메뉴 건너뛰기




Volumn 151, Issue 4, 2009, Pages 270-273

Should we be applying warfarin pharmacogenetics to clinical practice? No, not now

Author keywords

[No Author keywords available]

Indexed keywords

WARFARIN; ANTICOAGULANT AGENT; CYP2C9 PROTEIN, HUMAN; MENADIONE EPOXIDASE; MIXED FUNCTION OXIDASE; UNSPECIFIC MONOOXYGENASE;

EID: 69149098714     PISSN: 00034819     EISSN: 15393704     Source Type: Journal    
DOI: 10.7326/0003-4819-151-4-200908180-00009     Document Type: Review
Times cited : (42)

References (31)
  • 2
    • 70349139112 scopus 로고    scopus 로고
    • Patient's DNA may be signal to tailor medication
    • 30 December
    • Pollack A. Patient's DNA may be signal to tailor medication. The New York Times. 30 December 2008.
    • (2008) The New York Times
    • Pollack, A.1
  • 3
    • 58749095297 scopus 로고    scopus 로고
    • Cost-effectiveness of using pharmacogenetic information in warfarin dosing for patients with nonvalvular atrial fibrillation
    • PMID: 19153410
    • Eckman MH, Rosand J, Greenberg SM, Gage BF. Cost-effectiveness of using pharmacogenetic information in warfarin dosing for patients with nonvalvular atrial fibrillation. Ann Intern Med. 2009;150:73-83. [PMID: 19153410]
    • (2009) Ann Intern Med , vol.150 , pp. 73-83
    • Eckman, M.H.1    Rosand, J.2    Greenberg, S.M.3    Gage, B.F.4
  • 4
    • 60849097257 scopus 로고    scopus 로고
    • Estimation of the warfarin dose with clinical and pharmacogenetic data
    • International Warfarin Pharmacogenetics Consortium. PMID: 19228618
    • International Warfarin Pharmacogenetics Consortium. Estimation of the warfarin dose with clinical and pharmacogenetic data. N Engl J Med. 2009;360: 753-764 [PMID: 19228618]
    • (2009) N Engl J Med , vol.360 , pp. 753-764
  • 5
    • 0033608466 scopus 로고    scopus 로고
    • Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications
    • PMID: 10073515
    • Aithal GP, Day CP, Kesteven PJ, Daly AK. Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications. Lancet. 1999;353:717-719 [PMID: 10073515]
    • (1999) Lancet , vol.353 , pp. 717-719
    • Aithal, G.P.1    Day, C.P.2    Kesteven, P.J.3    Daly, A.K.4
  • 6
    • 33645849823 scopus 로고    scopus 로고
    • Influence of coagulation factor, vitamin K epoxide reductase complex subunit 1, and cytochrome P450 2C9 gene polymorphisms on warfarin dose requirements
    • PMID: 16580898
    • Aquilante CL, Langaee TY, Lopez LM, Yarandi HN, Tromberg JS, Mohuczy D, et al. Influence of coagulation factor, vitamin K epoxide reductase complex subunit 1, and cytochrome P450 2C9 gene polymorphisms on warfarin dose requirements. Clin Pharmacol Ther. 2006;79:291-302. [PMID: 16580898]
    • (2006) Clin Pharmacol Ther , vol.79 , pp. 291-302
    • Aquilante, C.L.1    Langaee, T.Y.2    Lopez, L.M.3    Yarandi, H.N.4    Tromberg, J.S.5    Mohuczy, D.6
  • 7
    • 45949103309 scopus 로고    scopus 로고
    • Pharmacology and management of the vitamin K antagonists: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
    • American College of Chest Physicians 8th Edition. PMID: 18574265
    • American College of Chest Physicians. Pharmacology and management of the vitamin K antagonists: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest. 2008;133:160S-198S. [PMID: 18574265]
