Clinical assessment of effects of botanical supplementation on cytochrome P450 phenotypes in the elderly: St John's Wort, garlic oil, Panax ginseng and Ginkgo biloba

Drugs and Aging

Volumn 22, Issue 6, 2005, Pages 525-539

  Gurley, Bill J ^a   Gardner, Stephanie F ^a   Hubbard, Martha A ^a   Keith Williams, D ^b   Brooks Gentry, W ^b   Cui, Yanyan ^c   Ang, Catharina Y W ^c  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^c NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 HYDROXYCHLORZOXAZONE; ALPHA HYDROXYMIDAZOLAM; CAFFEINE; CHLORZOXAZONE; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; DEBRISOQUINE; GARLIC OIL; GINKGO BILOBA EXTRACT; GINSENG EXTRACT; HYPERICUM PERFORATUM EXTRACT; MIDAZOLAM; PARAXANTHINE;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FOOD DRUG INTERACTION; GINKGO BILOBA; GINSENG; HERB; HUMAN; HUMAN EXPERIMENT; HYPERICUM PERFORATUM; METABOLISM; NORMAL HUMAN; PHENOTYPE; PHYTOCHEMISTRY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STATISTICAL SIGNIFICANCE; SUPPLEMENTATION;

ADMINISTRATION, ORAL; AGED; ALLYL COMPOUNDS; CAFFEINE; CHLORZOXAZONE; CYTOCHROME P-450 ENZYME SYSTEM; DIETARY SUPPLEMENTS; DRUG ADMINISTRATION SCHEDULE; FEMALE; GINKGO BILOBA; HERB-DRUG INTERACTIONS; HUMANS; HYPERICUM; ISOENZYMES; MALE; MIDAZOLAM; PANAX; PHENOTYPE; PLANT PREPARATIONS; SULFIDES;

EID: 22344453862     PISSN: 1170229X     EISSN: None     Source Type: Journal    
DOI: 10.2165/00002512-200522060-00006     Document Type: Article

References (62)

