The impact of ovarian stimulation for IVF on the developing embryo

Reproduction

Volumn 139, Issue 1, 2010, Pages 23-34

  Santos, Margarida Avo ^a   Kuijk, Ewart W ^a   Macklon, Nick S ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATASE INHIBITOR; CLOMIFENE; ESTROGEN; FOLLITROPIN; GONADORELIN AGONIST; GONADORELIN ANTAGONIST; GONADOTROPIN; HUMAN MENOPAUSAL GONADOTROPIN; LUTEINIZING HORMONE; PROGESTERONE; RECOMBINANT FOLLITROPIN;

ANEUPLOIDY; CHROMOSOME ABERRATION; CHROMOSOME MOSAICISM; CHROMOSOME SEGREGATION; DISOMY; DRUG MEGADOSE; EMBRYO; EMBRYO DEVELOPMENT; ENDOMETRIUM; EPIGENETICS; FEMALE INFERTILITY; FERTILIZATION IN VITRO; HORMONAL REGULATION; HUMAN; INTRACYTOPLASMIC SPERM INJECTION; LOW DRUG DOSE; LUTEAL PHASE; MATERNAL AGE; NIDATION; NONHUMAN; OOCYTE RETRIEVAL; OVARY FOLLICLE DEVELOPMENT; OVARY HYPERSTIMULATION; OVARY POLYCYSTIC DISEASE; PERINATAL PERIOD; PREGNANCY OUTCOME; PREGNANCY RATE; PRIORITY JOURNAL; REVIEW; SPONTANEOUS ABORTION;

ANIMALS; EMBRYO IMPLANTATION; EMBRYO, MAMMALIAN; EMBRYONIC DEVELOPMENT; EPIGENESIS, GENETIC; FEMALE; FERTILIZATION IN VITRO; FOLLICLE STIMULATING HORMONE; HUMANS; INFERTILITY; OOCYTES; OVULATION INDUCTION; PREGNANCY; PREGNANCY OUTCOME;

EID: 75149121970     PISSN: 14701626     EISSN: 17417899     Source Type: Journal    
DOI: 10.1530/REP-09-0187     Document Type: Review

References (109)

1. Aboulghar MA, Mansour RT, Serour GI, Ramzy AM & Amin YM 1997 Oocyte quality in patients with severe ovarian hyperstimulation syndrome. Fertility and Sterility 68 1017-1021.
2. Albertini DF, Sanfins A & Combelles CM 2003 Origins and manifestations of oocyte maturation competencies. Reproductive Biomedicine Online 6 410-415.
3. Andersen AN, Devroey P & Arce JC 2006 Clinical outcome following stimulation with highly purified hMG or recombinant FSH in patients undergoing IVF: a randomized assessor-blind controlled trial. Human Reproduction 21 3217-3227.
4. Baart EB, Martini E, Eijkemans MJ, Van Opstal D, Beckers NG, Verhoeff A, Macklon NS & Fauser BC 2007 Milder ovarian stimulation for in vitro fertilization reduces aneuploidy in the human preimplantation embryo: a randomized controlled trial. Human Reproduction 22 980-988.
5. Boomsma CM, Kavelaars A, Eijkemans MJ, Lentjes EG, Fauser BC, Heijnen CJ & Macklon NS 2009 Endometrial secretion analysis identifies a cytokine profile predictive of pregnancy in IVF. Human Reproduction 24 1427-1435.
6. Boxmeer JC, Steegers-Theunissen RP, Lindemans J, Wildhagen MF, Martini E, Steegers EA & Macklon NS 2008 Homocysteine metabolism in the pre-ovulatory follicle during ovarian stimulation. Human Reproduction 23 2570-2576.
7. Casan EM, Raga F & Polan ML 1999 GnRH mRNA and protein expression in human preimplantation embryos. Molecular Human Reproduction 5 234-239.
8. Champion MD & Hawley RS 2002 Playing for half the deck: the molecular biology of meiosis. Nature Cell Biology 4 Suppl 50-56.
9. Champlin AK, Kuzia SJ, Rice BA & Mobraaten LE 1987 Cell surface characteristics of blastocysts from spontaneously ovulating and gonadotropin-treated mice. Biology of Reproduction 36 439-444.
10. Child TJ, Phillips SJ, Abdul-Jalil AK, Gulekli B & Tan SL 2002 A comparison of in vitro maturation and in vitro fertilization for women with polycystic ovaries. Obstetrics and Gynecology 100 665-670.
