.
    • (1986) Drug Res. , vol.36 , pp. 433-436
    • Hülsen, H.1    Doser, C.2    Mechelke, F.3
  • 7
    • 0024411596 scopus 로고
    • Influence of carbohydrates on the cytotoxicity of an aqueous mistletoe drug and of purified mistletoe lectins tested on human T-leukemia cells
    • 7. Doser, C., Doser, M.H., Hülsen, H. & Mechelke, F. (1989) Influence of carbohydrates on the cytotoxicity of an aqueous mistletoe drug and of purified mistletoe lectins tested on human T-leukemia cells. Drug Res. 39, 647-651.
    • (1989) Drug Res. , vol.39 , pp. 647-651
    • Doser, C.1    Doser, M.H.2    Hülsen, H.3    Mechelke, F.4
  • 8
    • 0024397491 scopus 로고
    • Modulatory potency of the β-galactoside-specific lectin from mistletoe extract (Iscador) on the host defense system in vivo in rabbits and patients
    • 8. Hajto, T., Hostanska, K. & Gabius, H.-J. (1989) Modulatory potency of the β-galactoside-specific lectin from mistletoe extract (Iscador) on the host defense system in vivo in rabbits and patients. Cancer Res. 49, 4803-4808.
    • (1989) Cancer Res. , vol.49 , pp. 4803-4808
    • Hajto, T.1    Hostanska, K.2    Gabius, H.-J.3
  • 9
    • 0027465312 scopus 로고
    • Comparative studies on the immunoactive action of galactoside-specific mistletoe lectin. Pure substance compared to the standardized extract
    • 9. Beuth, J., Ko, K.L., Tunggal, L., Geisel, J. & Pulverer, G. (1993) Comparative studies on the immunoactive action of galactoside-specific mistletoe lectin. Pure substance compared to the standardized extract. Drug Res. 43, 166-169.
    • (1993) Drug Res. , vol.43 , pp. 166-169
    • Beuth, J.1    Ko, K.L.2    Tunggal, L.3    Geisel, J.4    Pulverer, G.5
  • 10
    • 14744291476 scopus 로고
    • Ribosome-inactivating proteins from plants: Present status and future prospects
    • 10. Stirpe, F., Barbieri, L., Battelli, M.G., Soria, M. & Lappi, D.A. (1992) Ribosome-inactivating proteins from plants: Present status and future prospects. Bio/Technol. 10, 405-412.
    • (1992) Bio/Technol. , vol.10 , pp. 405-412
    • Stirpe, F.1    Barbieri, L.2    Battelli, M.G.3    Soria, M.4    Lappi, D.A.5
  • 11
    • 0030070330 scopus 로고    scopus 로고
    • Sialylated oligosaccharide-specific plant lectin from Japanese elderberry (Sambucus sieboldiana) bark tissue has a homologous structure to type II ribosome-inactivating proteins, ricin and abrin
    • 11. Kaku, H., Tanaka, Y., Tazaki, K., Minami, E., Mizuno, H. & Shibuya, N. (1996) Sialylated oligosaccharide-specific plant lectin from Japanese elderberry (Sambucus sieboldiana) bark tissue has a homologous structure to type II ribosome-inactivating proteins, ricin and abrin. J. Biol. Chem. 271, 1480-1485.
    • (1996) J. Biol. Chem. , vol.271 , pp. 1480-1485
    • Kaku, H.1    Tanaka, Y.2    Tazaki, K.3    Minami, E.4    Mizuno, H.5    Shibuya, N.6
  • 12
    • 0032408254 scopus 로고    scopus 로고
    • Purification and activity study of the A-and B-chains of cinnamomin, a type II ribosome-inactivating protein
    • 12. Pu, Z., Xie, L., Wang, E. & Liu, W.Y. (1998) Purification and activity study of the A-and B-chains of cinnamomin, a type II ribosome-inactivating protein. Biol. Chem. 379, 1413-1418.