    • (2008) Chest , vol.133
  • 8
    • 0031015345 scopus 로고    scopus 로고
    • Human P450 metabolism of warfarin
    • PMID: 9014207
    • Kaminsky LS, Zhang ZY. Human P450 metabolism of warfarin. Pharmacol Ther. 1997;73:67-74. [PMID: 9014207]
    • (1997) Pharmacol Ther , vol.73 , pp. 67-74
    • Kaminsky, L.S.1    Zhang, Z.Y.2
  • 9
    • 21144448879 scopus 로고    scopus 로고
    • Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose
    • PMID: 15930419
    • Rieder MJ, Reiner AP, Gage BF, Nickerson DA, Eby CS, McLeod HL, et al. Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose. N Engl J Med. 2005;352:2285-2293 [PMID: 15930419]
    • (2005) N Engl J Med , vol.352 , pp. 2285-2293
    • Rieder, M.J.1    Reiner, A.P.2    Gage, B.F.3    Nickerson, D.A.4    Eby, C.S.5    McLeod, H.L.6
  • 11
    • 12344331747 scopus 로고    scopus 로고
    • Pharmacodynamic resistance to warfarin associated with a Val66Met substitution in vitamin K epoxide reductase complex subunit I
    • DOI 10.1160/TH04-08-0540
    • Harrington DJ, Underwood S, Morse C, Shearer MJ, Tuddenham EG, Mumford AD. Pharmacodynamic resistance to warfarin associated with a Val66Met substitution in vitamin K epoxide reductase complex subunit 1. Thromb Haemost. 2005;93:23-26 [PMID: 15630486] (Pubitemid 40124250)
    • (2005) Thrombosis and Haemostasis , vol.93 , Issue.1 , pp. 23-26
    • Harrington, D.J.1    Underwood, S.2    Morse, C.3    Shearer, M.J.4    Tuddenham, E.G.D.5    Mumford, A.D.6
  • 13
    • 59649117935 scopus 로고    scopus 로고
    • The largest prospective warfarin-treated cohort supports genetic forecasting
    • PMID: 18574025
    • Wadelius M, Chen LY, Lindh JD, Eriksson N, Ghori MJ, Bumpstead S, et al. The largest prospective warfarin-treated cohort supports genetic forecasting. Blood. 2009;113:784-792 [PMID: 18574025]
    • (2009) Blood , vol.113 , pp. 784-792
    • Wadelius, M.1    Chen, L.Y.2    Lindh, J.D.3    Eriksson, N.4    Ghori, M.J.5    Bumpstead, S.6
  • 14
    • 34547112822 scopus 로고    scopus 로고
    • Building individualized medicine: Prevention of adverse reactions to warfarin therapy
    • PMID: 17496169
    • Krynetskiy E, McDonnell P. Building individualized medicine: prevention of adverse reactions to warfarin therapy. J Pharmacol Exp Ther. 2007;322:427-434 [PMID: 17496169]
    • (2007) J Pharmacol Exp Ther , vol.322 , pp. 427-434
    • Krynetskiy, E.1    McDonnell, P.2
  • 15
    • 13844315559 scopus 로고    scopus 로고
    • CYP2C9 gene variants, drug dose, and bleeding risk in warfarin-treated patients: A HuGEnet systematic review and meta-analysis
    • DOI 10.1097/01.GIM.0000153664.65759.CF
    • Sanderson S, Emery J, Higgins J. CYP2C9 gene variants, drug dose, and bleeding risk in warfarin-treated patients: a HuGEnet systematic review and meta-analysis. Genet Med. 2005;7:97-104. [PMID: 15714076] (Pubitemid 40261834)
    • (2005) Genetics in Medicine , vol.7 , Issue.2 , pp. 97-104
    • Sanderson, S.1    Emery, J.2    Higgins, J.3
  • 16
    • 38049181030 scopus 로고    scopus 로고
    • Pharmacogenetics of warfarin: Regulatory, scientific, and clinical issues
    • PMID: 17906972
