Imidazoline NNC77-0074 stimulates insulin secretion and inhibits glucagon release by control of Ca2+-dependent exocytosis in pancreatic α- and β-cells

European Journal of Pharmacology

Volumn 466, Issue 1-2, 2003, Pages 213-221

  Høy, Marianne ^a   Olsen, Hervør L ^a   Andersen, Henrik S ^a   Bokvist, Krister ^a,d   Buschard, Karsten ^b   Hansen, John ^a   Jacobsen, Palle ^a   Petersen, Jacob S ^a   Rorsman, Patrik ^c   Gromada, Jesper ^a,d  

^a NOVO NORDISK A S   (Denmark)

^b Kommune hospitalet ^*  (Denmark)

^c LUND UNIVERSITY   (Sweden)

^d Lilly Research Laboratories   (Germany)

Author keywords

Exocytosis; Glucagon; Imidazoline compound; Insulin; Pancreatic islet

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTIDIABETIC AGENT; CALCINEURIN; DIAZOXIDE; EFAROXAN; GLUCOSE; IMIDAZOLINE DERIVATIVE; NNC 77 0074; PERTUSSIS TOXIN; PHENTOLAMINE; PHOSPHOPROTEIN PHOSPHATASE; POTASSIUM CHANNEL; POTASSIUM CHLORIDE; PROTEIN KINASE C; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL ISOLATION; CELL STRAIN; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG INHIBITION; ELECTRIC ACTIVITY; ENZYME ACTIVITY; EVOKED RESPONSE; EXOCYTOSIS; FEMALE; GLUCAGON RELEASE; INSULIN RELEASE; MEASUREMENT; MEMBRANE DEPOLARIZATION; MOUSE; NONHUMAN; PANCREAS CELL; PANCREAS ISLET; PRIORITY JOURNAL; RECORDING; SOMATIC CELL; STIMULATION;

EID: 10744220078     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(03)01537-1     Document Type: Article

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