Synthesis and biological evaluation of oxadiazole derivatives as inhibitors of soluble guanylyl cyclase

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 3, 2010, Pages 1288-1296

  von Wantoch Rekowski, Margarete ^a   Pyriochou, Anastasia ^b   Papapetropoulos, Nektarios ^b   Stößel, Anne ^a   Papapetropoulos, Andreas ^b   Giannis, Athanassios ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b UNIVERSITY OF PATRAS   (Greece)

Author keywords

Inhibitor; Oxadiazole synthesis; Soluble guanylyl cyclase

Indexed keywords

11,12,13,13A TETRAHYDRO 3H,9H[1,2,4]OXADIAZOLO[4,3 A]PYRROLO[2,1 C][1,4]BENZODIAZEPINE 3,9 DIONE; 12 OXO 6,12 DIHYDROQUINAZOLINO[2,3 C][1,4]BENZOXAZINE; 1H[1,2,4]OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; 2 BROMO 12 OXO 6,12 DIHYDROQUINAZOLINO[2,3 C][1,4]BENZOXAZINE; 6H[1,2,4]OXADIAZOLO[4,3 D]PYRIDO[3,2 B][1,4]OXAZIN 9 ONE; 8 (4 METHOXYPHENYL) 4H[1,2,4]OXADIAZOLO[3,4 C][1,4]BENZOXAZIN 1 ONE; 8 [3 (TRIFLUOROMETHYL)PHENYL] 4H[1,2,4]OXADIAZOLO[3,4 C][1,4]BENZOXAZIN 1 ONE; 8 BROMO 2,4 DIHYDRO 1H[1,2,4]TRIAZOLO[3,4 C][1,4]BENZOXAZIN 1 ONE; 8 BROMO 4H[1,2,4]OXADIAZOLE[3,4 C]BENZOXAZIN 1 ONE; 9 CHLORO 12 OXO 6,12 DIHYDROQUINAZOLINO[2,3 C][1,4]BENZOXAZINE; GUANYLATE CYCLASE INHIBITOR; NS 2028; OXADIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; AORTA; ARTICLE; DRUG ACTIVITY; DRUG INHIBITION; DRUG SCREENING; DRUG SYNTHESIS; NONHUMAN; RAT; SMOOTH MUSCLE FIBER;

ANIMALS; AORTA; CELLS, CULTURED; CYCLIC GMP; GUANYLATE CYCLASE; MYOBLASTS, SMOOTH MUSCLE; OXADIAZOLES; RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR;

RATTUS;

EID: 75149135228     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.12.027     Document Type: Article

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