메뉴 건너뛰기




Volumn 425, Issue 3, 2010, Pages 575-583

Androgen regulation of the prostatic tumour suppressor NKX3.1 is mediated by its 3′ untranslated region

Author keywords

3 untranslated region (3 UTR); Androgen receptor; Gene regulation; NKX3.1; Prostate cancer

Indexed keywords

ANDROGEN RECEPTORS; BICALUTAMIDE; BIOINFORMATIC ANALYSIS; CHROMATIN IMMUNOPRECIPITATION; DELETION ANALYSIS; DIHYDROTESTOSTERONE; DNA-BINDING DOMAIN; ELECTROPHORETIC MOBILITY SHIFT ASSAY; HOMEODOMAIN TRANSCRIPTION FACTOR; PROSTATE CANCER CELLS; PROSTATE CANCERS; REGULATORY MECHANISM; REPORTER ASSAY; RESPONSE ELEMENTS; SITE DIRECTED MUTAGENESIS; TRANSCRIPTION START SITE; TUMOUR SUPPRESSOR; TUMOURS; UNTRANSLATED REGIONS;

EID: 74349113090     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20091109     Document Type: Article
Times cited : (23)

References (51)
  • 3
    • 0035740251 scopus 로고    scopus 로고
    • Contribution of the androgen receptor to prostate cancer predisposition and progression
    • Buchanan, G., Irvine, R. A., Coetzee, G. A. and Tilley, W. D. (2001) Contribution of the androgen receptor to prostate cancer predisposition and progression. Cancer Metastasis Rev. 20, 207-223
    • (2001) Cancer Metastasis Rev , vol.20 , pp. 207-223
    • Buchanan, G.1    Irvine, R.A.2    Coetzee, G.A.3    Tilley, W.D.4
  • 4
    • 0024205612 scopus 로고
    • The human androgen receptor: Complementary deoxyribonucleic acid cloning, sequence analysis and gene expression in prostate
    • Lubahn, D. B., Joseph, D. R., Sar, M., Tan, J., Higgs, H. N., Larson, R. E., French, F. S. and Wilson, E. M. (1988) The human androgen receptor: complementary deoxyribonucleic acid cloning, sequence analysis and gene expression in prostate. Mol. Endocrinol. 2, 1265-1275
    • (1988) Mol. Endocrinol , vol.2 , pp. 1265-1275
    • Lubahn, D.B.1    Joseph, D.R.2    Sar, M.3    Tan, J.4    Higgs, H.N.5    Larson, R.E.6    French, F.S.7    Wilson, E.M.8
  • 5
    • 0037340162 scopus 로고    scopus 로고
    • Selective DNA recognition by the androgen receptor as a mechanism for hormone-specific regulation of gene expression
    • Verrijdt, G., Haelens, A. and Claessens, F. (2003) Selective DNA recognition by the androgen receptor as a mechanism for hormone-specific regulation of gene expression. Mol. Genet. Metab. 78, 175-185
    • (2003) Mol. Genet. Metab , vol.78 , pp. 175-185
    • Verrijdt, G.1    Haelens, A.2    Claessens, F.3
  • 6
    • 0027056581 scopus 로고
    • A consensus DNA-binding site for the androgen receptor
    • Roche, P. J., Hoare, S. A. and Parker, M. G. (1992) A consensus DNA-binding site for the androgen receptor. Mol. Endocrinol. 6, 2229-2235
    • (1992) Mol. Endocrinol , vol.6 , pp. 2229-2235
    • Roche, P.J.1    Hoare, S.A.2    Parker, M.G.3
  • 7
    • 2342558431 scopus 로고    scopus 로고
    • Androgen receptor in prostate cancer
    • Heinlein, C. A. and Chang, C. (2004) Androgen receptor in prostate cancer. Endocr. Rev. 25, 276-308
    • (2004) Endocr. Rev , vol.25 , pp. 276-308
    • Heinlein, C.A.1    Chang, C.2
  • 9
    • 0034234783 scopus 로고    scopus 로고
    • Targeted disruption of the Nkx3.1 gene in mice results in morphogenetic defects of minor salivary glands: Parallels to glandular duct morphogenesis in prostate
    • Schneider, A., Brand, T., Zweigerdt, R. and Arnold, H. (2000) Targeted disruption of the Nkx3.1 gene in mice results in morphogenetic defects of minor salivary glands: parallels to glandular duct morphogenesis in prostate. Mech. Dev. 95, 163-174
    • (2000) Mech. Dev , vol.95 , pp. 163-174
    • Schneider, A.1    Brand, T.2    Zweigerdt, R.3    Arnold, H.4
  • 10
