메뉴 건너뛰기




Volumn 26, Issue 1, 2010, Pages 47-52

Recent insights into the pathogenesis of colorectal cancer

Author keywords

Colorectal cancer; Epimutation; Genome wide association studies; MicroRNA

Indexed keywords

MICRORNA; T CELL FACTOR PROTEIN;

EID: 74249097210     PISSN: 02671379     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOG.0b013e328332b850     Document Type: Review
Times cited : (71)

References (51)
  • 1
    • 4043181214 scopus 로고    scopus 로고
    • Cancer genes and the pathways they control
    • Vogelstein B, Kinzler KW. Cancer genes and the pathways they control. Nat Med 2004; 10:789-799.
    • (2004) Nat Med , vol.10 , pp. 789-799
    • Vogelstein, B.1    Kinzler, K.W.2
  • 2
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, biogenesis, mechanism, and function
    • Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004; 116:281-297.
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 3
    • 58149357365 scopus 로고    scopus 로고
    • Genome-wide association studies in cancer
    • Easton DF, Eeles RA. Genome-wide association studies in cancer. Hum Mol Genet 2008; 17:R109-R115.
    • (2008) Hum Mol Genet , vol.17
    • Easton, D.F.1    Eeles, R.A.2
  • 4
    • 34547498546 scopus 로고    scopus 로고
    • A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21
    • Tomlinson I, Webb E, Carvajal-Carmona L, et al. A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21. Nat Genet 2007; 39:984-988.
    • (2007) Nat Genet , vol.39 , pp. 984-988
    • Tomlinson, I.1    Webb, E.2    Carvajal-Carmona, L.3
  • 5
    • 34547092701 scopus 로고    scopus 로고
    • Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24
    • Zanke BW, Greenwood CM, Rangrej J, et al. Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24. Nat Genet 2007; 39:989-994.
    • (2007) Nat Genet , vol.39 , pp. 989-994
    • Zanke, B.W.1    Greenwood, C.M.2    Rangrej, J.3
  • 6
    • 42649124305 scopus 로고    scopus 로고
    • Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21
    • Tenesa A, Farrington SM, Prendergast JG, et al. Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. Nat Genet 2008; 40:631-637.
    • (2008) Nat Genet , vol.40 , pp. 631-637
    • Tenesa, A.1    Farrington, S.M.2    Prendergast, J.G.3
  • 7
    • 37549072226 scopus 로고    scopus 로고
    • Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk
    • Jaeger E, Webb E, Howarth K, et al. Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk. Nat Genet 2008; 40:26-28.
    • (2008) Nat Genet , vol.40 , pp. 26-28
    • Jaeger, E.1    Webb, E.2    Howarth, K.3
  • 8
    • 35648937584 scopus 로고    scopus 로고
    • A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk
    • Broderick P, Carvajal-Carmona L, Pittman AM, et al. A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk. Nat Genet 2007; 39:1315-1317.
    • (2007) Nat Genet , vol.39 , pp. 1315-1317
    • Broderick, P.1    Carvajal-Carmona, L.2    Pittman, A.M.3
  • 10
    • 56749176944 scopus 로고    scopus 로고
    • Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer
    • Houlston RS, Webb E, Broderick P, et al. Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. Nat Genet 2008; 40:1426-1435.
    • (2008) Nat Genet , vol.40 , pp. 1426-1435
    • Houlston, R.S.1    Webb, E.2    Broderick, P.3
  • 11
    • 67349245787 scopus 로고    scopus 로고
    • New insights into the aetiology of colorectal cancer from genome-wide association studies
    • Tenesa A, Dunlop MG. New insights into the aetiology of colorectal cancer from genome-wide association studies. Nat Rev Genet 2009; 10:353-358.
    • (2009) Nat Rev Genet , vol.10 , pp. 353-358
    • Tenesa, A.1    Dunlop, M.G.2
  • 12
    • 60549116326 scopus 로고    scopus 로고
    • Meta association of colorectal cancer confirms risk alleles at 8q24 and 18q21
    • Curtin K, Lin WY, George R, et al. Meta association of colorectal cancer confirms risk alleles at 8q24 and 18q21. Cancer Epidemiol Biomarkers Prev 2009; 18:616-621.
    • (2009) Cancer Epidemiol Biomarkers Prev , vol.18 , pp. 616-621
    • Curtin, K.1    Lin, W.Y.2    George, R.3
  • 13
    • 50649105955 scopus 로고    scopus 로고
    • Comprehensive resequence analysis of a 136 kb region of human chromosome 8q24 associated with prostate and colon cancers
    • Yeager M, Xiao N, Hayes RB, et al. Comprehensive resequence analysis of a 136 kb region of human chromosome 8q24 associated with prostate and colon cancers. Hum Genet 2008; 124:161-170.
