Emerging therapies in traumatic hemorrhage control

Current Opinion in Critical Care

Volumn 15, Issue 6, 2009, Pages 560-568

  Sambasivan, Chitra N ^a   Schreiber, Martin A ^b  

^a Department of Surgery ^*  (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Hemostatic dressings; Hemostatic resuscitation; Hypotensive resuscitation; Novel resuscitation fluids; Tourniquets

Indexed keywords

ANTIFIBRINOLYTIC AGENT; ARGIPRESSIN[1 DEAMINO]; DESMOPRESSIN; PROTHROMBIN COMPLEX; PYRUVIC ACID DERIVATIVE; RECOMBINANT BLOOD CLOTTING FACTOR 7A;

BLEEDING; CRYSTALLOID; EMERGENCY CARE; ERYTHROCYTE CONCENTRATE; FLUID RESUSCITATION; GAUZE DRESSING; HEMOSTASIS; HUMAN; HYPOTENSION; INJURY; OUTCOME ASSESSMENT; RESUSCITATION; REVIEW; RISK ASSESSMENT; SURGICAL APPROACH; SURVIVAL; THROMBOCYTE TRANSFUSION; TOURNIQUET;

BANDAGES; HEMORRHAGE; HUMANS; RESUSCITATION; WOUNDS AND INJURIES;

EID: 74949098318     PISSN: 10705295     EISSN: 15317072     Source Type: Journal    
DOI: 10.1097/MCC.0b013e328331f57c     Document Type: Review

References (95)