    • 0029768633 scopus 로고    scopus 로고
    • Prostate-specific and androgen-dependent expression of a novel homeobox gene
    • Bieberich, C. J., Fujita, K., He, W. W. and Jay, G. (1996) Prostate-specific and androgen-dependent expression of a novel homeobox gene. J. Biol. Chem. 271, 31779-31782
    • (1996) J. Biol. Chem , vol.271 , pp. 31779-31782
    • Bieberich, C.J.1    Fujita, K.2    He, W.W.3    Jay, G.4
  • 11
    • 0031194107 scopus 로고    scopus 로고
    • A novel human prostate-specific, androgen-regulated homeobox gene (NKX3.1) that maps to 8p21, a region frequently deleted in prostate cancer
    • He, W. W., Sciavolino, P. J., Wing, J., Augustus, M., Hudson, P., Meissner, P. S., Curtis, R. T., Shell, B. K., Bostwick, D. G., Tindall, D. J. et al. (1997) A novel human prostate-specific, androgen-regulated homeobox gene (NKX3.1) that maps to 8p21, a region frequently deleted in prostate cancer. Genomics 43, 69-77
    • (1997) Genomics , vol.43 , pp. 69-77
    • He, W.W.1    Sciavolino, P.J.2    Wing, J.3    Augustus, M.4    Hudson, P.5    Meissner, P.S.6    Curtis, R.T.7    Shell, B.K.8    Bostwick, D.G.9    Tindall, D.J.10
  • 12
    • 0031919917 scopus 로고    scopus 로고
    • Isolation and androgen regulation of the human homeobox cDNA, NKX3.1
    • Prescott, J. L., Blok, L. and Tindall, D. J. (1998) Isolation and androgen regulation of the human homeobox cDNA, NKX3.1. Prostate 35, 71-80
    • (1998) Prostate , vol.35 , pp. 71-80
    • Prescott, J.L.1    Blok, L.2    Tindall, D.J.3
  • 18
    • 13944249886 scopus 로고    scopus 로고
    • Deletion, methylation, and expression of the NKX3.1 suppressor gene in primary human prostate cancer
    • Asatiani, E., Huang, W. X., Wang, A., Rodriguez Ortner, E., Cavalli, L. R., Haddad, B. R. and Gelmann, E. P. (2005) Deletion, methylation, and expression of the NKX3.1 suppressor gene in primary human prostate cancer. Cancer Res. 65, 1164-1173
    • (2005) Cancer Res , vol.65 , pp. 1164-1173
    • Asatiani, E.1    Huang, W.X.2    Wang, A.3    Rodriguez Ortner, E.4    Cavalli, L.R.5    Haddad, B.R.6    Gelmann, E.P.7
  • 19
    • 31144453084 scopus 로고    scopus 로고
    • Analysis of NKX3.1 expression in prostate cancer tissues and correlation with clinicopathologic features
    • Aslan, G., Irer, B., Tuna, B., Yorukoglu, K., Saatcioglu, F. and Celebi, I. (2006) Analysis of NKX3.1 expression in prostate cancer tissues and correlation with clinicopathologic features. Pathol. Res. Pract. 202, 93-98
    • (2006) Pathol. Res. Pract , vol.202 , pp. 93-98
    • Aslan, G.1    Irer, B.2    Tuna, B.3    Yorukoglu, K.4    Saatcioglu, F.5    Celebi, I.6
  • 20
    • 0035091517 scopus 로고    scopus 로고
    • Expression studies and mutational analysis of the androgen regulated homeobox gene NKX3.1 in benign and malignant prostate epithelium
    • Ornstein, D. K., Cinquanta, M., Weiler, S., Duray, P. H., Emmert-Buck, M. R., Vocke, C. D., Linehan, W. M. and Ferretti, J. A. (2001) Expression studies and mutational analysis of the androgen regulated homeobox gene NKX3.1 in benign and malignant prostate epithelium. J. Urol. 165, 1329-1334
    • (2001) J. Urol , vol.165 , pp. 1329-1334
    • Ornstein, D.K.1    Cinquanta, M.2    Weiler, S.3    Duray, P.H.4    Emmert-Buck, M.R.5    Vocke, C.D.6    Linehan, W.M.7    Ferretti, J.A.8
  • 21
    • 0030822020 scopus 로고    scopus 로고
    • Coding region of NKX3.1, a prostate-specific homeobox gene on 8p21, is not mutated in human prostate cancers
    • Voeller, H. J., Augustus, M., Madike, V., Bova, G. S., Carter, K. C. and Gelmann, E. P. (1997) Coding region of NKX3.1, a prostate-specific homeobox gene on 8p21, is not mutated in human prostate cancers. Cancer Res. 57, 4455-4459
