메뉴 건너뛰기




Volumn 139, Issue 2, 2010, Pages 465-478

Transforming growth factor beta (TGFB) signaling is activated during porcine implantation: Proposed role for latency-associated peptide interactions with integrins at the conceptus-maternal interface

Author keywords

[No Author keywords available]

Indexed keywords

BETA1 INTEGRIN; BETA3 INTEGRIN; BETA5 INTEGRIN; BETA6 INTEGRIN; BETA8 INTEGRIN; CD51 ANTIGEN; INTEGRIN; LATENCY ASSOCIATED PEPTIDE; PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

EID: 75149138398     PISSN: 14701626     EISSN: 17417899     Source Type: Journal    
DOI: 10.1530/REP-09-0447     Document Type: Article
Times cited : (50)

References (71)
  • 1
    • 0037196163 scopus 로고    scopus 로고
    • The integrin alphaVbeta6 binds and activates latent TGFbeta3
    • Annes JP, Rifkin DB & Munger JS 2002 The integrin alphaVbeta6 binds and activates latent TGFbeta3. FEBS Letters 511 65-68.
    • (2002) FEBS Letters , vol.511 , pp. 65-68
    • Annes, J.P.1    Rifkin, D.B.2    Munger, J.S.3
  • 3
    • 2942653435 scopus 로고    scopus 로고
    • Integrin alphaVbeta6-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1
    • Annes JP, Chen Y, Munger JS & Rifkin DB 2004 Integrin alphaVbeta6-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1. Journal of Cell Biology 165 723-734.
    • (2004) Journal of Cell Biology , vol.165 , pp. 723-734
    • Annes, J.P.1    Chen, Y.2    Munger, J.S.3    Rifkin, D.B.4
  • 4
    • 18844381390 scopus 로고    scopus 로고
    • Blastocysts don't go it alone. Extrinsic signals fine-tune the intrinsic developmental program of trophoblast cells
    • Armant DR 2005 Blastocysts don't go it alone. Extrinsic signals fine-tune the intrinsic developmental program of trophoblast cells. Developmental Biology 280 260-280.
    • (2005) Developmental Biology , vol.280 , pp. 260-280
    • Armant, D.R.1
  • 5
    • 28244449083 scopus 로고    scopus 로고
    • Increased expression of integrin alpha(v)beta3 contributes to the establishment of autocrine TGF-beta signaling in scleroderma fibroblasts
    • Asano Y, Ihn H, Yamane K, Jinnin M, Mimura Y & Tamaki K 2005a Increased expression of integrin alpha(v)beta3 contributes to the establishment of autocrine TGF-beta signaling in scleroderma fibroblasts. Journal of Immunology 175 7708-7718.
    • (2005) Journal of Immunology , vol.175 , pp. 7708-7718
    • Asano, Y.1    Ihn, H.2    Yamane, K.3    Jinnin, M.4    Mimura, Y.5    Tamaki, K.6
  • 6
    • 25444501226 scopus 로고    scopus 로고
    • Involvement of alphavbeta5 integrin-mediated activation of latent transforming growth factor beta1 in autocrine transforming growth factor beta signaling in systemic sclerosis fibroblasts
    • Asano Y, Ihn H, Yamane K, Jinnin M, Mimura Y & Tamaki K 2005b Involvement of alphavbeta5 integrin-mediated activation of latent transforming growth factor beta1 in autocrine transforming growth factor beta signaling in systemic sclerosis fibroblasts. Arthritis and Rheumatism 52 2897-2905.
    • (2005) Arthritis and Rheumatism , vol.52 , pp. 2897-2905
    • Asano, Y.1    Ihn, H.2    Yamane, K.3    Jinnin, M.4    Mimura, Y.5    Tamaki, K.6
  • 7
    • 0032514841 scopus 로고    scopus 로고
    • Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all alpha v integrins
    • Bader BL, Rayburn H, Crowley D & Hynes RO 1998 Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all alpha v integrins. Cell 95 507-519.