1. Stewart RM, CorneilleMG, Johnston J, et al. Transparent and open discussion of errors does not increase malpractice risk in trauma patients. Ann Surg 2006; 243:645-649; discussion 649-651.
2. Brohi K, Cohen MJ,GanterMT, et al. Acute coagulopathy of trauma: hypoperfusion induces systemic anticoagulation and hyperfibrinolysis. J Trauma-Injury Infect Crit Care 2008; 64:1211-1217; discussion 1217.
3. MacLeod JB, Lynn M, McKenney MG, et al. Early coagulopathy predicts mortality in trauma. J Trauma-Injury Infect Crit Care 2003; 55:39-44.
4. Brohi K, Singh J, HeronM, et al. Acute traumatic coagulopathy. J Trauma-Injury Infect Crit Care 2003; 54:1127-1130.
5. Niles SE, McLaughlin DF, Perkins JG, et al. Increased mortality associated with the early coagulopathy of trauma in combat casualties. J Trauma 2008; 64:1459-1463; discussion 1463-11455
6. Trauma ACoSCo. Advanced trauma life support for doctors. Chicago, IL: American College of Surgeons; 2008.
7. Spinella PC, Perkins JG,Grathwohl KW, et al. Effect of plasma and red blood cell transfusions on survival in patients with combat related traumatic injuries. J Trauma-Injury Infect Crit Care 2008; 64:S69-77; discussion S77-S68.
8. Hess JR, Holcomb JB, Hoyt DB. Damage control resuscitation: the need for specific blood products to treat the coagulopathy of trauma. Transfusion 2006; 46:685-686.
9. Holcomb JB, Jenkins D, Rhee P, et al. Damage control resuscitation: directly addressing the early coagulopathy of trauma. J Trauma-Injury Infect Crit Care 2007; 62:307-310.
10. Holcomb JB, Wade CE, Michalek JE, et al. Increased plasma and platelet to red blood cell ratios improves outcome in 466 massively transfused civilian trauma patients. Ann Surg 2008; 248:447-458.
11. Gonzalez EA, Moore FA, Holcomb JB, et al. Fresh frozen plasma should be given earlier to patients requiring massive transfusion. J Trauma-Injury Infect Crit Care 2007; 62:112-119.
12. Holcomb JB, McMullin NR, Pearse L, et al. Causes of death in U.S. Special Operations Forces in the global war on terrorism: 2001-2004. Ann Surg 2007; 245:986-991.
13. Kelly JF, Ritenour AE, McLaughlin DF, et al. Injury severity and causes of death from Operation Iraqi Freedom and Operation Enduring Freedom: 2003-2004 versus 2006. J Trauma 2008; 64:S21-S26; discussion S26-S27.
14. Tien HC, Spencer F, Tremblay LN, et al. Preventable deaths from hemorrhage at a level I Canadian trauma center. J Trauma-Injury Infect Crit Care 2007; 62:142-146.
15. Zink KA, Sambasivan CN, Holcomb JB, et al. A high ratio of plasma and platelets to packed red blood cells in the first 6 h of massive transfusion improves outcomes in a large multicenter study. Am J Surg 2009; 197:565- 570; discussion 570.
16. Gunter OL Jr, Au BK, Isbell JM, et al. Optimizing outcomes in damage control resuscitation: identifying blood product ratios associated with improved survival. J Trauma 2008; 65:527-534.
17. Johansson PI, Stensballe J, Rosenberg I, et al. Proactive administration of platelets and plasma for patients with a ruptured abdominal aortic aneurysm: evaluating a change in transfusion practice. Transfusion 2007; 47:593-598.
18. Sperry JL, Ochoa JB, Gunn SR, et al. An FFP:PRBC transfusion ratio >/=1:1.5 is associated with a lower risk of mortality after massive transfusion. J Trauma 2008; 65:986-993.
19. Duchesne JC, Hunt JP, Wahl G, et al. Review of current blood transfusions strategies in a mature level I trauma center: were we wrong for the last 60 years? J Trauma 2008; 65:272-276; discussion 276-278.
20. Teixeira PG, Inaba K, Shulman I, et al. Impact of plasma transfusion in massively transfused trauma patients. J Trauma 2009; 66:693-697.
21. Maegele M, Lefering R, Paffrath T, et al. Red-blood-cell to plasma ratios transfused during massive transfusion are associated with mortality in severe multiple injury: a retrospective analysis from the Trauma Registry of the Deutsche Gesellschaft fur Unfallchirurgie. Vox Sang 2008; 95:112-119.