11. Devroey P & Fauser BC 2007 Preimplantation aneuploidy screening: a research tool for now. Lancet 370 1985-1986.
12. Doldi N, Persico P, De Santis L, Rabellotti E, Papaleo E & Ferrari A 2005 Consecutive cycles in in vitro fertilization-embryo transfer. Gynecological Endocrinology 20 132-136.
13. Ebisch IM, Thomas CM, Peters WH, Braat DD & Steegers-Theunissen RP 2007 The importance of folate, zinc and antioxidants in the pathogenesis and prevention of subfertility. Human Reproduction Update 13 163-174.
14. Elbling L & Colot M 1985 Abnormal development and transport and increased sister-chromatid exchange in preimplantation embryos following superovulation in mice. Mutation Research 147 189-195.
15. Elizur SE & Tulandi T 2008 Drugs in infertility and fetal safety. Fertility and Sterility 89 1595-1602.
16. Eppig JJ 2001 Oocyte control of ovarian follicular development and function in mammals. Reproduction 122 829-838.
17. Ertzeid G & Storeng R 1992 Adverse effects of gonadotrophin treatment on pre- and postimplantation development in mice. Journal of Reproduction and Fertility 96 649-655.
18. Ertzeid G & Storeng R 2001 The impact of ovarian stimulation on implantation and fetal development in mice. Human Reproduction 16 221-225.
19. Fauser BC, Devroey P & Macklon NS 2005 Multiple birth resulting from ovarian stimulation for subfertility treatment. Lancet 365 1807-1816.
20. Filicori M, Cognigni GE, Taraborrelli S, Spettoli D, Ciampaglia W & de Fatis CT 1999 Low-dose human chorionic gonadotropin therapy can improve sensitivity to exogenous follicle-stimulating hormone in patients with secondary amenorrhea. Fertility and Sterility 72 1118-1120.
21. Fleming TP, Kwong WY, Porter R, Ursell E, Fesenko I, Wilkins A, Miller DJ, Watkins AJ & Eckert JJ 2004 The embryo and its future. Biology of Reproduction 71 1046-1054.
22. Fortier AL, Lopes FL, Darricarrere N, Martel J & Trasler JM 2008 Superovulation alters the expression of imprinted genes in the midgestation mouse placenta. Human Molecular Genetics 17 1653-1665.
23. Fowden AL, Sibley C, Reik W & Constancia M 2006 Imprinted genes, placental development and fetal growth. Hormone Research 65 50-58.
24. van der Gaast MH, Eijkemans MJ, van der Net JB, de Boer EJ, Burger CW, van Leeuwen FE, Fauser BC & Macklon NS 2006 Optimum number of oocytes for a successful first IVF treatment cycle. Reproductive Biomedicine Online 13 476-480.
25. Gidley-Baird AA, O'Neill C, Sinosich MJ, Porter RN, Pike IL & Saunders DM 1986 Failure of implantation in human in vitro fertilization and embryo transfer patients: the effects of altered progesterone/estrogen ratios in humans and mice. Fertility and Sterility 45 69-74.
26. Golbus MS 1981 The influence of strain, maternal age, and method of maturation on mouse oocyte aneuploidy. Cytogenetics and Cell Genetics 31 84-90.
27. Gosden R, Trasler J, Lucifero D & Faddy M 2003 Rare congenital disorders, imprinted genes, and assisted reproductive technology. Lancet 361 1975-1977.
28. Griesinger G, Kolibianakis EM, Diedrich K & Ludwig M 2008 Ovarian stimulation for IVF has no quantitative association with birthweight: a registry study. Human Reproduction 23 2549-2554.
29. Grundker C, Gunthert AR, Westphalen S & Emons G 2002 Biology of the gonadotropin-releasing hormone system in gynecological cancers. European Journal of Endocrinology 146 1-14.
30. Hanoch J, Lavy Y, Holzer H, Hurwitz A, Simon A, Revel A & Laufer N 1998 Young low responders protected from untoward effects of reduced ovarian response. Fertility and Sterility 69 1001-1004.
31. Hansmann I & El-Nahass E 1979 Incidence of nondisjunction in mouse oocytes. Cytogenetics and Cell Genetics 24 115-121.
32. Hassold T & Hunt P 2001 To err (meiotically) is human: the genesis of human aneuploidy. Nature Reviews. Genetics 2 280-291.
