KATP channel openers facilitate glutamate uptake by GluTs in rat primary cultured astrocytes

Neuropsychopharmacology

Volumn 33, Issue 6, 2008, Pages 1336-1342

  Sun, Xiu Lan ^a   Zeng, Xiao Ning ^a   Zhou, Fang ^a   Dai, Cui Ping ^a   Ding, Jian Hua ^a   Hu, Gang ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Glutamate uptake; Iptakalim; KATP channel opener; Mitochondria

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; 2 CYANO 1 (1,1 DIMETHYLPROPYL) 3 (3 PYRIDYL)GUANIDINE; 5 HYDROXYDECANOIC ACID; ADENOSINE TRIPHOSPHATE; DIAZOXIDE; GLUTAMATE TRANSPORTER; GLUTAMIC ACID; IPTAKALIM; PINACIDIL; PROTEIN KINASE C; REACTIVE OXYGEN METABOLITE; 5-HYDROXYDECANOIC ACID; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; AGENTS AFFECTING WATER, MOLECULE OR ION TRANSPORT; DECANOIC ACID DERIVATIVE; HYDROXYACID; POTASSIUM CHANNEL BLOCKING AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BLOOD BRAIN BARRIER; CELL CULTURE; CONTROLLED STUDY; DOWN REGULATION; DRUG INHIBITION; DRUG MECHANISM; DRUG UPTAKE; ENZYME PHOSPHORYLATION; MITOCHONDRION; NEUROPROTECTION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; SARCOLEMMA; ANALYSIS OF VARIANCE; ANIMAL; BRAIN CORTEX; CHANNEL GATING; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; DRUG INTERACTION; METABOLISM; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

1-METHYL-4-PHENYLPYRIDINIUM; AMINO ACID TRANSPORT SYSTEM X-AG; ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; CEREBRAL CORTEX; DECANOIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; GLUTAMIC ACID; HYDROXY ACIDS; ION CHANNEL GATING; KATP CHANNELS; MEMBRANE TRANSPORT MODULATORS; POTASSIUM CHANNEL BLOCKERS; PROTEIN KINASE C; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES;

EID: 42049097234     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.npp.1301501     Document Type: Article

References (49)

