Central ghrelin gastroprotection involves nitric oxide/prostaglandin cross-talk

British Journal of Pharmacology

Volumn 154, Issue 3, 2008, Pages 688-697

  Sibilia, V ^a   Pagani, F ^a   Rindi, G ^b   Lattuada, N ^a   Rapetti, D ^c   De Luca, V ^a   Campanini, N ^b   Bulgarelli, I ^c   Locatelli, V ^c   Guidobono, F ^a   Netti, C ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF PARMA   (Italy)

^c UNIVERSITY OF MILANO BICOCCA   (Italy)

Author keywords

Celecoxib; Cyclooxygenase; Ethanol; Gastric ulcers; Ghrelin; Indomethacin; Nitric oxide; Prostaglandins; SC560

Indexed keywords

5 (4 CHLOROPHENYL) 1 (4 METHOXYPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOLE; ALCOHOL; CELECOXIB; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GHRELIN; INDOMETACIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG MECHANISM; IMMUNOREACTIVITY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; STOMACH MUCOSA; STOMACH ULCER;

ANIMALS; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DINOPROSTONE; ETHANOL; GASTRIC MUCOSA; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GHRELIN; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; STOMACH ULCER;

EID: 44349100318     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/bjp.2008.120     Document Type: Article

References (48)

1. Boku K, Ohno T, Saeki T, Hayashi H, Hayashi I, Katori M et al. (2001). Adaptive cytoprotection mediated by prostaglandin I(2) is attributable to sensitization of CRGP-containing sensory nerves. Gastroenterology 120: 134-143.
2. Brzozowski T, Konturek PC, Konturek SJ, Kwiecieñ S, Drozdowicz D, Bielanski W et al. (2004). Exogenous and endogenous ghrelin in gastroprotection against stress-induced gastric damage. Regul Pept 120: 39-51.
3. Brzozowski T, Konturek PC, Sliwowski Z, Pajdo R, Drozdowicz D, Kwiecien S et al. (2006a). Prostaglandin/cyclooxygenase pathway in ghrelin-induced gastroprotection against ischemia-reperfusion injury. J Pharmacol Exp Ther 319: 477-487.
4. Brzozowski T, Konturek PC, Sliwowski Z, Drozdowicz D, Kwiecien S, Pawlik M et al. (2006b). Neural aspects of ghrelin-induced gastroprotection against mucosal injury induced by noxious agents. J Physiol Pharmacol 57 (Suppl): 663-676.
5. Cao JM, Ong H, Chen C (2006). Effects of ghrelin and synthetic GH secretagogues on the cardiovascular system. Trends Endocrinol Metab 17: 13-18.
6. Chomczynski P, Sacchi N (1987). Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162: 156-159.
7. Chow JY, Ma L, Cho CH (1998). Effect of cigarette smoke on ethanol-induced gastric mucosal lesions: the role of nitric oxide and neutrophils. Eur J Pharmacol 342: 253-260.
8. Cocchi D, Maccarinelli G, Sibilia V, Tulipano G, Torsello A, Pazzaglia UE et al. (2005). GH-releasing peptides and bone. J Endocrinol Invest 28: 11-14.
9. Cuzzocrea S, Salvemini D (2007). Molecular mechanisms involved in the reciprocal regulation of cyclooxygenase and nitric oxide synthase enzymes. Kidney Int 71: 290-297.
10. Date Y, Nakazato M, Murakami N, Kojima M, Kangawa K, Matsukura S (2001). Ghrelin acts in the central nervous system to stimulate gastric acid secretion. Biochem Biophys Res Commun 280: 904-907.
11. Dembiñski A, Warzecha Z, Ceranowicz P, Bielañski W, Cieszkowski J, Dembiñski M et al. (2005). Variable effect of ghrelin administration on pancreatic development in young rats. Role of insulin-like growth factor-1. J Physiol Pharmacol 56: 555-570.