1. Eisenberg DM, Davis RB, Ettner SL, et al. Trends in alternative medicine use in the United States, 1990-1997: results of a follow-up national survey. JAMA 1998; 280: 1569-75
2. Klepser TB, Doucette WR, Horton MR, et al. Assessment of patient's perceptions and beliefs regarding herbal therapies. Pharmacotherapy 2000; 20: 83-7
3. Kaufman DW, Kelly JP, Rosenberg L, et al. Recent patterns of medication use in the ambulatory adult population of the United States. JAMA 2002; 287: 337-44
4. Izzo AA, Ernst E. Interactions between herbal medicines and prescribed drugs: a systematic review. Drugs 2001; 61: 2163-75
5. Ang-Lee MK, Moss J, Yuan C. Herbal medicines and perioperative care. JAMA 2001; 286: 208-16
6. Brazier NC, Levine MAH. Drug-herb interaction among commonly used conventional medicines: a compendium for health care professionals. Am J Ther 2003; 10: 163-9
7. Gurley BJ, Hagan DW. Herbal and dietary supplement interactions with drugs. In: McCabe BJ, Frankel EH, Wolfe JJ, editors. Handbook of food-drug interactions. Boca Raton: CRC Press, 2003: 259-293
8. Nelson L, Perrone J. Herbal and alternative medicine. Emerg Med Clin North Am 2000; 18: 709-22
9. Gunther S, Patterson RE, Kristal AR, et al. Demographic and health-related correlates of herbal and specialty supplement use. J Am Diet Assoc 2004; 104: 27-34
10. Skinner CM, Rangasami J. Preoperative use of herbal medicines: a patient survey. Br J Anaesth 2002; 89: 792-5
11. Rhee SM, Garg VK, Hershey CO. Use of complementary and alternative medicines by ambulatory patients. Arch Intern Med 2004; 164: 1004-9
12. Adusumilli PS, Ben-Porat L, Pereira M, et al. The prevalence and predictors of herbal medicine use in surgical patients. J Am Coll Surg 2004; 198: 583-90
13. Foster DF, Phillips RS, Hamel B. Alternative medicine use in older Americans. J Am Geriatr Soc 2000; 48: 1560-5
14. Cohen RJ, Ek K, Pan CX. Complementary and alternative medicine (CAM) use by older adults: a comparison of self report and physician chart documentation. J Gerontol 2002; 57A: M223-7
15. Dergal JM, Gold JL, Laxer DA, et al. Potential interactions between herbal medicines and conventional drug therapies used by older adults attending a memory clinic. Drugs Aging 2002; 19: 879-86
16. Wang Z, Gorski JC, Hamman MA, et al. The effects of St John's wort (Hypericum perforatum) on human cytochrome P450 activity. Clin Pharmacol Ther 2001; 70: 317-26
17. Gurley BJ, Gardner SF, Hubbard MA, et al. Cytochrome P450 phenotypic ratios for predicting herb-drug interactions in humans. Clin Pharmacol Ther 2002; 72: 276-82
18. Markowitz JS, Donovan JL, DeVane CL, et al. Multiple-dose administration of Ginkgo biloba did not affect cytochrome P-450 2D6 or 3A4 activity in normal volunteers. J Clin Psychopharmacol 2003; 23: 576-81
19. Markowitz JS, DeVane CL, Chavin KD, et al. Effects of garlic (Allium sativum L.) supplementation on cytochrome P450 2D6 and 3A4 activity in healthy volunteers. Clin Pharmacol Ther 2003; 74: 170-7
20. Anderson GD, Rosito G, Mohustsy MA, et al. Drug interaction potential of soy extract and Panax ginseng. J Clin Pharmacol 2003; 43: 643-8
21. Gorski JC, Huang S-M, Pinto A, et al. The effect of Echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo. Clin Pharmacol Ther 2004; 75: 89-100
22. Wentworth JM, Agostini M, Love J, et al. St John's wort, a herbal antidepressant, activates the steroid X receptor. J Endocrinol 2000; 166: R11-6
23. Moore LB, Goodwin B, Jones SA, et al. St John's wort induces hepatic drug metabolism through activation of the pregnane X receptor. Proc Natl Acad Sci U S A 2000; 97: 7500-2
24. Piscitelli SC, Burstein AH, Welden N, et al. The effect of garlic supplements on the pharmacokinetics of saquinavir. Clin Infect Dis 2002; 34: 234-8
25. Gold PE, Cahill L, Wenk GL. The lowdown on Ginkgo biloba. Sci Am 2003 Apr; 288 (4): 86-91
26. Kales HC, Blow FC, Welsh DE, et al. Herbal products and other supplements: use by elderly veterans with depression and dementia and their caregivers. J Geriatr Psychiatry Neurol 2004; 17: 25-31
27. Anderson GD, Rosito G, Mohustsy MA, et al. Drug interaction potential of soy extract and Panax ginseng. J Clin Pharmacol 2003; 43: 643-8
28. Kinirons MT, Crome P. Clinic pharmacokinetic considerations in the elderly. Clin Pharmacokinet 1997; 33: 302-12
29. Tanaka E. In vivo age-related changes in hepatic drug-oxidizing capacity in humans. J Clin Pharm Ther 1998; 23: 247-55
30. McLean AJ, Le Couteur DG. Aging biology and geriatric clinical pharmacology. Pharmacol Rev 2004; 56: 163-84
31. Fuhr U, Rost KL. Simple and reliable CYP1A2 phenotyping by the paraxanthine/caffeine ratio in plasma and in saliva. Pharmacogenetics 1994; 4: 109-16
32. Frye RF, Matzke GR, Adedoyin A, et al. Validation of the five-drug 'Pittsburgh cocktail' approach for assessment of selective regulation of drug-metabolizing enzymes. Clin Pharmacol Ther 1997; 62: 365-76
33. Streetman DS, Bertino JS, Nafziger AN. Phenotyping of drug metabolizing enzymes in adults: a review of in vivo cytochrome P450 phenotyping probes. Pharmacogenetics 2000; 10: 187-216
