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Volumn 82, Issue 11, 2008, Pages 5618-5630

Increased loss of CCR5+ CD45RA- CD4+ T cells in CD8+ lymphocyte-depleted simian immunodeficiency virus-infected rhesus monkeys

(18)  Veazey, Ronald S a   Acierno, Paula M b   McEvers, Kimberly J b   Baumeister, Susanne H C b   Foster, Gabriel J b   Rett, Melisa D b   Newberg, Michael H b   Kuroda, Marcelo J a   Williams, Kenneth b   Kim, Eun Young c   Wolinsky, Steven M c   Rieber, E Peter d   Piatak Jr , Michael e   Lifson, Jeffrey D e   Montefiori, David C f   Brown, Charles R g   Hirsch, Vanessa M g   Schmitz, Jörn E b,h  


Author keywords

[No Author keywords available]

Indexed keywords

CD45RA ANTIGEN; CHEMOKINE RECEPTOR CCR5 ANTAGONIST;

EID: 43949125182     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.02748-07     Document Type: Article
Times cited : (30)

References (78)
  • 1
    • 27744609130 scopus 로고    scopus 로고
    • Studies using a viral challenge and CD8 T cell depictions on the roles of cellular and humoral immunity in the control of an SHIV-89.6P challenge in DNA/MVA-vaccinated macaques
    • Amara, R. R., C. Ibegbu, F. Villinger, D. C. Montefiori, S. Sharma, P. Nigam, Y. Xu, H. M. McClure, and H. L. Robinson. 2005. Studies using a viral challenge and CD8 T cell depictions on the roles of cellular and humoral immunity in the control of an SHIV-89.6P challenge in DNA/MVA-vaccinated macaques. Virology 343:246-255.
    • (2005) Virology , vol.343 , pp. 246-255
    • Amara, R.R.1    Ibegbu, C.2    Villinger, F.3    Montefiori, D.C.4    Sharma, S.5    Nigam, P.6    Xu, Y.7    McClure, H.M.8    Robinson, H.L.9
  • 2
    • 0036899797 scopus 로고    scopus 로고
    • Premature ageing of the immune system: The cause of AIDS?
    • Appay, V., and S. L. Rowland-Jones. 2002. Premature ageing of the immune system: the cause of AIDS? Trends Immunol. 23:580-585.
    • (2002) Trends Immunol , vol.23 , pp. 580-585
    • Appay, V.1    Rowland-Jones, S.L.2
  • 3
    • 33749320950 scopus 로고    scopus 로고
    • Bystander T cell activation - implications for HIV infection and other diseases
    • Bangs, S. C., A. J. McMichael, and X. N. Xu. 2006. Bystander T cell activation - implications for HIV infection and other diseases. Trends Immunol. 27:518-524.
    • (2006) Trends Immunol , vol.27 , pp. 518-524
    • Bangs, S.C.1    McMichael, A.J.2    Xu, X.N.3
  • 6
    • 0028041344 scopus 로고
    • + cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection
    • + cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection. J. Virol. 68:6103-6110.
    • (1994) J. Virol , vol.68 , pp. 6103-6110
    • Borrow, P.1    Lewicki, H.2    Hahn, B.H.3    Shaw, G.M.4    Oldstone, M.B.5
  • 9
    • 34249808840 scopus 로고    scopus 로고
    • Unique pathology in simian immunodeficiency virus-infected rapid progrcssor macaques is consistent with a pathogenesis distinct from that of classical AIDS
    • Brown, C. R., M. Czapiga, J. Kabat, Q. Dang, I. Ourmanov, Y. Nishimura, M. A. Martin, and V. M. Hirsch. 2007. Unique pathology in simian immunodeficiency virus-infected rapid progrcssor macaques is consistent with a pathogenesis distinct from that of classical AIDS. J. Virol. 81:5594-5606.
    • (2007) J. Virol , vol.81 , pp. 5594-5606
    • Brown, C.R.1    Czapiga, M.2    Kabat, J.3    Dang, Q.4    Ourmanov, I.5    Nishimura, Y.6    Martin, M.A.7    Hirsch, V.M.8
  • 10
    • 0036719574 scopus 로고    scopus 로고
    • Antibodies, viruses and vaccines
    • Burton, D. R. 2002. Antibodies, viruses and vaccines. Nat. Rev. Immunol. 2:706-713.