22. Malone DL, Hess JR, Fingerhut A. Massive transfusion practices around the globe and a suggestion for a common massive transfusion protocol. J Trauma- Injury Infect Crit Care 2006; 60:S91-S96.
23. Fox CJ, Gillespie DL, Cox ED, et al. The effectiveness of a damage control resuscitation strategy for vascular injury in a combat support hospital: results of a case control study. J Trauma 2008; 64:S99-S106; discussion S106-S107.
24. Borgman MA, Spinella PC, Perkins JG, et al. The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital. J Trauma-Injury Infect Crit Care 2007; 63:805-813.
25. Hess JR, Holcomb JB. Transfusion practice in military trauma. Transfus Med 2008; 18:143-150.
26. Snyder CW, Weinberg JA, McGwin G Jr, et al. The relationship of blood product ratio to mortality: survival benefit or survival bias? J Trauma 2009; 66:358-362; discussion 362-1354
27. Scalea TM, Bochicchio KM, Lumpkins K, et al. Early aggressive use of fresh frozen plasma does not improve outcome in critically injured trauma patients. Ann Surg 2008; 248:578-584.
28. Dodd RY. Current risk for transfusion transmitted infections. Curr Opin Hematol 2007; 14:671-676.
29. Khan H, Belsher J, Yilmaz M, et al. Fresh-frozen plasma and platelet transfusions are associated with development of acute lung injury in critically ill medical patients. Chest 2007; 131:1308-1314.
30. Fraga GP, Bansal V, Coimbra R. Transfusion of blood products in trauma: an update. J Emerg Med 2009. [Epub ahead of print]
31. Triulzi DJ. Transfusion-related acute lung injury: current concepts for the clinician. Anesth Analg 2009; 108:770-776.
32. Hendrickson JE, Hillyer CD. Noninfectious serious hazards of transfusion. Anesth Analg 2009; 108:759-769.
33. Chaiwat O, Lang JD, Vavilala MS, et al. Early packed red blood cell transfusion and acute respiratory distress syndrome after trauma. Anesthesiology 2009; 110:351-360.
34. Pepe PE, Dutton RP, Fowler RL. Preoperative resuscitation of the trauma patient. Curr Opin Anaesthesiol 2008; 21:216-221.
35. Bilkovski RN, Rivers EP, Horst HM. Targeted resuscitation strategies after injury. Curr Opin Crit Care 2004; 10:529-538.
36. Geeraedts LM Jr, Kaasjager HA, van Vugt AB, et al. Exsanguination in trauma: a review of diagnostics and treatment options. Injury 2009; 40:11-20.
37. Bickell WH, Bruttig SP, Millnamow GA, et al. The detrimental effects of intravenous crystalloid after aortotomy in swine. Surgery 1991; 110:529-536.
38. Bickell WH, Bruttig SP, Millnamow GA, et al. Use of hypertonic saline/dextran versus lactated Ringer's solution as a resuscitation fluid after uncontrolled aortic hemorrhage in anesthetized swine. Ann Emerg Med 1992; 21:1077-1085.
39. Kowalenko T, Stern S, Dronen S, et al. Improved outcome with hypotensive resuscitation of uncontrolled hemorrhagic shock in a swine model. J Trauma 1992; 33:349-353; discussion 361-1342
40. Stern SA, Dronen SC, Wang X. Multiple resuscitation regimens in a nearfatal porcine aortic injury hemorrhage model. Acad Emerg Med 1995; 2: 89-97.
41. Capone AC, Safar P, Stezoski W, et al. Improved outcome with fluid restriction in treatment of uncontrolled hemorrhagic shock. J Am Coll Surg 1995; 180:49-56.
42. Owens TM, Watson WC, Prough DS, et al. Limiting initial resuscitation of uncontrolled hemorrhage reduces internal bleeding and subsequent volume requirements. J Trauma 1995; 39:200-207; discussion 208-209.
43. Riddez L, Johnson L, Hahn RG. Central and regional hemodynamics during crystalloid fluid therapy after uncontrolled intra-abdominal bleeding. J Trauma 1998; 44:433-439.
44. Solomonov E, Hirsh M, Yahiya A, et al. The effect of vigorous fluid resuscitation in uncontrolled hemorrhagic shock after massive splenic injury. Crit Care Med 2000; 28:749-754.
45. Lu YQ, Cai XJ, Gu LH, et al. Experimental study of controlled fluid resuscitation in the treatment of severe and uncontrolled hemorrhagic shock. J Trauma 2007; 63:798-804.
