A novel human prostate-specific, androgen-regulated homeobox gene (NKX3.1) that maps to 8p21, a region frequently deleted in prostate cancer

Genomics

Volumn 43, Issue 1, 1997, Pages 69-77

  He, Wei Wu ^a,e   Sciavolino, Peter J ^b   Wing, John ^a   Augustus, Meena ^a   Hudson, Peter ^a   Meissner, P Scott ^a   Curtis, R Thomas ^a   Shell, Brenda K ^a   Bostwick, David G ^c   Tindall, Donald J ^c   Gelmann, Edward P ^d   Abate Shen, Cory ^b   Carter, Kenneth C ^a  

^a GLAXOSMITHKLINE   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c MAYO GRADUATE SCHOOL   (United States)

^d GEORGETOWN UNIVERSITY   (United States)

^e Origen Technologies   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; COMPLEMENTARY DNA; MESSENGER RNA;

ARTICLE; CHROMOSOME 8P; CONTROLLED STUDY; GENE DELETION; GENE EXPRESSION; GENETIC REGULATION; HOMEOBOX; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROSTATE; PROSTATE CANCER; TISSUE SPECIFICITY; TUMOR CELL LINE;

EID: 0031194107     PISSN: 08887543     EISSN: None     Source Type: Journal    
DOI: 10.1006/geno.1997.4715     Document Type: Article

References (36)