12. Ferraz JG, Sharkey KA, Reuter BK, Asfaha S, Tigley AW, Brown ML et al. (1997). Induction of cyclooxygenase 1 and 2 in the rat stomach during endotoxemia: role in resistance to damage. Gastroenterology 113: 195-204.
13. Fujino K, Inui A, Asakawa A, Kihara N, Fujimura M, Fujimiya M (2003). Ghrelin induces fasted motor activity of the gastrointestinal tract in conscious fed rats. J Physiol 550: 227-240.
14. Ghelardoni S, Carnicelli V, Frascarelli S, Ronca-Testoni S, Zucchi R (2006). Ghrelin tissue distribution: comparison between gene and protein expression. J Endocrinol Invest 29: 115-121.
15. Ghigo E, Broglio F, Arvat E, Maccario M, Papotti M, Muccioli G (2005). Ghrelin: more than a natural GH secretagogue and/or an orexigenic factor. Clin Endocrinol 62: 1-17.
16. Goso Y, Ueno M, Hotta K, Ishihara K (2007). Protective effects of the whisky congeners on ethanol-induced gastric mucosal damage. Alcohol Clin Exp Res 31: 390-394.
17. Guidobono F, Coluzzi M, Pagani F, Pecile A, Netti C (1994). Amylin given by central and peripheral routes inhibits acid gastric secretion. Peptides 15: 699-702.
18. Harada N, Okajima K, Uchiba M, Katsuragi T (2003). Contribution of capsaicin-sensitive sensory neurons to stress-induced increases in gastric tissue levels of prostaglandins in rats. Am J Physiol Gastrointest Liver Physiol 285: G1214-G1224.
19. Kim S, Huri DA, Snyder SH (2005). Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2. Science 310: 1966-1970.
20. Kishimoto Y, Wada K, Nakamoto K, Ashida K, Kamisaki Y, Kawasaki H et al. (1997). Quantitative analysis of cyclooxygenase-2 gene expression on acute gastric injury induced by ischemia-reperfusion in rats. Life Sci 60: PL127-PL133.
21. Ko JK, Cho CH (1999). Co-regulation of mucosal nitric oxide and prostaglandin in gastric adaptive cytoprotection. Inflamm Res 48: 471-478.
22. Kojima M, Hosoda H, Matsuo H, Kangawa K (2001). Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor. Trends Endocrinol Met 12: 118-122.
23. Kojima M, Kangawa K (2005). Ghrelin: structure and function. Physiol Rev 85: 495-522.
24. Konturek PK, Brzozowski T, Konturek SJ, Dembiñski A (1990). Role of epidermal growth factor, prostaglandin, and sulfhydryls in stress-induced gastric lesions. Gastroenterology 99: 1607-1615.
25. Konturek PC, Brzozowski T, Pajdo R, Nikiforuk A, Kwiecien S, Harsch I et al. (2004). Ghrelin - a new gastroprotective factor in gastric mucosa. J Physiol Pharmacol 55: 325-336.
26. Martin MJ, Marhuenda E, Perez-Guerrero C, Franco JM (1994). Antiulcer effect of naringin on gastric lesions induced by ethanol in rats. Pharmacology 49: 144-150.
27. Masuda Y, Tanaka T, Inomata N, Ohnuma N, Tanaka S, Itoh Z et al. (2000). Ghrelin stimulates gastric acid secretion and motility in rats. Biochem Biophys Res Commun 276: 905-908.
28. Matsuhashi T, Otaka M, Odashima M, Jin M, Komatsu K, Wada I et al. (2007). Protective effect of a novel rice extract against ethanol-induced gastric mucosal injury in rat. Dig Dis Sci 52: 434-441.
29. Mitchell JA, Larkin S, Williams TJ (1995). Cyclooxygenase-2: regulation and relevance in inflammation. Biochem Pharmacol 50: 1535-1542.
30. Mizuno H, Sakamoto C, Matsuda K, Wada K, Uchida T, Noguchi H et al. (1997). Induction of cyclooxygenase 2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice. Gastroenterology 112: 387-397.
31. Peskar BM (2001). Role of cyclooxygenase isoforms in gastric mucosal defence. J Physiol Paris 95: 3-9.
