Mycobacterial antigen(s) induce anergy by altering TCR- and TCR/CD28-induced signalling events: Insights into T-cell unresponsiveness in leprosy

Molecular Immunology

Volumn 47, Issue 5, 2010, Pages 943-952

  Dagur, Pradeep K ^a   Sharma, Bhawna ^a   Kumar, Gavish ^a   Khan, Naim A ^c   Katoch, Vishwa M ^b   Sengupta, Utpal ^a   Joshi, Beenu ^a  

^a NATIONAL JALMA INSTITUTE FOR LEPROSY AND OTHER MYCOBACTERIAL DISEASES   (India)

^b INDIAN COUNCIL OF MEDICAL RESEARCH   (India)

^c UNIVERSITÉ DE BOURGOGNE   (France)

Author keywords

Anergy; IL 2; Mycobacteria; T cell activation; TCR CD28 signalling

Indexed keywords

CALCIUM CHANNEL; CD28 ANTIGEN; CD69 ANTIGEN; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; IONOMYCIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 14; MITOGEN ACTIVATED PROTEIN KINASE 3; MYCOBACTERIUM ANTIGEN; PROTEIN KINASE C; PROTEIN KINASE ZAP 70; T LYMPHOCYTE RECEPTOR; THAPSIGARGIN; TRANSCRIPTION FACTOR NFAT3;

ANTIGEN EXPRESSION; ARTICLE; CALCIUM TRANSPORT; CELL LYSATE; CLONAL ANERGY; CONTROLLED STUDY; CYTOKINE RELEASE; DOWNSTREAM SIGNALLING; ENZYME PHOSPHORYLATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LEPROSY; LYMPHOCYTE PROLIFERATION; LYMPHOCYTE TRANSFORMATION; MYCOBACTERIUM LEPRAE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

ANTIGENS, BACTERIAL; ANTIGENS, CD; ANTIGENS, CD28; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; CALCIUM; CELL PROLIFERATION; CLONAL ANERGY; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKIN-2; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; IONOMYCIN; IONOPHORES; JURKAT CELLS; LECTINS, C-TYPE; LEPROSY; LYMPHOCYTE ACTIVATION; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 3; MYCOBACTERIUM LEPRAE; NFATC TRANSCRIPTION FACTORS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROMOTER REGIONS, GENETIC; PROTEIN KINASE C; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES; THAPSIGARGIN; ZAP-70 PROTEIN-TYROSINE KINASE;

CORYNEBACTERINEAE; MYCOBACTERIUM LEPRAE;

EID: 74449092844     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2009.11.009     Document Type: Article

References (46)

