Involvement of a cannabinoid in endothelium-derived hyperpolarizing factor-mediated coronary vasorelaxation

European Journal of Pharmacology

Volumn 335, Issue 2-3, 1997, Pages 205-209

  Randall, Michael D ^a   Kendall, David A ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Anandamide; Cannabinoid (endocannabinoid), endogenous; EDHF (endothelium derived hyperpolarizing factor); Endothelium; Heart, rat; SR141716A

Indexed keywords

ANANDAMIDE; BRADYKININ; CANNABINOID; CANNABINOID RECEPTOR ANTAGONIST; CLOTRIMAZOLE; ENDOTHELIUM DERIVED HYPERPOLARIZING FACTOR; N(G) NITROARGININE METHYL ESTER; POTASSIUM CHANNEL STIMULATING AGENT; RIMONABANT; TETRABUTYLAMMONIUM;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; ENDOTHELIUM; HEART; IN VITRO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; VASODILATATION;

ANIMALS; ARACHIDONIC ACIDS; BIOLOGICAL FACTORS; BRADYKININ; CALCIUM CHANNEL BLOCKERS; CANNABINOIDS; CLOTRIMAZOLE; CORONARY VESSELS; ENDOCANNABINOIDS; MALE; MUSCLE, SMOOTH, VASCULAR; PIPERIDINES; POLYUNSATURATED ALKAMIDES; POTASSIUM CHANNEL BLOCKERS; PYRAZOLES; QUATERNARY AMMONIUM COMPOUNDS; RATS; RATS, WISTAR; RECEPTORS, CANNABINOID; RECEPTORS, DRUG; VASODILATION;

EID: 0030868833     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)01237-5     Document Type: Article

References (17)

1. Bauersachs J., Hecker M., Busse R. Display of the characteristics of endothelium-derived hyperpolarising factor by a cytochrome P450-derived arachidonic metabolite in the coronary microcirculation. Br. J. Pharmacol. 113:1994;1548-1553.
2. Baydoun A.R., Woodward B. Effects of bradykinin in the rat isolated perfused heart: Role of kinin receptors and endothelium-derived relaxing factor. Br. J. Pharmacol. 103:1991;1829-1833.
3. Campbell W.B., Gebremedhim D., Pratt P.F., Harder D.R. Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors. Circ. Res. 78:1996;415-423.
4. Corriu C., Feletou M., Canet E., Vanhoutte P.M. Inhibitors of the cytochrome P450-mono-oxygenase and endothelium-dependent hyperpolarization in the guinea-pig isolated carotid artery. Br. J. Pharmacol. 117:1996;607-610.
5. Devane W.A., Hanus L., Breuer A., Pertwee R.G., Stevenson L.A., Griffin G., Gibson D., Mandelbaum A., Etinger A., Mechoulam R. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science. 258:1992;1946-1949.
6. Di Marzo V., Fontana A., Cadas H., Schinelli S., Cimino G., Schwartz J.C., Piomelli D. Formation and inactivation of endogenous cannabinoid anandamide in central neurons. Nature. 372:1994;686-691.
7. Fulton D., Mahboubi K., McGiff J.C., Quilley J. Cytochrome P450-dependent effects of bradykinin in the rat heart. Br. J. Pharmacol. 114:1995;99-102.
8. Hecker M., Bara A.T., Bauersachs J., Busse R. Characterisation of endothelium-derived hyperpolarising factor as a cytochrome P450-derived arachidonic acid metabolite in mammals. J. Physiol. 481:1994;407-414.
9. McCulloch A.I., Bottrill F.E., Randall M.D., Hiley C.R. Characterisation and modulation of EDHF-mediated relaxations in the rat isolated superior mesenteric arterial bed. Br. J. Pharmacol. 120:1997;1431-1438.
10. Pinto A., Abrahams N.G., Mullane K.M. Arachidonic acid-induced endothelial-dependent relaxation of canine coronary arteries: Contribution of a cytochrome P450 dependent pathway. J. Pharmacol. Exp. Ther. 240:1987;856-863.
11. Plane, F., Holland, M., Waldron, G.J., Garland, C.J., Boyle, J.P., 1997. Evidence that anandamide and EDHF act via different mechanisms in rat isolated mesenteric arteries. Br. J. Pharmacol., in press.
12. Randall M.D., Alexander S.P.H., Bennett T., Boyd E.A., Fry J.R., Gardiner S.M., Kemp P.A., McCulloch A.I., Kendall D.A. An endogenous cannabinoid as an endothelium-derived vasorelaxant. Biochem. Biophys. Res. Commun. 229:1996;114-120.
13. Randall M.D., Gardiner S.M., Bennett T. Enhanced cardiac preconditioning in the isolated heart of the ((mREN-2)27) transgenic hypertensive rat. Cardiovasc. Res. 33:1997;400-409.
14. Randall, M.D., McCulloch, A.I., Kendall, D.A., 1997b. Comparative pharmacology of endothelium-derived hyperpolarizing factor and anandamide in rat isolated mesentery. Eur. J. Pharmacol., in press.
15. Rinaldi-Carmona M., Barth F., Héauleme M., Shire D., Calandra B., Congy C., Martinez S., Maruani J., Néliat G., Caput D., Ferrara P., Soubrié P., Breliere J.C., Le Fur G. SR 141716A, a potent and selective antagonist of the brain cannabinoid receptor. FEBS Lett. 350:1994;240-244.
16. Singer H.A., Saye J.A., Peach M.J. Effects of cytochrome P450 inhibitors on endothelium-dependent relaxation in rabbit aorta. Blood Vessels. 21:1984;223-230.
17. Zygmunt P.M., Edwards G., Weston A.H., Davies S.C., Högestätt E.D. Effects of cytochrome P450 inhibitors on EDHF-mediated relaxation in the rat hepatic artery. Br. J. Pharmacol. 118:1996;1147-1152.