    • Gage BF, Lesko LJ. Pharmacogenetics of warfarin: regulatory, scientific, and clinical issues. J Thromb Thrombolysis. 2008;25:45-51. [PMID: 17906972]
    • (2008) J Thromb Thrombolysis , vol.25 , pp. 45-51
    • Gage, B.F.1    Lesko, L.J.2
  • 17
    • 0034977223 scopus 로고    scopus 로고
    • Genetic mechanisms for hypersensitivity and resistance to the anticoagulant Warfarin
    • PMID: 11412812
    • Linder MW. Genetic mechanisms for hypersensitivity and resistance to the anticoagulant Warfarin. Clin Chim Acta. 2001;308:9-15. [PMID: 11412812]
    • (2001) Clin Chim Acta , vol.308 , pp. 9-15
    • Linder, M.W.1
  • 18
    • 33750000877 scopus 로고    scopus 로고
    • A case study of acenocoumarol sensitivity and genotype-phenotype discordancy explained by combinations of polymorphisms in VKORC1 and CYP2C9
    • PMID: 16869821
    • Rettie AE, Farin FM, Beri NG, Srinouanprachanh SL, Rieder MJ, Thijssen HH. A case study of acenocoumarol sensitivity and genotype-phenotype discordancy explained by combinations of polymorphisms in VKORC1 and CYP2C9. Br J Clin Pharmacol. 2006;62:617-620 [PMID: 16869821]
    • (2006) Br J Clin Pharmacol , vol.62 , pp. 617-620
    • Rettie, A.E.1    Farin, F.M.2    Beri, N.G.3    Srinouanprachanh, S.L.4    Rieder, M.J.5    Thijssen, H.H.6
  • 21
    • 36549030324 scopus 로고    scopus 로고
    • Randomized trial of genotype-guided versus standard warfarin dosing in patients initiating oral anticoagulation
    • Couma-Gen Investigators PMID: 17989110
    • Couma-Gen Investigators. Randomized trial of genotype-guided versus standard warfarin dosing in patients initiating oral anticoagulation. Circulation. 2007; 116:2563-2570 [PMID: 17989110]
    • (2007) Circulation , vol.116 , pp. 2563-2570
  • 22
    • 11244332058 scopus 로고    scopus 로고
    • A polymorphism in the VKORC1 gene is associated with an interindividual variability in the dose-anticoagulant effect of warfarin
    • DOI 10.1182/blood-2004-06-2111
    • D'Andrea G, D'Ambrosio RL, Di Perna P, Chetta M, Santacroce R, Brancaccio V, et al. A polymorphism in the VKORC1 gene is associated with an interindividual variability in the dose-anticoagulant effect of warfarin. Blood. 2005;105:645-649 [PMID: 15358623] (Pubitemid 40070748)
    • (2005) Blood , vol.105 , Issue.2 , pp. 645-649
    • D'Andrea, G.1    D'Ambrosio, R.L.2    Di Perna, P.3    Chetta, M.4    Santacroce, R.5    Brancaccio, V.6    Grandone, E.7    Margaglione, M.8
  • 23
    • 39449086981 scopus 로고    scopus 로고
    • CYP2C9 genotype-guided warfarin prescribing enhances the efficacy and safety of anticoagulation: A prospective randomized controlled study
    • DOI 10.1038/sj.clpt.6100316, PII 6100316
    • Caraco Y, Blotnick S, Muszkat M. CYP2C9 genotype-guided warfarin prescribing enhances the efficacy and safety of anticoagulation: a prospective randomized controlled study. Clin Pharmacol Ther. 2008;83:460-470 [PMID: 17851566] (Pubitemid 351272635)
    • (2008) Clinical Pharmacology and Therapeutics , vol.83 , Issue.3 , pp. 460-470
    • Caraco, Y.1    Blotnick, S.2    Muszkat, M.3
  • 25
    • 0037012465 scopus 로고    scopus 로고
    • Association between CYP2C9 genetic variants and anticoagulation-related outcomes during warfarin therapy
    • PMID: 11926893
