Activating δPKC antagonizes the protective effect of ERK1/2 inhibition against stroke in rats

Brain Research

Volumn 1251, Issue , 2009, Pages 256-261

  Castañeda, Dora ^a   Zhao, Heng ^a   Mochly Rosen, Daria ^a   Steinberg, Gary K ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

PKC; Cerebral ischemia; ERK1 2; MEK ERK cascade

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; DELTA V1 1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PROTEIN KINASE C; PROTEIN KINASE C ACTIVATOR; PROTEIN KINASE C INHIBITOR; RECEPTOR FOR ACTIVATED C KINASE 1; UNCLASSIFIED DRUG; 1,3 BUTADIENE DERIVATIVE; ENZYME INHIBITOR; NEUROPROTECTIVE AGENT; NITRILE; PROTEIN KINASE C DELTA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; MALE; NEUROPROTECTION; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RAT; REPERFUSION; STROKE; ANIMAL; DISEASE MODEL; DRUG ADMINISTRATION; DRUG ANTAGONISM; DRUG COMBINATION; DRUG EFFECT; ENZYMOLOGY; METABOLISM; PATHOPHYSIOLOGY; PHOSPHORYLATION; PHYSIOLOGY; REPERFUSION INJURY; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; UPREGULATION;

RATTUS;

ANIMALS; BRAIN ISCHEMIA; BUTADIENES; DISEASE MODELS, ANIMAL; DRUG ADMINISTRATION SCHEDULE; DRUG THERAPY, COMBINATION; ENZYME INHIBITORS; MALE; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEUROPROTECTIVE AGENTS; NITRILES; PHOSPHORYLATION; PROTEIN KINASE C-DELTA; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; SIGNAL TRANSDUCTION; STROKE; UP-REGULATION;

EID: 58149402202     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2008.11.051     Document Type: Article

References (34)

