ERK/MAPK regulation of the androgen responsiveness of breast cancer cells

Advances in Experimental Medicine and Biology

Volumn 617, Issue , 2008, Pages 429-435

  Azzam, Diana G ^a   Tay, Jasmine W T ^a   Greeve, Melissa A ^a   Harvey, Jennet M ^a   Bentel, Jacqueline M ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; ANDROSTANOLONE; ANTIESTROGEN; ESTROGEN RECEPTOR ALPHA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; AR PROTEIN, HUMAN; MAP2K1 PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1;

ANTINEOPLASTIC ACTIVITY; BREAST CANCER; CANCER RESISTANCE; CELL CYCLE G1 PHASE; CELL CYCLE REGULATION; CELL PROLIFERATION; CELL STRAIN MCF 7; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME ACTIVATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; ARTICLE; BREAST TUMOR; GENETICS; METABOLISM; MUTATION; PATHOLOGY; TUMOR CELL LINE; WESTERN BLOTTING;

BLOTTING, WESTERN; BREAST NEOPLASMS; CELL LINE, TUMOR; DIHYDROTESTOSTERONE; HUMANS; MAP KINASE KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; MUTATION; RECEPTORS, ANDROGEN;

EID: 46749105195     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-0-387-69080-3_41     Document Type: Conference Paper

References (22)

1. Lea OA, Kvinnsland S, Thorsen T (1989) Improved measurement of androgen receptors in human breast cancer. Cancer Res 49:7162-7167.
2. Birrell SN, Hall RE, Tilley WD (1998) Role of the androgen receptor in human breast cancer. J Mammary Gland Biol Neoplasia 3:95-103.
3. Cooperative Breast Cancer Group CBC (1964) Testosterone propionate therapy in breast cancer. J Amer Med Assoc 188:1069-1072.
4. Ingle JN, Twito DI, Schaid DJ, et al. (1991) Combination hormonal therapy with tamoxifen plus fluoxymesterone versus tamoxifen alone in postmenopausal women with metastatic breast cancer. An updated analysis. Cancer 67:886-891.
5. Dauvois S, Li SM, Martel C, et al. (1989) Inhibitory effect of androgens on DMBA-induced mammary carcinoma in the rat. Breast Cancer Res Treat 14:299-306.
6. Ortmann J, Prifti S, Bohlmann MK, et al. (2002) Testosterone and 5 alpha-dihydrotestosterone inhibit in vitro growth of human breast cancer cell lines. Gynecol Endocrinol 16:113-120.
7. Torii S, Yamamoto T, Tsuchiya Y, et al. (2006) ERK MAP kinase in G1 cell cycle progression and cancer. Cancer Sci 97:697-702.
8. Keen JC, Davidson NE (2003) The biology of breast carcinoma. Cancer 97:825-833.
9. Roskoski R, Jr (2004) The ErbB/HER receptor protein-tyrosine kinases and cancer. Biochem Biophys Res Commun 319:1-11.
10. Sivaraman VS, Wang H, Nuovo GJ, et al. (1997) Hyperexpression of mitogen-activated protein kinase in human breast cancer. J Clin Invest 99:1478-1483.
11. Gee JM, Robertson JF, Ellis IO, et al. (2001) Phosphorylation of ERK1/2 mitogen-activated protein kinase is associated with poor response to anti-hormonal therapy and decreased patient survival in clinical breast cancer. Int J Cancer 95:247-254.
12. Oh AS, Lorant LA, Holloway JN, et al. (2001) Hyperactivation of MAPK induces loss of ERalpha expression in breast cancer cells. Mol Endocrinol 15:1344-1359.
13. Kurokawa H, Lenferink AE, Simpson JF, et al. (2000) Inhibition of HER2/neu (erbB-2) and mitogen-activated protein kinases enhances tamoxifen action against HER2-overexpressing, tamoxifen-resistant breast cancer cells. Cancer Res 60:5887-5894.
14. Shou J, Massarweh S, Osborne CK, et al. (2004) Mechanisms of tamoxifen resistance: increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer. J Natl Cancer Inst 96:926-935.
15. Yeh S, Lin HK, Kang HY, et al. (1999) From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells. Proc Natl Acad Sci USA 96:5458-5463.
16. Gioeli D, Ficarro SB, Kwiek JJ, et al. (2002) Androgen receptor phosphorylation. Regulation and identification of the phosphorylation sites. J Biol Chem 277:29304-29314.
17. Greeve MA, Allan RK, Harvey JM, et al. (2004) Inhibition of MCF-7 breast cancer cell proliferation by 5alpha-dihydrotestosterone; a role for p21(Cip1/Waf1). J Mol Endocrinol 32:793-810.
18. Mansour SJ, Matten WT, Hermann AS, et al. (1994) Transformation of mammalian cells by constitutively active MAP kinase kinase. Science 265:966-970.
19. Lange CA, Shen T, Horwitz KB (2000) Phosphorylation of human progesterone receptors at serine-294 by mitogen-activated protein kinase signals their degradation by the 26S proteasome. Proc Natl Acad Sci USA 97:1032-1037.
20. Lapointe J, Labrie C (2001) Role of the cyclin-dependent kinase inhibitor p27(Kip1) in androgeninduced inhibition of CAMA-1 breast cancer cell proliferation. Endocrinology 142:4331-4338.
21. Yeap BB, Krueger RG, Leedman PJ (1999) Differential posttranscriptional regulation of androgen receptor gene expression by androgen in prostate and breast cancer cells. Endocrinology 140:3282-3291.
22. Tsihlias J, Zhang W, Bhattacharya N, et al. (2000) Involvement of p27Kip1 in G1 arrest by high dose 5 alpha-dihydrotestosterone in LNCaP human prostate cancer cells. Oncogene 19:670-679.