The twin questions of personalized medicine: Who are you and whom do you most resemble?

Genome Medicine

Volumn 1, Issue 1, 2009, Pages

  Kohane, Isaac S ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HFE PROTEIN;

CLINICAL PRACTICE; GENE EXPRESSION; GENE MUTATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENETICS; GENOTYPE; HEALTH CARE PERSONNEL; HEMOCHROMATOSIS; HOMOZYGOSITY; HUMAN; MEDICAL DECISION MAKING; MEDICAL EDUCATION; NOTE; PATIENT INFORMATION; PERSONALIZED MEDICINE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 67649480496     PISSN: None     EISSN: 1756994X     Source Type: Journal    
DOI: 10.1186/gm4     Document Type: Note

References (23)

1. Wikipedia: Personalized medicine [http://en.wikipedia.org/wiki/Personalized_ medicine]
2. Burke W, Zimmern RL: Ensuring the appropriate use of genetic tests. Nat Rev Genet 2004, 5:955.
3. Pauker SG, Kassirer JP: Decision analysis. N Engl J Med 1987, 316: 250-258.
4. Crawley L: The paradox of race in the Bidil debate. J Natl Med Assoc 2007, 99:821-822.
5. Allocco DJ, Song Q, Gibbons GH, Ramoni MF, Kohane IS: Geography and genography: prediction of continental origin using randomly selected single nucleotide polymorphisms. BMC Genomics 2007, 8:68.
6. Miller MB, Schwander K, Rao DC: Genotyping errors and their impact on genetic analysis. Adv Genet 2008, 60:141-152.
7. Heckerman DE, Nathwani BN: Toward normative expert systems: Part II. Probability-based representations for efficient knowledge acquisition and inference. Methods Inf Med 1992, 31:106-116.
8. Harris NL: Probabilistic belief networks for genetic counseling. Comput Methods Programs Biomed 1990, 32:37-44.
9. Lasker RD: The diabetes control and complications trial: implications for policy and practice. N Engl J Med 1993, 329:1035-1036.
10. Slamon DJ, Leyland-Jones B, Shak S, Fuchs H, Paton V, Bajamonde A, Fleming T, Eiermann W, Wolter J, Pegram M, Baselga J, Norton L: Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 2001, 344:783-792.
11. Pichichero ME: A review of evidence supporting the American Academy of Pediatrics recommendation for prescribing cephalosporin antibiotics for penicillin-allergic patients. Pediatrics 2005, 115:1048-1057.
12. Beutler E, Gelbart T, West C, Lee P, Adams M, Blackstone R, Pockros P, Kosty M, Venditti CP, Phatak PD, Seese NK, Chorney KA, Ten Elshof AE, Gerhard GS, Chorney M: Mutation analysis in hereditary hemochromatosis. Blood Cells Mol Dis 1996, 22:187-194; discussion 194a-194b.
13. Jouanolle AM, Gandon G, Jézéquel P, Blayau M, Campion ML, Yaouanq J, Mosser J, Fergelot P, Chauvel B, Bouric P, Carn G, Andrieux N, Gicquel I, Le Gall JY, David V: Haemochromatosis and HLA-H. Nat Genet 1996, 14:251-252.
14. Beutler E, Felitti V, Koziol J, Ho N, Gelbart T: Penetrance of 845G?A (C282Y) hereditary haemochromatosis mutation in the USA. Lancet 2002, 359:211-218.
15. Scotet V, Mérour MC, Mercier AY, Chanu B, Le Faou T, Raguénes O, Le Gac G, Mura C, Nousbaum JB, Férec C: Hereditaryhemochromatosis: effect of excessive alcohol consumption on disease expression in patients homozygous for the C282Y mutation. Am J Epidemiol 2003 158:129-134.
16. Bacon BR, Britton RS: Clinical penetrance of hereditary hemochromatosis. N Engl J Med 2008, 358:291-292.
17. Kohane IS, Masys DR, Altman RB: The incidentalome: a threat to genomic medicine. JAMA 2006, 296:212-215.
18. Mandl KD, Kohane I: Tectonic shifts in the health information economy. N Engl J Med 2008, 358:1732-1737.
19. Policy Issues Associated with Undertaking a New Large U.S. Population Cohort Study of Genes, Environment, and Disease; 2007.
20. Pauker SG, Pauker SP: Prescriptive models to support decision making in genetics. Birth Defects Orig Artic Ser 1987, 23:279-296.
21. Szolovits P, Pauker SG: Categorical and probabilistic reasoning in medical diagnosis. Artif Intell Med 1978, 11:115-144.
22. Schwartz WB, Patil RS, Szolovits P: Artificial intelligence in medicine: where do we stand? N Engl J Med 1987, 316:685-688.
23. Arrow KJ: Social Choice and Individual Values. New York: Wiley; 1951.