Suberoyl bis-hydroxamic acid induces p53-dependent apoptosis of MCF-7 breast cancer cells

Acta Pharmacologica Sinica

Volumn 29, Issue 12, 2008, Pages 1459-1466

  Zhuang, Zhi Gang ^a   Fei, Fei ^b   Chen, Ying ^b   Jin, Wei ^b  

^a TONGJI UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

Author keywords

Apoptosis; p53 pathway; Suberoyl bis hydroxamic acid

Indexed keywords

DNA; FLUORESCENT DYE; HYDROXAMIC ACID DERIVATIVE; PROTEIN BAX; PROTEIN P21; PROTEIN P53; PUMA PROTEIN; SMALL INTERFERING RNA; SUBEROYL BIS HYDROXAMIC ACID; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; BAX PROTEIN, HUMAN; BBC3 PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; HISTONE DEACETYLASE; HYDROXAMIC ACID; ONCOPROTEIN; SUBEROYL BIS-HYDROXAMIC ACID;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CELL STRAIN MCF 7; CELL STRUCTURE; CONTROLLED STUDY; DRUG EFFECT; DRUG SYNTHESIS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANIMAL; BREAST TUMOR; DRUG ANTAGONISM; FEMALE; GENETICS; METABOLISM; TUMOR CELL LINE;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BCL-2-ASSOCIATED X PROTEIN; BREAST NEOPLASMS; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE INHIBITOR P21; FEMALE; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; MEMBRANE POTENTIAL, MITOCHONDRIAL; PROTO-ONCOGENE PROTEINS; RNA, SMALL INTERFERING; TUMOR SUPPRESSOR PROTEIN P53;

EID: 64549164161     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2008.00906.x     Document Type: Article

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