    • (1998) Biol. Chem. , vol.379 , pp. 1413-1418
    • Pu, Z.1    Xie, L.2    Wang, E.3    Liu, W.Y.4
  • 13
    • 0020433058 scopus 로고
    • Isolation and characterization of viscumin, a toxic lectin from Viscum album L. (mistletoe)
    • 13. Olsnes, S., Stirpe, F., Sandvig, K. & Phil, A. (1982) Isolation and characterization of viscumin, a toxic lectin from Viscum album L. (mistletoe). J. Biol. Chem. 257, 13263-13270.
    • (1982) J. Biol. Chem. , vol.257 , pp. 13263-13270
    • Olsnes, S.1    Stirpe, F.2    Sandvig, K.3    Phil, A.4
  • 14
    • 0022974277 scopus 로고
    • Mistletoe lectins and their A and B chains
    • 14. Franz, H. (1986) Mistletoe lectins and their A and B chains. Oncology 43, 23-24.
    • (1986) Oncology , vol.43 , pp. 23-24
    • Franz, H.1
  • 15
    • 0024296613 scopus 로고
    • The site of action of the A-chain of mistletoe lectin I on eukaryotic ribosomes. The RNA N-glycosidase activity of the prolein
    • 15. Endo, Y., Tsurugi, K. & Franz, H. (1988) The site of action of the A-chain of mistletoe lectin I on eukaryotic ribosomes. The RNA N-glycosidase activity of the prolein. FEBS Lett. 231, 378-380.
    • (1988) FEBS Lett. , vol.231 , pp. 378-380
    • Endo, Y.1    Tsurugi, K.2    Franz, H.3
  • 17
    • 0000941433 scopus 로고
    • Improved procedures for isolation and standardization of mistletoe lectins and their subunits: Implications for the analysis of lectin pattern of the European mistletoe
    • Basu, J., Kundu, M. & Chakrabarti, D., eds, M/S Wiley, New Delhi
    • 17. Eifler, R., Pfüller, K., Göckeritz, W. & Püller, U. (1994) Improved procedures for isolation and standardization of mistletoe lectins and their subunits: implications for the analysis of lectin pattern of the European mistletoe. In Lectins Biology-Biochemistry Clinical Biochemistry (Basu, J., Kundu, M. & Chakrabarti, D., eds), Vol. 9, pp. 144-151. M/S Wiley, New Delhi.
    • (1994) Lectins Biology-Biochemistry Clinical Biochemistry , vol.9 , pp. 144-151
    • Eifler, R.1    Pfüller, K.2    Göckeritz, W.3    Püller, U.4
  • 18
    • 0031009206 scopus 로고    scopus 로고
    • Modulation of cytotoxicity and enhancement of cytokine release induced by Viscum album L. extracts or mistletoe lectins
    • 18. Ribéreau-Gayon, G., Jung, M.L., Frantz, M. & Anton, R. (1997) Modulation of cytotoxicity and enhancement of cytokine release induced by Viscum album L. extracts or mistletoe lectins. Anti-Cancer Drugs 8, S3-S8.
    • (1997) Anti-cancer Drugs , vol.8
    • Ribéreau-Gayon, G.1    Jung, M.L.2    Frantz, M.3    Anton, R.4
  • 19
    • 0032516664 scopus 로고    scopus 로고
    • Induction of apoptosis by the N-acetyl-galactosamine-specific toxic lectin from Viscum album L. is associated with a decrease of nuclear p53 and bcl-2 proteins and induction of telomeric associations
    • 19. Büssing, A., Multani, A.S., Pathak, S., Pfüller, U. & Schietzel, M. (1998) Induction of apoptosis by the N-acetyl-galactosamine-specific toxic lectin from Viscum album L. is associated with a decrease of nuclear p53 and bcl-2 proteins and induction of telomeric associations. Cancer Lett. 130, 57-68.