    • (1998) Cell , vol.95 , pp. 507-519
    • Bader, B.L.1    Rayburn, H.2    Crowley, D.3    Hynes, R.O.4
  • 10
    • 33748309166 scopus 로고    scopus 로고
    • Adhesion-mediated mechano-sensitivity: A time to experiment, and a time to theorize
    • Bershadsky A, Kozlov M & Geiger B 2006 Adhesion-mediated mechano-sensitivity: a time to experiment, and a time to theorize. Current Opinion in Cell Biology 18 472-481.
    • (2006) Current Opinion in Cell Biology , vol.18 , pp. 472-481
    • Bershadsky, A.1    Kozlov, M.2    Geiger, B.3
  • 11
    • 0029909968 scopus 로고    scopus 로고
    • Spatial and temporal analyses of integrin and Muc-1 expression in porcine uterine epithelium and trophectoderm in vivo
    • Bowen JA, Bazer FW & Burghardt RC 1996 Spatial and temporal analyses of integrin and Muc-1 expression in porcine uterine epithelium and trophectoderm in vivo. Biology of Reproduction 55 1098-1106.
    • (1996) Biology of Reproduction , vol.55 , pp. 1098-1106
    • Bowen, J.A.1    Bazer, F.W.2    Burghardt, R.C.3
  • 13
    • 66949173415 scopus 로고    scopus 로고
    • Enhanced focal adhesion assembly reflects increased mechanosensation and mechanotransduction at maternal-conceptus interface and uterine wall during ovine pregnancy
    • Burghardt RC, Burghardt JR, Taylor JD II, Reeder AT, Nguen BT, Spencer TE, Bayless KJ & Johnson GA 2009 Enhanced focal adhesion assembly reflects increased mechanosensation and mechanotransduction at maternal-conceptus interface and uterine wall during ovine pregnancy. Reproduction 137 567-582.
    • (2009) Reproduction , vol.137 , pp. 567-582
    • Burghardt, R.C.1    Burghardt, J.R.2    Taylor II, J.D.3    Reeder, A.T.4    Nguen, B.T.5    Spencer, T.E.6    Bayless, K.J.7    Johnson, G.A.8
  • 14
    • 0028937160 scopus 로고
    • Biochemical evidence for the autophosphorylation and transphosphorylation of transforming growth factor beta receptor kinases
    • Chen F & Weinberg RA 1995 Biochemical evidence for the autophosphorylation and transphosphorylation of transforming growth factor beta receptor kinases. PNAS 92 1565-1569.
    • (1995) PNAS , vol.92 , pp. 1565-1569
    • Chen, F.1    Weinberg, R.A.2
  • 15
    • 0030770411 scopus 로고    scopus 로고
    • Latent transforming growth factor beta1 activation in situ: Quantitative and functional evidence after low-dose gamma-irradiation
    • Ehrhardt EJ, Segarini P, Tsang ML, Carroll AG & Barcellos-Hoff MH 1997 Latent transforming growth factor beta1 activation in situ: quantitative and functional evidence after low-dose gamma-irradiation. FASEB Journal 11 991-1002.
    • (1997) FASEB Journal , vol.11 , pp. 991-1002
    • Ehrhardt, E.J.1    Segarini, P.2    Tsang, M.L.3    Carroll, A.G.4    Barcellos-Hoff, M.H.5
  • 16
    • 73349138903 scopus 로고    scopus 로고
    • Secreted phosphoprotein 1 (SPP1, osteopontin) binds to integrin alphavbeta6 on porcine trophectoderm cells and integrin alphavbeta3 on uterine luminal epithelial cells, and promotes trophectoderm cell adhesion and migration
    • Erikson DW, Burghardt RC, Bayless KJ & Johnson GA 2009 Secreted phosphoprotein 1 (SPP1, osteopontin) binds to integrin alphavbeta6 on porcine trophectoderm cells and integrin alphavbeta3 on uterine luminal epithelial cells, and promotes trophectoderm cell adhesion and migration. Biology of Reproduction 81 814-825.
    • (2009) Biology of Reproduction , vol.81 , pp. 814-825
    • Erikson, D.W.1    Burghardt, R.C.2    Bayless, K.J.3    Johnson, G.A.4
  • 17
    • 0036081239 scopus 로고    scopus 로고
    • Latent transforming growth factor-beta activation in mammary gland: Regulation by ovarian hormones affects ductal and alveolar proliferation
    • Ewan KB, Shyamala G, Ravani SA, Tang Y, Akhurst R, Wakefield L & Barcellos-Hoff MH 2002 Latent transforming growth factor-beta activation in mammary gland: regulation by ovarian hormones affects ductal and alveolar proliferation. American Journal of Pathology 160 2081-2093.