    • (2008) Hum Genet , vol.124 , pp. 161-170
    • Yeager, M.1    Xiao, N.2    Hayes, R.B.3
  • 14
    • 56049119387 scopus 로고    scopus 로고
    • Refinement of the basis and impact of common 11q23.1 variation to the risk of developing colorectal cancer
    • Pittman AM, Webb E, Carvajal-Carmona L, et al. Refinement of the basis and impact of common 11q23.1 variation to the risk of developing colorectal cancer. Hum Mol Genet 2008; 17:3720-3727.
    • (2008) Hum Mol Genet , vol.17 , pp. 3720-3727
    • Pittman, A.M.1    Webb, E.2    Carvajal-Carmona, L.3
  • 15
    • 59849094771 scopus 로고    scopus 로고
    • Chromosome 8q23.3 and 11q23.1 variants modify colorectal cancer risk in Lynch syndrome
    • Wijnen JT, Brohet RM, van Eijk R, et al. Chromosome 8q23.3 and 11q23.1 variants modify colorectal cancer risk in Lynch syndrome. Gastroenterology 2009; 136:131-137.
    • (2009) Gastroenterology , vol.136 , pp. 131-137
    • Wijnen, J.T.1    Brohet, R.M.2    Van Eijk, R.3
  • 16
    • 58149386907 scopus 로고    scopus 로고
    • Investigation of the colorectal cancer susceptibility region on chromosome 8q24.21 in a large German case-control sample
    • Schafmayer C, Buch S, Volzke H, et al. Investigation of the colorectal cancer susceptibility region on chromosome 8q24.21 in a large German case- control sample. Int J Cancer 2009; 124:75-80.
    • (2009) Int J Cancer , vol.124 , pp. 75-80
    • Schafmayer, C.1    Buch, S.2    Volzke, H.3
  • 17
    • 66449107196 scopus 로고    scopus 로고
    • The colorectal cancer risk at 18q21 is caused by a novel variant altering SMAD7 expression
    • Pittman AM, Naranjo S, Webb E, et al. The colorectal cancer risk at 18q21 is caused by a novel variant altering SMAD7 expression. Genome Res 2009; 19:987-993.
    • (2009) Genome Res , vol.19 , pp. 987-993
    • Pittman, A.M.1    Naranjo, S.2    Webb, E.3
  • 18
    • 66749148254 scopus 로고    scopus 로고
    • Association of common genetic variants in SMAD7 and risk of colon cancer
    • Thompson CL, Plummer SJ, Acheson LS, et al. Association of common genetic variants in SMAD7 and risk of colon cancer. Carcinogenesis 2009; 30:982-986.
    • (2009) Carcinogenesis , vol.30 , pp. 982-986
    • Thompson, C.L.1    Plummer, S.J.2    Acheson, L.S.3
  • 19
    • 68149170044 scopus 로고    scopus 로고
    • The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling
    • Tuupanen S, Turunen M, Lehtonen R, et al. The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling. Nat Genet 2009; 41:885-890.
    • (2009) Nat Genet , vol.41 , pp. 885-890
    • Tuupanen, S.1    Turunen, M.2    Lehtonen, R.3
  • 20
    • 68149180901 scopus 로고    scopus 로고
    • The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer
    • Pomerantz MM, Ahmadiyeh N, Jia L, et al. The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer. Nat Genet 2009; 41:882-884.
    • (2009) Nat Genet , vol.41 , pp. 882-884
    • Pomerantz, M.M.1    Ahmadiyeh, N.2    Jia, L.3
  • 23
    • 67649425233 scopus 로고    scopus 로고
    • Over-and under-expressed microRNAs in human colorectal cancer
    • Motoyama K, Inoue H, Takatsuno Y, et al. Over- and under-expressed microRNAs in human colorectal cancer. Int J Oncol 2009; 34:1069-1075.
    • (2009) Int J Oncol , vol.34 , pp. 1069-1075
    • Motoyama, K.1    Inoue, H.2    Takatsuno, Y.3
  • 24
    • 66749160812 scopus 로고    scopus 로고
    • The miR-18a* microRNA functions as a potential tumor suppressor by targeting on K-Ras
    • Tsang WP, Kwok TT. The miR-18a* microRNA functions as a potential tumor suppressor by targeting on K-Ras. Carcinogenesis 2009; 30:953-959.
