A novel biologic hemostatic dressing (fibrin patch) reduces blood loss and resuscitation volume and improves survival in hypothermic, coagulopathic swine with grade V liver injury

Journal of Trauma - Injury, Infection and Critical Care

Volumn 64, Issue 1, 2008, Pages 75-80

  Delgado, Angel V ^a   Kheirabadi, Bijan S ^a   Fruchterman, Todd M ^b   Scherer, Michael ^a   Cortez, Douglas ^a   Wade, Charles E ^a   Dubick, Michael A ^a   Holcomb, John B ^a  

^a US ARMY INSTITUTE OF SURGICAL RESEARCH   (United States)

^b ETHICON INC   (United States)

Author keywords

Coagulopathy; Dressing; Hemorrhage; Hemostasis; Hypothermia; Swine

Indexed keywords

FIBRIN GLUE; PLACEBO;

ANIMAL EXPERIMENT; ARTICLE; BLEEDING; BLOOD CLOTTING DISORDER; BLOOD VOLUME; CONTROLLED STUDY; CORE TEMPERATURE; DATA ANALYSIS; FEMALE; FLUID RESUSCITATION; HEMATOCRIT; HEMODILUTION; HEMOSTASIS; HYPOTHERMIA; LIVER INJURY; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; PRIORITY JOURNAL; PROTHROMBIN TIME; SURVIVAL TIME; SWINE; THROMBOCYTE COUNT; WOUND DRESSING;

ANIMALS; BANDAGES; BLOOD COAGULATION DISORDERS; BLOOD COAGULATION TESTS; DISEASE MODELS, ANIMAL; FEMALE; FIBRIN TISSUE ADHESIVE; FLUID THERAPY; HEMORRHAGE; HEMOSTATIC TECHNIQUES; HEMOSTATICS; HYPOTHERMIA; LIVER; MALE; RESUSCITATION; SHOCK, HEMORRHAGIC; SUS SCROFA;

EID: 38149027698     PISSN: 00225282     EISSN: 15298809     Source Type: Journal    
DOI: 10.1097/TA.0b013e31815b843c     Document Type: Article

References (28)

1. Bellamy RF. The causes of death in conventional land warfare: implications for combat casualty care research. Mil Med. 1984;149:55-62.
2. Carr ME. Monitoring of hemostasis in combat trauma patients. Mil Med. 2004;169(12 suppl):11-15, 4.
3. Clifford CC. Treating traumatic bleeding in a combat setting. Mil Med. 2004;169(12 suppl):8-10, 4.
4. MacLeod J, Lynn M, McKenney MG, Cohn SM, Murtha M. Early coagulopathy predicts mortality in trauma. J Trauma. 2003;55:39:44.
5. McCallum AL. Update on trauma care in Canada. 5. Trauma and hypothermia. Can J Surg. 1990;33:457-460.
6. Cunning KA, Sugrue M, Sloane D, Deane SA. Hypothermia and severe trauma. Aust NZ J Surg. 1995;65:80-82.
7. Martinowitz U, Kenet G, Segal E, et al. Recombinant activated factor VII for adjunctive hemorrhage control in trauma. J Trauma. 2001;51:431-439.
8. Holcomb JB, Pusateri AE, Harris RA, et al. Dry fibrin sealant dressings reduce blood loss, resuscitation volume, and improve survival in hypothermic coagulopathic swine with grade V liver injuries. J Trauma. 1999;47:233-240.
9. Klemcke HG, Delgado A, Holcomb JB, et al. Effect of recombinant FVIIa in hypothermic, coagulopathic pigs with liver injuries. J Trauma. 2005;59:155-161.
10. Holcomb JB, Pusateri AE, Harris RA, et al. Effect of dry fibrin sealant dressings versus gauze packing on blood loss in grade V liver injuries in resuscitated swine. J Trauma. 1999;46:49-58.
11. SAS. SAS/STAT User's Guide (Online Doc V. 8). Cary, NC: SAS Institute, Inc.; 1999.
12. Hochberg Y. A sharper Bonferroni procedure for multiple significance testing. Biometrika. 1988;75:800-803.
13. Tyburski JG, Wilson RF, Dente C, Steffes C, Carlin AM. Factors affecting mortality rates in patients with abdominal vascular injuries. J Trauma. 2001;50:1020-1026.
14. Jurkovich GJ, Greiser WB, Luterman A, Curreri PW. Hypothermia in trauma victims: an ominous predictor of survival. J Trauma. 1987;27:1019-1024.
15. Luna GK, Maier RV, Pavlin EG, Anardi D, Copass MK, Oreskovich MR. Incidence and effect of hypothermia in seriously injured patients. J Trauma. 1987;27:1014-1018.
16. Ferrara A, MacArthur JD, Wright HK, Modlin IM, McMillen MA. Hypothermia and acidosis worsen coagulopathy in the patient requiring massive transfusion [Review]. Ned Tijdschr Geneeskd. 2006;150:1503-1507.
17. Bernabei AF, Levison MA, Bender JS. The effects of hypothermia and injury severity on blood loss during trauma laparotomy. J Trauma. 1992;33:835-839.
18. Safar PJ, Tisherman SA. Trauma resuscitation: what have we learned in the last 50 years? Curr Opin Anaesthesiol. 2003;16:133-138.
19. Hardaway RM. Mechanism of traumatic shock. Surg Gynecol Obstet. 1980;151:65-69.
20. McKinley BA, Gonzalez EA, Balldin BC, et al. Revisiting the "bloody vicious cycle". Shock. 2004;21:47, abstract 137.
21. Andeweg CS, Vingerhoedt NM, Van Vugt AB, Haerkens MH. Damage control surgery in poly traumatized patients. Ned Tijdschr Geneeskd. 2006;150:1503-1507.
22. Schreiber MA. Damage control surgery. Crit Care Clin. 2004;20:101-118.
23. Schreiber MA. Coagulopathy in the trauma patient. Curr Opin Crit Care. 2005;11:590-597.
24. Lucas CE, Denis R, Ledgerwood AM, Grabow D. The effects of Hespan on serum and lymphatic albumin, globulin, and coagulant protein. Ann Surg. 1988;207:416-420.
25. McCammon AT, Wright JP, Figueroa M, Nielsen VG. Hemodilution with albumin, but not Hextend, results in hypercoagulability as assessed by thrombelastography in rabbits: role of heparin-dependent serpins and factor VIII complex. Anesth Analg. 2002;95:844-850.
26. Jungheinrich C, Neff TA. Pharmacokinetics of hydroxyethyl starch. Clin Pharmacokinet. 2005;44:681-699.
27. Pusateri AE, Modrow HE, Harris RA, et al. Advanced hemostatic dressing development program: animal model selection criteria and results of a study of nine hemostatic dressings in a model of severe large venous hemorrhage and hepatic injury in Swine. J Trauma. 2003;55:518-526.
28. Pusateri AE, Delgado AV, Dick EJ Jr, Martinez RS, Holcomb JB, Ryan KL. Application of a granular mineral-based hemostatic agent (QuikClot) to reduce blood loss after grade V liver injury in swine. J Trauma. 2004;57:555-562.