1. Anderson CM, Swanson RA (2000). Astrocyte glutamate transport: review of properties, regulation, and physiological functions. Glia 32: 1-14.
2. Ashcroft FM (1988). Adenosine 5′-triphosphate-sensitive potassium channels. Annu Rev Neurosci 11: 97-118.
3. Brookes PS, Yoon Y, Robotham JL, Anders MW, Sheu SS (2004). Calcium, ATP, and ROS: a mitochondrial love-hate triangle. Am J Physiol Cell Physiol 287: C817-C833.
4. Busija DW, Lacza Z, Rajapakse N, Shimizu K, Kis B, Bari F et al (2004). Targeting mitochondrial ATP-sensitive potassium channels - a novel approach to neuroprotection. Brain Res Rev 46: 282-294.
5. Chaudhry FA, Lehre KP, van Lookeren Campagne M, Ottersen OP, Danbolt NC, Storm-Mathisen J (1995). Glutamate transporters in glial plasma membranes: highly differentiated localizations revealed by quantitativeultrastructural immunocytochemistry. Neuron 15: 711-720.
6. Danbolt NC (2001). Glutamate uptake. Prog Neurobiol 65: 1-105.
7. Farkas E, Institoris A, Domoki F, Mihaly A, Luiten PG, Bari F (2004). Diazoxide and dimethyl sulphoxide prevent cerebral hypoperfusion-related learning dysfunction and brain damage after carotid artery occlusion. Brain Res 1008: 252-260.
8. Ferrarese C, Begni B, Canevari C, Zoia C, Piolti R, Frigo M et al (2000). Glutamate uptake is decreased in platelets from Alzheimer's disease patients. Ann Neurol 47: 641-643.
9. Ganel R, Crosson CE (1998). Modulation of human glutamate transporter activity by phorbol ester. J Neurochem 70: 993-1000.
10. Garlid KD, Dos Santos PZ, Xie J, Costa AD, Paucek P (2003). Mitochondrial potassium transport: the role of the mitochondrial ATP-sensitive K(+) channel in cardiac function and cardioprotection. Biochim Biophys Acta 1606: 1-21.
11. Gegelashvili G, Schousboe A (1997). High affinity glutamate transporters: regulation of expression and activity. Mol Pharmacol 52: 6-15.
12. Genoud C, Quairiaux C, Steiner P, Hirling H, Welker E, Knott JW (2006). Plasticity of astrocytic coverage and glutamate transporter expression in adult mouse cortex. PLoS Biol 4: e343.
13. Haydon PG (2001). GLIA: listening and talking to the synapse. Nat Rev Neurosci 2: 185-193.
14. ATP: an inward rectifier subunit plus the sulfonylurea receptor. Science 270: 1166-1170.
15. Ivanova T, Beyer C (2003). Estrogen regulates tyrosine hydroxylase expression in the neonate mouse brain. J Neurobiol 54: 638-647.
16. Jayakumar AR, Panickar KS, Murthy ChR, Norenberg MD (2006). Oxidative stress and mitogen-activated protein kinase phosphorylation mediate ammonia-induced cell swelling and glutamate uptake inhibition in cultured astrocytes. J Neurosci 26: 4774-4784.
17. Jezek P, Zackova M, Ruzicka M, Skobisova E, Jaburek M (2004). Mitochondrial uncoupling proteins-Facts and fantasies. Physiol Res 53(Suppl 1): S199-S211.
18. Kalandadze A, Wu Y, Robinson MB (2002). Protein kinase C activation decreases cell surface expression of the GLT-1 subtype of glutamate transporter. Requirement of a carboxyl-terminal domain and partial dependence on serine 486. J Biol Chem 277: 45741-45750.
19. Lipton SA, Rosenberg PA (1994). Excitatory amino acids as a final common pathway for neurologic disorders. N Engl J Med 330: 613-622.
20. Liss B, Bruns R, Roeper J (1999). Alternative sulfonylurea receptor expression defines metabolic sensitivity of K-ATP channels in dopaminergic midbrain neurons. EMBO J 18: 833-846.
21. Liss B, Haeckel O, Wildmann J, Miki T, Seino S, Poeper J (2005). K-ATP channels promote the differential degeneration of dopaminergic midbrain neurons. Nat Neurosci 8: 1742-1751.
22. Marco IG, Michael BR (2004). Protein kinase C-dependent remodeling of glutamate transporter function. Mol Interv 4: 48-58.
23. Matsugami TR, Tanemura K, Mieda M, Nakatomi R, Yamada K, Kondo T et al (2006). From the Cover: indispensability of the glutamate transporters GLAST and GLT1 to brain development. Proc Natl Acad Sci USA 103: 12161-12166.
24. Matute C, Domercq M, Sanchez-Gomez MV (2006). Glutamate-mediated glial injury: mechanisms and clinical importance. Glia 53: 212-224.
25. Nicholls D, Attwell D (1990). The release and uptake of excitatory amino acids. Trends Pharmacol Sci 11: 462-468.
26. O'Shea RD, Lau CL, Farso MC, Diwakarla S, Zagami CJ, Svendsen BB et al (2006). Effects of lipopolysaccharide on glial phenotype and activity of glutamate transporters: evidence for delayed upregulation and redistribution of GLT-1. Neurochem Int 48: 604-610.
