Identifying protein stabilizing ligands using GroEL

Biopolymers

Volumn 93, Issue 3, 2010, Pages 237-251

  Naik, Subhashchandra ^a   Haque, Inamul ^a   Degner, Nick ^a   Kornilayev, Boris ^a   Bomhoff, Gregory ^a   Hodges, Jacob ^a   Khorassani, Ara Azad ^a   Katayama, Hiroo ^a   Morris, Jill ^a   Kelly, Jeffery ^b   Seed, John ^c   Fisher, Mark T ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c Edge Biosystems   (United States)

Author keywords

Binding; Chaperones; GroEL; Ligand; Misfolding; Osmolytes; Pharmacological

Indexed keywords

CHAPERONIN; COMBINATORIAL LIBRARY; GENE REPLACEMENT; GROEL; HUMAN DISEASE; MEDICAL PROFESSION; MISFOLDING; OSMOLYTES; PRIMARY REACTION; PROTEIN MISFOLDING; SCREENING ARRAYS; STABILIZING LIGANDS;

CHEMICAL DETECTION; DRUG THERAPY; GENE THERAPY; PROTEIN FOLDING;

LIGANDS;

CHAPERONE; CHAPERONIN; LIGAND; AMYLOID; ANTHRAX TOXIN; BETA 2 MICROGLOBULIN; PREALBUMIN; TRANSMEMBRANE CONDUCTANCE REGULATOR;

COMBINATORIAL LIBRARY; DRUG SCREENING; GENE REPLACEMENT THERAPY; HUMAN; PROTEIN FOLDING; PROTEIN STABILITY; REVIEW; BINDING AFFINITY; COMBINATORIAL CHEMISTRY; CONCENTRATION (PARAMETERS); IN VITRO STUDY; IN VIVO STUDY; LIGAND BINDING; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN IMMOBILIZATION; THERMODYNAMICS;

BETA 2-MICROGLOBULIN; CHAPERONIN 60; HUMANS; LIGANDS; MOLECULAR CHAPERONES; PROTEIN CONFORMATION; PROTEIN FOLDING; THERMODYNAMICS; THIOSULFATE SULFURTRANSFERASE; ULTRAFILTRATION;

EID: 75149120575     PISSN: 00063525     EISSN: 10970282     Source Type: Journal    
DOI: 10.1002/bip.21319     Document Type: Review

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