    • (1998) Cancer Lett. , vol.130 , pp. 57-68
    • Büssing, A.1    Multani, A.S.2    Pathak, S.3    Pfüller, U.4    Schietzel, M.5
  • 21
    • 0025730340 scopus 로고
    • Preproabrin: Genomic cloning and the expression of the A-chain in Escherichia coli
    • 21. Wood, K.A., Lord, J.M., Wawrzynczak, E.J. & Piatak, M. (1991) Preproabrin: genomic cloning and the expression of the A-chain in Escherichia coli. Eur. J. Biochem. 198, 723-732.
    • (1991) Eur. J. Biochem. , vol.198 , pp. 723-732
    • Wood, K.A.1    Lord, J.M.2    Wawrzynczak, E.J.3    Piatak, M.4
  • 23
    • 0030561207 scopus 로고    scopus 로고
    • A nonradioactive assay for ribosome-inactivating proteins
    • 23. Langer, M., Rothe, M., Eck, J., Möckel, B. & Zinke, H. (1996) A nonradioactive assay for ribosome-inactivating proteins. Anal. Biochem. 243, 150-153.
    • (1996) Anal. Biochem. , vol.243 , pp. 150-153
    • Langer, M.1    Rothe, M.2    Eck, J.3    Möckel, B.4    Zinke, H.5
  • 24
    • 0000847015 scopus 로고
    • Molecular cloning and sequencing of 18S rDNA fragments of six different ant species
    • 24. Baur, A., Buschinger, A. & Zimmermann, F.K. (1993) Molecular cloning and sequencing of 18S rDNA fragments of six different ant species. Insect Soc. 40, 325-335.
    • (1993) Insect Soc. , vol.40 , pp. 325-335
    • Baur, A.1    Buschinger, A.2    Zimmermann, F.K.3
  • 25
    • 0026615930 scopus 로고
    • Identity of the N-terminal sequences of the three A chains of mistletoe (Viscum album L.) lectins: Homology with ricin-like plant toxins and single-chain ribosome-inhibiting proteins
    • 25. Dietrich, J.B., Ribéreau-Gayon, G., Jung, M.L., Franz, H., Beck, J.P. & Anton, R. (1992) Identity of the N-terminal sequences of the three A chains of mistletoe (Viscum album L.) lectins: homology with ricin-like plant toxins and single-chain ribosome-inhibiting proteins. Anti-Cancer Drugs 3, 507-511.
    • (1992) Anti-cancer Drugs , vol.3 , pp. 507-511
    • Dietrich, J.B.1    Ribéreau-Gayon, G.2    Jung, M.L.3    Franz, H.4    Beck, J.P.5    Anton, R.6
  • 26
    • 0026731763 scopus 로고
    • The immunomodulatory β-galactoside-specific lectin from mistletoe: Partial sequence analysis, cell and tissue binding, and impact on intracellular biosignalling of monocytic leukemia cells
    • 26. Gabius, H.-J., Walzel, H., Joshi, S.S., Kruip, J., Kojima, S., Gerke, V., Kratzin, H. & Gabius, S. (1992) The immunomodulatory β-galactoside-specific lectin from mistletoe: Partial sequence analysis, cell and tissue binding, and impact on intracellular biosignalling of monocytic leukemia cells. Anticancer Res. 12, 669-676.
    • (1992) Anticancer Res. , vol.12 , pp. 669-676
    • Gabius, H.-J.1    Walzel, H.2    Joshi, S.S.3    Kruip, J.4    Kojima, S.5    Gerke, V.6    Kratzin, H.7    Gabius, S.8
  • 27
    • 0021760027 scopus 로고
    • The codon preference plot: Graphic analysis of protein coding sequences and prediction of gene expression
    • 27. Gribskov, M., Devereux, J. & Burgess, R. (1984) The codon preference plot: graphic analysis of protein coding sequences and prediction of gene expression. Nucleic Acids Res. 12, 539-549.
    • (1984) Nucleic Acids Res. , vol.12 , pp. 539-549
    • Gribskov, M.1    Devereux, J.2    Burgess, R.3
  • 28
    • 0024212067 scopus 로고
    • Rapid production of full-length cDNAs from rare transcripts: Amplification using a single gene-specific oligonucleotide primer
    • 28. Frohman, M.A., Dush, M.K. & Martin, G.R. (1988) Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer. Proc. Natl Acad. Sci. USA 85, 8998-9002.