33. Hayden C 2008 GnRH analogues: applications in assisted reproductive techniques. European Journal of Endocrinology 159 (Supplement 1) S17-S25.
34. Helmerhorst FM, Perquin DA, Donker D & Keirse MJ 2004 Perinatal outcome of singletons and twins after assisted conception: a systematic review of controlled studies. BMJ 328 261.
35. Hodges CA, Ilagan A, Jennings D, Keri R, Nilson J & Hunt PA 2002 Experimental evidence that changes in oocyte growth influence meiotic chromosome segregation. Human Reproduction 17 1171-1180.
36. Hoveyda F, Engmann L, Steele J, Lopez Bernal A & Barlow DH 2002 Ovarian response in three consecutive in vitro fertilization cycles. Fertility and Sterility 77 706-710.
37. Hugues JN, Soussis J, Calderon I, Balasch J, Anderson RA & Romeu A 2005 Does the addition of recombinant LH in WHO group II anovulatory women over-responding to FSH treatment reduce the number of developing follicles? A dose-finding study Human Reproduction 20 629-635.
38. Hutt KJ & Albertini DF 2007 An oocentric view of folliculogenesis and embryogenesis. Reproductive Biomedicine Online 14 758-764.
39. Isles AR & Holland AJ 2005 Imprinted genes and mother-offspring interactions. Early Human Development 81 73-77.
40. Jackson RA, Gibson KA, Wu YW & Croughan MS 2004 Perinatal outcomes in singletons following in vitro fertilization: a meta-analysis. Obstetrics and Gynecology 103 551-563.
41. Jacod BC, Lichtenbelt KD, Schuring-Blom GH, Laven JS, van Opstal D, Eijkemans MJ & Macklon NS 2008 Does confined placental mosaicism account for adverse perinatal outcomes in IVF pregnancies? Human Reproduction 23 1107-1112.
42. Kallen B, Finnstrom O, Nygren KG & Olausson PO 2005a In vitro fertilization (IVF) in Sweden: infant outcome after different IVF fertilization methods. Fertility and Sterility 84 611-617.
43. Kallen B, Finnstrom O, Nygren KG & Olausson PO 2005b In vitro fertilization (IVF) in Sweden: risk for congenital malformations after different IVF methods. Birth Defects Research. Part A, Clinical and Molecular Teratology 73 162-169.
44. Kanayama K & Osada H 2000 The yield of abnormal unfertilized eggs observed after repeated gonadotrophin-induced ovulation. Journal of International Medical Research 28 24-27.
45. Kapiteijn K, de Bruijn CS, de Boer E, de Craen AJ, Burger CW, van Leeuwen FE & Helmerhorst FM 2006 Does subfertility explain the risk of poor perinatal outcome after IVF and ovarian hyperstimulation? Human Reproduction 21 3228-3234.
46. Katz-Jaffe MG, Trounson AO & Cram DS 2005 Chromosome 21 mosaic human preimplantation embryos predominantly arise from diploid conceptions. Fertility and Sterility 84 634-643.
47. Kol S, Lightman A, Hillensjo T, Devroey P, Fauser B, Tarlatzis B, Mannaerts B & Itskovitz-Eldor J 1999 High doses of gonadotrophin- releasing hormone antagonist in in vitro fertilization cycles do not adversely affect the outcome of subsequent freeze-thaw cycles. Human Reproduction 14 2242-2244.
48. Kolibianakis EM & Devroey P 2004 No decrease occurs in the number of COCs retrieved with repeated IVF cycles. Human Reproduction 19 1927-1928.
49. Kolibianakis E, Osmanagaoglu K, Camus M, Tournaye H, Van Steirteghem A & Devroey P 2002 Effect of repeated assisted reproductive technology cycles on ovarian response. Fertility and Sterility 77 967-970.
50. Kolibianakis EM, Collins J, Tarlatzis BC, Devroey P, Diedrich K & Griesinger G 2006 Among patients treated for IVF with gonadotrophins and GnRH analogues, is the probability of live birth dependent on the type of analogue used? A systematic review and meta-analysis Human Reproduction Update 12 651-671.
51. Lambert RD 2003 Safety issues in assisted reproductive technology: aetiology of health problems in singleton ART babies. Human Reproduction 18 1987-1991.
52. Lawrence LT & Moley KH 2008 Epigenetics and assisted reproductive technologies: human imprinting syndromes. Seminars in Reproductive Medicine 26 143-152.