    • (2009) Carcinogenesis , vol.30 , pp. 953-959
    • Tsang, W.P.1    Kwok, T.T.2
  • 25
    • 48649099908 scopus 로고    scopus 로고
    • Regulation of the adenomatous polyposis coli gene by the miR-135 family in colorectal cancer
    • Nagel R, le Sage C, Diosdado B, et al. Regulation of the adenomatous polyposis coli gene by the miR-135 family in colorectal cancer. Cancer Res 2008; 68:5795-5802.
    • (2008) Cancer Res , vol.68 , pp. 5795-5802
    • Nagel, R.1    Le Sage, C.2    Diosdado, B.3
  • 26
    • 68049131195 scopus 로고    scopus 로고
    • MicroRNA-122a functions as a novel tumor suppressor downstream of adenomatous polyposis coli in gastrointestinal cancers
    • Wang X, Lam EK, Zhang J, et al. MicroRNA-122a functions as a novel tumor suppressor downstream of adenomatous polyposis coli in gastrointestinal cancers. Biochem Biophys Res Commun 2009; 387:376-380.
    • (2009) Biochem Biophys Res Commun , vol.387 , pp. 376-380
    • Wang, X.1    Lam, E.K.2    Zhang, J.3
  • 27
    • 38749089854 scopus 로고    scopus 로고
    • MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma
    • Schetter AJ, Leung SY, Sohn JJ, et al. MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma. JAMA 2008; 299:425-436.
    • (2008) JAMA , vol.299 , pp. 425-436
    • Schetter, A.J.1    Leung, S.Y.2    Sohn, J.J.3
  • 28
    • 67650720365 scopus 로고    scopus 로고
    • Differential expression of microRNA 181b and microRNA 21 in hyperplastic polyps and sessile serrated adenomas of the colon
    • Schmitz KJ, Hey S, Schinwald A, et al. Differential expression of microRNA 181b and microRNA 21 in hyperplastic polyps and sessile serrated adenomas of the colon. Virchows Arch 2009; 455:49-54.
    • (2009) Virchows Arch , vol.455 , pp. 49-54
    • Schmitz, K.J.1    Hey, S.2    Schinwald, A.3
  • 29
    • 67449156113 scopus 로고    scopus 로고
    • Locked nucleic acid in situ hybridization analysis of miR-21 expression during colorectal cancer development
    • Yamamichi N, Shimomura R, Inada K, et al. Locked nucleic acid in situ hybridization analysis of miR-21 expression during colorectal cancer development. Clin Cancer Res 2009; 15:4009-4016.
    • (2009) Clin Cancer Res , vol.15 , pp. 4009-4016
    • Yamamichi, N.1    Shimomura, R.2    Inada, K.3
  • 30
    • 34247593034 scopus 로고    scopus 로고
    • Impaired microRNA processing enhances cellular transformation and tumorigenesis
    • Kumar MS, Lu J, Mercer KL, et al. Impaired microRNA processing enhances cellular transformation and tumorigenesis. Nat Genet 2007; 39:673-677.
    • (2007) Nat Genet , vol.39 , pp. 673-677
    • Kumar, M.S.1    Lu, J.2    Mercer, K.L.3
  • 31
    • 61349141809 scopus 로고    scopus 로고
    • Clinicopathological significance of micro- RNA-31,-143 and -145 expression in colorectal cancer
    • Wang CJ, Zhou ZG, Wang L, et al. Clinicopathological significance of micro- RNA-31, -143 and -145 expression in colorectal cancer. Dis Markers 2009; 26:27-34.
    • (2009) Dis Markers , vol.26 , pp. 27-34
    • Wang, C.J.1    Zhou, Z.G.2    Wang, L.3
  • 32
    • 51049119231 scopus 로고    scopus 로고
    • Diagnostic and prognostic microRNAs in stage II colon cancer
    • Schepeler T, Reinert JT, Ostenfeld MS, et al. Diagnostic and prognostic microRNAs in stage II colon cancer. Cancer Res 2008; 68:6416-6424.
    • (2008) Cancer Res , vol.68 , pp. 6416-6424
    • Schepeler, T.1    Reinert, J.T.2    Ostenfeld, M.S.3
  • 33
    • 67649373019 scopus 로고    scopus 로고
    • Mechanism of growth inhibition by microRNA 145: The role of the IGF-I receptor signaling pathway
    • La RG, Badin M, Shi B, et al. Mechanism of growth inhibition by microRNA 145: the role of the IGF-I receptor signaling pathway. J Cell Physiol 2009; 220:485-491.