    • (2002) Nat. Rev. Immunol , vol.2 , pp. 706-713
    • Burton, D.R.1
  • 11
    • 0030053308 scopus 로고    scopus 로고
    • Molecular determinants of acute single-cell lysis by human immunodeficiency virus type 1
    • Cao, J., I. W. Park, A. Cooper, and J. Sodroski. 1996. Molecular determinants of acute single-cell lysis by human immunodeficiency virus type 1. J. Virol. 70:1340-1354.
    • (1996) J. Virol , vol.70 , pp. 1340-1354
    • Cao, J.1    Park, I.W.2    Cooper, A.3    Sodroski, J.4
  • 13
    • 33845473665 scopus 로고    scopus 로고
    • In HIV-1 pathogenesis the die is cast during primary infection
    • Centlivre, M., M. Sala, S. Wain-Hobson, and B. Berkhout. 2007. In HIV-1 pathogenesis the die is cast during primary infection. AIDS 21:1-11.
    • (2007) AIDS , vol.21 , pp. 1-11
    • Centlivre, M.1    Sala, M.2    Wain-Hobson, S.3    Berkhout, B.4
  • 15
    • 43749118364 scopus 로고    scopus 로고
    • Use of an anti-CD16 antibody for in vivo depletion of natural killer cells in rhesus macaques
    • in press
    • Choi, E. I., R. Wang, L. Peterson, N. L. Letvin, and K. A. Reimann. Use of an anti-CD16 antibody for in vivo depletion of natural killer cells in rhesus macaques. Immunology, in press.
    • Immunology
    • Choi, E.I.1    Wang, R.2    Peterson, L.3    Letvin, N.L.4    Reimann, K.A.5
  • 16
    • 23844524271 scopus 로고    scopus 로고
    • Highly sensitive SIV plasma viral load assay: Practical considerations, realistic performance expectations, and application to reverse engineering of vaccines for AIDS
    • Cline, A. N., J. W. Bess, M. Piatak, Jr., and J. D. Lifson. 2005. Highly sensitive SIV plasma viral load assay: practical considerations, realistic performance expectations, and application to reverse engineering of vaccines for AIDS. J. Med. Primatol. 34:303-312.
    • (2005) J. Med. Primatol , vol.34 , pp. 303-312
    • Cline, A.N.1    Bess, J.W.2    Piatak Jr., M.3    Lifson, J.D.4
  • 18
  • 19
    • 0001914545 scopus 로고    scopus 로고
    • Chemokine receptors and HIV entry
    • Doms, R. W. 2001. Chemokine receptors and HIV entry. AIDS 15(Suppl. 1):S34-S35.
    • (2001) AIDS , vol.15 , Issue.SUPPL. 1
    • Doms, R.W.1
  • 20
    • 0242320524 scopus 로고    scopus 로고
    • Disrupting T-cell homeostasis: How HIV-1 infection causes disease
    • Douek, D. C. 2003. Disrupting T-cell homeostasis: how HIV-1 infection causes disease. AIDS Rev. 5:172-177.
    • (2003) AIDS Rev , vol.5 , pp. 172-177
    • Douek, D.C.1
  • 23
    • 0030841029 scopus 로고    scopus 로고
    • Potential deleterious effect of anti-viral cytotoxic lymphocyte through the CD95 (FAS/APO-1)-mediated pathway during chronic HIV infection
    • Garcia, S., M. Fevrier, G. Dadaglio, H. Lecoeur, Y. Riviere, and M. L. Gougeon. 1997. Potential deleterious effect of anti-viral cytotoxic lymphocyte through the CD95 (FAS/APO-1)-mediated pathway during chronic HIV infection. Immunol. Lett. 57:53-58.