    • (2002) American Journal of Pathology , vol.160 , pp. 2081-2093
    • Ewan, K.B.1    Shyamala, G.2    Ravani, S.A.3    Tang, Y.4    Akhurst, R.5    Wakefield, L.6    Barcellos-Hoff, M.H.7
  • 18
    • 0028179437 scopus 로고
    • Transforming growth factor-β stimulates trophoblast oncofetal fibronectin synthesis in vitro: Implications for trophoblast implantation in vivo
    • Feinberg RF, Kliman HJ & Wang C-L 1994 Transforming growth factor-β stimulates trophoblast oncofetal fibronectin synthesis in vitro: implications for trophoblast implantation in vivo. Journal of Clinical Endocrinology and Metabolism 78 1241-1248.
    • (1994) Journal of Clinical Endocrinology and Metabolism , vol.78 , pp. 1241-1248
    • Feinberg, R.F.1    Kliman, H.J.2    Wang, C.-L.3
  • 20
    • 0020423107 scopus 로고
    • Establishment of pregnancy in the pig: II. Cellular remodeling of the porcine blastocyst during elongation on day 12 of pregnancy
    • Geisert RD, Brookbank JW, Roberts RM & Bazer FW 1982 Establishment of pregnancy in the pig: II. Cellular remodeling of the porcine blastocyst during elongation on day 12 of pregnancy. Biology of Reproduction 27 941-955.
    • (1982) Biology of Reproduction , vol.27 , pp. 941-955
    • Geisert, R.D.1    Brookbank, J.W.2    Roberts, R.M.3    Bazer, F.W.4
  • 21
    • 0023732890 scopus 로고
    • Molecular events in the processing of recombinant type 1 pre-pro-transforming growth factor beta to the mature polypeptide
    • Gentry LE, Lioubin MN, Purchio AF & Marquardt H 1988 Molecular events in the processing of recombinant type 1 pre-pro-transforming growth factor beta to the mature polypeptide. Molecular and Cellular Biology 8 4162-4168.
    • (1988) Molecular and Cellular Biology , vol.8 , pp. 4162-4168
    • Gentry, L.E.1    Lioubin, M.N.2    Purchio, A.F.3    Marquardt, H.4
  • 22
    • 0030902682 scopus 로고    scopus 로고
    • Effect of transforming growth factor-beta on the plasminogen activator system in cultured first trimester human cytotrophoblasts
    • Graham CH 1997 Effect of transforming growth factor-beta on the plasminogen activator system in cultured first trimester human cytotrophoblasts. Placenta 18 137-143.
    • (1997) Placenta , vol.18 , pp. 137-143
    • Graham, C.H.1
  • 23
    • 0025895269 scopus 로고
    • Mechanism of control of trophoblast invasion in situ
    • Graham CH & Lala PK 1991 Mechanism of control of trophoblast invasion in situ. Journal of Cellular Physiology 148 228-234.
    • (1991) Journal of Cellular Physiology , vol.148 , pp. 228-234
    • Graham, C.H.1    Lala, P.K.2
  • 24
    • 0029788026 scopus 로고    scopus 로고
    • Differential expression of beta transforming growth factors (TGF beta 1, TGF beta 2, and TGF beta 3) and their receptors (type I and type II) in peri-implantation porcine conceptuses
    • Gupta A, Bazer FW & Jaeger LA 1996 Differential expression of beta transforming growth factors (TGF beta 1, TGF beta 2, and TGF beta 3) and their receptors (type I and type II) in peri-implantation porcine conceptuses. Biology of Reproduction 55 796-802.
