Inhibition of adaptive immune responses leads to a fatal clinical outcome in SIV-infected pigtailed macaques but not vervet african green monkeys

PLoS Pathogens

Volumn 5, Issue 12, 2009, Pages

  Schmitz, Jörn E ^a   Zahn, Roland C ^a   Brown, Charles R ^b   Rett, Melisa D ^a   Li, Ming ^c   Tang, Haili ^c   Pryputniewicz, Sarah ^a   Byrum, Russell A ^b   Kaur, Amitinder ^a   Montefiori, David C ^c   Allan, Jonathan S ^d   Goldstein, Simoy ^b   Hirsch, Vanessa M ^b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

^d SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD20 ANTIBODY; OKT 8; RITUXIMAB; CD20 ANTIGEN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADAPTIVE IMMUNITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ARTICLE; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL PROLIFERATION; CERCOPITHECIDAE; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; DISEASE CONTROL; DISEASE FREE SURVIVAL; FATALITY; INFECTION; INHIBITION KINETICS; LYMPHOCYTE DEPLETION; MACACA; MEMORY T LYMPHOCYTE; NONHUMAN; PRIMARY INFECTION; SIMIAN IMMUNODEFICIENCY VIRUS; TREATMENT OUTCOME; VIREMIA; VIRUS INFECTION; VIRUS REACTIVATION; VIRUS REPLICATION; ANIMAL; CERCOPITHECUS; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; IMMUNOPHENOTYPING; IN SITU HYBRIDIZATION; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; VIROLOGY; WESTERN BLOTTING;

ANIMALIA; CERCOPITHECUS AETHIOPS; MACACA; SIMIAN IMMUNODEFICIENCY VIRUS;

ADAPTIVE IMMUNITY; ANIMALS; ANTIGENS, CD20; B-LYMPHOCYTE SUBSETS; BLOTTING, WESTERN; CD8-POSITIVE T-LYMPHOCYTES; CERCOPITHECUS AETHIOPS; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; IN SITU HYBRIDIZATION; LYMPHOCYTE DEPLETION; MACACA NEMESTRINA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; SIMIAN IMMUNODEFICIENCY VIRUS; VIREMIA;

EID: 74549210553     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1000691     Document Type: Article

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