34. Gurley BJ, Gardner SF, Hubbard MA, et al. In vivo assessment of botanical supplementation on human cytochrome P450 phenotypes: Citrus aurantium, Echinacea purpurea, milk thistle, and saw palmetto. Clin Pharmacol Ther 2004; 76: 428-40
35. Palmer JL, Scott RJ, Gibson A, et al. An interaction between cytochrome P450 probe substrates chlorzoxazone (CYP2E1) and midazolam (CYP3A). Br J Clin Pharmacol 2001; 52: 555-61
36. Holland DT, Godfredsen KA, Page T, et al. Simple high performance liquid chromatography method for the simultaneous determination of serum caffeine and paraxanthine following rapid sample preparation. J Chromatogr B Biomed Sci Appl 1998; 707: 105-10
37. Frye RF, Stiff DD. Determination of chlorzoxazone and 6-hydroxychlorzoxazone in human plasma and urine by high-performance liquid chromatography. J Chromatogr B Biomed Appl 1996; 686: 291-6
38. Frye RF, Branch RA. Improved high-performance liquid chromatographic determination of debrisoquine and 4-hydroxydebrisoquin in human urine following direct injection. J Chromatogr B Biomed Appl 1996; 677: 178-82
39. Sautou V, Chopineau J, Terrisse MP, et al. Solid-phase extraction of midazolam and two of its metabolites from plasma for high performance liquid chromatographic analysis. J Chromatogr 1991; 571: 298-304
40. Liu FF, Ang CYW, Heinze TM, et al. Evaluation of major active components in St. John's wort dietary supplements by high-performance liquid chromatography with photodiode array detection and electrospray mass spectrometric confirmation. J Chromatogr A 2000; 888: 85-92
41. Cui Y, Gurley B, Ang CYW, et al. Determination of hyperforin in human plasma using solid-phase extraction and high-performance liquid chromatography with ultraviolet detection. J Chromatogr B Analyt Technol Biomed Life Sci 2002; 780: 129-35
42. Lawson L, Wang Z, Hughes BG. Identification and HPLC quantitation of the sulfides and dialk(en)yl thiosulfinates in commercial garlic products. Planta Med 1991; 57: 363-70
43. Li W, Fitzloff JF. Simultaneous determination of terpene lactones and flavonoid aglycones in Ginkgo biloba by high-performance liquid chromatography with evaporative light scattering detection. J Pharm Biomed Anal 2002; 30: 67-75
44. Zhu B, Ou-Yang DS, Cheng Z, et al. Single plasma sampling to predict oral clearance of CYP3A probe midazolam. Acta Pharmacol Sin 2001; 22: 634-8
45. Cohen J. Statistical power analysis for the behavioral sciences. 2nd ed. Mahwah (NJ): Lawrence Erlbaum Associates Publishers, 1988: 19-42
46. Gurley BJ, Gardner SF, Hubbard MA, et al. In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4 phenotypes. Clin Pharmacol Ther 2005. In press
47. De Los Reyes GC, Koda RT. Determining hyperforin and hypericin content in eight brands of St. John's wort. Am J Health Syst Pharm 2002; 59: 545-7
48. Ganzera M, Zhao J, Khan IA. Hypericum perforatum: chemical profiling and quantitative results of St John's wort products by an improved high-performance liquid chromatography method. J Pharm Sci 2002; 91: 623-30
49. Wurglics M, Westerhoff K, Kaunzinger A, et al. Batch-to-batch reproducibility of St John's wort preparations. Pharmacopsychiatry 2001; 34 Suppl. 1: S152-6
50. Hunt CM, Strater S, Stave GM. Effect of normal aging on the activity of human hepatic cytochrome P450IIE1. Biochem Pharmacol 1990; 40: 1666-9
51. Nakajima T, Wang RS. Induction of cytochrome P450 by toluene. Int J Biochem 1994; 26: 1333-40
52. Koop DR, Tierney DJ. Multiple mechanisms in the regulation of ethanol-inducible cytochrome P450IIE1. Bioessays 1990; 12: 429-35
53. Chien JY, Thummel KE, Slattery JT. Pharmacokinetic consequences of induction of CYP2E1 by ligand stabilization. Drug Metab Dispos 1997; 25: 1165-75
54. Kenna JG, Jones RM. The organ toxicity of inhaled anesthetics. Anesth Analg 1995; 81: S51-66
55. Loizou GD, Crocker J. The effects of alcohol and diallyl sulphide on CYP2E1 activity in humans: a phenotyping study using chlorzoxazone. Hum Exp Toxicol 2001; 20: 321-7
56. Haber D, Siess M, Canivenc-Lavier M, et al. Differential effects of dietary diallyl sulfide and diallyl disulfide on rat intestinal and hepatic drug-metabolizing enzymes. J Toxicol Environ Health 1995; 44: 423-34
57. Siess M, Le Bon A, Canivenc-Lavier M, et al. Modification of hepatic drug-metabolizing enzymes in rats treated with alkyl sulfides. Cancer Lett 1997; 120: 195-201
58. Yang CS, Chhabra SK, Hong J, et al. Mechanisms of inhibition of chemical toxicity and carcinogenesis by diallyl sulfide (DAS) and related compounds from garlic. J Nutr 2001; 131: 1041S-5S
59. Chung KF, Dent G, McCuster M, et al. Effect of ginkgolide mixture (BN 52063) in antagonizing skin and platelet responses to platelet activating factor in man. Lancet 1987; I: 248-51
60. Duche JC, Barre J, Guinot P, et al. Effect of Ginkgo biloba extract on microsomal enzyme induction. Int J Clin Pharm Res 1989; 9: 165-8
61. Janetzky K, Morreale AP. Probable interaction between warfarin and ginseng. Am J Health Syst Pharm 1997; 54: 692-3
62. Yuan C-S, Wei G, Dey L, et al. American ginseng reduces warfarin's effect in healthy patients: a randomized controlled trial. Ann Intern Med 2004; 141: 23-7