Milder ovarian stimulation for in-vitro fertilization reduces aneuploidy in the human preimplantation embryo: A randomized controlled trial

Human Reproduction

Volumn 22, Issue 4, 2007, Pages 980-988

  Baart, Esther B ^a,b   Martini, Elena ^b   Eijkemans, Marinus J ^b   Van Opstal, Diane ^b   Beckers, Nicole G M ^b   Verhoeff, Arie ^c   Macklon, Nicolas S ^a   Fauser, Bart C J M ^a,b  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c Medisch Centrum Rijnmond Zuid   (Netherlands)

Author keywords

Aneuploidy; Embryo quality; In vitro fertilization; Ovarian stimulation; Preimplantation genetic screening

Indexed keywords

CHORIONIC GONADOTROPIN; FOLLITROPIN; GANIRELIX; GONADORELIN AGONIST; GONADORELIN ANTAGONIST; INHIBIN B; RECOMBINANT FOLLITROPIN; TRIPTORELIN;

ADULT; ANEUPLOIDY; ARTICLE; ARTIFICIAL INSEMINATION; CHROMOSOME SEGREGATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; EMBRYO; EMBRYO TRANSFER; FEMALE; FERTILIZATION IN VITRO; FLUORESCENCE IN SITU HYBRIDIZATION; FOLLITROPIN BLOOD LEVEL; GENETIC SCREENING; HUMAN; HUMAN TISSUE; INTRACYTOPLASMIC SPERM INJECTION; MAJOR CLINICAL STUDY; MATERNAL AGE; MEIOSIS; OOCYTE RETRIEVAL; OVARY HYPERSTIMULATION; PATIENT SELECTION; PREIMPLANTATION EMBRYO; RANDOMIZED CONTROLLED TRIAL; BIOLOGICAL MODEL; BIOPSY; BLASTOCYST; BLASTOMERE; CHROMOSOME; METABOLISM; METHODOLOGY; OVULATION INDUCTION; PRENATAL DIAGNOSIS; TREATMENT OUTCOME; ULTRASTRUCTURE;

ADULT; ANEUPLOIDY; BIOPSY; BLASTOCYST; BLASTOMERES; CHROMOSOMES; EMBRYO; FEMALE; FERTILIZATION IN VITRO; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MODELS, GENETIC; OVULATION INDUCTION; PREIMPLANTATION DIAGNOSIS; TREATMENT OUTCOME;

EID: 34347242092     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/del484     Document Type: Article

References (52)