    • Higashi MK, Veenstra DL, Kondo LM, Wittkowsky AK, Srinouanprachanh SL, Farin FM, et al. Association between CYP2C9 genetic variants and anticoagulation-related outcomes during warfarin therapy. JAMA. 2002;287: 1690-1698 [PMID: 11926893]
    • (2002) JAMA , vol.287 , pp. 1690-1698
    • Higashi, M.K.1    Veenstra, D.L.2    Kondo, L.M.3    Wittkowsky, A.K.4    Srinouanprachanh, S.L.5    Farin, F.M.6
  • 26
    • 38349126516 scopus 로고    scopus 로고
    • Influence of CYP2C9 and VKORC1 1173C/T genotype on the risk of hemorrhagic complications in African-American and European-American patients on warfarin
    • PMID: 17653141
    • Limdi NA, McGwin G, Goldstein JA, Beasley TM, Arnett DK, Adler BK, et al. Influence of CYP2C9 and VKORC1 1173C/T genotype on the risk of hemorrhagic complications in African-American and European-American patients on warfarin. Clin Pharmacol Ther. 2008;83:312-321 [PMID: 17653141]
    • (2008) Clin Pharmacol Ther , vol.83 , pp. 312-321
    • Limdi, N.A.1    McGwin, G.2    Goldstein, J.A.3    Beasley, T.M.4    Arnett, D.K.5    Adler, B.K.6
  • 27
    • 27644481779 scopus 로고    scopus 로고
    • A C1173T dimorphism in the VKORC1 gene determines coumarin sensitivity and bleeding risk
    • PMID: 16201835
    • Reitsma PH, van der Heijden JF, Groot AP, Rosendaal FR, Büller HR. A C1173T dimorphism in the VKORC1 gene determines coumarin sensitivity and bleeding risk. PLoS Med. 2005;2:e312. [PMID: 16201835]
    • (2005) PLoS Med , vol.2
    • Reitsma, P.H.1    Van Der Heijden, J.F.2    Groot, A.P.3    Rosendaal, F.R.4    Büller, H.R.5
  • 29
    • 0034283762 scopus 로고    scopus 로고
    • Influence of cytochrome P-450 CYP2C9 polymorphisms on warfarin sensitivity and risk of over-anticoagulation in patients on long-term treatment
    • Taube J, Halsall D, Baglin T. Influence of cytochrome P-450 CYP2C9 polymorphisms on warfarin sensitivity and risk of over-anticoagulation in patients on long-term treatment. Blood. 2000;96:1816-1819 [PMID: 10961881] (Pubitemid 30661066)
    • (2000) Blood , vol.96 , Issue.5 , pp. 1816-1819
    • Taube, J.1    Halsall, D.2    Baglin, T.3
  • 30
    • 67349185332 scopus 로고    scopus 로고
    • Genetic testing before anticoagulation? A systematic review of pharmacogenetic dosing of warfarin
    • PMID: 19306050
    • Kangelaris KN, Bent S, Nussbaum RL, Garcia DA, Tice JA. Genetic testing before anticoagulation? A systematic review of pharmacogenetic dosing of warfarin. J Gen Intern Med. 2009;24:656-664 [PMID: 19306050]
    • (2009) J Gen Intern Med , vol.24 , pp. 656-664
    • Kangelaris, K.N.1    Bent, S.2    Nussbaum, R.L.3    Garcia, D.A.4    Tice, J.A.5
  • 31
    • 27744485315 scopus 로고    scopus 로고
    • A prospective, randomized pilot trial of model-based warfarin dose initiation using CYP2C9 genotype and clinical data
    • PMID: 16160068
    • Hillman MA, Wilke RA, Yale SH, Vidaillet HJ, Caldwell MD, Glurich I, et al. A prospective, randomized pilot trial of model-based warfarin dose initiation using CYP2C9 genotype and clinical data. Clin Med Res. 2005;3:137-145 [PMID: 16160068]
    • (2005) Clin Med Res , vol.3 , pp. 137-145
    • Hillman, M.A.1    Wilke, R.A.2    Yale, S.H.3    Vidaillet, H.J.4    Caldwell, M.D.5    Glurich, I.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.