    • (1996) Biology of Reproduction , vol.55 , pp. 796-802
    • Gupta, A.1    Bazer, F.W.2    Jaeger, L.A.3
  • 25
    • 0031665234 scopus 로고    scopus 로고
    • Beta transforming growth factors (TGFss) at the porcine conceptus-maternal interface. Part I: Expression of TGFbeta1, TGFbeta2, and TGFbeta3 messenger ribonucleic acids
    • Gupta A, Ing NH, Bazer FW, Bustamante LS & Jaeger LA 1998 Beta transforming growth factors (TGFss) at the porcine conceptus-maternal interface. Part I: expression of TGFbeta1, TGFbeta2, and TGFbeta3 messenger ribonucleic acids. Biology of Reproduction 59 905-910.
    • (1998) Biology of Reproduction , vol.59 , pp. 905-910
    • Gupta, A.1    Ing, N.H.2    Bazer, F.W.3    Bustamante, L.S.4    Jaeger, L.A.5
  • 27
    • 15844376477 scopus 로고    scopus 로고
    • Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin
    • Huang XZ, Wu JF, Cass D, Erle DJ, Corry D, Young SG, Farese RV Jr & Sheppard D 1996 Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin. Journal of Cell Biology 133 921-928.
    • (1996) Journal of Cell Biology , vol.133 , pp. 921-928
    • Huang, X.Z.1    Wu, J.F.2    Cass, D.3    Erle, D.J.4    Corry, D.5    Young, S.G.6    Farese Jr, R.V.7    Sheppard, D.8
  • 28
    • 0026770377 scopus 로고
    • Integrins: Versatility, modulation, and signaling in cell adhesion
    • Hynes RO 1992 Integrins: versatility, modulation, and signaling in cell adhesion. Cell 69 11-25.
    • (1992) Cell , vol.69 , pp. 11-25
    • Hynes, R.O.1
  • 30
    • 23844542812 scopus 로고    scopus 로고
    • Functional effects of transforming growth factor beta on adhesive properties of porcine trophectoderm
    • Jaeger LA, Spiegel AK, Ing NH, Johnson GA, Bazer FW & Burghardt RC 2005 Functional effects of transforming growth factor beta on adhesive properties of porcine trophectoderm. Endocrinology 146 3933-3942.
    • (2005) Endocrinology , vol.146 , pp. 3933-3942
    • Jaeger, L.A.1    Spiegel, A.K.2    Ing, N.H.3    Johnson, G.A.4    Bazer, F.W.5    Burghardt, R.C.6
  • 31
    • 43049146157 scopus 로고    scopus 로고
    • The role of proteases in transforming growth factor-beta activation
    • Jenkins G 2008 The role of proteases in transforming growth factor-beta activation. International Journal of Biochemistry and Cell Biology 40 1068-1078.
    • (2008) International Journal of Biochemistry and Cell Biology , vol.40 , pp. 1068-1078
    • Jenkins, G.1
  • 35
    • 0034999039 scopus 로고    scopus 로고
    • Keratinocyte growth factor is up-regulated by estrogen in the porcine uterine endometrium and functions in trophectoderm cell proliferation and differentiation
    • Ka H, Jaeger LA, Johnson GA, Spencer TE & Bazer FW 2001 Keratinocyte growth factor is up-regulated by estrogen in the porcine uterine endometrium and functions in trophectoderm cell proliferation and differentiation. Endocrinology 142 2303-2310.
    • (2001) Endocrinology , vol.142 , pp. 2303-2310
    • Ka, H.1    Jaeger, L.A.2    Johnson, G.A.3    Spencer, T.E.4    Bazer, F.W.5
  • 36
    • 0030601935 scopus 로고    scopus 로고
    • Transforming growth factor-beta (TGF-beta) stimulates the expression of beta1 integrins and adhesion by rat mesangial cells
    • Kagami S, Kuhara T, Yasutomo K, Okada K, Loster K, Reutter W & Kuroda Y 1996 Transforming growth factor-beta (TGF-beta) stimulates the expression of beta1 integrins and adhesion by rat mesangial cells. Experimental Cell Research 229 1-6.
    • (1996) Experimental Cell Research , vol.229 , pp. 1-6
    • Kagami, S.1    Kuhara, T.2    Yasutomo, K.3    Okada, K.4    Loster, K.5    Reutter, W.6    Kuroda, Y.7
  • 40
    • 0025323789 scopus 로고
    • Microscopic examination of porcine conceptus-maternal interface between days 10 and 19 of pregnancy
    • Keys JL & King GJ 1990 Microscopic examination of porcine conceptus-maternal interface between days 10 and 19 of pregnancy. American Journal of Anatomy 188 221-238.
