Immunohistochemical localization of cerebrovascular cannabinoid CB1 receptor protein

Journal of Cardiovascular Pharmacology

Volumn 44, Issue 5, 2004, Pages 517-519

  Ashton, John C ^a   Appleton, Ian ^a   Darlington, Cynthia L ^a   Smith, Paul F ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

Cannabinoid; CB1 receptor protein; Cerebrovascular; Hypotension; Vascular smooth muscle; Vasodilation

Indexed keywords

CANNABINOID 1 RECEPTOR; RECEPTOR PROTEIN;

ADVENTITIA; ANIMAL TISSUE; ARTICLE; BRAIN ARTERY; BRAIN BLOOD VESSEL; BRAIN SLICE; CELL LABELING; ELASTIC FIBER; FLUORESCENCE ANALYSIS; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; TISSUE SECTION; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE;

3,3'-DIAMINOBENZIDINE; ANIMALS; ANTIBODY SPECIFICITY; CEREBRAL ARTERIES; CHROMOGENIC COMPOUNDS; ELASTIC TISSUE; FLUORESCENT ANTIBODY TECHNIQUE; FLUORESCENT DYES; IMMUNOHISTOCHEMISTRY; MUSCLE, SMOOTH, VASCULAR; NEW ZEALAND; RATS; RATS, WISTAR; RECEPTOR, CANNABINOID, CB1; STAINING AND LABELING; TUNICA INTIMA;

EID: 7444241888     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-200411000-00001     Document Type: Article

References (17)

1. Hillard CJ. Endocannabinoids and vascular function. J Pharmacol Exp Ther. 2000;294:27-32.
2. Kunos G, Jarai Z, Batkai S, et al. Endocannabinoids as cardiovascular modulators. Chem Phys Lipids. 2000a;108:159-168.
3. Hogesttat ED, Zygmunt PM. Cardiovascular, pharmacology of anandamide. Prostaglandins Leukot Essent Fatty Acids. 2002;66:343-351.
4. Kunos G, Batkai S, Offertaler, et al. The quest for a vascular endothelial cannabinoid receptor. Chem Phys Lipids. 2002;121:45-46.
5. Kunos G, Jarai Z, Karoly V, et al. Cardiovascular effects of endocannabinoids - the plot thickens. Prostaglandins Other Lipid Mediat. 2000b;61:71-84.
6. Niederhoffer N, Schmid K, Szabo B. The peripheral sympathetic nervous system is the major target of cannabinoids in eliciting cardiovascular depression. Nauyn-Schmiedebergs Archives of Pharmacology. 2003;367:434-443.
7. 2+ channel current. Am J Physiol. 1999;276:85-93.
8. Van den Bossche I, Vanheel B. Influence of cannabinoids on the delayed rectifier in freshly dissociated smooth muscle cells of the rat aorta. B J Pharmacol. 2000;131:85-93.
9. Batkai S, Jarai Z, Wagner JA, et al. Endocannabinoids acting at vascular CBl receptors mediate the vasodilated state in advanced liver cirrhosis. Nat Med. 2001;7:827-832.
10. Harris D, McCulloch AI, Kendall DA, et al. Characterization of vasorelaxant responses to anandamide in the rat mesenteric arterial bed. J Physiol. 2002;539:893-902.
11. Randall MD, Kendall DA. Involvement of a cannabinoid in endothelium-dependent hyperpolarizing factor-mediated coronary vasorelaxation. J Pharmacol. 1997;335:205-209.
12. Fleming I, Schermer B, Popp R, et al. Inhibition of the production of endothelium-dependent hyperpolarizing factor by cannabinoid receptor agonists. Br J Pharmacol. 1999;126:949-960.
13. Liu J, Gao B, Mirshahi F, et al. Functional CB1 cannabinoid receptors in vascular endothelial cells. Biochem J. 2000;346:835-840.
14. Sugiura T, Kodaka T, Nakane S, et al. Detection of an endogenous cannabimimetic molecule 2-Arachidonoylglycerol, and cannabinoid CB1 receptor mRNA in human vascular cells: Is 2-Arachidonoylglycerol a possible vasomodulator? Biochem Biophys Res Commun. 1998;243:838-843.
15. Ashton JC, Appleton I, Darlington CL, Smith PF. Cannabinoid CB1 receptor protein expression in the rat choroid plexus: A possible involvement of cannabinoids in the regulation of cerebrospinal fluid. Neurosci Lett. 2004;364:40-42.
16. Tsou K, Brown S, Sanudo-Pena MC, et al. Immunohistochemical distribution of cannabinoid CB1 receptor in the rat central nervous system. Neuroscience. 1998;83:393-411.
17. Elphick MR, Egertova M. The neurobiology and evolution of cannabinoid signalling. Philos Trans R Soc Lond B Biol Sci. 2001;356:381-408.