32. Rindi G, Torsello A, Locatelli V, Solcia E (2004). Ghrelin expression and actions: a novel peptide for an old cell type of the diffuse endocrine system. Exp Biol Med 229: 1007-1016.
33. Saeki T, Ohno T, Kamata K, Arai K, Mizuguchi S, Katori M et al. (2004). Mild irritant prevents ethanol-induced gastric mucosal microcirculatory disturbances through actions of calcitonin gene-related peptide and PGI2 in rats. Am J Physiol Gastrointest Liver Physiol 286: G68-G75.
34. Salvemini D, Misko TP, Masferrer JL, Seibert K, Currie MG, Needleman P (1993). Nitric oxide activates cyclooxygenase enzymes. Proc Natl Acad Sci USA 90: 7240-7244.
35. Salvemini D, Settle SL, Masferrer JL, Seibert K, Currie MG, Needleman P (1995). Regulation of prostaglandin production by nitric oxide; an in vivo analysis. Br J Pharmacol 114: 1171-1178.
36. Sawaoka H, Tsuji S, Tsujii M, Gunawan ES, Nakama A, Takei Y et al. (1997). Expression of the cyclooxygenase-2 gene in gastric epithelium. J Clin Gastroenterol 25: S105-S110.
37. Schmassmann A, Zoidl G, Peskar BM, Waser B, Schmassmann-Suhijar D, Gebbers JO et al. (2006). Role of the different isoforms of cyclooxygenase and nitric oxide synthase during gastric ulcer healing in cyclooxygenase-1 and -2 knockout mice. Am J Physiol Gastrointest Liver Physiol 290: G747-G756.
38. Sibilia V, Pagani F, Guidobono F, Locatelli V, Torsello A, Deghenghi R et al. (2002). Evidence for a central inhibitory role of growth hormone secretagogues and ghrelin on gastric acid secretion in conscious rats. Neuroendocrinology 75: 92-97.
39. Sibilia V, Rindi G, Pagani F, Rapetti D, Locatelli V, Torsello A et al. (2003). Ghrelin protects against ethanol-induced gastric ulcers in rats: studies on the mechanisms of action. Endocrinology 144: 353-359.
40. Sibilia V, Torsello A, Pagani F, Rapetti D, Lattuada N, Locatelli V et al. (2004). Effects of hexarelin against acid-independent and acid-dependent ulcerogens in the rat. Peptides 25: 2163-2170.
41. Sibilia V, Muccioli G, Deghenghi R, Pagani F, De Luca V, Rapetti D et al. (2006). Evidence for a role of the GHS-R1a receptors in ghrelin inhibition of gastric acid secretion in the rat. J Neuroendocrinol 18: 122-128.
42. Sibilia V, Pagani F, Lattuada N, De Luca V, Guidobono F, Soglian A et al. (2007). Ticlopidine prevents the formation but delays the healing of ethanol-induced gastric lesions in the rat. Pharmacol Res 55: 418-425.
43. Takahashi S, Shigeta J, Inoue H, Tanabe T, Okabe S (1998). Localization of cyclooxygenase-2 and regulation of its mRNA expression in gastric ulcers in rats. Am J Physiol 275: G1137-G1145.
44. Tanaka A, Hatazawa R, Takahira Y, Izumi N, Filaretova L, Takeuchi K (2007). Preconditioning stress prevents cold restraint stress-induced gastric lesions in rats: roles of COX-1, COX-2, and PLA2. Dig Dis Sci 52: 478-487.
45. Trudel L, Tomasetto C, Rio MC, Bouin M, Plourde V, Eberling P (2002). Ghrelin/motilin-related peptide is a potent prokinetic to reverse gastric postoperative ileus in rat. Am J Physiol Gastrointest Liver Physiol 282: G948-G952.
46. Wallace JL, Devchand PR (2005). Emerging roles for cyclooxygenase-2 in gastrointestinal mucosal defense. Br J Pharmacol 145: 275-282.
47. Wang G, Lee HM, Englander E, Greeley Jr GH (2002). Ghrelin - not just another stomach hormone. Regul Pept 105: 75-81.
48. Whittle BJ, Lopez-Belmonte J, Moncada S (1990). Regulation of gastric mucosal integrity by endogenous nitric oxide: interactions with prostanoids and sensory neuropeptides in the rat. Br J Pharmacol 99: 607-611.