    • (1988) Proc. Natl Acad. Sci. USA , vol.85 , pp. 8998-9002
    • Frohman, M.A.1    Dush, M.K.2    Martin, G.R.3
  • 29
    • 0023042283 scopus 로고
    • Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes
    • 29. Studier, F.W. & Moffatt, B.A. (1986) Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes. J. Mol. Biol. 189, 113-130.
    • (1986) J. Mol. Biol. , vol.189 , pp. 113-130
    • Studier, F.W.1    Moffatt, B.A.2
  • 32
    • 11944270350 scopus 로고
    • Removal of a proteolytic activity associated with aggregates formed from expression of creatine kinase in Escherichia coli leads to improved recovery of active enzyme
    • 32. Babbitt, P.C., West, B.L., Buechter, D.D., Kuntz, I.D. & Kenyon, G.L. (1990) Removal of a proteolytic activity associated with aggregates formed from expression of creatine kinase in Escherichia coli leads to improved recovery of active enzyme. Bio/Technology 8, 945-949.
    • (1990) Bio/Technology , vol.8 , pp. 945-949
    • Babbitt, P.C.1    West, B.L.2    Buechter, D.D.3    Kuntz, I.D.4    Kenyon, G.L.5
  • 33
    • 0024297354 scopus 로고
    • Multiple sequence alignment with hierarchical clustering
    • 33. Corpet, F. (1988) Multiple sequence alignment with hierarchical clustering. Nucleic Acids Res. 16, 10881-10890.
    • (1988) Nucleic Acids Res. , vol.16 , pp. 10881-10890
    • Corpet, F.1
  • 34
    • 0020398727 scopus 로고
    • The toxic A-chain of mistletoe lectin I: Isolation and its effect on cell-free protein synthesis
    • 34. Franz, H., Kindt, A., Ziska, P., Bielka, H., Benndorf, R. & Venker, L. (1982) The toxic A-chain of mistletoe lectin I: isolation and its effect on cell-free protein synthesis. Acta Biol. Med. Ger. 41, 4.
    • (1982) Acta Biol. Med. Ger. , vol.41 , pp. 4
    • Franz, H.1    Kindt, A.2    Ziska, P.3    Bielka, H.4    Benndorf, R.5    Venker, L.6
  • 35
    • 0024286995 scopus 로고
    • The site of action of six different ribosome-inactivating proteins from plants on eukaryotic ribosomes: The RNA N-glycosidase activity of the proteins
    • 35. Endo, Y., Tsurugi, K. & Lambert, J.M. (1988) The site of action of six different ribosome-inactivating proteins from plants on eukaryotic ribosomes: the RNA N-glycosidase activity of the proteins. Biochem. Biophys. Res. Commun. 150, 1032-1036.
    • (1988) Biochem. Biophys. Res. Commun. , vol.150 , pp. 1032-1036
    • Endo, Y.1    Tsurugi, K.2    Lambert, J.M.3
  • 36
    • 0026740874 scopus 로고
    • Structure of a ricin mutant showing rescue of activity by a noncatalytic residue
    • 36. Kim, Y., Misna, D., Monzingo, A.F., Ready, M.P., Frankel, A. & Robertus, J.D. (1992) Structure of a ricin mutant showing rescue of activity by a noncatalytic residue. Biochemistry 31, 3294-3296.
    • (1992) Biochemistry , vol.31 , pp. 3294-3296
    • Kim, Y.1    Misna, D.2    Monzingo, A.F.3    Ready, M.P.4    Frankel, A.5    Robertus, J.D.6
  • 37
    • 0028098025 scopus 로고
    • Ricin: Structure, mode of action, and some current applications
    • 37. Lord, J.M., Roberts, L.M. & Robertus, J.D. (1994) Ricin: structure, mode of action, and some current applications. FASEB J. 8, 201-208.
