Potassium Bromate Enhances N-Ethyl-N-Hydroxyethylnitrosamine–Induced Kidney Carcinogenesis Only at High Doses in Wistar Rats: Indication of the Existence of an Enhancement Threshold

Toxicologic Pathology

Volumn 37, Issue 7, 2009, Pages 983-991

  Wei, Min ^a   Hamoud, al Salmy ^a   Yamaguchi, Takashi ^a,b   Kakehashi, Anna ^a   Morimura, Keiichirou ^a   Doi, Kenichiro ^a   Kushida, Masahiko ^a   Kitano, Mitsuaki ^a   Wanibuchi, Hideki ^a   Fukushima, Shoji ^a,c  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b ZERIA PHARMACEUTICAL CO LTD   (Japan)

^c Japan Bioassay Research Center   (Japan)

Author keywords

enhancement effect; kidney carcinogenesis; potassium bromate; risk assessment; threshold

Indexed keywords

CARCINOGEN; DNA; N ETHYL N HYDROXYETHYLNITROSAMIN; POTASSIUM BROMATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCER SUSCEPTIBILITY; CARCINOGENIC ACTIVITY; CARCINOGENICITY; CONTROLLED STUDY; DNA DAMAGE; DOSE RESPONSE; KIDNEY CANCER; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; WISTAR RAT;

ANIMALS; BODY WEIGHT; BROMATES; CARCINOGENS; DEOXYGUANOSINE; DIETHYLNITROSAMINE; DNA DAMAGE; DNA REPAIR; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION; KIDNEY; KIDNEY NEOPLASMS; MALE; ORGAN SIZE; OXIDATIVE STRESS; RATS; RATS, WISTAR; RNA, MESSENGER;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 74949087106     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1177/0192623309351720     Document Type: Article

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