1. Albertini DF, Sanfins A and Combelles CM (2003) Origins and manifestations of oocyte maturation competencies. Reprod Biomed Online 6,410-415.
2. Baart EB, Martini E and Van Opstal D (2004a) Screening for aneuploidies of ten different chromosomes in two rounds of FISH: a short and reliable protocol. Prenat Diagn 24,955-961.
3. Baart EB, Van Opstal D, Los FJ, Fauser BC and Martini E (2004b) Fluorescence in situ hybridization analysis of two blastomeres from day 3 frozen-thawed embryos followed by analysis of the remaining embryo on day 5. Hum Reprod 19,685-693.
4. Baart EB, Martini E, van den Berg I, Macklon NS, Galjaard RJ, Fauser BC and Van Opstal D (2006) Preimplantation genetic screening reveals a high incidence of aneuploidy and mosaicism in embryos from young women undergoing IVF. Hum Reprod 21,223-233.
5. Baker SJ and Spears N (1999) The role of intra-ovarian interactions in the regulation of follicle dominance. Hum Reprod Update 5,153-165.
6. Beckers NG, Macklon NS, Eijkemans MJ and Fauser BC (2002) Women with regular menstrual cycles and a poor response to ovarian hyperstimulation for in vitro fertilization exhibit follicular phase characteristics suggestive of ovarian aging. Fertil Steril 78,291-297.
7. Bielanska M, Tan SL and Ao A (2002) Chromosomal mosaicism throughout human preimplantation development in vitro: incidence, type, and relevance to embryo outcome. Hum Reprod 17,413-419.
8. Boué J, Boué A and Lazar P (1975) Retrospective and prospective epidemiological studies of 1500 karyotyped spontaneous human abortions. Teratology 12,11-26.
9. Braude P, Bolton V and Moore S (1988) Human gene expression first occurs between the four- and eight-cell stages of preimplantation development. Nature 332,459-461.
10. Champion MD and Hawley RS (2002) Playing for half the deck: the molecular biology of meiosis. Nat Cell Biol 4 (Suppl.),s50-s56.
11. Cohen J and Munné S (2005) Comment 2 on Staessen et al. (2004). Two-cell biopsy and PGD pregnancy outcome. Hum Reprod 20,2363-2364.
12. Creus M, Penarrubia J, Fabregues F, Vidal E, Carmona F, Casamitjana R, Vanrell JA and Balasch J (2000) Day 3 serum inhibin B and FSH and age as predictors of assisted reproduction treatment outcome. Hum Reprod 15,2341-2346.
13. de Boer EJ, den Tonkelaar I, te Velde ER, Burger CW, Klip H and van Leeuwen FE (2002) A low number of retrieved oocytes at in vitro fertilization treatment is predictive of early menopause. Fertil Steril 77,978-985.
14. Delhanty JD (1997) Chromosome analysis by FISH in human preimplantation genetics. Hum Reprod 12,153-155.
15. Delhanty JD, Griffin DK, Handyside AH, Harper J, Atkinson GH, Pieters MH and Winston RM (1993) Detection of aneuploidy and chromosomal mosaicism in human embryos during preimplantation sex determination by fluorescent in situ hybridisation, (FISH). Hum Mol Genet 2,1183-1185.
16. Eppig JJ (2001) Oocyte control of ovarian follicular development and function in mammals. Reproduction 122,829-838.
17. Evers JL (2002) Female subfertility. Lancet 360,151-159.
18. Fauser BC and Van Heusden AM (1997) Manipulation of human ovarian function: physiological concepts and clinical consequences. Endocr Rev 18,71-106.
19. Fauser BC and Devroey P (2005) Why is the clinical acceptance of gonadotrophin-releasing hormone antagonist cotreatment during ovarian hyperstimulation for in vitro fertilization so slow? Fertil Steril 83,1607-1611.
20. Fauser BC, Devroey P, Yen SS, Gosden R, Crowley WF Jr, Baird DT and Bouchard P (1999) Minimal ovarian stimulation for IVF: appraisal of potential benefits and drawbacks. Hum Reprod 14,2681-2686.
21. Fauser BC, Devroey P and Macklon NS (2005) Multiple birth resulting from ovarian stimulation for subfertility treatment. Lancet 365,1807-1816.
22. Foote RH and Carney EW (1988) Factors limiting reproductive efficiency in selected laboratory animals. Ann NY Acad Sci 541,683-696.
23. Ghosh D, Stewart DR, Nayak NR, Lasley BL, Overstreet JW, Hendrickx AG and Sengupta J (1997) Serum concentrations of oestradiol-17beta, progesterone, relaxin and chorionic gonadotrophin during blastocyst implantation in natural pregnancy cycle and in embryo transfer cycle in the rhesus monkey. Hum Reprod 12,914-920.
24. Gianaroli L, Magli MC, Fiorentino F, Baldi M and Ferraretti AP (2003) Clinical value of preimplantation genetic diagnosis. Placenta 24(Suppl B), pS77-S83.
25. Gosden RG and Bownes M (1995) Cellular and molecular aspects of oocyte development. In Grudzinskas JG and Yovich JL (eds) Gametes - The Oocyte. Cambridge Reviews in Human Reproduction, Cambridge University Press, Cambridge, pp.23-53.
26. Groome NP, Illingworth PJ, O'Brien M, Pai R, Rodger FE, Mather JP and McNeilly AS (1996) Measurement of dimeric inhibin B throughout the human menstrual cycle. J Clin Endocrinol Metab 81,1401-1405.