    • (1997) Immunol. Lett , vol.57 , pp. 53-58
    • Garcia, S.1    Fevrier, M.2    Dadaglio, G.3    Lecoeur, H.4    Riviere, Y.5    Gougeon, M.L.6
  • 24
    • 33644822414 scopus 로고    scopus 로고
    • Pathogenesis of HIV infection: What the virus spares is as important as what it destroys
    • Grossman, Z., M. Meier-Schellersheim, W. E. Paul, and L. J. Picker. 2006. Pathogenesis of HIV infection: what the virus spares is as important as what it destroys. Nat. Med. 12:289-295.
    • (2006) Nat. Med , vol.12 , pp. 289-295
    • Grossman, Z.1    Meier-Schellersheim, M.2    Paul, W.E.3    Picker, L.J.4
  • 26
    • 0022454530 scopus 로고
    • Pathogenesis of lentivirus infections
    • Haase, A. T. 1986. Pathogenesis of lentivirus infections. Nature 322:130-136.
    • (1986) Nature , vol.322 , pp. 130-136
    • Haase, A.T.1
  • 27
    • 36849090750 scopus 로고    scopus 로고
    • HIV turns plasmacytoid dendritic cells (pDC) into TRAIL-expressing killer pDC and down-regulates HIV coreceptors by Toll-like receptor 7-induced IFN-alpha
    • Hardy, A. W., D. R. Graham, G. M. Shearer, and J. P. Herbeuval. 2007. HIV turns plasmacytoid dendritic cells (pDC) into TRAIL-expressing killer pDC and down-regulates HIV coreceptors by Toll-like receptor 7-induced IFN-alpha. Proc. Natl. Acad. Sci. USA 104:17453-17458.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 17453-17458
    • Hardy, A.W.1    Graham, D.R.2    Shearer, G.M.3    Herbeuval, J.P.4
  • 28
    • 33746763724 scopus 로고    scopus 로고
    • Aiming to induce broadly reactive neutralizing antibody responses with HIV-1 vaccine candidates
    • Haynes, B. F., and D. C. Montefiori. 2006. Aiming to induce broadly reactive neutralizing antibody responses with HIV-1 vaccine candidates. Expert Rev. Vaccines 5:347-363.
    • (2006) Expert Rev. Vaccines , vol.5 , pp. 347-363
    • Haynes, B.F.1    Montefiori, D.C.2
  • 30
    • 33746892252 scopus 로고    scopus 로고
    • HIV infection: First battle decides the war
    • Hel, Z., J. R. McGhee, and J. Mestecky. 2006. HIV infection: first battle decides the war. Trends Immunol. 27:274-281.
    • (2006) Trends Immunol , vol.27 , pp. 274-281
    • Hel, Z.1    McGhee, J.R.2    Mestecky, J.3
  • 31
    • 27744560468 scopus 로고    scopus 로고
    • CD4+ T-cell death induced by infectious and noninfectious HIV-1: Role of type 1 interferon-dependent, TRAIL/DR5-mediated apoptosis
    • Herbeuval, J. P., J. C. Grivel, A. Boasso, A. W. Hardy, C. Chougnet, M. J. Dolan, H. Yagita, J. D. Lifson, and G. M. Shearer. 2005. CD4+ T-cell death induced by infectious and noninfectious HIV-1: role of type 1 interferon-dependent, TRAIL/DR5-mediated apoptosis. Blood 106:3524-3531.
    • (2005) Blood , vol.106 , pp. 3524-3531
    • Herbeuval, J.P.1    Grivel, J.C.2    Boasso, A.3    Hardy, A.W.4    Chougnet, C.5    Dolan, M.J.6    Yagita, H.7    Lifson, J.D.8    Shearer, G.M.9
  • 32
    • 34247170486 scopus 로고    scopus 로고
    • HIV-1 immunopathogenesis: How good interferon turns bad
    • Herbeuval, J. P., and G. M. Shearer. 2007. HIV-1 immunopathogenesis: how good interferon turns bad. Clin. Immunol. 123:121-128.
    • (2007) Clin. Immunol , vol.123 , pp. 121-128
    • Herbeuval, J.P.1    Shearer, G.M.2
  • 33
    • 0028853992 scopus 로고
    • Induction of AIDS by simian immunodeficiency virus from an African green monkey: Species-specific variation in pathogenicity correlates with the extent of in vivo replication
    • Hirsch, V. M., G. Dapolito, P. R. Johnson, W. R. Elkins, W. T. London, R. J. Montali, S. Goldstein, and C. Brown. 1995. Induction of AIDS by simian immunodeficiency virus from an African green monkey: species-specific variation in pathogenicity correlates with the extent of in vivo replication. J. Virol. 69:955-967.