53. Lestou VS & Kalousek DK 1998 Confined placental mosaicism and intrauterine fetal growth. Archives of Disease in Childhood. Fetal and Neonatal Edition 79 F223-F226.
54. Li Y, Feng HL, Cao YJ, Zheng GJ, Yang Y, Mullen S, Critser JK & Chen ZJ 2006 Confocal microscopic analysis of the spindle and chromosome configurations of human oocytes matured in vitro. Fertility and Sterility 85 827-832.
55. Lubbadeh WF, Graves CN & Spahr SL 1980 Effect of repeated superovulation on ovulatory response of dairy cows. Journal of Animal Science 50 124-127.
56. Lucifero D, Chaillet JR & Trasler JM 2004 Potential significance of genomic imprinting defects for reproduction and assisted reproductive technology. Human Reproduction Update 10 3-18.
57. Ma WG, Song H, Das SK, Paria BC & Dey SK 2003 Estrogen is a critical determinant that specifies the duration of the window of uterine receptivity for implantation. PNAS 100 2963-2968.
58. Macklon NS, Geraedts JP & Fauser BC 2002 Conception to ongoing pregnancy: the 'black box' of early pregnancy loss. Human Reproduction Update 8 333-343.
59. Macklon NS, Stouffer RL, Giudice LC & Fauser BC 2006 The science behind 25 years of ovarian stimulation for in vitro fertilization. Endocrine Reviews 27 170-207.
60. Mann MR, Lee SS, Doherty AS, Verona RI, Nolen LD, Schultz RM & Bartolomei MS 2004 Selective loss of imprinting in the placenta following preimplantation development in culture. Development 131 3727-3735.
61. Mastenbroek S, Twisk M, van Echten-Arends J, Sikkema-Raddatz B, Korevaar JC, Verhoeve HR, Vogel NE, Arts EG, de Vries JW, Bossuyt PM et al. 2007 In vitro fertilization with preimplantation genetic screening. New England Journal of Medicine 357 9-17.
62. McKiernan SH & Bavister BD 1998 Gonadotrophin stimulation of donor females decreases post-implantation viability of cultured one-cell hamster embryos. Human Reproduction 13 724-729.
63. Mochtar MH, Van der V, Ziech M & van Wely M 2007 Recombinant luteinizing hormone (rLH) for controlled ovarian hyperstimulation in assisted reproductive cycles. Cochrane Database of Systematic Reviews 2 CD005070.
64. Munne S, Magli C, Adler A, Wright G, de Boer K, Mortimer D, Tucker M, Cohen J & Gianaroli T 1997 Treatment-related chromosome abnormalities in human embryos. Human Reproduction 12 780-784.
65. Ng EH, Yeung WS, Yee Lan Lau E, So WW & Ho PC 2000 High serum oestradiol concentrations in fresh IVF cycles do not impair implantation and pregnancy rates in subsequent frozen-thawed embryo transfer cycles. Human Reproduction 15 250-255.
66. Ng EH, Lau EY, Yeung WS & Ho PC 2003 Oocyte and embryo quality in patients with excessive ovarian response during in vitro fertilization treatment. Journal of Assisted Reproduction and Genetics 20 186-191.
67. Oishi M, Gohma H, Hashizume K, Taniguchi Y, Yasue H, Takahashi S, Yamada T & Sasaki Y 2006 Early embryonic death-associated changes in genome-wide gene expression profiles in the fetal placenta of the cow carrying somatic nuclear-derived cloned embryo. Molecular Reproduction and Development 73 404-409.
68. Ombelet W, Martens G, De Sutter P, Gerris J, Bosmans E, Ruyssinck G, Defoort P, Molenberghs G & Gyselaers W 2006 Perinatal outcome of 12,021 singleton and 3108 twin births after non-IVF-assisted reproduction: a cohort study. Human Reproduction 21 1025-1032.
69. Paulson RJ, Sauer MV & Lobo RA 1990 Embryo implantation after human in vitro fertilization: importance of endometrial receptivity. Fertility and Sterility 53 870-874.
70. Pelinck MJ, Hoek A, Simons AH & Heineman MJ 2002 Efficacy of natural cycle IVF: a review of the literature. Human Reproduction Update 8 129-139.
71. Pellicer A, Lightman A, Diamond MP, Russell JB & DeCherney AH 1987 Outcome of in vitro fertilization in women with low response to ovarian stimulation. Fertility and Sterility 47 812-815.