    • (1990) American Journal of Anatomy , vol.188 , pp. 221-238
    • Keys, J.L.1    King, G.J.2
  • 48
    • 0037437369 scopus 로고    scopus 로고
    • The integrin alphavbeta3 is a receptor for the latency-associated peptides of transforming growth factors beta1 and beta3
    • Ludbrook SB, Barry ST, Delves CJ & Horgan CM 2003 The integrin alphavbeta3 is a receptor for the latency-associated peptides of transforming growth factors beta1 and beta3. Biochemical Journal 369 311-318.
    • (2003) Biochemical Journal , vol.369 , pp. 311-318
    • Ludbrook, S.B.1    Barry, S.T.2    Delves, C.J.3    Horgan, C.M.4
  • 49
    • 0025215307 scopus 로고
    • Mechanism of activation of latent recombinant transforming growth factor beta 1 by plasmin
    • Lyons RM, Gentry LE, Purchio AF & Moses HL 1990 Mechanism of activation of latent recombinant transforming growth factor beta 1 by plasmin. Journal of Cell Biology 110 1361-1367.
    • (1990) Journal of Cell Biology , vol.110 , pp. 1361-1367
    • Lyons, R.M.1    Gentry, L.E.2    Purchio, A.F.3    Moses, H.L.4
  • 50
    • 0030300115 scopus 로고    scopus 로고
    • MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling
    • Macias-Silva M, Abdollah S, Hoodless PA, Pirone R, Attisano L & Wrana JL 1996 MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling. Cell 87 1215-1224.
    • (1996) Cell , vol.87 , pp. 1215-1224
    • Macias-Silva, M.1    Abdollah, S.2    Hoodless, P.A.3    Pirone, R.4    Attisano, L.5    Wrana, J.L.6
  • 51
    • 0023940794 scopus 로고
    • Latent high molecular weight complex of transforming growth factor beta 1. Purification from human platelets and structural characterization
    • Miyazono K, Hellman U, Wernstedt C & Heldin CH 1988 Latent high molecular weight complex of transforming growth factor beta 1. Purification from human platelets and structural characterization. Journal of Biological Chemistry 263 6407-6415.
    • (1988) Journal of Biological Chemistry , vol.263 , pp. 6407-6415
    • Miyazono, K.1    Hellman, U.2    Wernstedt, C.3    Heldin, C.H.4
  • 53
    • 0031670654 scopus 로고    scopus 로고
    • Interactions between growth factors and integrins: Latent forms of transforming growth factor-beta are ligands for the integrin alphavbeta1
    • Munger JS, Harpel JG, Giancotti FG & Rifkin DB 1998 Interactions between growth factors and integrins: latent forms of transforming growth factor-beta are ligands for the integrin alphavbeta1. Molecular Biology of the Cell 9 2627-2638.
    • (1998) Molecular Biology of the Cell , vol.9 , pp. 2627-2638
    • Munger, J.S.1    Harpel, J.G.2    Giancotti, F.G.3    Rifkin, D.B.4
  • 55
    • 0034109215 scopus 로고    scopus 로고
    • Activation of latent TGF-beta by thrombospondin-1: Mechanisms and physiology
    • Murphy-Ullrich JE & Poczatek M 2000 Activation of latent TGF-beta by thrombospondin-1: mechanisms and physiology. Cytokine and Growth Factor Reviews 11 59-69.
    • (2000) Cytokine and Growth Factor Reviews , vol.11 , pp. 59-69
    • Murphy-Ullrich, J.E.1    Poczatek, M.2
  • 57
    • 0030974902 scopus 로고    scopus 로고
    • Latent transforming growth factor-beta binding protein domains involved in activation and transglutaminase-dependent cross-linking of latent transforming growth factor-beta
    • Nunes I, Gleizes PE, Metz CN & Rifkin DB 1997 Latent transforming growth factor-beta binding protein domains involved in activation and transglutaminase-dependent cross-linking of latent transforming growth factor-beta. Journal of Cell Biology 136 1151-1163.
