Existence of no-observed effect levels for 2-amino-3,8-dimethylimidazo[4,5- f]quinoxaline on hepatic preneoplastic lesion development in BN rats

Cancer Letters

Volumn 231, Issue 2, 2006, Pages 304-308

  Wei, Min ^a   Hori, Taka Aki ^b   Ichihara, Toshio ^a   Wanibuchi, Hideki ^a   Morimura, Keiichirou ^a   Kang, Jin Seok ^a   Puatanachokchai, Rawiwan ^a   Fukushima, Shoji ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b Taishou Hospital   (Japan)

Author keywords

2 Amino 3,8 dimethylimidazo 4,5 f quinoxaline; Cancer risk assessment; Hepatocarcinogenesis; No observed effect level; Strain differences

Indexed keywords

2 AMINO 3,8 DIMETHYLIMIDAZO[4,5 F]QUINOXALINE; CARCINOGEN; GLUTATHIONE TRANSFERASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENOTOXICITY; LIVER CARCINOGENESIS; LIVER TUMOR; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CARCINOGENS; GLUTATHIONE S-TRANSFERASE PI; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; MALE; NO-OBSERVED-ADVERSE-EFFECT LEVEL; PRECANCEROUS CONDITIONS; QUINOXALINES; RATS; RATS, INBRED BN; RATS, INBRED F344;

ANIMALIA;

EID: 29844439528     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2005.02.029     Document Type: Article

References (21)

1. R. Preussmann The problem of thresholds in chemical carcinogenesis some views on theoretical and practical aspects J. Cancer Res. Clin. Oncol. 97 1980 1 14
2. M. Goldman Cancer risk of low-level exposure Science 271 1996 1821 1822
3. L. Tomatis, J. Huff, I. Hertz-Picciotto, D.P. Sandler, J. Bucher, and P. Boffetta Avoided and avoidable risks of cancer Carcinogenesis 18 1997 97 105
4. M. Terada, M. Nagao, M. Nakayasu, H. Sakamoto, F. Nakasato, and T. Sugimura Mutagenic activities of heterocyclic amines in Chinese hamster lung cells in culture Environ. Health Perspect. 67 1986 117 119
5. M.A. Johansson, and M. Jagerstad Occurrence of mutagenic/carcinogenic heterocyclic amines in meat and fish products, including pan residues, prepared under domestic conditions Carcinogenesis 15 1994 1511 1518
6. T. Kato, H. Ohgaki, H. Hasegawa, S. Sato, S. Takayama, and T. Sugimura Carcinogenicity in rats of a mutagenic compound, 2-amino-3,8-dimethylimidazo[4, 5-f]quinoxaline Carcinogenesis 9 1988 71 73
7. H. Kushida, K. Wakabayashi, H. Sato, M. Katami, R. Kurosaka, and M. Nagao Dose-response study of MeIQx carcinogenicity in F344 male rats Cancer Lett. 83 1994 31 35
8. S. Fukushima, H. Wanibuchi, K. Morimura, M. Wei, D. Nakae, and Y. Konishi Lack of a dose-response relationship for carcinogenicity in the rat liver with low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline or N-nitrosodiethylamine Jpn. J. Cancer Res. 93 2002 1076 1082
9. S. Fukushima, H. Wanibuchi, K. Morimura, M. Wei, D. Nakae, and Y. Konishi Lack of initiation activity in rat liver of low doses of 2-amino-3,8- dimethylimidazo[4,5-f]quinoxaline Cancer Lett. 191 2003 35 40
10. N. Ito, H. Tsuda, M. Tatematsu, T. Inoue, Y. Tagawa, and T. Aoki Enhancing effect of various hepatocarcinogens on induction of preneoplastic glutathione S-transferase placental form positive foci in rats-an approach for a new medium-term bioassay system Carcinogenesis 9 1988 387 394
11. H. Tsuda, S. Fukushima, H. Wanibuchi, K. Morimura, D. Nakae, and K. Imaida Value of GST-P positive preneoplastic hepatic foci in dose-response studies of hepatocarcinogenesis: evidence for practical thresholds with both genotoxic and nongenotoxic carcinogens. A review of recent work Toxicol. Pathol. 31 2003 80 86
12. M. Hoshi, K. Morimura, H. Wanibuchi, M. Wei, E. Okochi, and T. Ushijima No-observed effect levels for carcinogenicity and for in vivo mutagenicity of a genotoxic carcinogen Toxicol. Sci. 81 2004 273 279
13. G.A. Wood, J.E. Korkola, and M.C. Archer Tissue-specific resistance to cancer development in the rat: phenotypes of tumor-modifier genes Carcinogenesis 23 2002 1 9
14. M. Kitano, T. Ichihara, T. Matsuda, H. Wanibuchi, S. Tamano, and A. Hagiwara Presence of a threshold for promoting effects of phenobarbital on diethylnitrosamine-induced hepatic foci in the rat Carcinogenesis 19 1998 1475 1480
15. R.M. Pascale, M.M. Simile, M.R. DeMiglio, M.R. Muroni, L. Gaspa, T.A. Dragani, and F. Feo The BN rat strain carries dominant hepatocarcinogen resistance loci Carcinogenesis 17 1996 1765 1768
16. M.R. De Miglio, F. Canzian, R.M. Pascale, M.M. Simile, M.R. Muroni, and D. Calvisi Identification of genetic loci controlling hepatocarcinogenesis on rat chromosomes 7 and 10 Cancer Res. 59 1999 4651 4657
17. G.M. Williams, M.J. Iatropoulos, and A.M. Jeffrey Mechanistic basis for nonlinearities and thresholds in rat liver carcinogenesis by the DNA-reactive carcinogens 2-acetylaminofluorene and diethylnitrosamine Toxicol. Pathol. 28 2000 388 395
18. G.M. Williams, M.J. Iatropoulos, C.X. Wang, A.M. Jeffrey, S. Thompson, and B. Pittman Nonlinearities in 2-acetylaminofluorene exposure responses for genotoxic and epigenetic effects leading to initiation of carcinogenesis in rat liver Toxicol. Sci. 45 1998 152 161
19. G.M. Williams, M.J. Iatropoulos, and A.M. Jeffrey Thresholds for the effects of 2-acetylaminofluorene in rat liver Toxicol. Pathol. 32 Suppl. 2 2004 85 91
20. H. Yoshino, T. Ichihara, S. Tamano, H. Tsutsumi, K. Wanibuchi, and A. Morimura Estimation of a practical threshold level for 2-acetylaminofluene, a genotoxic liver carcinogen, in a 16-week feeding study with F344 rats Proc. 61st Ann. Meeting Jpn. Cancer Assoc. 204 2002 2685
21. S. Fukushima, H. Wanibuchi, K. Morimura, S. Iwai, D. Nakae, and H. Kishida Existence of a threshold for induction of aberrant crypt foci in the rat colon with low doses of 2-amino-1-methyl-6-phenolimidazo[4,5-b]pyridine Toxicol. Sci. 80 2004 109 114