Loss of NKX3.1 expression in human prostate cancers correlates with tumor progression

Cancer Research

Volumn 60, Issue 21, 2000, Pages 6111-6115

  Bowen, Cai ^a   Bubendorf, Lukas ^c,d   Voeller, H James ^a   Slack, Rebecca ^a   Willi, Niels ^d   Sauter, Guido ^a,d   Gasser, Thomas C ^d   Koivisto, Pasi ^e   Lack, Ernest E ^b   Kononen, Juha ^c   Kallioniemi, Olli P ^c   Gelmann, Edward P ^a  

^a GEORGETOWN UNIVERSITY   (United States)

^b GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF BASEL   (Switzerland)

^e TAMPERE UNIVERSITY HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

PROSTATE ANTIGEN;

ARTICLE; CANCER GROWTH; CHROMOSOME 8P; CONTROLLED STUDY; GENE LOCATION; HOMEOBOX; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION;

ANIMALS; DISEASE PROGRESSION; EPITHELIUM; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; GENES, TUMOR SUPPRESSOR; HOMEODOMAIN PROTEINS; HUMANS; IMMUNE SERA; IMMUNOHISTOCHEMISTRY; MALE; PROSTATIC NEOPLASMS; RABBITS; RECOMBINANT FUSION PROTEINS; RNA, MESSENGER; TESTIS; TRANSCRIPTION FACTORS;

EID: 0034326839     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. A novel human prostate-specific, androgen-regulated homeobox gene (NKX3.1) that maps to 8p21, a region frequently deleted in prostate cancer
2. Coding region of NKX3.1, prostate-specific homeobox gene on 8p21, is not mutated in human prostate cancers
3. Homozygous deletions at 8p22 and 8p21 in prostate cancer implicate these regions as the sites for candidate tumor suppressor genes
4. Analysis of 99 microdissected prostate carcinomas reveals a high frequency of allelic loss on chromosome 8p21-22
5. Loss of chromosome arm 8p loci in prostate cancer: Mapping by quantitative allelic imbalance
6. Allelic loss on chromosome 8p12-21 in microdissected prostate intraepithelial neoplasia
7. Roles for Nkx3.1 in prostate development and cancer
8. Expression profile of an androgen regulated prostate specific homeobox gene NKX3.1 in primary prostate cancer
9. Tissue microarrays for high-throughput molecular profiling of tumor specimens
10. Prediction of prognosis for prostatic adenocarcinoma by combined histologic grading and clinical staging
11. Isolation and androgen regulation of the human homeobox cDNA, NKX3.1
12. Methylation of estrogen and progesterone receptor gene 5' CpG islands correlates with lack of estrogen and progesterone receptor gene expression in breast tumors
13. Demethylation of the estrogen receptor gene in estrogen receptor-negative breast cancer cells can reactivate estrogen receptor gene expression
14. The androgen-dependent rat prostate protein, Probasin, is a heparin binding protein that co-purifies with heparin-binding growth factor-1
15. Large fragment of the probasin promoter targets high levels of transgene expression to the prostate of transgenic mice
16. Prostate cancer in a transgenic mouse
17. Prostate-specific and androgen-dependent expression of a novel homeobox gene
18. Mediolateral patterning of somites: Multiple axial signals, including Sonic hedgehog, regulate Nkx-3.1 expression