    • (2009) J Cell Physiol , vol.220 , pp. 485-491
    • La, R.G.1    Badin, M.2    Shi, B.3
  • 34
    • 62249137047 scopus 로고    scopus 로고
    • Role of miR-143 targeting KRAS in colorectal tumorigenesis
    • Chen X, Guo X, Zhang H, et al. Role of miR-143 targeting KRAS in colorectal tumorigenesis. Oncogene 2009; 28:1385-1392.
    • (2009) Oncogene , vol.28 , pp. 1385-1392
    • Chen, X.1    Guo, X.2    Zhang, H.3
  • 35
    • 67749143728 scopus 로고    scopus 로고
    • Modulation of microRNA processing by p53
    • Suzuki HI, Yamagata K, Sugimoto K, et al. Modulation of microRNA processing by p53. Nature 2009; 460:529-533.
    • (2009) Nature , vol.460 , pp. 529-533
    • Suzuki, H.I.1    Yamagata, K.2    Sugimoto, K.3
  • 36
    • 70350731129 scopus 로고    scopus 로고
    • Epigenetic regulation of microRNA expression in colorectal cancer
    • Epub ahead of print
    • Bandres E, Agirre X, Bitarte N, et al. Epigenetic regulation of microRNA expression in colorectal cancer. Int J Cancer 2009 [Epub ahead of print].
    • (2009) Int J Cancer
    • Bandres, E.1    Agirre, X.2    Bitarte, N.3
  • 37
    • 49249121155 scopus 로고    scopus 로고
    • Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer
    • Toyota M, Suzuki H, Sasaki Y, et al. Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer. Cancer Res 2008; 68:4123-4132.
    • (2008) Cancer Res , vol.68 , pp. 4123-4132
    • Toyota, M.1    Suzuki, H.2    Sasaki, Y.3
  • 38
    • 33747628074 scopus 로고    scopus 로고
    • Identification by real-time PCR of 13 mature microRNAs differentially expressed in colorectal cancer and nontumoral tissues
    • Bandres E, Cubedo E, Agirre X, et al. Identification by real-time PCR of 13 mature microRNAs differentially expressed in colorectal cancer and nontumoral tissues. Mol Cancer 2006; 5:29.
    • (2006) Mol Cancer , vol.5 , pp. 29
    • Bandres, E.1    Cubedo, E.2    Agirre, X.3
  • 39
    • 34249822779 scopus 로고    scopus 로고
    • Transcriptional activation of miR-34a contributes to p53-mediated apoptosis
    • Raver-Shapira N, Marciano E, Meiri E, et al. Transcriptional activation of miR-34a contributes to p53-mediated apoptosis. Mol Cell 2007; 26:731-743.
    • (2007) Mol Cell , vol.26 , pp. 731-743
    • Raver-Shapira, N.1    Marciano, E.2    Meiri, E.3
  • 40
    • 35649020283 scopus 로고    scopus 로고
    • MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B
    • Fabbri M, Garzon R, Cimmino A, et al. MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proc Natl Acad Sci U S A 2007; 104:15805-15810.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 15805-15810
    • Fabbri, M.1    Garzon, R.2    Cimmino, A.3
  • 41
    • 64049086575 scopus 로고    scopus 로고
    • MiR-101 downregulation is involved in cyclooxygenase-2 overexpression in human colon cancer cells
    • Strillacci A, Griffoni C, Sansone P, et al. MiR-101 downregulation is involved in cyclooxygenase-2 overexpression in human colon cancer cells. Exp Cell Res 2009; 315:1439-1447.
    • (2009) Exp Cell Res , vol.315 , pp. 1439-1447
    • Strillacci, A.1    Griffoni, C.2    Sansone, P.3
  • 42
    • 68749097208 scopus 로고    scopus 로고
    • MicroRNA-143 targets DNA methyltransferases 3A in colorectal cancer
    • Ng EK, Tsang WP, Ng SS, et al. MicroRNA-143 targets DNA methyltransferases 3A in colorectal cancer. Br J Cancer 2009; 101:699-706.
    • (2009) Br J Cancer , vol.101 , pp. 699-706
    • Ng, E.K.1    Tsang, W.P.2    Ng, S.S.3
  • 43
    • 0037099602 scopus 로고    scopus 로고
    • A hereditary nonpolyposis colorectal carcinoma case associated with hypermethylation of the MLH1 gene in normal tissue and loss of heterozygosity of the unmethylated allele in the resulting microsatellite instability-high tumor
    • Gazzoli I, Loda M, Garber J, et al. A hereditary nonpolyposis colorectal carcinoma case associated with hypermethylation of the MLH1 gene in normal tissue and loss of heterozygosity of the unmethylated allele in the resulting microsatellite instability-high tumor. Cancer Res 2002; 62:3925-3928.
