Protein kinase C delta: A master regulator of apoptosis in neointimal thickening?

Cardiovascular Research

Volumn 85, Issue 3, 2010, Pages 407-408

  Fischer, Jens W ^a  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

4 [3 (4 BENZYL 1 PIPERIDINYL)PROPIONYL] 2,3,4,5 TETRAHYDRO 7 METHOXY 1,4 BENZOTHIAZEPINE; BECLIN 1; CASPASE 3; CCAAT ENHANCER BINDING PROTEIN ALPHA; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; PACLITAXEL; PROTEIN KINASE C DELTA; RAPAMYCIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTERY INJURY; ARTERY INTIMA PROLIFERATION; ATHEROSCLEROSIS; CELL PROLIFERATION; CELL SURVIVAL; DRUG ELUTING STENT; EDITORIAL; ENZYME ACTIVATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN FUNCTION; RESTENOSIS; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER;

ANIMALS; APOPTOSIS; HYPERPLASIA; MUSCLE, SMOOTH, VASCULAR; PROTEIN KINASE C-DELTA; RATS; THIAZEPINES; TUNICA INTIMA;

EID: 74249109342     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvp390     Document Type: Editorial

References (15)

1. Pasterkamp G, de Kleijn DP, Borst C. Arterial remodeling in atherosclerosis, resteno-sis and after alteration of blood flow: potential mechanisms and clinical implications. Cardiovasc Res 2000;45:843-852.
2. Rodriguez-Menocal L, St-Pierre M, Wei Y, Khan S, Mateu D, Calfa M et al. The origin of post-injury neointimal cells in the rat balloon injury model. Cardiovasc Res 2009;81: 46-53.
3. Mehta SR, Yusuf S, Peters RJ, Bertrand ME, Lewis BS, Natarajan MK et al. Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study. Lancet 2001; 358:527-533.
4. Leitges M, Mayr M, Braun U, Mayr U, Li C, Pfister G et al. Exacerbated vein graft arteriosclerosis in protein kinase Cdelta-null mice. J Clin Invest 2001;108: 1505-1512.
5. Mecklenbrauker I, Kalled SL, Leitges M, Mackay F, Tarakhovsky A. Regulation of B-cell survival by BAFF-dependent PKC delta-mediated nuclear signalling. Nature 2004;431: 456-461.
6. Chen JL, Lin HH, Kim KJ, Lin A, Forman HJ, Ann DK. Novel roles for protein kinase C delta-dependent signaling pathways in acute hypoxic stress-induced autophagy. J Biol Chem 2008;283:34432-34444.
7. Churchill EN, Ferreira JC, Brum PC, Szweda LI, Mochly-Rosen D. Ischaemic preconditioning improves proteasomal activity and increases the degradation of dPKC during reperfusion. Cardiovasc Res 2010;85:385-394.
8. Zhao M, Duan XF, Zhao XY, Zhang B, Lu Y, Liu W et al. Protein kinase C delta stimulates proteasome-dependent degradation of C/EBP alpha during apoptosis induction of leukemic cells. PLoS One 2009;4:e6552.
9. Yamanouchi D, Kato K, Ryer EJ, Zhang F, Liu B. Protein kinase C delta mediates arterial injury responses through regulation of vascular smooth muscle cell apoptosis. Car-diovasc Res 2010;85:434-443.
10. Hampson P, Chahal H, Khanim F, Hayden R, Mulder A, Assi LK et al. PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC. Blood 2005;106:1362-1368.
11. Inagaki K, Kihara Y, Hayashida W, Izumi T, Iwanaga Y, Yoneda T et al. Anti-ischemic effect of a novel cardioprotective agent, JTV519, is mediated through specific activation of delta-isoform of protein kinase C in rat ventricular myocardium. Circulation 2000;101:797-804.
12. Ikeno F, Inagaki K, Rezaee M, Mochly-Rosen D. Impaired perfusion after myocardial infarction is due to reperfusion-induced delta PKC-mediated myocardial damage. Cardiovasc Res 2007;73:699-709.
13. Castaneda D, Zhao H, Mochly-Rosen D, Steinberg GK. Activating delta PKC antagonizes the protective effect of ERK1/2 inhibition against stroke in rats. Brain Res 2009; 1251:256-261.
14. Clarke MC, Littlewood TD, Figg N, Maguire JJ, Davenport AP, Goddard M et al. Chronic apoptosis of vascular smooth muscle cells accelerates atherosclerosis and promotes calcification and medial degeneration. Circ Res 2008;102: 1529-1538.
15. Shizukuda Y, Helisch A, Yokota R, Ware JA. Downregulation of protein kinase cdelta activity enhances endothelial cell adaptation to hypoxia. Circulation 1999;100: 1909-1916.