    • (1997) Cancer Res , vol.57 , pp. 4455-4459
    • Voeller, H.J.1    Augustus, M.2    Madike, V.3    Bova, G.S.4    Carter, K.C.5    Gelmann, E.P.6
  • 24
    • 33646342738 scopus 로고    scopus 로고
    • NKX3.1 stabilizes p53, inhibits AKT activation, and blocks prostate cancer initiation caused by PTEN loss
    • Lei, Q., Jiao, J., Xin, L., Chang, C. J., Wang, S., Gao, J., Gleave, M. E., Witte, O. N., Liu, X. and Wu, H. (2006) NKX3.1 stabilizes p53, inhibits AKT activation, and blocks prostate cancer initiation caused by PTEN loss. Cancer Cell 9, 367-378
    • (2006) Cancer Cell , vol.9 , pp. 367-378
    • Lei, Q.1    Jiao, J.2    Xin, L.3    Chang, C.J.4    Wang, S.5    Gao, J.6    Gleave, M.E.7    Witte, O.N.8    Liu, X.9    Wu, H.10
  • 25
    • 33748371876 scopus 로고    scopus 로고
    • Identification of an inhibitory cis-element in the promoter region of human homeobox gene NKX3.1
    • Anli, J., Pengju, Z., Xiaoyan, H., Wenwei, C., Zhifang, L., Feng, K., Huiqing, Y. and Jianye, Z. (2006) Identification of an inhibitory cis-element in the promoter region of human homeobox gene NKX3.1. Prostate. 66, 1339-1346
    • (2006) Prostate , vol.66 , pp. 1339-1346
    • Anli, J.1    Pengju, Z.2    Xiaoyan, H.3    Wenwei, C.4    Zhifang, L.5    Feng, K.6    Huiqing, Y.7    Jianye, Z.8
  • 28
    • 33746875609 scopus 로고    scopus 로고
    • Effects of 9-cis retinoic acid on human homeobox gene NKX3.1 expression in prostate cancer cell line LNCaP
    • Jiang, A. L., Zhang, P. J., Chen, W. W., Liu, W. W., Yu, C. X., Hu, X. Y., Zhang, X. Q. and Zhang, J. Y. (2006) Effects of 9-cis retinoic acid on human homeobox gene NKX3.1 expression in prostate cancer cell line LNCaP. Asian J. Androl. 8, 435-441
    • (2006) Asian J. Androl , vol.8 , pp. 435-441
    • Jiang, A.L.1    Zhang, P.J.2    Chen, W.W.3    Liu, W.W.4    Yu, C.X.5    Hu, X.Y.6    Zhang, X.Q.7    Zhang, J.Y.8
  • 29
    • 33751190311 scopus 로고    scopus 로고
    • Transcriptional regulation of the homeobox gene NKX3.1 by all-trans retinoic acid in prostate cancer cells
    • Thomas, M. A., Hodgson, M. C., Loermans, S. D., Hooper, J., Endersby, R. and Bentel, J. M. (2006) Transcriptional regulation of the homeobox gene NKX3.1 by all-trans retinoic acid in prostate cancer cells. J. Cell. Biochem. 99, 1409-1419
    • (2006) J. Cell. Biochem , vol.99 , pp. 1409-1419
    • Thomas, M.A.1    Hodgson, M.C.2    Loermans, S.D.3    Hooper, J.4    Endersby, R.5    Bentel, J.M.6
  • 31
    • 33748935383 scopus 로고    scopus 로고
    • Multiple androgen response elements cooperate in androgen regulated activity of the type 1 neutral endopeptidase promoter
    • Zheng, R., Shen, R., Goodman, Jr, O. B. and Nanus, D. M. (2006) Multiple androgen response elements cooperate in androgen regulated activity of the type 1 neutral endopeptidase promoter. Mol. Cell. Endocrinol. 259, 10-21
    • (2006) Mol. Cell. Endocrinol , vol.259 , pp. 10-21
    • Zheng, R.1    Shen, R.2    Goodman Jr, O.B.3    Nanus, D.M.4
  • 32
    • 6944239803 scopus 로고    scopus 로고
    • Identification of a functional peroxisome proliferator activated receptor response element in the 3′ untranslated region of the human bcl-2 gene
    • Butts, B. D., Tran, N. L. and Briehl, M. M. (2004) Identification of a functional peroxisome proliferator activated receptor response element in the 3′ untranslated region of the human bcl-2 gene. Int. J. Oncol. 24, 1305-1310
    • (2004) Int. J. Oncol , vol.24 , pp. 1305-1310
    • Butts, B.D.1    Tran, N.L.2    Briehl, M.M.3
  • 33
    • 0034086611 scopus 로고    scopus 로고