    • (1995) J. Virol , vol.69 , pp. 955-967
    • Hirsch, V.M.1    Dapolito, G.2    Johnson, P.R.3    Elkins, W.R.4    London, W.T.5    Montali, R.J.6    Goldstein, S.7    Brown, C.8
  • 39
    • 0028337166 scopus 로고
    • Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome
    • Koup, R. A., J. T. Safrit, Y. Cao, C. A. Andrews, G. McLeod, W. Borkowsky, C. Farthing, and D. D. Ho. 1994. Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome. J. Virol. 68:4650-4655.
    • (1994) J. Virol , vol.68 , pp. 4650-4655
    • Koup, R.A.1    Safrit, J.T.2    Cao, Y.3    Andrews, C.A.4    McLeod, G.5    Borkowsky, W.6    Farthing, C.7    Ho, D.D.8
  • 41
    • 0032482190 scopus 로고    scopus 로고
    • Analysis of Gag-specific cytotoxic T lymphocytes in simian immunodeficiency virus-infected rhesus monkeys by cell staining with a tetrameric major histocompatibility complex class I-peptide complex
    • Kuroda, M. J., J. E. Schmitz, D. H. Barouch, A. Craiu, T. M. Allen, A. Sette, D. I. Watkins, M. A. Forman, and N. L. Letvin. 1998. Analysis of Gag-specific cytotoxic T lymphocytes in simian immunodeficiency virus-infected rhesus monkeys by cell staining with a tetrameric major histocompatibility complex class I-peptide complex. J. Exp. Med. 187:1373-1381.
    • (1998) J. Exp. Med , vol.187 , pp. 1373-1381
    • Kuroda, M.J.1    Schmitz, J.E.2    Barouch, D.H.3    Craiu, A.4    Allen, T.M.5    Sette, A.6    Watkins, D.I.7    Forman, M.A.8    Letvin, N.L.9
  • 42
    • 0033137113 scopus 로고    scopus 로고
    • Emergence of CTL coincides with clearance of virus during primary simian immunodeficiency virus infection in rhesus monkeys
    • Kuroda, M. J., J. E. Schmitz, W. A. Charini, C. E. Nickerson, M. A. Lifton, C. I. Lord, M. A. Forman, and N. L. Letvin. 1999. Emergence of CTL coincides with clearance of virus during primary simian immunodeficiency virus infection in rhesus monkeys. J. Immunol. 162:5127-5133.
    • (1999) J. Immunol , vol.162 , pp. 5127-5133
    • Kuroda, M.J.1    Schmitz, J.E.2    Charini, W.A.3    Nickerson, C.E.4    Lifton, M.A.5    Lord, C.I.6    Forman, M.A.7    Letvin, N.L.8
  • 43
    • 0032926838 scopus 로고    scopus 로고
    • Comparative analysis of cytotoxic T lymphocytes in lymph nodes and peripheral blood of simian immunodeficiency virus-infected rhesus monkeys
    • Kuroda, M. J., J. E. Schmitz, W. A. Charini, C. E. Nickerson, C. I. Lord, M. A. Forman, and N. L. Letvin. 1999. Comparative analysis of cytotoxic T lymphocytes in lymph nodes and peripheral blood of simian immunodeficiency virus-infected rhesus monkeys. J. Virol. 73:1573-1579.
    • (1999) J. Virol , vol.73 , pp. 1573-1579
    • Kuroda, M.J.1    Schmitz, J.E.2    Charini, W.A.3    Nickerson, C.E.4    Lord, C.I.5    Forman, M.A.6    Letvin, N.L.7
  • 44
    • 34047168915 scopus 로고    scopus 로고
    • Current concepts in AIDS pathogenesis: Insights from the SIV/macaque model
    • Lackner, A. A., and R. S. Veazey. 2007. Current concepts in AIDS pathogenesis: insights from the SIV/macaque model. Annu. Rev. Med. 58:461-476.