1. Acuto O., and Michel F. CD28-mediated co-stimulation: a quantitative support for TCR signaling. Nat. Rev. Immunol. 3 (2003) 939-951
2. Adler H.S., Kubsch S., Graulich E., Ludwig S., Knop J., and Steinbrink K. Activation of MAP kinase p38 is critical for the cell-cycle-controlled suppressor function of regulatory T-cells. Blood 109 (2007) 4351-4359
3. Antas P.R.Z., Oliveria E.B., Milagres A.S., Franken K.C., Ottenhoff T.H.M., Klatser P., Sarno E.N., and Sampaio E.P. Kinetics of T-cell activation molecules in response to Mycobacterium tuberculosis antigens. Mem. Inst. Oswaldo, Cruz, Rio de Janerio 97 (2002) 1097-1099
4. Berry N., and Nishizuka Y. Protein kinase C and T-cell activation. Eur. J. Biochem. 189 (1990) 205-214
5. Bhattacharya S., Ghosh S., Sen P., Roy S., and Majumdar S. Selective impairment of protein kinase C isotypes in murine macrophage by Leishmania donovani. Mol. Cell. Biochem. 216 (2001) 47-57
6. Boncristiano M., Paccani R.S., Barone S., Ulivieri C., Patrussi L., Ilver D., Amedei A., et al. The Helicobacter pylori vacuolating toxin inhibits T-Cell activation by two independent mechanisms. J. Exp. Med. 198 (2003) 1887-1897
7. Cantrell D. T-cell antigen receptor signal transduction pathways. Annu. Rev. Immunol. 14 (1996) 259-274
8. Carter A.B., Monick M.M., and Hunnighhake G.W. Both ERK and p38 are necessary for cytokine gene expression. Am. J. Respir. Cell. Mol. Biol. 20 (1999) 751-758
9. Chan J., Fan X.D., Hunter S.W., Brennan P.J., and Bloom B.R. Lipoarabinomannan, a possible virulence factor involved in persistence of Mycobacterium tuberculosis within macrophages. Infect. Immun. 59 (1991) 1755-1761
10. Chattree V., Khanna N., and Rao D.N. Alterations in T cell signal transduction by M. leprae antigens is associated with downregulation of second messengers PKC, calcium, calcineurin, MAPK and various transcription factors in leprosy patients. Mol. Immunol. 44 (2007) 2066-2077
11. Crabtree G.R. Contingent genetic regulatory events in T-lymphocytes activation. Science 243 (1989) 355-361
12. Deist F.L., Hivroz C., Partiseti M., Thomas C., Buc H.A., Oleastro M., Belohradsky B., et al. A primary T-cell immunodeficiency associated with defective transmembrane calcium influx. Blood 85 (1995) 1053-1062
13. Dillon T.J., Karpitsk V., Wetze S.A., Parker D.C., Shaw S.A., and Stork P.J.S. Ectopic B-Raf expression enhances extracellular signal-regulated kinase (ERK) signalling in T-cells and prevents antigen-presenting cell induced anergy. J Biol. Chem. 19 (2003) 35940-35949
14. Ferriere F., Khan N.A., Meyniel J.P., and Deschaux P. 5-Hydroxytryptamine-induced calcium-channel gating in rainbow trout (Oncorhynchus mykiss) peripheral blood lymphocytes. Biochem. J. 323 (1997) 251-258
15. Feske S., Giltnane J., Dolmectsch R., Staudt L.M., and Rao A. Gene regulation mediated by calcium signals in T lymphocytes. Nat. Immunol. 2 (2001) 316-324
16. Gajewski T.F., Qian D., Fields P., and Fitch F.W. Anergic T-lymphocyte clones have altered inositol phosphate, calcium and tyrosine kinase signalling pathways. Proc. Natl. Acad. Sci. U.S.A. 91 (1994) 38-42
17. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260 (1985) 3440-3450
18. Hardy K., and Chaudhri G. Activation and signal transduction via mitogen-activated protein (MAP) kinases in T lymphocytes. Immunol. Cell. Biol. 75 (1997) 528-545
19. + regulatory T-cells. J. Immunol. 177 (2006) 2186-2194
20. Huang J., Lo P.-F., Zal T., Gascoigne N.R.J., Smith B.A., Levin S.D., and Grey H.M. CD28 plays a critical role in the segregation of PKC-θ within the immunologic synapse. Proc. Natl. Acad. Sci. U.S.A. 99 (2002) 9369-9373
21. Joshi B., Kedouchi S., Dagur P.K., Hichami A., Sengupta U., and Khan N.A. On cell signalling mechanism of Mycobaterium leprae soluble antigen (MLSA) in Jurkat T-cells. Mol. Cell. Biochem. 287 (2006) 157-164
22. Kaplan G., and Cohn Z.A. Cellular immunity in lepromatous and tuberculoid leprosy. Immunol. Lett. 11 (1985) 205-209
23. Kim J.-E., and White F.M. Quantitative analysis of phosphotyrosine signalling networks triggered by CD3 and CD28 costimulation in Jurkat cells. J. Immunol. 176 (2006) 2833-2843
