An intronic polymorphism of IRF4 gene influences gene transcription in vitro and shows a risk association with childhood acute lymphoblastic leukemia in males

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1802, Issue 2, 2010, Pages 292-300

  Do, Thuy N ^a   Ucisik Akkaya, Esma ^a   Davis, Charronne F ^a   Morrison, Brittany A ^a   Dorak, M Tevfik ^a  

^a HUMIGEN LLC   (United States)

Author keywords

Genetic Predisposition to Disease; Interferon Regulatory Factor 4; Luciferase Reporter Assay; Lymphoblastic Leukemia, Acute, Childhood; Polymorphism, Single Nucleotide; Sex Effect

Indexed keywords

CYTOSINE; DNA BINDING PROTEIN; ESTROGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR 4; THYMINE; TRANSCRIPTION FACTOR REL;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ALLELE; AMINO ACID SUBSTITUTION; ARTICLE; B LYMPHOCYTE DIFFERENTIATION; CARCINOGENESIS; CELL LINE; CHILD; CHILDHOOD LEUKEMIA; CONTROLLED STUDY; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE LINKAGE DISEQUILIBRIUM; GENE OVEREXPRESSION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; HOMOZYGOSITY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOSURVEILLANCE; IN VITRO STUDY; INTRON; LEUKEMOGENESIS; LYMPHOCYTE DIFFERENTIATION; MAJOR CLINICAL STUDY; MALE; NEWBORN; PRESCHOOL CHILD; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FAMILY; SCHOOL CHILD; SEX DIFFERENCE; T LYMPHOCYTE; UNITED KINGDOM; WILD TYPE;

3' UNTRANSLATED REGIONS; B-LYMPHOCYTES; CELL DIFFERENTIATION; CHILD; EXONS; FEMALE; HLA-DR ANTIGENS; HUMANS; INFANT, NEWBORN; INTERFERON REGULATORY FACTORS; INTRONS; MALE; MUTAGENESIS, SITE-DIRECTED; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROMOTER REGIONS, GENETIC; REFERENCE VALUES; T-LYMPHOCYTES; TRANSCRIPTION, GENETIC; WALES;

EID: 74149093117     PISSN: 09254439     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbadis.2009.10.015     Document Type: Article

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