    • (2007) Annu. Rev. Med , vol.58 , pp. 461-476
    • Lackner, A.A.1    Veazey, R.S.2
  • 45
    • 18844372332 scopus 로고    scopus 로고
    • Understanding the generation and function of memory T cell subsets
    • Lanzavecchia, A., and F. Sallusto. 2005. Understanding the generation and function of memory T cell subsets. Curr. Opin. Immunol. 17:326-332.
    • (2005) Curr. Opin. Immunol , vol.17 , pp. 326-332
    • Lanzavecchia, A.1    Sallusto, F.2
  • 46
    • 0038717548 scopus 로고    scopus 로고
    • Immunopathogenesis and immunotherapy in AIDS virus infections
    • Letvin, N. L., and B. D. Walker. 2003. Immunopathogenesis and immunotherapy in AIDS virus infections. Nat. Med. 9:861-866.
    • (2003) Nat. Med , vol.9 , pp. 861-866
    • Letvin, N.L.1    Walker, B.D.2
  • 47
    • 0029062573 scopus 로고
    • Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein
    • Li, C. J., D. J. Friedman, C. Wang, V. Metelev, and A. B. Pardee. 1995. Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein. Science 268:429-431.
    • (1995) Science , vol.268 , pp. 429-431
    • Li, C.J.1    Friedman, D.J.2    Wang, C.3    Metelev, V.4    Pardee, A.B.5
  • 52
    • 0031985775 scopus 로고    scopus 로고
    • Administration of an anti-CD8 monoclonal antibody interferes with the clearance of chimeric simian/human immunodeficiency virus during primary infections of rhesus macaques
    • Matano, T., R. Shibata, C. Siemon, M. Connors, H. C. Lane, and M. A. Martin. 1998. Administration of an anti-CD8 monoclonal antibody interferes with the clearance of chimeric simian/human immunodeficiency virus during primary infections of rhesus macaques. J. Virol. 72:164-169.
    • (1998) J. Virol , vol.72 , pp. 164-169
    • Matano, T.1    Shibata, R.2    Siemon, C.3    Connors, M.4    Lane, H.C.5    Martin, M.A.6
  • 53
    • 17844374605 scopus 로고    scopus 로고
    • Massive infection and loss of memory CD4(+) T cells in multiple tissues during acute SIV infection
    • Mattapallil, J. J., D. C. Douek, B. Hill, Y. Nishimura, M. Martin, and M. Roederer. 2005. Massive infection and loss of memory CD4(+) T cells in multiple tissues during acute SIV infection. Nature 434:1093-1097.
    • (2005) Nature , vol.434 , pp. 1093-1097
    • Mattapallil, J.J.1    Douek, D.C.2    Hill, B.3    Nishimura, Y.4    Martin, M.5    Roederer, M.6
  • 54
    • 1642424237 scopus 로고    scopus 로고
    • T-cell dynamics during acute SIV infection
    • Mattapallil, J. J., N. L. Letvin, and M. Roederer. 2004. T-cell dynamics during acute SIV infection. AIDS 18:13-23.
    • (2004) AIDS , vol.18 , pp. 13-23
    • Mattapallil, J.J.1    Letvin, N.L.2    Roederer, M.3
  • 55
    • 4644289983 scopus 로고    scopus 로고
    • Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tract
    • Mehandru, S., M. A. Poles, K. Tenner-Racz, A. Horowitz, A. Hurley, C. Hogan, D. Boden, P. Racz, and M. Markowitz. 2004. Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tract. J. Exp. Med. 200:761-770.
    • (2004) J. Exp. Med , vol.200 , pp. 761-770
    • Mehandru, S.1    Poles, M.A.2    Tenner-Racz, K.3    Horowitz, A.4    Hurley, A.5    Hogan, C.6    Boden, D.7    Racz, P.8    Markowitz, M.9
  • 57
    • 0023907054 scopus 로고
    • Evaluation of antiviral drugs and neutralizing antibodies to human immunodeficiency virus by a rapid and sensitive microtiter infection assay
    • Montefiori, D. C., W. E. Robinson, Jr., S. S. Schuffman, and W. M. Mitchell. 1988. Evaluation of antiviral drugs and neutralizing antibodies to human immunodeficiency virus by a rapid and sensitive microtiter infection assay. J. Clin. Microbiol. 26:231-235.
