Protein kinase C delta mediates arterial injury responses through regulation of vascular smooth muscle cell apoptosis

Cardiovascular Research

Volumn 85, Issue 3, 2010, Pages 434-443

  Yamanouchi, Dai ^a   Kato, Kaori ^a   Ryer, Evan J ^b   Zhang, Fan ^a   Liu, Bo ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Angioplasty; Apoptosis; Protein kinase C; Restenosis

Indexed keywords

ADENOVIRUS VECTOR; PROTEIN KINASE C DELTA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTERY INJURY; ARTERY INTIMA PROLIFERATION; ARTERY MUSCLE; ARTICLE; CAROTID ARTERY INJURY; CAROTID ARTERY LIGATION; CONTROLLED STUDY; ENZYME INDUCTION; EXPERIMENTAL MODEL; GENE DELETION; GENE OVEREXPRESSION; GENE TRANSFER; HUMAN; HUMAN TISSUE; IN-STENT RESTENOSIS; MALE; MOUSE; NONHUMAN; PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE FIBER; WILD TYPE;

ANGIOPLASTY, BALLOON; ANIMALS; APOPTOSIS; CAROTID ARTERY INJURIES; CELLS, CULTURED; HUMANS; MALE; MICE; MICE, KNOCKOUT; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PROTEIN KINASE C-DELTA; RATS; RATS, SPRAGUE-DAWLEY; TUNICA INTIMA;

EID: 74249091716     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvp328     Document Type: Article

References (31)