27. Prensa L, Parent A (2001). The nigrostriatal pathway in the rat: a single-axon study of the relationship between dorsal and ventral tier nigral neurons and the striosome/matrix striatal compartments. J Neurosci 21: 7247-7260.
28. Robinson MB (1998). The family of sodium-dependent glutamate transporters: a focus on the GLT-1/EAAT2 subtype. Neurochem Int 33: 479-491.
29. Rothstein JD, Martin L, Levey AI, Dykes-Hoberg M, Jin L, Wu D et al (1994). Localization of neuronal and glial glutamate transporters. Neuron 13: 713-725.
30. Sargent CA, Sleph PG, Dzwonczyk S, Normandin D, Antonaccio MJ, Grover GJ (1993). Cardioprotective effects of the cyanoguanidine potassium channel opener P-1075. J Cardiovasc Pharmacol 22: 564-570.
31. Schousboe A, Waagepetersen HS (2005). Role of astrocytes in glutamate homeostasis: implications for excitotoxicity. Neurotox Res 8: 221-225.
32. Seino S (1999). ATP-sensitive potassium channels: a model of heteromultimeric potassium channel/receptor assemblies. Annu Rev Physiol 61: 337-362.
33. Starkov AA (1997). 'Mild' uncoupling of mitochondria. Biosci Rep 17: 273-279.
34. Sung U, Apparsundaram S, Galli A, Kahlig KM, Savchenko V, Schroeter S et al (2003). A regulated interaction of syntaxin 1A with the antidepressant-sensitive norepinephrine transporter establishes catecholamine clearance capacity. J Neurosci 23: 1697-1709.
35. Tai KK, McCrossan ZA, Abbott GW (2003). Activation of mitochondrial ATP-sensitive potassium channels increases cell viability against rotenone-induced cell death. J Neurochem 84: 1193-1200.
36. Takayasu Y, Iino M, Shimamoto K, Tanaka K, Ozawa S (2006). Glial glutamate transporters maintain one-to-one relationship at the climbing fiber-Purkinje cell synapse by preventing glutamate spillover. J Neurosci 26: 6563-6572.
37. Thomzig A, Wenzel M, Karschin C, Eaton MJ, Skatchkov SN, Veh RW (2001). Kir6.1 is the principal pore-forming subunit of astrocyte but not neuronal plasma membrane K-ATP channels. Mol Cell Neurosci 18: 671-690.
38. Wadiche JI, Gersdorff H (2006). Long-distance signaling via presynaptic glutamate transporters. Nat Neurosci 9: 1352-1353.
39. Wang H (1998). Cardiovascular ATP-sensitive K+ channel as a new molecular target for development of antihypertensive drugs. Acta pharmacologica Sinica 19: 397-402.
40. Wang H (2003). Pharmacological characteristics of the novel antihypertensive drug, iptakalim hydrochloride, and its molecular mechanisms. Drug Develop Res 58: 65-68.
41. Wang H, Zhang YL, Tang XC, Feng HS, Hu G (2004). Targetin g ischemic stroke with a novel opener of ATP-sensitive potassium channels in the brain. Mol Pharmacol 66: 1160-1168.
42. Wang S, Hu LF, Zhang Y, Sun T, Sun YH, Ding JH et al (2006). Effects of systemic administration of iptakalim on extracellular neurotransmitter levels in the striatum of unilateral 6-hydroxydopamine-lesioned rats. Neuropsychopharmacology 31: 933-940.
43. Xie W, Wang H, Ding J, Wang H, Hu G (2005). Anti-proliferating effect of iptakalim, a novel KATP channel opener, in cultured rabbit pulmonary arterial smooth muscle cells. Eur J Pharmacol 511: 81-87.
44. Yang Y, Liu X, Ding JH, Sun J, Long Y, Wang F et al (2004). Effects of iptakalim on rotenone-induced cytotoxicity and dopamine release from PC12 cells. Neurosci Lett 366: 53-57.
45. Yao HH, Ding JH, Zhou F, Wang F, Hu LF, Sun T et al (2005). Enhancement of glutamate uptake mediates the neuroprotection exerted by activating group II or III metabotropic glutamate receptors on astrocytes. J Neurochem 92: 948-961.
46. Yao Z, Gross GJ (1994). A comparison of adenosine-induced cardioprotection and ischemic preconditioning in dogs. Efficacy, time course, and role of KATP channels. Circulation 89: 1229-1236.
47. Zawar C, Plant TD, Schirra C, Konnerth A, Neumcke B (1999). Cell-type specific expression of ATP-sensitive potassium channels in the rat hippocampus. J Physiol 514(Part 2): 327-341.
48. Zhou F, Yao HH, Wu JY, Yang YJ, Ding JH, Hu G (2006). Activation of Group II/III metabotropic glutamate receptors attenuates LPS-induced astroglial neurotoxicity via promoting glutamate uptake. J Neurosci Res 84: 268-277.
49. Zini S, Tremblay E, Pollard H, Moreau J, Ben Ari Y (1993). Regional distribution of sulfonylurea receptors in the brain of rodent and primate. Neuroscience 55: 1085-1091.