    • Identification of functional estrogen response elements in the gene coding for the potent angiogenic factor vascular endothelial growth factor
    • Hyder, S. M., Nawaz, Z., Chiappetta, C. and Stancel, G. M. (2000) Identification of functional estrogen response elements in the gene coding for the potent angiogenic factor vascular endothelial growth factor. Cancer Res. 60, 3183-3190
    • (2000) Cancer Res , vol.60 , pp. 3183-3190
    • Hyder, S.M.1    Nawaz, Z.2    Chiappetta, C.3    Stancel, G.M.4
  • 34
    • 0028889752 scopus 로고
    • Novel location and function of a thyroid hormone response element
    • Bigler, J. and Eisenman, R. N. (1995) Novel location and function of a thyroid hormone response element. EMBO J. 14, 5710-5723
    • (1995) EMBO J , vol.14 , pp. 5710-5723
    • Bigler, J.1    Eisenman, R.N.2
  • 35
    • 0024323295 scopus 로고
    • A general method of site-specific mutagenesis using a modification of the Thermus aquaticus polymerase chain reaction
    • Nelson, R. M. and Long, G. L. (1989) A general method of site-specific mutagenesis using a modification of the Thermus aquaticus polymerase chain reaction. Anal. Biochem. 180, 147-151
    • (1989) Anal. Biochem , vol.180 , pp. 147-151
    • Nelson, R.M.1    Long, G.L.2
  • 36
    • 0024380087 scopus 로고
    • Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells
    • Schreiber, E., Matthias, P., Muller, M. M. and Schaffner, W. (1989) Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells. Nucleic Acids Res. 17, 6419
    • (1989) Nucleic Acids Res , vol.17 , pp. 6419
    • Schreiber, E.1    Matthias, P.2    Muller, M.M.3    Schaffner, W.4
  • 37
    • 0034802618 scopus 로고    scopus 로고
    • Use of chromatin immunoprecipitation to clone novel E2F target promoters
    • Weinmann, A. S., Bartley, S. M., Zhang, T., Zhang, M. Q. and Farnham, P. J. (2001) Use of chromatin immunoprecipitation to clone novel E2F target promoters. Mol. Cell. Biol. 21, 6820-6832
    • (2001) Mol. Cell. Biol , vol.21 , pp. 6820-6832
    • Weinmann, A.S.1    Bartley, S.M.2    Zhang, T.3    Zhang, M.Q.4    Farnham, P.J.5
  • 38
    • 0031017102 scopus 로고    scopus 로고
    • An androgen response element in a far upstream enhancer region is essential for high, androgen-regulated activity of the prostate-specific antigen promoter
    • Cleutjens, K. B., van der Korput, H. A., van Eekelen, C. C., van Rooij, H. C., Faber, P. W. and Trapman, J. (1997) An androgen response element in a far upstream enhancer region is essential for high, androgen-regulated activity of the prostate-specific antigen promoter. Mol. Endocrinol. 11, 148-161
    • (1997) Mol. Endocrinol , vol.11 , pp. 148-161
    • Cleutjens, K.B.1    van der Korput, H.A.2    van Eekelen, C.C.3    van Rooij, H.C.4    Faber, P.W.5    Trapman, J.6
  • 41
    • 0029865240 scopus 로고    scopus 로고
    • Two androgen response regions cooperate in steroid hormone regulated activity of the prostate-specific antigen promoter
    • Cleutjens, K. B., van Eekelen, C. C., van der Korput, H. A., Brinkmann, A. O. and Trapman, J. (1996) Two androgen response regions cooperate in steroid hormone regulated activity of the prostate-specific antigen promoter. J. Biol. Chem. 271, 6379-6388
    • (1996) J. Biol. Chem , vol.271 , pp. 6379-6388
    • Cleutjens, K.B.1    van Eekelen, C.C.2    van der Korput, H.A.3    Brinkmann, A.O.4    Trapman, J.5
  • 43
    • 34250860909 scopus 로고    scopus 로고
    • Identification of androgen response elements in the insulin-like growth factor I upstream promoter
    • Wu, Y., Zhao, W., Zhao, J., Pan, J., Wu, Q., Zhang, Y., Bauman, W. A. and Cardozo, C. P. (2007) Identification of androgen response elements in the insulin-like growth factor I upstream promoter. Endocrinology 148, 2984-2993