24. Koster F.T., Scollard D.M., Umland E.T., Fishbein D.B., Hanly W.C., Brennan P.J., and Nelson K.E. Cellular and humoral immune response to a phenolic glycolipid antigen (Phen GL-1) in patients with leprosy. Clin. Microbiol. 25 (1987) 551-556
25. Li Y.Q., Hii C.S., Der C.J., and Ferrante A. Direct evidence that ERK regulates the production/secretion of interleukin-2 in PHA/PMA-stimulated T lymphocytes. Immunology 96 (1999) 524-528
26. Macain F., Garcia-cozar F., Sin-Hyeog I., Horton H.F., Byrne M.C., and Rao A. Transcriptional mechanisms underlying lymphocyte tolerance. Cell 109 (2002) 719-731
27. + T-cell activation by interfering with proximal T-cell-receptor signaling. Infect. Immun. 77 10 (2009) 4574-4583
28. 2+ signalling by Mycobacterium tuberculosis is associated with reduced phagosome-lysosome fusion and increased survival within human macrophages. J. Exp. Med. 191 (2000) 287-302
29. Matata B.A., and Galinuanes M. Peroxynitrite is an essential component of cytokines production mechanism in human monocytes through modulation of nuclear factor-κB DNA binding activity. J. Biol. Chem. 277 (2002) 2330-2335
30. McCaffrey P.G., Perrino B.A., Soderling T.R., and Rao A. NF-ATp, a T lymphocyte DNA-binding protein that is a target for calcineurin and immunosuppressive drugs. J. Biol. Chem. 268 (1993) 3747-3752
31. Mohagheghpour N., Gelber R.H., Larrick J.W., Sasaki D.T., Brennan P.J., and Engleman E.G. Defective cell-mediated immunity in leprosy: failure of T-cells from lepromatous leprosy patients to respond to Mycobacterium leprae is associated with defective expression of interleukin-2 receptors and is not reconstituted by Interleukin-2. J. Immunol. 135 (1985) 1443-1449
32. Molloy A.T., Gaudernack G., Levis W.R., Cohn Z.A., and Kaplan G. Suppression of T-cell proliferation by Mycobacterium leprae and its products: the role of lipopolysaccharide. Proc. Natl. Acad. Sci. U.S.A. 87 (1990) 973-977
33. Huse M. The T-cell signaling network. J. Cell. Sci. 122 (2009) 1269-1273
34. Nath I., and Singh R. The suppressive effect of M. leprae on the in vitro proliferation responses of lymphocytes from patients with leprosy. Clin. Exp. Immunol. 42 (1980) 203-210
35. Nigam P., Mukhija R.D., Agrawal A.K., Sati T.R., and Kapoor K.K. Serum cations (calcium and magnesium) in leprosy. Ind. J. Lepr. 57 (1985) 529-533
36. Ohkusu-Tsukada K., Tominaga N., Udono H., and Yui K. Regulation of the maintenance of peripheral T-cell anergy by TAB1-mediated p38-α activation. Mol. Cell. Biol. 24 (2004) 6957-6966
37. Paccani R.S., Tonello .F., Ghittoni R., Natale M., Muraro L., D'Elios M.M., Tang W.J., et al. Anthrax toxins suppress T lymphocyte activation by disrupting antigen receptor signalling. J. Exp. Med. 201 (2005) 325-331
38. Rooney J.W., Hodge M.R., McCaffrey P.G., Rao A., and Glimcher L.H. A common factor regulates both Th1- and Th2-specific cytokine gene expression. EMBO J. 13 (1994) 625-633
39. Schreiber E., Matthias P., Muller M.M., and Schaffner W. Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells. Nucleic Acids Res. 17 (1989) 6419-16419
40. Schwartz R.H. A cell culture model for T lymphocyte clonal anergy. Science 248 (1990) 1349-1356
41. Schwartz R.H. Models of T-cell anergy: Is there a common molecular mechanism?. J. Exp. Med. 184 (1996) 1-8
42. Sharma N., Sharma V.K., Gupta A., Kaur I., Kaur S., and Ganguly N.K. Alterations in early biochemical events following T-cell activation in leprosy patients. Clin. Immunol. Immunopathol. 88 (1998) 142-149
43. Shaw J.P., Utz P.J., Durand D.B., Toole J.J., Emmel E.A., and Crabtree G.R. Identification of a putative regulator of early T-cell activation genes. Science 241 (1988) 202-205
44. + T-cells express perturbed AP-1 and NF-kB transcription factors (superantigen/T lymphocyte/interleukin 2 gene regulation/transcription factor). Proc. Natl. Acad. Sci. U.S.A. 93 (1996) 979-984
45. Vergne I., Chua J., Singh S.B., and Deretic V. Cell biology of Mycobacterium tuberculosis phagosome. Annu. Rev. Cell Dev. Biol. 20 (2004) 367-394
46. Zea A.H., Ochoa M.T., Ghosh P., Longo D.L., Moreno L.H., and Ochoa A.C. Changes in expression of signal transduction proteins in T-lymphocytes of patients with leprosy. Infect. Immun. 66 (1998) 499-504