27. Harper JC, Boelaert K, Geraedts J, Harton G, Kearns WG, Moutou C, Muntjewerff N, Repping S, SenGupta S, Scriven PN, et al. (2006) ESHRE PGD Consortium data collection V: Cycles from January to December 2002 with pregnancy follow-up to October 2003. Hum Reprod 21,3-21.
28. Hassold T and Hunt P (2001) To err (meiotically) is human: the genesis of human aneuploidy. Nat Rev Genet 2,280-291.
29. Hodges CA, Ilagan A, Jennings D, Keri R, Nilson J and Hunt PA (2002) Experimental evidence that changes in oocyte growth influence meiotic chromosome segregation. Hum Reprod 17,1171-1180.
30. Hohmann FP, Macklon NS and Fauser BC (2003) A randomized comparison of two ovarian stimulation protocols with gonadotrophin-releasing hormone (GnRH) antagonist cotreatment for in vitro fertilization commencing recombinant follicle-stimulating hormone on cycle day 2 or 5 with the standard long GnRH agonist protocol. J Clin Endocrinol Metab 88,166-173.
31. Huisman GJ, Fauser BC, Eijkemans MJ and Pieters MH (2000) Implantation rates after in vitro fertilization and transfer of a maximum of two embryos that have undergone three to five days of culture. Fertil Steril 73,117-122.
32. Inge GB, Brinsden PR and Elder KT (2005) Oocyte number per live birth in IVF: were Steptoe and Edwards less wasteful? Hum Reprod 20,588-592.
33. Katz-Jaffe MG, Trounson AO and Cram DS (2004) Mitotic errors in chromosome 21 of human preimplantation embryos are associated with non-viability. Mol Hum Reprod 10,143-147.
34. Katz-Jaffe MG, Trounson AO and Cram DS (2005) Chromosome 21 mosaic human preimplantation embryos predominantly arise from diploid conceptions. Fertil Steril 84,634-643.
35. Lightfoot DA, Kouznetsova A, Mahdy E, Wilbertz J and Hoog C (2006) The fate of mosaic aneuploid embryos during mouse development. Dev Biol 289,384-394.
36. Macklon NS, Stouffer RL, Giudice LC and Fauser BC (2006) The science behind 25 years of ovarian stimulation for IVF. Endocr Rev 27,170-207.
37. Munné S (2006) Chromosome abnormalities and their relationship to morphology and development of human embryos. Reprod Biomed Online 12,234-253.
38. Munné S, Magli C, Adler A, Wright G, de Boer K, Mortimer D, Tucker M, Cohen J and Gianaroli L (1997) Treatment-related chromosome abnormalities in human embryos. Hum Reprod 12,780-784.
39. Munné S, Marquez C, Magli C, Morton P and Morrison L (1998) Scoring criteria for preimplantation genetic diagnosis of numerical abnormalities for chromosomes X, Y, 13, 16, 18 and 21. Mol Hum Reprod 4,863-870.
40. Munné S, Sandalinas M, Escudero T, Velilla E, Walmsley R, Sadowy S, Cohen J and Sable D (2003) Improved implantation after preimplantation genetic diagnosis of aneuploidy. Reprod Biomed Online 7,91-97.
41. Norwitz ER, Schust DJ and Fisher SJ (2001) Implantation and the survival of early pregnancy. N Engl J Med 345,1400-1408.
42. Pehlivan T, Rubio C, Rodrigo L, Romero J, Remohi J, Simon C and Pellicer A (2003) Impact of preimplantation genetic diagnosis on IVF outcome in implantation failure patients. Reprod Biomed Online 6,232-237.
43. Platteau P, Staessen C, Michiels A, Van Steirteghem A, Liebaers I and Devroey P (2005) Preimplantation genetic diagnosis for aneuploidy screening in patients with unexplained recurrent miscarriages. Fertil Steril 83,393-397.
44. Pocock SJ (1977) Group sequential methods in the design and analysis of clinical trials, Biometrika 64,191-199
45. Staessen C, Platteau P, Van Assche E, Michiels A, Tournaye H, Camus M, Devroey P, Liebaers I and Van Steirteghem A (2004) Comparison of blastocyst transfer with or without preimplantation genetic diagnosis for aneuploidy screening in couples with advanced maternal age: a prospective randomized controlled trial. Hum Reprod 19,2849-2858.
46. Stevens VC (1997) Some reproductive studies in the baboon. Hum Reprod Update 3,533-540.
47. Taylor A (2003) ABC of subfertility: extent of the problem. BMJ 327,434-436.
48. Thornhill AR, deDie-Smulders CE, Geraedts JP, Harper JC, Harton GL, Lavery SA, Moutou C, Robinson MD, Schmutzler AG, Scriven PN, et al. (2005) ESHRE PGD Consortium 'Best practice guidelines for clinical preimplantation genetic diagnosis (PGD) and preimplantation genetic screening (PGS)'. Hum Reprod 20,35-48.
49. Vorsanova SG, Kolotii AD, Iourov IY, Monakhov VV, Kirillova EA, Soloviev IV and Yurov YB (2005) Evidence for high frequency of chromosomal mosaicism in spontaneous abortions revealed by interphase FISH analysis. J Histochem Cytochem 53,375-380.
50. Wilcox AJ, Weinberg CR, O'Connor JF, Baird DD, Schlatterer JP, Canfield RE, Armstrong EG and Nisula BC (1988) Incidence of early loss of pregnancy. N Engl J Med 319,189-194.
51. Yuan L, Liu JG, Hoja MR, Wilbertz J, Nordqvist K and Hoog C (2002) Female germ cell aneuploidy and embryo death in mice lacking the meiosis-specific protein SCP3. Science 296,1115-1118.
52. Zeleznik AJ and Hillier SG (1984) The role of gonadotrophins in the selection of the preovulatory follicle. Clin Obstet Gynecol 27,927-940.