On the origin of ion selectivity in the Cys-loop receptor family

Journal of Molecular Neuroscience

Volumn 40, Issue 1-2, 2010, Pages 70-76

  Sine, Steven M ^a   Wang, Hai Long ^a   Hansen, Scott ^b   Taylor, Palmer ^b  

^a MAYO CLINIC   (United States)

^b San Diego   (United States)

Author keywords

Acetylcholine binding protein; Cys loop receptor family; Ion conductance and selectivity; Molecular dynamics simulation; Single channel recording

Indexed keywords

ACETYLCHOLINE; ANION; BINDING PROTEIN; CATION; CYSTEINE; NICOTINIC RECEPTOR; SULFATE;

ALPHA HELIX; CONFERENCE PAPER; CRYSTALLIZATION; HUMAN; HYDRATION; HYDROPHOBICITY; ION CONDUCTANCE; ION CURRENT; ION TRANSPORT; LIPID BILAYER; MEMBRANE POTENTIAL; MOLECULAR DYNAMICS; MOTION; MUSCLE; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN STRUCTURE; SEQUENCE ALIGNMENT; SIMULATION; X RAY CRYSTALLOGRAPHY;

ANIMALS; CATIONS; HUMANS; HYDROPHOBICITY; ION CHANNEL GATING; ION CHANNELS; MEMBRANE LIPIDS; MEMBRANE POTENTIALS; NEUROMUSCULAR JUNCTION; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, NICOTINIC; SYNAPTIC MEMBRANES;

EID: 75049085160     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12031-009-9260-1     Document Type: Conference Paper

References (26)