46. Skarda DE, Mulier KE, George ME, et al. Eight hours of hypotensive versus normotensive resuscitation in a porcine model of controlled hemorrhagic shock. Acad Emerg Med 2008; 15:845-852.
47. Mapstone J, Roberts I, Evans P. Fluid resuscitation strategies: a systematic review of animal trials. J Trauma 2003; 55:571-589.
48. Bickell WH, Wall MJ Jr, Pepe PE, et al. Immediate versus delayed fluid resuscitation for hypotensive patients with penetrating torso injuries. N Engl J Med 1994; 331:1105-1109.
49. Sampalis JS, Tamim H, Denis R, et al. Ineffectiveness of on-site intravenous lines: is prehospital time the culprit? J Trauma 1997; 43:608-615; discussion 615-1607
50. Hambly PR, Dutton RP. Excess mortality associated with the use of a rapid infusion system at a level 1 trauma center. Resuscitation 1996; 31:127-133.
51. Dutton RP, Mackenzie CF, Scalea TM. Hypotensive resuscitation during active hemorrhage: impact on in-hospital mortality. J Trauma 2002; 52:1141-1146.
52. Revell M, Greaves I, Porter K. Endpoints for fluid resuscitation in hemorrhagic shock. J Trauma 2003; 54:S63-S67.
53. Beekley AC. Damage control resuscitation: a sensible approach to the exsanguinating surgical patient. Crit Care Med 2008; 36:S267-S274.
54. Blackbourne LH. Combat damage control surgery. Crit Care Med 2008; 36:S304-S310.
55. Gan TJ, Bennett-Guerrero E, Phillips-Bute B, et al. Hextend, a physiologically balanced plasma expander for large volume use in major surgery: a randomized phase III clinical trial. Hextend Study Group. Anesth Analg 1999; 88:992-998.
56. Perioperative Fluid Therapy (Kindle Edition). Informa Healthcare USA, Inc; 2006.
57. Bunn F, Trivedi D, Ashraf S. Colloid solutions for fluid resuscitation. Cochrane Database Syst Rev 2008:CD001319.
58. Ertmer C, Rehberg S, Van Aken H, et al. Relevance of nonalbumin colloids in intensive care medicine. Best Pract Res Clin Anaesthesiol 2009; 23:193-212.
59. Davidson IJ. Renal impact of fluid management with colloids: a comparative review. Eur J Anaesthesiol 2006; 23:721-738.
60. Van der Linden P, Ickx BE. The effects of colloid solutions on hemostasis. Can J Anaesth 2006; 53:S30-S39.
61. Finfer S, Bellomo R, McEvoy S, et al. Effect of baseline serum albumin concentration on outcome of resuscitation with albumin or saline in patients in intensive care units: analysis of data from the saline versus albumin fluid evaluation (SAFE) study. Br Med J 2006; 333:1044.
62. Myburgh J, Cooper DJ, Finfer S, et al. Saline or albumin for fluid resuscitation in patients with traumatic brain injury. N Engl J Med 2007; 357:874-884.
63. Montgomery CM, Fairhurst AS, Webb JL. Metabolic studies on heart mitochondria. III. The action of parapyruvate on alpha-ketoglutaric oxidase. J Biol Chem 1956; 221:369-376.
64. Cai B, Deitch EA, Grande D, et al. Anti-inflammatory resuscitation improves survival in hemorrhage with trauma. J Trauma 2009; 66:1632-1639; discussion 1639-1640.
65. Champion HR, Bellamy RF, Roberts CP, et al. A profile of combat injury. J Trauma 2003; 54:S13-S19.
66. Sauaia A, Moore FA, Moore EE, et al. Epidemiology of trauma deaths: a reassessment. J Trauma 1995; 38:185-193.
67. Acheson EM, Kheirabadi BS, Deguzman R, et al. Comparison of hemorrhage control agents applied to lethal extremity arterial hemorrhages in swine. J Trauma 2005; 59:865-874; discussion 874-1865
68. Alam HB, Chen Z, Jaskille A, et al. Application of a zeolite hemostatic agent achieves 100% survival in a lethal model of complex groin injury in swine. J Trauma 2004; 56:974-983.
69. Pusateri AE, Holcomb JB, Kheirabadi BS, et al. Making sense of the preclinical literature on advanced hemostatic products. J Trauma 2006; 60:674-682.
70. Kozen BG, Kircher SJ, Henao J, et al. An alternative hemostatic dressing: comparison of CELOX, HemCon, and QuikClot. Acad Emerg Med 2008; 15:74-81.
71. Carraway JW, Kent D, Young K, et al. Comparison of a new mineral based hemostatic agent to a commercially available granular zeolite agent for hemostasis in a swine model of lethal extremity arterial hemorrhage. Resuscitation 2008; 78:230-235.
