Rational mutational analysis of a multidrug MFS transporter CaMdr1p of Candida albicans by employing a membrane environment based computational approach

PLoS Computational Biology

Volumn 5, Issue 12, 2009, Pages

  Kapoor, Khyati ^a   Rehan, Mohd ^a   Kaushiki, Ajeeta ^a   Pasrija, Ritu ^a,b   Lynn, Andrew M ^a   Prasad, Rajendra ^a  

^a JAWAHARLAL NEHRU UNIVERSITY   (India)

^b RANBAXY LABORATORIES LTD   (India)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CANDIDA; COMPUTATIONAL METHODS; ENTROPY; GENE ENCODING; GENE EXPRESSION; INFORMATION THEORY; MEMBRANES; YEAST;

AZOLE RESISTANCES; CANDIDA ALBICANS; COMPUTATIONAL APPROACH; EFFLUX TRANSPORTER; GENES ENCODING; IN-DEPTH KNOWLEDGE; MUTATIONAL ANALYSIS; OVEREXPRESSIONS; PATHOGENICS; RELATIVE ENTROPY;

PROTEINS;

ALANINE; MEMBRANE PROTEIN; PROTEIN CAMDR1P; UNCLASSIFIED DRUG; GLYCOPROTEIN P; P GLYCOPROTEIN 2; P-GLYCOPROTEIN 2;

AMINO ACID SEQUENCE; ARTICLE; CANDIDA ALBICANS; CONTROLLED STUDY; ENTROPY; MUTATIONAL ANALYSIS; NONHUMAN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN STRUCTURE; SACCHAROMYCES CEREVISIAE; SEQUENCE ALIGNMENT; SITE DIRECTED MUTAGENESIS; BINDING SITE; BIOLOGICAL MODEL; CELL MEMBRANE; CHEMISTRY; COMPUTER SIMULATION; GENETICS; METABOLISM; METHODOLOGY; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; PROTEIN BINDING; STRUCTURE ACTIVITY RELATION;

CANDIDA ALBICANS; SACCHAROMYCES CEREVISIAE;

AMINO ACID SEQUENCE; BINDING SITES; CANDIDA ALBICANS; CELL MEMBRANE; COMPUTER SIMULATION; DNA MUTATIONAL ANALYSIS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; P-GLYCOPROTEINS; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 74549157702     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1000624     Document Type: Article

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