Addition of an alginate to a modified zeolite improves hemostatic performance in a swine model of lethal groin injury

Journal of Trauma - Injury, Infection and Critical Care

Volumn 66, Issue 3, 2009, Pages 612-620

  Li, Jiang ^a   Yan, Wei ^b   Jing, Li ^a   Xueyong, Li ^a   Yuejun, Li ^a   Wangzhou, Li ^a   Shaozong, Chen ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Battlefield injury; Extremity; Hemostatic agent zeolite; Uncontrolled hemorrhage

Indexed keywords

ALGINIC ACID; CALCIUM; QUIKCLOT; SILVER; UNCLASSIFIED DRUG; ZEOLITE; ZINC; HEMOSTATIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ARTERY INJURY; ARTICLE; BLEEDING; BLOOD CLOT; CONTROLLED STUDY; ESCHERICHIA COLI; FEMALE; FEMORAL ARTERY; FEMORAL VEIN; HEMOSTASIS; HISTOPATHOLOGY; INGUINAL REGION; INJURY; LETHALITY; MALE; MORTALITY; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; SURVIVAL; SWINE; THIGH; VEIN INJURY; WOUND DRESSING; ANIMAL; BANDAGE; BLEEDING TIME; COMPARATIVE STUDY; DISEASE MODEL; DRUG COMBINATION; DRUG EFFECT; HEMORRHAGIC SHOCK; MICROBIOLOGICAL EXAMINATION; SURGICAL INFECTION; WOUND HEALING;

ALGINATES; ANIMALS; BACTERIOLOGICAL TECHNIQUES; BANDAGES; BLEEDING TIME; DISEASE MODELS, ANIMAL; DRUG COMBINATIONS; ESCHERICHIA COLI; FEMALE; FEMORAL ARTERY; FEMORAL VEIN; GROIN; HEMORRHAGE; HEMOSTATICS; MALE; PSEUDOMONAS AERUGINOSA; SHOCK, HEMORRHAGIC; SILVER; STAPHYLOCOCCUS AUREUS; SURGICAL WOUND INFECTION; SWINE; WOUND HEALING; ZEOLITES; ZINC;

EID: 68149164138     PISSN: 00225282     EISSN: 15298809     Source Type: Journal    
DOI: 10.1097/TA.0b013e318160ff4d     Document Type: Article

References (17)

1. Groves J. Operations in urban environments. Mil Rev. 1998;78:31-40.
2. Milton TR. Urban operations: future war. Mil Rev. 1994;74:37- 46.
3. MabryRL, Holcomb JB, Baker AM, et al. United States Army Rangers in Somalia: an analysis of combat casualties on an urban battlefield. J Trauma. 2000;49:515-529.
4. Biliski TR, Baker BC, Grove JR, et al. Battlefield casualties treated at Camp Rhino, Afghanistan: lessons learned. J Trauma. 2003; 54:814-822.
5. Bellamy RF. The cause of death in conventional land warfare: implications for combat casualty care research. Mil Med. 1984; 149:55- 62.
6. Alam HB, Uy GB, Miller D, et al. Comparative analysis of hemostatic agents in a swine model of lethal groin injury. J Trauma. 2003;54:1077-1082.
7. Pusateri AE, Delgado AV, Dick EJ, et al. Application of a granular mineral-based hemostatic agent (QuikClot) to reduce blood loss after grade V liver injury in swine. J Trauma. 2004;57:555-562.
8. Alam HB, Chen Z, Jaskille A, et al. Application of a zeolite hemostatic agent achieves 100% survival in a lethal model of complex groin injury in Swine. J Trauma. 2004;56:974 -983.
9. Ostomel TA, Stoimenov PK, Holden PA, et al. Host-guest composites for induced hemostasis and therapeutic healing in traumatic injuries. J Thromb Thrombolysis. 2006;22:55- 67.
10. Ahuja N, Ostomel TA, Rhee P, et al. Testing of modified zeolite hemostatic dressings in a large animal model of lethal groin injury. J Trauma. 2006;61:1312-1320.
11. Breck DW. Zeolite Molecular Sieves. New York: Wiley; 1974.
12. Acheson EM, Kheirabadi BS, Deguzman R, et al. Comparison of hemorrhage control agents applied to lethal extremity arterial hemorrhages in swine. J Trauma. 2005;59:865- 874.
13. Committee on Fluid Resuscitation for Combat Casualties. Fluid Resuscitation: State of the Science for Treating Combat Casualties and Civilian Injuries. Report of the Institute of Medicine. Washington, DC: National Academy Press; 1999:1-7.
14. Bellamy R, Safar P, Tisherman SA, et al. Suspended animation for delayed resuscitation. Crit Care Med. 1996;24:S24 -S47.
15. Joint Technical Coordinating Group for Mutations Effective Evaluation of Wound Data and Munitions Effectiveness in Vietnam (WDMEV). Vol. I. Final report. Alexandria, VA: Defense Technical Information Center (AD879516); 1970.
16. Wright JK, Kalns J, Wolf EA, et al. Thermal injury resulting from application of a granular mineral hemostatic agent. J Trauma. 2004; 57:224 -230.
17. McManus J, Hurtado T, Pusateri A, et al. A case series describing thermal injury resulting from zeolite use for hemorrhage control in combat operations. Prehosp Emerg Care. 2007;11:67-71.