72. Pellicer A, Ruiz A, Castellvi RM, Calatayud C, Ruiz M, Tarin JJ, Miro F & Bonilla-Musoles F 1989 Is the retrieval of high numbers of oocytes desirable in patients treated with gonadotrophin-releasing hormone analogues (GnRHa) and gonadotrophins? Human Reproduction 4 536-540.
73. Pellicer A, Valbuena D, Cano F, Remohi J & Simon C 1996 Lower implantation rates in high responders: evidence for an altered endocrine milieu during the preimplantation period. Fertility and Sterility 65 1190-1195.
74. Raga F, Casan EM, Kruessel J, Wen Y, Bonilla-Musoles F & Polan ML 1999 The role of gonadotropin-releasing hormone in murine preimplantation embryonic development. Endocrinology 140 3705-3712.
75. Rao GD & Tan SL 2005 In vitro maturation of oocytes. Seminars in Reproductive Medicine 23 242-247.
76. Reefhuis J, Honein MA, Schieve LA, Correa A, Hobbs CA & Rasmussen SA 2009 Assisted reproductive technology and major structural birth defects in the United States. Human Reproduction 24 360-366.
77. Regan L, Owen EJ & Jacobs HS 1990 Hypersecretion of luteinising hormone, infertility, and miscarriage. Lancet 336 1141-1144.
78. Reinblatt SL & Buckett W 2008 In vitro maturation for patients with polycystic ovary syndrome. Seminars in Reproductive Medicine 26 121-126.
79. Roberts R, Iatropoulou A, Ciantar D, Stark J, Becker DL, Franks S & Hardy K 2005 Follicle-stimulating hormone affects metaphase I chromosome alignment and increases aneuploidy in mouse oocytes matured in vitro. Biology of Reproduction 72 107-118.
80. Sato A, Otsu E, Negishi H, Utsunomiya T & Arima T 2007 Aberrant DNA methylation of imprinted loci in superovulated oocytes. Human Reproduction 22 26-35.
81. Schieve LA,Meikle SF, Ferre C, Peterson HB, Jeng G &Wilcox LS 2002 Low and very low birth weight in infants conceived with use of assisted reproductive technology. New England Journal of Medicine 346 731-737.
82. Schimberni M, Morgia F, Colabianchi J, Giallonardo A, Piscitelli C, Giannini P, Montigiani M & Sbracia M 2008 Natural-cycle in vitro fertilization in poor responder patients: a survey of 500 consecutive cycles. Fertility and Sterility 92 1297-1301.
83. Shapiro BS, Richter KS, Harris DC & Daneshmand ST 2001 Dramatic declines in implantation and pregnancy rates in patients who undergo repeated cycles of in vitro fertilization with blastocyst transfer after one or more failed attempts. Fertility and Sterility 76 538-542.
84. Shi W& Haaf T 2002 Aberrant methylation patterns at the two-cell stage as an indicator of early developmental failure. Molecular Reproduction and Development 63 329-334.
85. Shiota K & Yamada S 2005 Assisted reproductive technologies and birth defects. Congenital Anomalies 45 39-43.
86. Shoham Z 2002 The clinical therapeutic window for luteinizing hormone in controlled ovarian stimulation. Fertility and Sterility 77 1170-1177.
87. Silberstein T, Trimarchi JR, Gonzalez L, Keefe DL & Blazar AS 2005 Pregnancy outcome in in vitro fertilization decreases to a plateau with repeated cycles. Fertility and Sterility 84 1043-1045.
88. Simon C, Cano F, Valbuena D, Remohi J & Pellicer A 1995 Clinical evidence for a detrimental effect on uterine receptivity of high serum oestradiol concentrations in high and normal responder patients. Human Reproduction 10 2432-2437.
89. Simon C, Garcia Velasco JJ, Valbuena D, Peinado JA, Moreno C, Remohi J & Pellicer A 1998 Increasing uterine receptivity by decreasing estradiol levels during the preimplantation period in high responders with the use of a follicle-stimulating hormone step-down regimen. Fertility and Sterility 70 234-239.
90. Siristatidis CS, Maheshwari A & Bhattacharya S 2009 In vitro maturation in sub fertile women with polycystic ovarian syndrome undergoing assisted reproduction. Cochrane Database of Systematic Reviews 1 CD006606.
91. Smith FM, Garfield AS & Ward A 2006 Regulation of growth and metabolism by imprinted genes. Cytogenetic and Genome Research 113 279-291.