    • (1994) FASEB J. , vol.8 , pp. 201-208
    • Lord, J.M.1    Roberts, L.M.2    Robertus, J.D.3
  • 39
    • 0019432633 scopus 로고
    • Ricin B chain is a product of gene duplication
    • 39. Villafranca, J.E. & Robertus, J.D. (1981) Ricin B chain is a product of gene duplication. J. Biol. Chem. 256, 554-556.
    • (1981) J. Biol. Chem. , vol.256 , pp. 554-556
    • Villafranca, J.E.1    Robertus, J.D.2
  • 40
    • 0023091105 scopus 로고
    • Structure and evolution of ricin B chain
    • 40. Rutenber, E., Ready, M. & Robertus, J.D. (1987) Structure and evolution of ricin B chain. Nature 326, 624-626.
    • (1987) Nature , vol.326 , pp. 624-626
    • Rutenber, E.1    Ready, M.2    Robertus, J.D.3
  • 41
    • 0001776594 scopus 로고    scopus 로고
    • Glycosylation pattern of mistletoe lectins
    • Effects of Antinutrients on the Nutritional Value of Legume Diets (Bardocz, S., Pfüller, U. & Pusztai, A., eds)
    • 41. Zimmermann, R. & Pfüller, U. (1998) Glycosylation pattern of mistletoe lectins. In COST 98, Vol. 5. Effects of Antinutrients on the Nutritional Value of Legume Diets (Bardocz, S., Pfüller, U. & Pusztai, A., eds). pp. 55-62.
    • (1998) Cost 98 , vol.5 , pp. 55-62
    • Zimmermann, R.1    Pfüller, U.2
  • 42
    • 0009750837 scopus 로고    scopus 로고
    • European Patent EP 0751,221,B1. Official Publications of The European Communities, Luxembourg
    • 42. Lentzen, H., Eck, J., Baur, A. & Zinke, H. (1998) Recombinant mistletoe lectin (rML). European Patent EP 0751,221,B1. Official Publications of The European Communities, Luxembourg.
    • (1998) Recombinant Mistletoe Lectin (rML)
    • Lentzen, H.1    Eck, J.2    Baur, A.3    Zinke, H.4
  • 43
    • 0032549633 scopus 로고    scopus 로고
    • Elderberry (Sambucus nigra) contains truncated Neu5Ac(α-2,6)Gal/GalNAc-binding type 2 ribosome-inactivating proteins
    • 43. Peumans, W.J., Roy, S., Barre, A., Rouge, P., van Leuven, F. & van Damme, E.J. (1998) Elderberry (Sambucus nigra) contains truncated Neu5Ac(α-2,6)Gal/GalNAc-binding type 2 ribosome-inactivating proteins. FEBS Lett. 425, 35-39.
    • (1998) FEBS Lett. , vol.425 , pp. 35-39
    • Peumans, W.J.1    Roy, S.2    Barre, A.3    Rouge, P.4    Van Leuven, F.5    Van Damme, E.J.6
  • 44
    • 0025939115 scopus 로고
    • Structure of ricin B-chain at 2.5 Å resolution
    • 44. Rutenber, E. & Robertus, J.D. (1991) Structure of ricin B-chain at 2.5 Å resolution. Proteins 10, 260-269.
    • (1991) Proteins , vol.10 , pp. 260-269
    • Rutenber, E.1    Robertus, J.D.2
  • 46
    • 0033524919 scopus 로고    scopus 로고
    • Pokeweed antiviral protein access ribosomes by binding to L3
    • 46. Hudak, K.A., Dinman, J.D. & Turner, N.E. (1999) Pokeweed antiviral protein access ribosomes by binding to L3. J. Biol. Chem. 274, 3895-3864.
    • (1999) J. Biol. Chem. , vol.274 , pp. 3895-13864
    • Hudak, K.A.1    Dinman, J.D.2    Turner, N.E.3
  • 47
    • 0029791975 scopus 로고    scopus 로고
    • Concanavalin A and mistletoe lectin I differentially activate cation entry and exocytosis in human neutrophils: Lectins may activate multiple subtypes of cation channels
    • 47. Wenzel-Seifert, K., Krautwurst, D., Lentzen, H. & Seifert, R. (1996) Concanavalin A and mistletoe lectin I differentially activate cation entry and exocytosis in human neutrophils: Lectins may activate multiple subtypes of cation channels. J. Leukocyte Biol. 60, 345-351.
