Induction of antigen-specific immune tolerance by TGF-β-induced CD4+Foxp3+ regulatory T cells

International Journal of Clinical and Experimental Medicine

Volumn 2, Issue 3, 2009, Pages 212-220

  Fan, Huimin ^a   Wang, Julie ^b   Zhou, Xiaohui ^a,b   Liu, Zhongmin ^a   Zheng, Song Guo ^b  

^a TONGJI UNIVERSITY   (China)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Foxp3; Immunoregulation; Regulatory T cells; TGF ; Transplant tolerance

Indexed keywords

TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA;

ADOPTIVE TRANSFER; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN SPECIFICITY; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CONTROLLED STUDY; IMMUNOLOGICAL TOLERANCE; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE;

EID: 74549131548     PISSN: None     EISSN: 19405901     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Sakaguchi S, Yamaguchi T, Nomura T and Ono M. Regulatory T cells and immune tolerance. Cell 2008; 133:775-787.
2. Zheng SG. The Critical Role of TGF-beta1 in the Development of Induced Foxp3+ Regulatory T Cells. Int J Clin Exp Med 2008; 1:192-202.
3. Kang SM, Tang Q and Bluestone JA. CD4+CD25+ regulatory T cells in transplantation: progress, challenges and prospects. Am J Transplant 2007; 7:1457-1463.
4. Dijke IE, Korevaar SS, Caliskan K, Balk AH, Maat AP, Weimar W and Baan CC. Inadequate immune regulatory function of CD4+CD25 bright+FoxP3+ T cells in heart transplant patients who experience acute cellular rejection. Transplantation 2009; 87:1191-1200.
5. Trenado A, Sudres M, Tang Q, Maury S, Charlotte F, Grégoire S, Bonyhadi M, Klatzmann D, Salomon BL and Cohen JL. Ex vivo-expanded CD4+CD25+ immunoregulatory T cells prevent graft-versus-host-disease by inhibiting activation/differentiation of pathogenic T cells. J Immunol 2006; 176:1266-1273.
6. Pu LY, Wang XH, Zhang F, Li XC, Yao AH, Yu Y, Lv L and Li GQ. Adoptive transfusion of ex vivo donor alloantigen-stimulated CD4(+)CD25(+) regulatory T cells ameliorates rejection of DAto-Lewis rat liver transplantation. Surgery 2007; 142:67-73.
7. Adeegbe D, Bayer AL, Levy RB and Malek TR. Cutting edge: allogeneic CD4+CD25+Foxp3+ T regulatory cells suppress autoimmunity while establishing transplantation tolerance. J Immunol 2006; 176:7149-7153.
8. Nishimura E, Sakihama T, Setoguchi R, Tanaka K and Sakaguchi S. Induction of antigen-specific immunologic tolerance by in vivo and in vitro antigen-specific expansion of naturally arising Foxp3+CD25+CD4+ regulatory T cells. Int Immunol 2004; 16: 1189-1201.
9. Trani J, Moore DJ, Jarrett BP, Markmann JW, Lee MK, Singer A, Lian MM, Tran B, Caton AJ and Markmann JF. CD25+ immunoregulatory CD4 T cells mediate acquired central transplantation tolerance. J Immunol 2003; 170:279-286.
10. van Maurik A, Herber M, Wood KJ and Jones ND. Cutting edge: CD4+CD25+ alloantigen-specific immunoregulatory cells that can prevent CD8+ T cell-mediated graft rejection: implications for anti-CD154 immunotherapy. J Immunol 2002; 169:5401-5404.
11. Pasare C and Medzhitov R. Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science 2003; 299:1033-1036.
12. Valencia X, Stephens G, Goldbach-Mansky R, Wilson M, Shevach EM and Lipsky PE. TNF downmodulates the function of human CD4+CD25hi T-regulatory cells. Blood 2006; 108:253-261.
13. Xu L, Kitani A, Fuss I and Strober W. Cutting edge: regulatory T cells induce CD4+CD25-Foxp3- T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-β. J Immunol 2007; 178:6725-6729.
14. Zheng SG, Wang J and Horwitz DA. Cutting Edge: Foxp3+CD4+CD25+ Regulatory T Cells Induced by IL-2 and TGF-{beta} Are Resistant to Th17 Conversion by IL-6. J Immunol 2008; 180: 7112-7116.
15. Zheng SG, Gray JD, Ohtsuka K, Yamagiwa S and Horwitz DA. Generation ex vivo of TGF-beta-producing regulatory T cells from CD4+CD25- precursors. J Immunol 2002; 169:4183-4189.
16. Chen W, Jin W, Hardegen N, Lei KJ, Li L, Marinos N, McGrady G and Wahl SM. onversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 2003; 198: 1875-1886.
17. Zheng SG, Wang JH, Gray JD, Soucier H and Horwitz DA. Natural and induced CD4+CD25+ cells educate CD4+CD25- cells to develop suppressive activity: the role of IL-2, TGF-beta, and IL-10. J Immunol 2004; 172: 5213-5221.
18. Zheng SG, Wang J, Wang P, Gray JD and Horwitz DA. IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells. J Immunol 2007;178: 2018-2027.
19. Peng Y, Laouar Y, Li MO, Green EA and Flavell RA. TGF-beta regulates in vivo expansion of Foxp3-expressing CD4+CD25+ regulatory T cells responsible for protection against diabetes. Proc Natl Acad Sci U S A 2004; 101: 4572-4527.
20. DiPaolo RJ, Glass DD, Bijwaard KE and Shevach EM. CD4+CD25+ T cells prevent the development of organ-specific autoimmune disease by inhibiting the differentiation of autoreactive effector T cells. J Immunol 2005;175: 7135-7142.
21. Fantini MC, Becker C, Tubbe I, Nikolaev A, Lehr HA and Galle P, Neurath MF. Transforming growth factor beta induced FoxP3+ regulatory T cells suppress Th1 mediated experimental colitis. Gut 2006; 55:671-680.
22. Zheng SG, Wang JH, Koss MN, Quismorio F Jr, Gray JD and Horwitz DA. CD4+ and CD8+ regulatory T cells generated ex vivo with IL-2 and TGF-beta suppress a stimulatory graft-versus-host disease with a lupus-like syndrome. J Immunol 2004; 172:1531-1539.
23. Zheng SG, Meng L, Wang JH, Watanabe M, Barr ML, Cramer DV, Gray JD and Horwitz DA. Transfer of regulatory T cells generated ex vivo modifies graft rejection through induction of tolerogenic CD4+CD25+ cells in the recipient Int Immunol. 2006; 18:279-289.
24. Hori S, Nomura T and Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003; 299:1057-1061.
25. Salama AD, Najafian N, Clarkson MR, Harmon WE and Sayegh MH. Regulatory CD25+ T cells in human kidney transplant recipients. J Am Soc Nephrol 2003;14:1643-1651.
26. Long E and Wood KJ. Understanding FOXP3: progress towards achieving transplantation olerance. Transplantation 2007; 84:459-461.
27. Jonuleit H., Schmitt E., Kakirman H., Stassen M., Knop J and Enk AH. Infectious tolerance: human CD25+ regulatory T cells convey suppressor activity to conventional CD4(+) T helper cells. J Exp Med 2002; 196:255-260.
28. Dieckmann D, Bruett CH, Ploettner H, Lutz MB and Schuler G. Human CD4+CD25+ regulatory, contact-dependent T cells induce interleukin 10-producing, contact-independent type 1-like regulatory T cells. J Exp Med 2002; 196:247-253.