72. Arnaud F, Tomori T, Carr W, et al. Exothermic reaction in zeolite hemostatic dressings: QuikClot ACS and ACS+. Ann Biomed Eng 2008; 36:1708-1713.
73. Arnaud F, Tomori T, Saito R, et al. Comparative efficacy of granular and bagged formulations of the hemostatic agent QuikClot. J Trauma 2007; 63:775-782.
74. Ward KR, Tiba MH, Holbert WH, et al. Comparison of a new hemostatic agent to current combat hemostatic agents in a swine model of lethal extremity arterial hemorrhage. J Trauma 2007; 63:276-283; discussion 283-1274
75. Kheirabadi BS, Acheson EM, Deguzman R, et al. The potential utility of fibrin sealant dressing in repair of vascular injury in swine. J Trauma 2007; 62:94-103.
76. Delgado AV, Kheirabadi BS, Fruchterman TM, et al. A novel biologic hemostatic dressing (fibrin patch) reduces blood loss and resuscitation volume and improves survival in hypothermic, coagulopathic swine with grade V liver injury. J Trauma 2008; 64:75-80.
77. Kheirabadi BS, Edens JW, Terrazas IB, et al. Comparison of new hemostatic granules/powders with currently deployed hemostatic products in a lethal model of extremity arterial hemorrhage in swine. J Trauma 2009; 66:316- 326; discussion 327-1318
78. Li J, Yan W, Jing L, et al. Addition of an alginate to a modified zeolite improves hemostatic performance in a swine model of lethal groin injury. J Trauma 2009; 66:612-620.
79. Velmahos GC, Tabbara M, Spaniolas K, et al. Self-expanding hemostatic polymer for control of exsanguinating extremity bleeding. J Trauma 2009; 66:984-988.
80. Plurad D, Chandrasoma S, Best C, et al. A complication of intracorporeal use of QuikClot for pelvic hemorrhage. J Trauma 2009; 66:1482-1484.
81. Starnes BW, Beekley AC, Sebesta JA, et al. Extremity vascular injuries on the battlefield: tips for surgeons deploying to war. J Trauma 2006; 60:432-442.
82. Welling DR, Burris DG, Hutton JE, et al. A balanced approach to tourniquet use: lessons learned and relearned. J Am Coll Surg 2006; 203:106-115.
83. Kragh JF Jr, Walters TJ, Baer DG, et al. Practical use of emergency tourniquets to stop bleeding in major limb trauma. J Trauma 2008; 64:S38-S49; discussion S49-S50.
84. Doyle GS, Taillac PP. Tourniquets: a review of current use with proposals for expanded prehospital use. Prehosp Emerg Care 2008; 12:241-256.
85. Tien HC, Jung V, Rizoli SB, et al. An evaluation of tactical combat casualty care interventions in a combat environment. J Am Coll Surg 2008; 207:174-178.
86. Walters TJ, Mabry RL. Issues related to the use of tourniquets on the battlefield. Mil Med 2005; 170:770-775.
87. Mabry R, McManus JG. Prehospital advances in the management of severe penetrating trauma. Crit Care Med 2008; 36:S258-S266.
88. Kragh JF Jr, Walters TJ, Baer DG, et al. Survival with emergency tourniquet use to stop bleeding in major limb trauma. Ann Surg 2009; 249:1-7.
89. Beekley AC, Sebesta JA, Blackbourne LH, et al. Prehospital tourniquet use in Operation Iraqi Freedom: effect on hemorrhage control and outcomes. J Trauma 2008; 64:S28-S37; discussion S37.
90. Perkins JG, Cap AP, Weiss BM, et al. Massive transfusion and nonsurgical hemostatic agents. Crit Care Med 2008; 36:S325-S339.
91. Spinella PC, Perkins JG, McLaughlin DF, et al. The effect of recombinant activated factor VII on mortality in combat-related casualties with severe trauma and massive transfusion. J Trauma 2008; 64:286-293; discussion 293-1284
92. Cai B, Brunner M, Wang H, et al. Ethyl pyruvate improves survival in awake hemorrhage. J Mol Med 2009; 87:423-433.
93. Cai B, Chen F, Lin X, et al. Anti-inflammatory adjuvant in resuscitation fluids improves survival in hemorrhage. Crit Care Med 2009; 37:860-868.
94. Fink MP. Ethyl pyruvate: a novel anti-inflammatory agent. J Intern Med 2007; 261:349-362.
95. Fink MP. Ethyl pyruvate. Curr Opin Anaesthesiol 2008; 21:160-167.