Toward tissue-selective pancreatic B-cells KATP channel openers belonging to 3-alkylamino-7-halo-4H-1,2,4-benzothiadiazine 1,1-dioxides

Journal of Medicinal Chemistry

Volumn 46, Issue 15, 2003, Pages 3342-3353

  De Tullio, Pascal ^a   Becker, Bénédicte ^c   Boverie, Stéphane ^a   Dabrowski, Michael ^b   Wahl, Philip ^d   Antoine, Marie Hélène ^c   Somers, Fabian ^a   Sebille, Sophie ^a   Ouedraogo, Raogo ^c   Hansen, John Bondo ^d   Lebrun, Philippe ^c   Pirotte, Bernard ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^d NOVO NORDISK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

3 (ETHYLAMINO) 7 FLUORO 4H 1,2,4 BENZOTHIAZIDIAZINE 1,1 DIOXIDE; 7 CHLORO 3 (1,1 DIMETHYLPROPYL)AMINO 4H 1,2,4 BENZOTHIADIAZINE 1,1 DIOXIDE; ADENOSINE TRIPHOSPHATE; ALIPHATIC AMINE; CHLORINE; CYCLOBUTANE DERIVATIVE; DIAZOXIDE; FLUORINE; HALOGEN; HYDROCARBON; IODINE; NITROGEN; OXIDE; PINACIDIL; POTASSIUM CHANNEL; RADIOISOTOPE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; AORTA; ARTICLE; ATOM; CELL SECRETION; CHEMICAL MODIFICATION; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; ELECTROPHYSIOLOGY; IC 50; IN VITRO STUDY; INHIBITION KINETICS; INSULIN RELEASE; MUSCLE RELAXATION; NONHUMAN; PANCREAS ISLET BETA CELL; RAT; SMOOTH MUSCLE FIBER; STRUCTURE ACTIVITY RELATION; TISSUE; VASCULAR SMOOTH MUSCLE; VASODILATATION;

ADENOSINE TRIPHOSPHATE; ANIMALS; AORTA; BENZOTHIADIAZINES; DIAZOXIDE; FEMALE; GLUCOSE; INSULIN; ION CHANNEL GATING; ISLETS OF LANGERHANS; ISOMERISM; MOLECULAR CONFORMATION; MUSCLE RELAXATION; MUSCLE, SMOOTH, VASCULAR; OOCYTES; ORGAN SPECIFICITY; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS LAEVIS;

EID: 0037479902     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm021117w     Document Type: Article

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