A genetic polymorphism of the α2-adrenergic receptor increases autonomic responses to stress

Journal of Applied Physiology

Volumn 96, Issue 6, 2004, Pages 2231-2239

  Finley Jr , J Clayton ^a   O'Leary, Michael ^a   Wester, Derin ^a   MacKenzie, Steven ^b   Shepard, Neil ^c   Farrow, Stephen ^b   Lockette, Warren ^b,d,e,f,g  

^a NAVAL MEDICAL CENTER SAN DIEGO   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^e UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^f Naval Special Warfare Command   (United States)

^g Space and Naval Warfare Systems Center Pacific   (United States)

Author keywords

Baroreceptors; Hypertension; Lower body negative pressure; Motion sickness; Single nucleotide polymorphism

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; NORADRENALIN; RESTRICTION ENDONUCLEASE; CHLORAMPHENICOL ACETYLTRANSFERASE; PRIMER DNA;

3' UNTRANSLATED REGION; ADRENAL MEDULLA; ADRENERGIC SYSTEM; ALLELE; ANIMAL CELL; ARTICLE; AUTONOMIC NERVOUS SYSTEM; CENTRAL NERVOUS SYSTEM; CHROMOSOME 10; CONTROLLED STUDY; CORIOLIS PHENOMENON; DNA PROBE; ESSENTIAL HYPERTENSION; EXOCYTOSIS; FEMALE; GENE EXPRESSION; GENE MUTATION; GENETIC POLYMORPHISM; GENETIC TRANSFECTION; GENOTYPE; HEART OUTPUT; HUMAN; HUMAN EXPERIMENT; HYPOTENSION; MALE; MENTAL STRESS; MOTION SICKNESS; NONHUMAN; NORADRENALIN RELEASE; NORMAL HUMAN; PHENOTYPE; PRIORITY JOURNAL; REPORTER GENE; SINGLE NUCLEOTIDE POLYMORPHISM; SOUTHERN BLOTTING; STRESS; SWEATING; SYNAPTOSOME; VENOUS RETURN; ANIMAL; CHO CELL; GENETICS; HAMSTER; HEART RATE; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PATHOPHYSIOLOGY; PHYSIOLOGY; POLYMERASE CHAIN REACTION;

3' UNTRANSLATED REGIONS; ANIMALS; AUTONOMIC NERVOUS SYSTEM; BASE SEQUENCE; CHLORAMPHENICOL O-ACETYLTRANSFERASE; CHO CELLS; CRICETINAE; DNA PRIMERS; FEMALE; GENOTYPE; HEART RATE; HUMANS; MALE; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; RECEPTORS, ADRENERGIC, ALPHA-2; STRESS; TRANSFECTION;

EID: 2442716478     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/japplphysiol.00527.2003     Document Type: Article

References (33)

