New R/S-3,4-dihydro-2,2-dimethyl-6-halo-4-(phenylaminothiocarbonylamino)-2H- 1-benzopyrans structurally related to (±)-cromakalim as tissue-selective pancreatic β-cell KATP channel openers

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 10, 2008, Pages 5704-5719

  Sebille, Sophie ^a   de Tullio, Pascal ^a   Florence, Xavier ^a   Becker, Bénédicte ^b   Antoine, Marie Hélène ^b   Michaux, Catherine ^c   Wouters, Johan ^c   Pirotte, Bernard ^a   Lebrun, Philippe ^b  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^c UNIVERSITY OF NAMUR   (Belgium)

Author keywords

Benzopyrans; Cromakalim analogues; KATP channels; Potassium channel openers

Indexed keywords

3,4 DIHYDRO 2,2 DIMETHYL 6 HALO 4 (PHENYLAMINOTHIOCARBONYLAMINO) 2H 1 BENZOPYRAN; 7 CHLORO 3 ISOPROPYLAMINO 4H 1,2,4 BENZOTHIADIAZINE 1,1 DIOXIDE; CHROMAN DERIVATIVE; CROMAKALIM; DIAZOXIDE; DIMETHYLCHROMAN DERIVATIVE; PINACIDIL; POTASSIUM CHANNEL STIMULATING AGENT; THIOUREA DERIVATIVE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CONFORMATION; DRUG POTENCY; IC 50; INSULIN RELEASE; NONHUMAN; PANCREAS ISLET BETA CELL; RAT; STRUCTURE ACTIVITY RELATION; VASCULAR RING; VASCULAR SMOOTH MUSCLE; VASODILATATION;

ANIMALS; AORTA; ATP-BINDING CASSETTE TRANSPORTERS; BENZOPYRANS; CROMAKALIM; DIAZOXIDE; DRUG EVALUATION, PRECLINICAL; INSULIN-SECRETING CELLS; MOLECULAR STRUCTURE; PINACIDIL; POTASSIUM CHANNELS; QUANTUM THEORY; RATS; RATS, WISTAR; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TEMPERATURE; TIME FACTORS;

EID: 43949145610     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.03.065     Document Type: Article

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