    • (1997) Journal of Cell Biology , vol.136 , pp. 1151-1163
    • Nunes, I.1    Gleizes, P.E.2    Metz, C.N.3    Rifkin, D.B.4
  • 60
    • 0024382711 scopus 로고
    • Inhibition of endothelial cell movement by pericytes and smooth muscle cells: Activation of a latent transforming growth factor-beta 1-like molecule by plasmin during co-culture
    • Sato Y & Rifkin DB 1989 Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-beta 1-like molecule by plasmin during co-culture. Journal of Cell Biology 109 309-315.
    • (1989) Journal of Cell Biology , vol.109 , pp. 309-315
    • Sato, Y.1    Rifkin, D.B.2
  • 61
    • 27644538315 scopus 로고    scopus 로고
    • Integrin-mediated activation of latent transforming growth factor beta
    • Sheppard D 2005 Integrin-mediated activation of latent transforming growth factor beta. Cancer Metastasis Reviews 24 395-402.
    • (2005) Cancer Metastasis Reviews , vol.24 , pp. 395-402
    • Sheppard, D.1
  • 63
    • 49049110677 scopus 로고    scopus 로고
    • Integrins and the activation of latent transforming growth factor beta1 - an intimate relationship
    • Wipff PJ & Hinz B 2008 Integrins and the activation of latent transforming growth factor beta1 - an intimate relationship. European Journal of Cell Biology 87 601-615.
    • (2008) European Journal of Cell Biology , vol.87 , pp. 601-615
    • Wipff, P.J.1    Hinz, B.2
  • 64
    • 37249044357 scopus 로고    scopus 로고
    • Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix
    • Wipff PJ, Rifkin DB, Meister JJ & Hinz B 2007 Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix. Journal of Cell Biology 179 1311-1323.
    • (2007) Journal of Cell Biology , vol.179 , pp. 1311-1323
    • Wipff, P.J.1    Rifkin, D.B.2    Meister, J.J.3    Hinz, B.4
  • 68
    • 0034650486 scopus 로고    scopus 로고
    • Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis
    • Yu Q & Stamenkovic I 2000 Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis. Genes and Development 14 163-176.
    • (2000) Genes and Development , vol.14 , pp. 163-176
    • Yu, Q.1    Stamenkovic, I.2
  • 69
    • 0028987192 scopus 로고
    • Transforming growth factor-beta 1 modulates beta 1 and beta 5 integrin receptors and induces the de novo expression of the alpha v beta 6 heterodimer in normal human keratinocytes: Implications for wound healing
    • Zambruno G, Marchisio PC, Marconi A, Vaschieri C, Melchiori A, Giannetti A & De Luca M 1995 Transforming growth factor-beta 1 modulates beta 1 and beta 5 integrin receptors and induces the de novo expression of the alpha v beta 6 heterodimer in normal human keratinocytes: implications for wound healing. Journal of Cell Biology 129 853-865.
    • (1995) Journal of Cell Biology , vol.129 , pp. 853-865
    • Zambruno, G.1    Marchisio, P.C.2    Marconi, A.3    Vaschieri, C.4    Melchiori, A.5    Giannetti, A.6    De Luca, M.7
  • 70
    • 0029786212 scopus 로고    scopus 로고
    • Receptor-associated Mad homologues synergize as effectors of the TGF-beta response
    • Zhang Y, Feng X, We R & Derynck R 1996 Receptor-associated Mad homologues synergize as effectors of the TGF-beta response. Nature 383 168-172.
    • (1996) Nature , vol.383 , pp. 168-172
    • Zhang, Y.1    Feng, X.2    We, R.3    Derynck, R.4
  • 71
    • 0035984003 scopus 로고    scopus 로고
    • beta8 integrins are required for vascular morphogenesis in mouse embryos
    • Zhu J, Motejlek K, Wang D, Zang K, Schmidt A & Reichardt LF 2002 beta8 integrins are required for vascular morphogenesis in mouse embryos. Development 129 2891-2903.
    • (2002) Development , vol.129 , pp. 2891-2903
    • Zhu, J.1    Motejlek, K.2    Wang, D.3    Zang, K.4    Schmidt, A.5    Reichardt, L.F.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.