1. O Beckstein K Tai MS Sansom 2004 Not ions alone: Barriers to ion permeation in nanopores and channels Journal of the American Chemical Society 126 14694 14695 10.1021/ja045271e 1:CAS:528:DC%2BD2cXovFSmu7s%3D 15535674 (Pubitemid 39532132)
2. N Bocquet H Nury M Baaden C Le Poupon JP Changeux M Delarue, et al. 2009 X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation Nature 457 111 114 10.1038/nature07462 1:CAS:528: DC%2BD1MXhtVGhug%3D%3D 18987633
3. G Cymes Y Ni C Grosman 2005 Probing ion channel pores one proton at a time Nature 438 975 980 10.1038/nature04293 1:CAS:528:DC%2BD2MXhtlSksrjN 16355215 (Pubitemid 43093964)
4. DA Doyle J Morais Cabral RA Pfuetzner A Kuo JM Gulbis SL Cohen, et al. 1998 The structure of the potassium channel: Molecular basis of K+ conduction and selectivity Science 280 69 77 10.1126/science.280.5360.69 1:CAS:528:DyaK1cXitlWksrY%3D 9525859 (Pubitemid 28169082)
5. R Dutzler EB Campbell M Cadene BT Chait R MacKinnon 2002 Gating the selectivity filter in ClC chloride channels Nature 415 287 294 10.1038/415287a 1:CAS:528:DC%2BD38XptlWksA%3D%3D 11796999 (Pubitemid 34087544)
6. SB Hansen TT Talley Z Radic P Taylor 2004 Structural and ligand recognition characteristics of an acetylcholine binding protein from Aplysia californica Journal of Biological Chemistry 279 24197 24202 10.1074/jbc. M402452200 1:CAS:528:DC%2BD2cXksV2isb4%3D 15069068 (Pubitemid 38725280)
7. SB Hansen G Sulzenbacher T Huxford P Marchot P Taylor Y Bourne 2005 Structural characterization of agonist and antagonist-bound acetylcholine- binding protein from Aplysia californica European Molecular Biology Organization Journal 24 3635 3646 1:CAS:528:DC%2BD2MXhtFaht7vF
8. SB Hansen H-L Wang P Taylor SM Sine 2008 An ion selectivity filter in the extracellular domain of Cys-loop receptors reveals determinants of ion conductance Journal of Biological Chemistry 283 36066 36070 10.1074/jbc. C800194200 1:CAS:528:DC%2BD1cXhsFWnsrrO 18940802
9. RJ Hilf R Dutzler 2008 X-ray structure of a prokaryotic pentameric ligand-gated ion channel Nature 452 375 379 10.1038/nature06717 1:CAS:528:DC%2BD1cXjsFCnsLw%3D 18322461
10. R Hilf R Dutzler 2009 Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel Nature 457 115 118 10.1038/nature07461 1:CAS:528:DC%2BD1MXhtVGgsA%3D%3D 18987630
11. G Hummer JC Rasaiah JP Noworyta 2001 Water conduction through the hydrophobic channel of a carbon nanotube Nature 414 188 190 10.1038/35102535 1:CAS:528:DC%2BD3MXosFait7k%3D 11700553 (Pubitemid 33051229)
12. K Imoto C Busch B Sakmann M Mishina T Konno, et al. 1988 Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance Nature 335 645 648 10.1038/335645a0 1:CAS:528:DyaL1cXmt1Cqs7w%3D 2459620 (Pubitemid 18237577)
13. J Kehoe JM McIntosh 1998 Two distinct nicotinic receptors, one pharmacologically similar to the vertebrate alpha7-containing receptor, mediate Cl currents in aplysia neurons Journal of Neuroscience 18 8198 8213 1:CAS:528:DyaK1cXms1ehtb4%3D 9763466
14. SP Kelley JI Dunlop EF Kirkness JJ Lambert JA Peters 2003 A cytoplasmic region determines single-channel conductance in 5-HT3 receptors Nature 424 321 324 10.1038/nature01788 1:CAS:528:DC%2BD3sXlsVGjs7k%3D 12867984 (Pubitemid 36899374)
15. CA Lewis CF Stevens 1983 Acetylcholine receptor channel ionic selectivity: ions experience an aqueous environment Proceedings of the National Academy of Sciences of the United States of America 80 6110 6113 10.1073/pnas.80.19.6110 1:CAS:528:DyaL3sXlslShtr8%3D 6310616
16. C Miller H Hughes 1992 Hunting for the pore of voltage-gated channels Current Biology 2 573 575 10.1016/0960-9822(92)90146-2 1:CAS:528: DyaK3sXhvVSlsQ%3D%3D 15336027
17. A Miyazawa Y Fujiyoshi N Unwin 2003 Structure and gating mechanism of the acetylcholine receptor pore Nature 423 949 955 10.1038/nature01748 1:CAS:528:DC%2BD3sXkvVKmsrY%3D 12827192 (Pubitemid 36806903)
18. PJ Reeves N Callewaert R Contreras HG Khorana 2002 Structure and function in rhodopsin: High-level expression of rhodopsin with restricted and homogeneous N-glycosylation by a tetracycline-inducible N- acetylglucosaminyltransferase I-negative HEK293S stable mammalian cell line Proceedings of the National Academy of Sciences of the United States of America 99 13419 13424 10.1073/pnas.212519299 1:CAS:528:DC%2BD38XotVKmsr8%3D 12370423 (Pubitemid 35215396)
19. OS Smart JG Neduvelil X Wang BA Wallace MS Sansom 1996 HOLE: A program for the analysis of the pore dimensions of ion channel structural models Journal of Molecular Graphics 14 354-360 376 1:CAS:528:DyaK2sXjvFGlsbw%3D
20. SA Spronk DE Elmore DA Dougherty 2006 Voltage-dependent hydration and conduction properties of the hydrophobic pore of the mechanosensitive channel of small conductance Biophysical Journal 90 3555 3569 10.1529/biophysj.105.080432 1:CAS:528:DC%2BD28Xkt1Okt7k%3D 16500980
21. M Sotomayor TA van der Straaten U Ravaioli K Schulten 2006 Electrostatic properties of the mechanosensitive channel of small conductance MscS Biophysical Journal 90 3496 3510 10.1529/biophysj.105.080069 1:CAS:528:DC%2BD28Xkt1Okt70%3D 16513774
22. M Sotomayor V Vasquez E Perozo K Schulten 2007 Ion conduction through MscS as determined by electrophysiology and simulation Biophysical Journal 92 886 902 10.1529/biophysj.106.095232 1:CAS:528:DC%2BD2sXht1eiu78%3D 17114233 (Pubitemid 46203218)
23. Tasneem, A., Iyer, L., Jakobsson, E., & Aravand, L. (2005). Identification of the prokaryotic ligand-gated ion channels and their implications for the mechanisms and origins of animal Cys-loop receptors. Genome Biology, 6, R4.
24. N Unwin 2005 Refined structure of the nicotinic acetylcholine receptor at 4 Å resolution Journal of Molecular Biology 346 967 989 10.1016/j.jmb.2004.12.031 1:CAS:528:DC%2BD2MXhtFGrsbs%3D 15701510 (Pubitemid 40215523)
25. HL Wang X Cheng P Taylor JA McCammon SM Sine 2008 Control of ion permeation through the nicotinic receptor channel PLoS Comput Biol 4 e41 10.1371/journal.pcbi.0040041 18282090 (Pubitemid 351328510)
26. Y Zhou JH Morais-Cabral A Kaufman R MacKinnon 2001 Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 Å resolution Nature 414 43 48 10.1038/35102009 1:CAS:528:DC%2BD3MXot1Wqsbg%3D 11689936 (Pubitemid 33041616)