    • (2002) Cancer Res , vol.62 , pp. 3925-3928
    • Gazzoli, I.1    Loda, M.2    Garber, J.3
  • 44
    • 2442424419 scopus 로고    scopus 로고
    • Germline epimutation of MLH1 in individuals with multiple cancers
    • Suter CM, Martin DI, Ward RL. Germline epimutation of MLH1 in individuals with multiple cancers. Nat Genet 2004; 36:497-501.
    • (2004) Nat Genet , vol.36 , pp. 497-501
    • Suter, C.M.1    Martin, D.I.2    Ward, R.L.3
  • 45
    • 33846973361 scopus 로고    scopus 로고
    • Inheritance of a cancerassociated MLH1 germ-line epimutation
    • Hitchins MP, Wong JJ, Suthers G, et al. Inheritance of a cancerassociated MLH1 germ-line epimutation. N Engl J Med 2007; 356:697-705.
    • (2007) N Engl J Med , vol.356 , pp. 697-705
    • Hitchins, M.P.1    Wong, J.J.2    Suthers, G.3
  • 46
    • 45749135888 scopus 로고    scopus 로고
    • Further evidence for heritability of an epimutation in one of 12 cases with MLH1 promoter methylation in blood cells clinically displaying HNPCC
    • Morak M, Schackert HK, Rahner N, et al. Further evidence for heritability of an epimutation in one of 12 cases with MLH1 promoter methylation in blood cells clinically displaying HNPCC. Eur J Hum Genet 2008; 16:804-811.
    • (2008) Eur J Hum Genet , vol.16 , pp. 804-811
    • Morak, M.1    Schackert, H.K.2    Rahner, N.3
  • 47
    • 33749122904 scopus 로고    scopus 로고
    • Heritable germline epimutation of MSH2 in a family with hereditary nonpolyposis colorectal cancer
    • Chan TL, Yuen ST, Kong CK, et al. Heritable germline epimutation of MSH2 in a family with hereditary nonpolyposis colorectal cancer. Nat Genet 2006; 38:1178-1183.
    • (2006) Nat Genet , vol.38 , pp. 1178-1183
    • Chan, T.L.1    Yuen, S.T.2    Kong, C.K.3
  • 48
    • 58149144567 scopus 로고    scopus 로고
    • Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 30 exons of TACSTD1
    • Ligtenberg MJ, Kuiper RP, Chan TL, et al. Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 30 exons of TACSTD1. Nat Genet 2009; 41:112-117.
    • (2009) Nat Genet , vol.41 , pp. 112-117
    • Ligtenberg, M.J.1    Kuiper, R.P.2    Chan, T.L.3
  • 49
    • 67650383819 scopus 로고    scopus 로고
    • Germline hypermethylation of MLH1 and EPCAM deletions are a frequent cause of Lynch syndrome
    • Niessen RC, Hofstra RM, Westers H, et al. Germline hypermethylation of MLH1 and EPCAM deletions are a frequent cause of Lynch syndrome. Genes Chromosomes Cancer 2009; 48:737-744.
    • (2009) Genes Chromosomes Cancer , vol.48 , pp. 737-744
    • Niessen, R.C.1    Hofstra, R.M.2    Westers, H.3
  • 50
    • 64249108224 scopus 로고    scopus 로고
    • Large genomic rearrangements and germline epimutations in Lynch syndrome
    • Gylling A, Ridanpaa M, Vierimaa O, et al. Large genomic rearrangements and germline epimutations in Lynch syndrome. Int J Cancer 2009; 124:2333-2340.
    • (2009) Int J Cancer , vol.124 , pp. 2333-2340
    • Gylling, A.1    Ridanpaa, M.2    Vierimaa, O.3
  • 51
    • 59749085710 scopus 로고    scopus 로고
    • Deletions removing the last exon of TACSTD1 constitute a distinct class of mutations predisposing to Lynch syndrome
    • Kovacs ME, Papp J, Szentirmay Z, et al. Deletions removing the last exon of TACSTD1 constitute a distinct class of mutations predisposing to Lynch syndrome. Hum Mutat 2009; 30:197-203.
    • (2009) Hum Mutat , vol.30 , pp. 197-203
    • Kovacs, M.E.1    Papp, J.2    Szentirmay, Z.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.