1. Abboud FM. The sympathetic nervous system in hypertension. Hypertension 4: 208-225, 1982.
2. Antonaccio MR, Robson RD, and Burrel R. Effects of clonidine on baroreceptor function in anesthetized dogs. Eur J Pharmacol 30: 6-14, 1975.
3. Badoer E, Head GA, Korner PI. Effects of intracisternal and intravenous α-methyldopa and clonidine of hemodynamics and baroreceptor-heart rate reflex properties in conscious rabbits. J Cardiovasc Pharmacol 5: 760-767, 1983.
4. 1 adrenergic receptor gene and hypertension. Circulation 104: 187-190, 2001.
5. 1 adrenergic receptor gene detected with BglI. Nucleic Acids Res 16: 7754, 1988.
6. Calhoun DA and Mutinga ML. Race, family history of hypertension, and sympathetic response to cold pressor testing. Blood Press 6: 209-213, 1997.
7. Cheung BS, Money KE, Kohl RL, and Kinter LB. Investigation of anti-motion sickness drugs in the squirrel monkey. J Clin Pharmacol 32: 163-175, 1992.
8. Cornelium CE and Fredland RA. Fasting hyperbilirubinemia in normal squirrel monkeys. Lab Anim Sci 42: 35-37, 1992.
9. 2-adrenergic phenotypic traits in normotensive humans at genetic risk of hereditary (essential) hypertension. J Hypertens 16: 779-792, 1998.
10. Eisenhofer G, Cox HS, and Esler MD. Noradrenaline reuptake and plasma dihydroxyphenylglycol during sustained changes in sympathetic activation in rabbits. J Auton Nerv Syst 32: 217-231, 1991.
11. 2-AR antagonists and clonidine on the hemodynamic response to acute hypovolemia in conscious rabbits. Eur J Pharmacol 216: 265-272, 1992.
12. Farrow S, Banta G, and Lockette W. Effect of the α2-AR antagonist yohimbine on orthostatic tolerance. Hypertension 15: 877-880, 1990.
13. Fast A. Reflex sweating in patients with spinal cord injury: a review. Arch Phys Med Rehabil 58: 435-457, 1977.
14. 2 adrenergic receptor is associated with increased platelet aggregation, baroreceptor sensitivity, and salt excretion in normotensive men. Am J Hypertens 8: 863-869, 1995.
15. Goldstein DS, Grossman E, Listwak S, and Folio CJ. Sympathetic reactivity during a yohimbine challenge test in essential hypertension. Hypertension 18, Suppl III: 40-48, 1991.
16. Graybiel A, Woods C, and Miller E. Diagnostic criteria for grading the severity of acute motion sickness. Aerospace Med 39: 453-456, 1968.
17. Kasagi F, Akahoshi M, and Shimaoka K. Relation between cold pressor test and development of hypertension based on 28-year follow-up. Hypertension 25: 71-76, 1995.
18. 2-adrenoceptor 2A-subtype. Neuropharmacology 44: 882-892, 2003.
19. 2 receptor and hypertension in blacks. Am J Hypertens 8: 390-394, 1995.
20. Lockette W, Shepard N, Lyos A, Boismier T, and Mers A. Altered Coriolis stress susceptibility in essential hypertension. Am J Hypertens 4: 645-650, 1991.
21. 2-adrenoceptor-2a adrenergic subtype. Science 273: 801-803, 1996.
22. Magnifico F, Misra VP, Murray NM, and Mathias CJ. The sympathetic skin response in peripheral autonomic failure. Clin Auton Res 8: 133-138, 1998.
23. 2-adrenergic receptor subtype. Hypertension 34: 403-407, 1999.
24. Markovitz JH, Raczynski JM, Wallace D, Chettur V, and Chesney MA. Cardiovascular reactivity to video game predicts subsequent blood pressure increases in young men: The CARDIA study. Psychosom Med 60: 186-189, 1998.
25. Miller EF and Graybiel A. A provocative test for grading susceptibility to motion sickness yielding a single numerical score. Acta Otolaryngol Suppl (Stockh) 274: 1-22, 1970.
26. 2-adrenergic receptor mechanisms in the renal nerve mediated natriuresis and diuresis produced by acute volume expansion. J Auton Nerv Syst 36: 47-54, 1991.
27. Patel KP and Zeigler DW. Renal nerves are involved in the natriuresis and diuresis produced by central administration of clonidine in the rat. Proc Soc Exp Biol Med 202: 81-87, 1993.
28. Rea RF and Hamdan M. Baroreflex control of muscle sympathetic nerve activity in borderline hypertension. Circulation 82: 856-862, 1990.
29. 2-adrenoceptor subtypes. Annu Rev Pharmacol Toxicol 33: 243-279, 1993.
30. Sanders JS, Mark AL, and Ferguson DW. Importance of aortic baroreflex in regulation of sympathetic responses during hypotension. Evidence from direct sympathetic nerve recordings in humans. Circulation 79: 83-92, 1989.
31. Stern RM, Hu S, Uijtdehaage SH, Muth ER, Xu LH, and Koch KL. Asian hypersusceptibility to motion sickness. Hum Hered 46: 7-14, 1996.
32. - in secretion from the skin during progressive increase in exercise intensity. Eur J Appl Physiol 64: 557-561, 1992.
33. Toto-Moukous J, Um JP, Jon JP, and Hagbe P. Hemodynamic reactivity factors to cold pressor test in blacks with sustained essential hypertension. Am J Hypertens 6: 824-829, 1993.