Oral epithelium as a surrogate tissue for assessing smoking-induced molecular alterations in the lungs

Cancer Prevention Research

Volumn 1, Issue 1, 2008, Pages 39-44

  Bhutani, Manisha ^a   Pathak, Ashutosh Kumar ^a   Fan, You Hong ^a   Liu, Diane D ^b   Lee, J Jack ^b   Tang, Hongli ^a   Kurie, Jonathan M ^a   Morice, Rodolfo C ^a   Kim, Edward S ^a   Hong, Waun Ki ^a   Mao, Li ^a,c  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b Department of Biostatistics and Applied Mathematics ^*  (United States)

^c UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACID ANHYDRIDE HYDROLASE; BIOLOGICAL MARKER; FRAGILE HISTIDINE TRIAD PROTEIN; TUMOR PROTEIN;

ADENOCARCINOMA; ADULT; AGED; ARTICLE; BIOLOGICAL MODEL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIAGNOSTIC PROCEDURE; DNA METHYLATION; FEMALE; GENETICS; HUMAN; LUNG TUMOR; MALE; METABOLISM; MIDDLE AGED; MOUTH MUCOSA; PATHOLOGY; PROMOTER REGION; RANDOMIZED CONTROLLED TRIAL; SMOKING; SMOKING CESSATION; TUMOR SUPPRESSOR GENE;

ACID ANHYDRIDE HYDROLASES; ADENOCARCINOMA; ADULT; AGED; BIOLOGICAL MARKERS; DNA METHYLATION; FEMALE; GENES, P16; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; MOLECULAR DIAGNOSTIC TECHNIQUES; MOUTH MUCOSA; NEOPLASM PROTEINS; PROMOTER REGIONS, GENETIC; SMOKING; TOBACCO USE CESSATION;

EID: 52649102609     PISSN: 19406207     EISSN: 19406215     Source Type: Journal    
DOI: 10.1158/1940-6207.CAPR-08-0058     Document Type: Article

References (20)

1. Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ. Cancer statistics, 2007. CA Cancer J Clin 2007;57:43-66.
2. Spira A, Ettinger DS. Multidisciplinary management of lung cancer. N Engl J Med 2004;350: 379-92.
3. Peto R, Darby S, Deo H, Silcocks P, Whitley E, Doll R. Smoking, smoking cessation, and lung cancer in the UK since 1950: combination of national statistics with two case-control studies. BMJ 2000;321: 323-9.
4. Mao L. Molecular abnormalities in lung carcinogenesis and their potential clinical implications. Lung Cancer 2001;34:S27-34.
5. Soria JC, Rodriguez M, Liu DD, Lee JJ, Hong WK, Mao L. Aberrant promoter methylation of multiple genes in bronchial brush samples from former cigarette smokers. Cancer Res 2002;62:351-5.
6. Sozzi G, Sard L, De Gregorio L, et al. Association between cigarette smoking and FHITgene alterations in lung cancer. Cancer Res 1997;57: 2121-3.
7. Cohen V, Khuri FR. Chemoprevention of lung cancer. Curr Opin Pulm Med 2004;10:279-83.
8. Herman JG, Graff JR, Myohanen S, Nelkin BD, Baylin SB. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci U S A 1996;93:9821-6.
9. Iliopoulos D, Guler G, Han SY, et al. Fragile genes as biomarkers: epigenetic control of WWOX and FHITin lung, breast and bladder cancer. Oncogene 2005;24:1625-33.
10. Woolson RF, Clarke WR. Statistical methods for the analysis of biomedical data. 2nd ed. New York: John Wiley and Sons; 2002.
11. Tsao AS, Kim ES, Hong WK. Chemoprevention of cancer. CA Cancer J Clin 2004;54:150-80.
12. Hong WK, Sporn MB. Recent advances in chemoprevention of cancer. Science 1997;278: 1073-7.
13. Belinsky SA, Klinge DM, Dekker JD, et al. Gene promoter methylation in plasma and sputum increases with lung cancer risk. Clin Cancer Res 2005;11:6505-11.
14. Kennedy TC, Proudfoot SP, Franklin WA, et al. Cytopathological analysis of sputum in patients with airflow obstruction and significant smoking histories. Cancer Res 1996;56:4673-8.
15. Wright GS, Gruidl ME. Early detection and prevention of lung cancer. Curr Opin Oncol 2000;12: 143-8.
16. Pathak AK, Bhutani M, Kumar S, Mohan A, Guleria R. Circulating cell-free DNA in plasma/serum of lung cancer patients as a potential screening and prognostic tool. Clin Chem 2006;52:1833-42.
17. Herman JG, Merlo A, Mao L, et al. Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. Cancer Res 1995;55: 4525-30.
18. de Fraipont F, Moro-Sibilot D, Michelland S, Brambilla E, Brambilla C, Favrot MC. Promoter methylation of genes in bronchial lavages: a marker for early diagnosis of primary and relapsing nonsmall cell lung cancer? Lung Cancer 2005;50: 199-209.
19. Mao L, Lee JS, Kurie JM, et al. Clonal genetic alterations in the lung of current and former smokers. J Natl Cancer Inst 1997;89:857-62.
20. Wistuba II, Mao L, Gazdar AF. Smoking molecular damage in bronchial epithelium. Oncogene 2002;21:7298-306.