    • (1996) J. Leukocyte Biol. , vol.60 , pp. 345-351
    • Wenzel-Seifert, K.1    Krautwurst, D.2    Lentzen, H.3    Seifert, R.4
  • 48
    • 0031794944 scopus 로고    scopus 로고
    • Effect of a recombinant lectin, Viscum album agglutinin on the secretion of interleukin-12 in cultured human peripheral blood mononucleated cells and on NK-cell mediated cytoxicity of rat splenocytes in vitro and in vivo
    • 48. Hajto, T., Hostanska, K., Weber, K., Zinke, H., Fischer, J., Mengs, U., Lentzen, H. & Saller, R. (1998) Effect of a recombinant lectin, Viscum album agglutinin on the secretion of interleukin-12 in cultured human peripheral blood mononucleated cells and on NK-cell mediated cytoxicity of rat splenocytes in vitro and in vivo. Nat. Immun. 16, 34-46.
    • (1998) Nat. Immun. , vol.16 , pp. 34-46
    • Hajto, T.1    Hostanska, K.2    Weber, K.3    Zinke, H.4    Fischer, J.5    Mengs, U.6    Lentzen, H.7    Saller, R.8
  • 49
    • 0030853637 scopus 로고    scopus 로고
    • Effects of mistletoe lectin I on human blood cell lines and peripheral blood cells: Cytotoxicity, apoptosis and induction of cytokines
    • 49. Möckel, B., Schwarz, T., Zinke, H., Eck, J., Langer, M. & Lentzen, H. (1997) Effects of mistletoe lectin I on human blood cell lines and peripheral blood cells: cytotoxicity, apoptosis and induction of cytokines. Drug Res. 47, 1145-1151.
    • (1997) Drug Res. , vol.47 , pp. 1145-1151
    • Möckel, B.1    Schwarz, T.2    Zinke, H.3    Eck, J.4    Langer, M.5    Lentzen, H.6
  • 51
    • 0020405898 scopus 로고
    • Action of viscumin, a toxic lectin from mistletoe, on cells in culture
    • 51. Stirpe, F., Sandvig, K., Olsnes, S. & Phil, A. (1982) Action of viscumin, a toxic lectin from mistletoe, on cells in culture. J. Biol. Chem. 257, 13271-13277.
    • (1982) J. Biol. Chem. , vol.257 , pp. 13271-13277
    • Stirpe, F.1    Sandvig, K.2    Olsnes, S.3    Phil, A.4
  • 52
    • 0017142394 scopus 로고
    • Toxicity, distribution and elimination of the cancerostatic lectins abrin and ricin after parenteral injection into mice
    • 52. Fodstad, O., Olsnes, S. & Phil, A. (1976) Toxicity, distribution and elimination of the cancerostatic lectins abrin and ricin after parenteral injection into mice. Br. J. Cancer 34, 418-425.
    • (1976) Br. J. Cancer , vol.34 , pp. 418-425
    • Fodstad, O.1    Olsnes, S.2    Phil, A.3
  • 53
    • 0009682393 scopus 로고    scopus 로고
    • Toxic and immunostimulating effects of mistletoe and related toxic lectins
    • Effects of Antinutrients on the Nutritional Value of Legume Diet (Bardocz, S., Glenncser, E. & Pusztai, A., eds), European Commission, Luxembourg
    • 53. Pfüller, U. (1996) Toxic and immunostimulating effects of mistletoe and related toxic lectins. In COST 98, Effects of Antinutrients on the Nutritional Value of Legume Diet (Bardocz, S., Glenncser, E. & Pusztai, A., eds), Vol. I, pp. 46-54. European Commission, Luxembourg.
    • (1996) Cost 98 , vol.1 , pp. 46-54
    • Pfüller, U.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.