92. Staessen C, Platteau P, Van Assche E, Michiels A, Tournaye H, Camus M, Devroey P, Liebaers I & Van Steirteghem A 2004 Comparison of blastocyst transfer with or without preimplantation genetic diagnosis for aneuploidy screening in couples with advanced maternal age: a prospective randomized controlled trial. Human Reproduction 19 2849-2858.
93. Street ME, Seghini P, Fieni S, Ziveri MA, Volta C, Martorana D, Viani I, Gramellini D & Bernasconi S 2006 Changes in interleukin-6 and IGF system and their relationships in placenta and cord blood in newborns with fetal growth restriction compared with controls. European Journal of Endocrinology 155 567-574.
94. Sullivan MW, Stewart-Akers A, Krasnow JS, Berga SL & Zeleznik AJ 1999 Ovarian responses in women to recombinant follicle-stimulating hormone and luteinizing hormone (LH): a role for LH in the final stages of follicular maturation. Journal of Clinical Endocrinology and Metabolism 84 228-232.
95. Teklenburg G & Macklon NS 2009 In vitro models for the study of early human embryo-endometrium interactions. Reproductive Sciences 16 811-818.
96. Valbuena D, Martin J, de Pablo JL, Remohi J, Pellicer A & Simon C 2001 Increasing levels of estradiol are deleterious to embryonic implantation because they directly affect the embryo. Fertility and Sterility 76 962-968.
97. Van Blerkom J & Davis P 2001 Differential effects of repeated ovarian stimulation on cytoplasmic and spindle organization in metaphase II mouse oocytes matured in vivo and in vitro. Human Reproduction 16 757-764.
98. Van der Auwera I & D'Hooghe T 2001 Superovulation of female mice delays embryonic and fetal development. Human Reproduction 16 1237-1243.
99. Vanneste E, Voet T, Le Caignec C, Ampe M, Konings P, Melotte C, Debrock S, Amyere M, Vikkula M, Schuit F et al. 2009 Chromosome instability is common in human cleavage-stage embryos. Nature Medicine 15 577-583.
100. Verberg MF, Macklon NS, Nargund G, Frydman R, Devroey P, Broekmans FJ & Fauser BC 2009 Mild ovarian stimulation for IVF. Human Reproduction Update 15 13-29.
101. Vogel R & Spielmann H 1992 Genotoxic and embryotoxic effects of gonadotropin-hyperstimulated ovulation of murine oocytes, preimplantation embryos, and term fetuses. Reproductive Toxicology 6 329-333.
102. de Vrijer B, Davidsen ML, Wilkening RB, Anthony RV & Regnault TR 2006 Altered placental and fetal expression of IGFs and IGF-binding proteins associated with intrauterine growth restriction in fetal sheep during early and mid-pregnancy. Pediatric Research 60 507-512.
103. Wang YA, Sullivan EA, Black D, Dean J, Bryant J & Chapman M 2005 Preterm birth and low birth weight after assisted reproductive technology-related pregnancy in Australia between 1996 and 2000. Fertility and Sterility 83 1650-1658.
104. Wang JG, Douglas NC, Dicken C, Nakhuda GS, Guarnaccia MM & Sauer MV 2008 Cryopreservation of supernumerary high quality embryos predicts favorable outcomes for patients undergoing repeated cycles of in vitro fertilization. Fertility and Sterility 89 368-374.
105. Weghofer A, Munne S, Brannath W, Chen S, Barad D, Cohen J & Gleicher N 2008 The impact of LH-containing gonadotropin stimulation on euploidy rates in preimplantation embryos: antagonist cycles. Fertility and Sterility 92 937-942.
106. Wennerholm UB, Hamberger L, Nilsson L, Wennergren M, Wikland M & Bergh C 1997 Obstetric and perinatal outcome of children conceived from cryopreserved embryos. Human Reproduction 12 1819-1825.
107. Yang WJ, Hwu YM, Lee RK, Li SH & Fleming S 2009 Early-cleavage is a reliable predictor for embryo implantation in the GnRH agonist protocols but not in the GnRH antagonist protocols. Reproductive Biology and Endocrinology 7 20.
108. Zamudio NM, Chong S & O'Bryan MK 2008 Epigenetic regulation in male germ cells. Reproduction 136 131-146.
109. Ziebe S, Bangsboll S, Schmidt KL, Loft A, Lindhard A & Nyboe Andersen A 2004 Embryo quality in natural versus stimulated IVF cycles. Human Reproduction 19 1457-1460.