    • (2007) Endocrinology , vol.148 , pp. 2984-2993
    • Wu, Y.1    Zhao, W.2    Zhao, J.3    Pan, J.4    Wu, Q.5    Zhang, Y.6    Bauman, W.A.7    Cardozo, C.P.8
  • 44
    • 0035132653 scopus 로고    scopus 로고
    • Molecular analysis of the prostate-specific antigen upstream gene enhancer
    • Farmer, G., Connolly, Jr, E. S., Mocco, J. and Freedman, L. P. (2001) Molecular analysis of the prostate-specific antigen upstream gene enhancer. Prostate 46, 76-85
    • (2001) Prostate , vol.46 , pp. 76-85
    • Farmer, G.1    Connolly Jr, E.S.2    Mocco, J.3    Freedman, L.P.4
  • 45
    • 0033306830 scopus 로고    scopus 로고
    • Identification of the deoxyribonucleic acid-binding site of a regulatory protein involved in prostatespecific and androgen receptor-dependent gene expression
    • Patrikainen, L., Shan, J., Porvari, K. and Vihko, P. (1999) Identification of the deoxyribonucleic acid-binding site of a regulatory protein involved in prostatespecific and androgen receptor-dependent gene expression. Endocrinology 140, 2063-2070
    • (1999) Endocrinology , vol.140 , pp. 2063-2070
    • Patrikainen, L.1    Shan, J.2    Porvari, K.3    Vihko, P.4
  • 46
    • 35548958147 scopus 로고    scopus 로고
    • New androgen receptor genomic targets show an interaction with the ETS1 transcription factor
    • Massie, C. E., Adryan, B., Barbosa-Morais, N. L., Lynch, A. G., Tran, M. G., Neal, D. E. and Mills, I. G. (2007) New androgen receptor genomic targets show an interaction with the ETS1 transcription factor. EMBO Rep. 8, 871-878
    • (2007) EMBO Rep , vol.8 , pp. 871-878
    • Massie, C.E.1    Adryan, B.2    Barbosa-Morais, N.L.3    Lynch, A.G.4    Tran, M.G.5    Neal, D.E.6    Mills, I.G.7
  • 47
  • 48
    • 0042266417 scopus 로고    scopus 로고
    • The role of hepatocyte nuclear factor-3α (Forkhead Box A1) and androgen receptor in transcriptional regulation of prostatic genes
    • Gao, N., Zhang, J., Rao, M. A., Case, T. C., Mirosevich, J., Wang, Y., Jin, R., Gupta, A., Rennie, P. S. and Matusik, R. J. (2003) The role of hepatocyte nuclear factor-3α (Forkhead Box A1) and androgen receptor in transcriptional regulation of prostatic genes. Mol. Endocrinol. 17, 1484-1507
    • (2003) Mol. Endocrinol , vol.17 , pp. 1484-1507
    • Gao, N.1    Zhang, J.2    Rao, M.A.3    Case, T.C.4    Mirosevich, J.5    Wang, Y.6    Jin, R.7    Gupta, A.8    Rennie, P.S.9    Matusik, R.J.10
  • 50
    • 32244431931 scopus 로고    scopus 로고
    • Foxa1 and Foxa2 interact with the androgen receptor to regulate prostate and epididymal genes differentially
    • Yu, X., Gupta, A., Wang, Y., Suzuki, K., Mirosevich, J., Orgebin-Crist, M. C. and Matusik, R. J. (2005) Foxa1 and Foxa2 interact with the androgen receptor to regulate prostate and epididymal genes differentially. Ann. N.Y. Acad. Sci. 1061, 77-93
    • (2005) Ann. N.Y. Acad. Sci , vol.1061 , pp. 77-93
    • Yu, X.1    Gupta, A.2    Wang, Y.3    Suzuki, K.4    Mirosevich, J.5    Orgebin-Crist, M.C.6    Matusik, R.J.7
  • 51
    • 33846603663 scopus 로고    scopus 로고
    • Androgen receptor coregulators and their involvement in the development and progression of prostate cancer
    • Chmelar, R., Buchanan, G., Need, E. F., Tilley, W. and Greenberg, N. M. (2007) Androgen receptor coregulators and their involvement in the development and progression of prostate cancer. Int. J. Cancer 120, 719-733
    • (2007) Int. J. Cancer , vol.120 , pp. 719-733
    • Chmelar, R.1    Buchanan, G.2    Need, E.F.3    Tilley, W.4    Greenberg, N.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.