1. Adams, M. D., Kelley, J. M., Gocayne, J. D., Dubnick, M., Polymeropoulos, M. H., et al. (1991). Complementary DNA sequencing: Expressed sequence tags and human genome project. Science 252: 1651-1656.
2. Adams, M. D., Dubnick, M., Kerlavage, A. R., Moreno, R., Kelley, J. M., et al. (1992). Sequence identification of 2,375 human brain genes. Nature 355: 632-634.
3. Adams, M. D., Kerlavage, A. R., Fleischmann, R. D., Fuldner, R. A., Bult, C. J., Lee, N. H., Kirkness, E. F., Weinstock, K. G., Gocayne, J. D., et al. (1995). Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. Nature 377: 3-174.
4. Altschul, S. F., Gish, W., Miller, W., Myers, E. W., and Lipman, D. J. (1990). Basic local alignment search tool. J. Mol. Biol. 215: 403-410.
5. Azpiazu, N., and Frasch, M. (1993). tinman and bagpipe: Two homeo box genes that determine cell fates in the dorsal mesoderm of Drosophila. Genes Dev. 7: 1325-1340.
6. Berns, E. M., de Boer, W., and Mulder, E. (1986). Androgen-dependent growth regulation of and release of specific protein(s) by the androgen receptor containing human prostate tumor cell line LNCaP. Prostate 9: 247-259.
7. Blok, L. J., Kumar, M. V., and Tindall, D. J. (1995). Isolation of cDNAs that are differentially expressed between androgen-dependent and androgen-independent prostate carcinoma cells using differential display PCR. Prostate 26: 213-224.
8. Bodmer, R., Jan, L. Y., and Jan, Y. N. (1990). A new homeobox-containing gene, msh-2, is transiently expressed early during mesoderm formation of Drosophila. Development 110: 661-669.
9. Bodmer, R. (1993). The gene tinman is required for the specification of the heart and visceral muscles in Drosophila. Development 118: 719-729.
10. Bova, G. S., Carter, B. S., Bussemakers, J. G., Emi, M., Fujiwara, Y., Kyprianou, N., Jacobs, S. C., Robinson, J. C., Epstein, J. I., Walsh, P. C., and Isaacs, W. B. (1993). Homozygous deletion and frequent allelic loss of chromosome 8p22 loci in human prostate cancer. Cancer Res. 53: 3869-3873.
11. Emi, M., Fujiwara, Y. I., and Nakamura, Y. (1993). A primary genetic linkage map of 14 polymorphic loci for the short arm of chromosome 8. Genomics 15: 530-534.
12. Fujita, K., He, W-W., Gelmann, E. P., and Jay, G. (1997). Developmental expression of Nkx-3.1: Potential role in epithelial cell differentiation. Submitted for publication.
13. Fujiwara, Y., Emi, M., Ohata, H., Kato, Y., Nakajima, T., Mori, T., and Nakamura, Y. (1993). Evidence for the presence of two tumor suppressor genes on chromosome 8p for colorectal carcinoma. Cancer Res. 53: 1172-1174.
14. Fujiwara, H., Ohata, H., Emi, M., Okui, K., Koyama, K., Tsuchiya, E., Nakajima, T., Monden, M., Mori, T., Kurimasa, A., Oshimura, M., and Nakamura, Y. (1994). A 3-Mb physical map of the chromosome region 8p21-p22, including a 600-kb region commonly deleted in human hepatocellular carcinoma, colorectal cancer, and non-small cell lung cancer. Genes Chromosomes Cancer 10: 7-14.
15. Gehring, W. J., Affolter, M., and Burglin, T. (1994a). Homeodomain proteins. Annu. Rev. Biochem. 63: 487-526.
16. Gehring, W. J., Qian, Y. Q., Billeter, M., Furukubo-Tokunaga, K., Schier, A. F., Resendez-Perez, D., Affolter, M., Otting, G., and Wuthrich, K. (1994b). Homeodomain-DNA recognition. Cell 78: 211-223.
17. Harvey, R. P. (1996). NK-2 homeobox genes and heart development. Dev. Biol. 178: 203-216.
18. Ichikawa, T., Nihei, N., Suzuki, H., Oshimura, M., Emi, M., Nakamura, Y., Havata, I., Isaacs, J. T., and Shimazaki, J. (1994). Suppression of metastasis of rat prostatic cancer by introducing human chromosome 8. Cancer Res. 54: 2299-2302.
19. ISCN (1995). "An International System for Human Cytogenetic Nomenclature" (F. Mitelman, Ed.); Karger, Basel.
20. Johnson, C. V., Singer, R. H., and Lawrence, J. B. (1991a). Fluorescent detection of nuclear RNA and DNA: Implications for genome organization. Methods Cell Biol. 35: 73-99.
21. Johnson, C. V., McNeil, J. A., Carter, K. C., and Lawrence, J. B. (1991b). A simple, rapid technique for precise mapping of multiple sequences in two colors using a single optical filter set. Genet. Anal. Tech. Appl. 8: 75-76.
22. Kim, Y., and Nirenberg, M. (1989). Drosophila NK-homeobox genes. Proc. Natl. Acad. Sci. USA 86: 7716-7720.
23. Konig, J. J., Kamst, E., Hagemeijer, A., Romijn, J. C., Horoszewicz, J., and Schroder, F. H. (1989). Cytogenetic characterization of androgen responsive and unresponsive sublines of the human prostatic carcinoma cell line LNCaP. Urol. Res. 17: 79-86.
24. Lawrence, J. B., Villnave, C. A., and Singer, R. H. (1988). Sensitive high-resolution chromatin and chromosome mapping in situ: Presence and orientation of two closely integrated copies of EBV in a lymphoma line. Cell 52: 51-61.
25. Lints, T. J., Parsons, L. M., Hartley, L., Lyons, I., and Harvey, R. P. (1993). Nkx-2.5: A novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants. Development 119: 419-431.
26. MacGrogan, D., Levy, A., Bostwick, D., Wagner, M., Wells, D., and Bookstein, R. (1994). Loss of chromosome arm 8p loci in prostate cancer: Mapping by quantitative allelic imbalance. Genes Chromosomes Cancer 10: 151-159.
27. Macoska, J. A., Trybus, T. M., Benson, P. D., Sakr, W. A., Grignon, D. J., Wojno, K. D., Pietruk, T., and Powell, I. J. (1995). Evidence for three tumor suppressor gene loci on chromosome 8p in human prostate cancer. Cancer Res. 55: 5390-5395.
28. Olea, N., Sakabe, K., Soto, A. M., and Sonnenschein, C. (1990). The proliferative effect of "anti-androgens" on the androgen-sensitive human prostate tumor cell line LNCaP. Endocrinology 126: 1457-1463.
29. Prescott, J. L., Blok, L., and Tindall, D. J. (1997). Isolation and androgen regulation of a novel human homeobox gene, hNKX3.1. Submitted for publication.
30. Price, M., Lazzaro, D., Pohl, T., Mattel, M-G., Ruther, U., Olivo, J. D., Duboule, D., and Di Lauro, R. (1992). Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain. Neuron 8: 241-255.
31. Sambrook, J., Fritsch, E. F., and Maniatis, T. (1989). "Molecular Cloning: A Laboratory Manual," Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
32. Sciavolino, P. J., Abrams, E. W., Yang, L., Austenberg, L. P., Shen, M. M., and Abate-Shen, C. (1997). Tissue-specific expression of murine Nkx3.1 in the male urogenital system. Dev. Dyn. 209: 127-138.
33. Suzuki, H., Emi, M., Komiya, A., Fujiwara, Y., Yatani, R., Nakamura, Y., and Shimazaki, J. (1995). Localization of a tumor suppressor gene associated with progression of human prostate cancer within a 1.2 Mb region of 8p22-p21.3. Genes Chromosomes Cancer 13: 168-174.
34. Tonissen, K. F., Drysdale, T. A., Lints, T. J., Harvey, R. P., and Krieg, P. A. (1994). XNkx-2.5, a Xenopus gene related to Nkx-2.5 and tinman: Evidence for a conserved role in cardiac development. Dev. Biol. 162: 325-328.
35. Trapman, J., Sleddens, H. F., van der Weiden, M. M., Dinjens, W. N., Konig, J. J., Schroder, F. H., Faber, P. W., and Bosman, P. T. (1994). Loss of heterozygosity of chromosome 8 microsatellite loci implicates a candidate tumor suppressor gene between the loci D8S87 and D8SI33 in human prostate cancer. Cancer Res. 54: 6061-6064.
36. Vocke, C. D., Pozzatti, R. O., Bostwick, D. G., Florence, C. D., Jennings, S. B., Strup, S. E., Duray, P. H., Liotta, L. A., Emmert-Buck, M. R., and Linehan, W. M. (1996). Analysis of 99 microdissected prostate carcinomas reveals a high frequency of allelic loss on chromosome 8p12-21. Cancer Res. 56, 2411-2416.