1. Basu A., and Tu H. Activation of ERK during DNA damage-induced apoptosis involves protein kinase Cdelta. Biochem. Biophys. Res. Commun. 334 (2005) 1068-1073
2. Bhalla U.S., Ram P.T., and Iyengar R. MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network. Science 297 (2002) 1018-1023
3. Mochly-Rosen D., and Bright R. The role of protein kinase C in cerebral ischemia and reperfusion injury. Stroke 36 (2005) 2781-2790
4. RA, Bright R., Dembner J.M., Perez-Pinzon M.A., Steinberg G., Yenari M., and Mochly-Rosen D. Protein kinase C delta mediates cerebral reperfusion injury in vivo. J. Neurosci. 24 (2004) 6880-6888
5. Bright R., Steinberg G.K., and Mochly-Rosen D. DeltaPKC mediates microcerebrovascular dysfunction in acute ischemia and in chronic hypertensive stress in vivo. Brain Res. 1144 (2007) 146-155
6. Carroll M.P., and May W.S. Protein kinase C-mediated serine phosphorylation directly activates Raf-1 in murine hematopoietic cells. J. Biol. Chem. 269 (1994) 1249-1256
7. Farrokhnia N., Roos M.W., Terent A., and Lennmyr F. Differential early mitogen-activated protein kinase activation in hyperglycemic ischemic brain injury in the rat. Eur. J. Clin. Invest. 35 (2005) 457-463
8. Ferrer I., Friguls B., Dalfo E., and Planas A.M. Early modifications in the expression of mitogen-activated protein kinase (MAPK/ERK), stress-activated kinases SAPK/JNK and p38, and their phosphorylated substrates following focal cerebral ischemia. Acta Neuropathol. (Berl.) 105 (2003) 425-437
9. Ginnan R., Guikema B.J., Singer H.A., and Jourd'heuil D. PKC-delta mediates activation of ERK1/2 and induction of iNOS by IL-1beta in vascular smooth muscle cells. Am. J. Physiol. Cell Physiol. 290 (2006) C1583-1591
10. Gu Z., Jiang Q., and Zhang G. Extracellular signal-regulated kinase 1/2 activation in hippocampus after cerebral ischemia may not interfere with postischemic cell death. Brain Res. 901 (2001) 79-84
11. Hasegawa Y., Morioka M., Hasegawa S., Matsumoto J., Kawano T., Kai Y., Yano S., Fukunaga K., and Kuratsu J. Therapeutic time window and dose dependence of neuroprotective effects of sodium orthovanadate following transient middle cerebral artery occlusion in rats. J. Pharmacol. Exp. Ther. 317 (2006) 875-881
12. Henriksson M., Stenman E., Vikman P., and Edvinsson L. MEK1/2 inhibition attenuates vascular ETA and ETB receptor alterations after cerebral ischaemia. Exp. Brain. Res. 178 (2007) 470-476
13. Hornberg J., Tijssen M., and Lankelma J. Synergistic activation of signalling to extracellular signal-regulated kinases 1 and 2 by epidermal growth factor and 4 beta-phorbol 12-myristate 12-acetate. Eur. J. Biochem. 271 (2004) 3905-3913
14. Irving E.A., Barone F.C., Reith A.D., Hadingham S.J., and Parsons A.A. Differential activation of MAPK/ERK and p38/SAPK in neurones and glia following focal cerebral ischaemia in the rat. Brain Res. Mol. Brain Res. 77 (2000) 65-75
15. Jin K., Mao X.O., Eshoo M.W., Nagayama T., Minami M., Simon R.P., and Greenberg D.A. Microarray analysis of hippocampal gene expression in global cerebral ischemia. Ann. Neurol. 50 (2001) 93-103
16. Kilic E., Kilic U., Soliz J., Bassetti C.L., Gassmann M., and Hermann D.M. Brain-derived erythropoietin protects from focal cerebral ischemia by dual activation of ERK-1/-2 and Akt pathways. FASEB J. 19 (2005) 2026-2028
17. Kolch W., Heidecker G., Kochs G., Hummel R., Vahidi H., Mischak H., Finkenzeller G., Marme D., and Rapp U. Protein kinase C alpha activates RAF-1 by direct phosphorylation. Nature 364 (1993) 249-252
18. Kuriyama M., Taniguchi T., Shirai Y., Sasaki A., Yoshimura A., and Saito N. Activation and translocation of PKCdelta is necessary for VEGF-induced ERK activation through KDR in HEK293T cells. Biochem. Biophys. Res. Commun. 325 (2004) 843-851
19. Maier C., Sun G., Kunis D., Yenari M., and Steinberg G. Delayed induction and long-term effects of mild hypothermia in a focal model of transient cerebral ischemia: neurological outcome and infarct size. J. Neurosurg. 94 (2001) 90-96
20. Molina-Holgado E., Ortiz S., Molina-Holgado F., and Guaza C. Induction of COX-2 and PGE(2) biosynthesis by IL-1beta is mediated by PKC and mitogen-activated protein kinases in murine astrocytes. Br. J. Pharmacol. 131 (2000) 152-159
21. Namura S., Iihara K., Takami S., Nagata I., Kikuchi H., Matsushita K., Moskowitz M.A., Bonventre J.V., and Alessandrini A. Intravenous administration of MEK inhibitor U0126 affords brain protection against forebrain ischemia and focal cerebral ischemia. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 11569-11574
22. Niimura M., Takagi N., Takagi K., Funakoshi H., Nakamura T., and Takeo S. Effects of hepatocyte growth factor on phosphorylation of extracellular signal-regulated kinase and hippocampal cell death in rats with transient forebrain ischemia. Eur. J. Pharmacol. 535 (2006) 114-124
23. Noshita N., Sugawara T., Hayashi T., Lewen A., Omar G., and Chan P.H. Copper/zinc superoxide dismutase attenuates neuronal cell death by preventing extracellular signal-regulated kinase activation after transient focal cerebral ischemia in mice. J. Neurosci. 22 (2002) 7923-7930
24. Raval A.P., Dave K.R., Prado R., Katz L.M., Busto R., Sick T.J., Ginsberg M.D., Mochly-Rosen D., and Perez-Pinzon M.A. Protein kinase C delta cleavage initiates an aberrant signal transduction pathway after cardiac arrest and oxygen glucose deprivation. J. Cereb. Blood Flow Metab. 25 (2005) 730-741
25. Roux P.P., and Blenis J. ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions. Microbiol. Mol. Biol. Rev. 68 (2004) 320-344
26. Saklatvala J., Davis W., and Guesdon F. Interleukin 1 (IL1) and tumour necrosis factor (TNF) signal transduction. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 351 (1996) 151-157
27. Sawe N., Steinberg G., and Zhao H. Dual roles of the MAPK/ERK1/2 cell signaling pathway after stroke. J. Neurosci. Res. (2008)
28. Wang Z.Q., Wu D.C., Huang F.P., and Yang G.Y. Inhibition of MEK/ERK 1/2 pathway reduces pro-inflammatory cytokine interleukin-1 expression in focal cerebral ischemia. Brain Res. 996 (2004) 55-66
29. Xu X., Chua C.C., Gao J., Hamdy R.C., and Chua B.H. Humanin is a novel neuroprotective agent against stroke. Stroke 37 (2006) 2613-2619
30. Zablocka B., Dluzniewska J., Zajac H., and Domanska-Janik K. Opposite reaction of ERK and JNK in ischemia vulnerable and resistant regions of hippocampus: involvement of mitochondria. Brain Res. Mol. Brain Res. 110 (2003) 245-252
31. Zhao H., Sapolsky R.M., and Steinberg G.K. Interrupting reperfusion as a stroke therapy: ischemic postconditioning reduces infarct size after focal ischemia in rats. J. Cereb. Blood Flow Metab. 26 (2006) 1114-1121
32. Zhao H., Shimohata T., Wang J.Q., Sun G., Schaal D.W., Sapolsky R.M., and Steinberg G.K. Akt contributes to neuroprotection by hypothermia against cerebral ischemia in rats. J. Neurosci. 25 (2005) 9794-9806
33. Zhao H., Yenari M.A., Cheng D., Sapolsky R.M., and Steinberg G.K. Biphasic cytochrome c release after transient global ischemia and its inhibition by hypothermia. J. Cereb. Blood Flow Metab. 25 (2005) 1119-1129
34. Zhao H., Yenari M.A., Sapolsky R.M., and Steinberg G.K. Mild postischemic hypothermia prolongs the time window for gene therapy by inhibiting cytochrome C release. Stroke 35 (2004) 572-577