    • (1988) J. Clin. Microbiol , vol.26 , pp. 231-235
    • Montefiori, D.C.1    Robinson Jr., W.E.2    Schuffman, S.S.3    Mitchell, W.M.4
  • 58
    • 0030900764 scopus 로고    scopus 로고
    • The anatomical basis of intestinal immunity
    • Mowat, A. M., and J. L. Viney. 1997. The anatomical basis of intestinal immunity. Immunol. Rev. 156:145-166.
    • (1997) Immunol. Rev , vol.156 , pp. 145-166
    • Mowat, A.M.1    Viney, J.L.2
  • 59
    • 0003673874 scopus 로고    scopus 로고
    • Guide for the care and use of laboratory animals. National Academic Press, Washington, DC
    • National Research Council. 1996. Guide for the care and use of laboratory animals. National Academic Press, Washington, DC.
    • (1996) National Research Council
  • 61
    • 33745363316 scopus 로고    scopus 로고
    • Immunopathogenesis of acute AIDS virus infection
    • Picker, L. J. 2006. Immunopathogenesis of acute AIDS virus infection. Curr. Opin. Immunol. 18:399-405.
    • (2006) Curr. Opin. Immunol , vol.18 , pp. 399-405
    • Picker, L.J.1
  • 66
    • 20744444986 scopus 로고    scopus 로고
    • + lymphocyte depletion on virus containment after simian immunodeficiency virus SIVmac251 challenge of live attenuated SIVmac239Δ3-vaccinated rhesus macaques. J. Virol. 79:8131-8141.
    • + lymphocyte depletion on virus containment after simian immunodeficiency virus SIVmac251 challenge of live attenuated SIVmac239Δ3-vaccinated rhesus macaques. J. Virol. 79:8131-8141.
  • 71
    • 0037432776 scopus 로고    scopus 로고
    • Defective CD8 T cell memory following acute infection without CD4 T cell help
    • Sun, J. C., and M. J. Bevan. 2003. Defective CD8 T cell memory following acute infection without CD4 T cell help. Science 300:339-342.
    • (2003) Science , vol.300 , pp. 339-342
    • Sun, J.C.1    Bevan, M.J.2
  • 72
    • 1342308333 scopus 로고    scopus 로고
    • The mucosal immune system and HIV-1 infection
    • Veazey, R., and A. Lackner. 2003. The mucosal immune system and HIV-1 infection. AIDS Rev. 5:245-252.
    • (2003) AIDS Rev , vol.5 , pp. 245-252
    • Veazey, R.1    Lackner, A.2
  • 75
    • 0037333823 scopus 로고    scopus 로고
    • + T cells express high levels of CCR5 and are rapidly depleted in simian immunodeficiency virus infection
    • + T cells express high levels of CCR5 and are rapidly depleted in simian immunodeficiency virus infection. J. Infect. Dis. 187:769-776.
    • (2003) J. Infect. Dis , vol.187 , pp. 769-776
    • Veazey, R.S.1    Marx, P.A.2    Lackner, A.A.3
  • 77
    • 0034663135 scopus 로고    scopus 로고
    • Defining CTL-induced pathology: Implications for HIV
    • Wodarz, D., and D. C. Krakauer. 2000. Defining CTL-induced pathology: implications for HIV. Virology 274:94-104.
    • (2000) Virology , vol.274 , pp. 94-104
    • Wodarz, D.1    Krakauer, D.C.2
  • 78
    • 0028176064 scopus 로고
    • T-cell-mediated immunopathology versus direct cytolysis by virus: Implications for HIV and AIDS
    • Zinkernagel, R. M., and H. Hengartner. 1994. T-cell-mediated immunopathology versus direct cytolysis by virus: implications for HIV and AIDS. Immunol. Today 15:262-268.
    • (1994) Immunol. Today , vol.15 , pp. 262-268
    • Zinkernagel, R.M.1    Hengartner, H.2


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