1. Kent KC, Liu B. Intimal hyperplasia\-still here after all these years!. Ann Vasc Surg 2004;18:135-137.
2. Tsai S, Butler J, Rafii S, Liu B, Kent KC. The role of progenitor cells in the development of intimal hyperplasia. J Vasc Surg 2009;49:502-510.
3. Newby AC, Zaltsman AB. Molecular mechanisms in intimal hyperplasia. J Pathol 2000;190:300-309.
4. McCaffrey TA, Consigli S, Du B, Falcone DJ, Sanborn TA, Spokojny AM et al. Decreased type II/type I TGF-beta receptor ratio in cells derived from human atherosclerotic lesions. Conversion from an antiproliferative to profibrotic response to TGF-beta1. J Clin Invest 1995;96:2667-2675.
5. Yamanouchi D, Banno H, Nakayama M, Sugimoto M, Fujita H, Kobayashi M et al. Hydrophilic statin suppresses vein graft intimal hyperplasia via endothelial cell-tropic Rho-kinase inhibition. J Vasc Surg 2005;42:757-764.
6. Stennicke HR, Salvesen GS. Properties of the caspases. Biochim Biophys Acta 1998; 1387:17-31.
7. Kato K, Yamanouchi D, Kamiya K, Zhang F, Kent KC, Liu B. Caspase-mediated protein kinase C-delta cleavage is necessary for apoptosis of vascular smooth muscle cells. Am J Physiol Heart Circ Physiol 2009; doi:10.1152/ajpheart.00274. 2009, published online ahead of print October 2009.
8. Leitges M, Mayr M, Braun U, Mayr U, Li C, Pfister G et al. Exacerbated vein graft arteriosclerosis in protein kinase Cdelta-null mice. J Clin Invest 2001;108:1505-1512.
9. Chen JL, Lin HH, Kim KJ, Lin A, Ou JH, Ann DK. PKC delta signaling: a dual role in regulating hypoxic stress-induced autophagy and apoptosis. Autophagy 2009;5: 244-246.
10. Miyamoto A, Nakayama K, Imaki H, Hirose S, Jiang Y, Abe M et al. Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta. Nature 2002;416:865-869.
11. Liu B, Ryer EJ, Kundi R, Kamiya K, Itoh H, Faries PL et al. Protein kinase C-delta regulates migration and proliferation of vascular smooth muscle cells through the extracellular signal-regulated kinase 1/2. J Vasc Surg 2007;45:160-168.
12. Fukumoto S, Nishizawa Y, Hosoi M, Koyama H, Yamakawa K, Ohno S et al. Protein kinase C delta inhibits the proliferation of vascular smooth muscle cells by suppressing G1 cyclin expression. J Biol Chem 1997;272:13816-13822.
13. Ginnan R, Singer HA. PKC-delta-dependent pathways contribute to PDGF-stimulated ERK1/2 activation in vascular smooth muscle. Am J Physiol Cell Physiol 2005;288:C1193-C1201.
14. Lee LK, Kent KC. Infrainguinal occlusive disease: endovascular intervention is the first line therapy. Adv Surg 2008;42:193-204.
15. Mwipatayi BP, Hockings A, Hofmann M, Garbowski M, Sieunarine K. Balloon angioplasty compared with stenting for treatment of femoropopliteal occlusive disease: a meta-analysis. J Vasc Surg 2008;47:461-469.
16. Zhang F, Tsai S, Kato K, Yamanouchi D, Wang C, Rafii S et al. Transforming growth factor-beta promotes recruitment of bone marrow cells and bone marrow-derived mesenchymal stem cells through stimulation of MCP-1 production in vascular smooth muscle cells. J Biol Chem 2009;284:17564-17574.
17. Ryer EJ, Hom RP, Sakakibara K, Nakayama KI, Nakayama K, Faries PL et al. PKCdelta is necessary for Smad3 expression and transforming growth factor beta-induced fibronectin synthesis in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 2006;26:780-786.
18. Li Y, Takeshita K, Liu PY, Satoh M, Oyama N, Mukai Y et al. Smooth muscle Notch1 mediates neointimal formation after vascular injury. Circulation 2009; 119:2686-2692.
19. Clowes AW, Reidy MA, Clowes MM. Mechanisms of stenosis after arterial injury. Lab Invest 1983;49:208-215.
20. Prus K, Edstrom A, Wallin M. Actin-induced stimulation of microtubule-associated ATPase activity. FEBS Lett 1981;125:49-52.
21. Hollenbeck ST, Sakakibara K, Faries PL, Workhu B, Liu B, Kent KC. Stem cell factor and c-kit are expressed by and may affect vascular SMCs through an auto-crine pathway. J Surg Res 2004;120:288-294.
22. Edlin RS, Tsai S, Yamanouchi D, Wang C, Liu B, Kent KC. Characterization of primary and restenotic atherosclerotic plaque from the superficial femoral artery: Potential role of Smad3 in regulation of SMC proliferation. J Vasc Surg 2009;49:1289-1295.
23. Banno H, Takei Y, Muramatsu T, Komori K, Kadomatsu K. Controlled release of small interfering RNA targeting midkine attenuates intimal hyperplasia in vein grafts. J Vasc Surg 2006;44:633-641.
24. Schober A, Zernecke A. Chemokines in vascular remodeling. Thromb Haemost 2007;97:730-737.
25. Simons M. VEGF and restenosis: the rest of the story. Arterioscler Thromb Vasc Biol 2009;29:439-440.
26. Zampetaki A, Zhang Z, Hu Y, Xu Q. Biomechanical stress induces IL-6 expression in smooth muscle cells via Ras/Rac1-p38 MAPK-NF-kappaB signaling pathways. Am J Physiol Heart Circ Physiol 2005;288:H2946-H2954.
27. Ryer EJ, Sakakibara K, Wang C, Sarkar D, Fisher PB, Faries PL et al. Protein kinase C delta induces apoptosis of vascular smooth muscle cells through induction of the tumor suppressor p53 by both p38-dependent and p38-independent mechanisms. J Biol Chem 2005;280:35310-35317.
28. Schubl S, Tsai S, Ryer EJ, Wang C, Hu J, Kent KC et al. Upregulation of protein kinase cdelta in vascular smooth muscle cells promotes inflammation in abdominal aortic aneurysm. J Surg Res 2009;153:181-187.
29. Itoh H, Yamamura S, Ware JA, Zhuang S, Mii S, Liu B et al. Differential effects of protein kinase C on human vascular smooth muscle cell proliferation and migration. Am J Physiol Heart Circ Physiol 2001;281:H359-H370.
30. Skaletz-Rorowski A, Eschert H, Leng J, Stallmeyer B, Sindermann JR, Pulawski E et al. PKC delta-induced activation of MAPK pathway is required for bFGF-stimulated proliferation of coronary smooth muscle cells. Cardiovasc Res 2005;67:142-150.
31. Furukawa Y, Matsumori A, Ohashi N, Shioi T, Ono K, Harada A et al. Anti-monocyte chemoattractant protein-1/monocyte chemotactic and activating factor antibody inhibits neointimal hyperplasia in injured rat carotid arteries. Circ Res 1999;84:306-314.